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dc.contributor.authorSilva, Michel Alves da
dc.date.accessioned2023-12-21T18:57:53Z-
dc.date.available2023-12-21T18:57:53Z-
dc.date.issued2018-03-23
dc.identifier.citationSILVA, Michel Alves da. Aspectos clínicos epidemiológicos das neoplasias da cavidade oral de caninos e avaliação de diferentes protocolos no tratamento do melanoma oral. 2018. 95 f. Tese (Doutorado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2018.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/10135-
dc.description.abstractOs objetivos deste estudo foram apresentar os aspectos epidemiológicos clínicos de cães tratados com neoplasias na cavidade bucal no setor de oncologia do Hospital Veterinário da Universidade Federal Rural do Rio de Janeiro entre os anos de 2011 e 2017 por meio de um estudo retrospectiv estudo de todos os prontuários e avaliação multicêntrica de diversos tratamentos em que foram submetidos 63 cães com diagnóstico de melanoma na cavidade bucal entre 2012 e 2016, analisando as informações obtidas por idade, raça, sexo, tamanho do tumor, estadiamento do tumor, evolução clínica, estabelecer um protocolo terapêutico mais apropriado para o tratamento dessa neoplasia. As neoplasias que afetam a cavidade bucal dos cães são bastante heterogêneas. Aqueles que apresentam características de malignidade apresentam prognóstico desfavorável para a biologia do tumor e a dificuldade de estabelecer margem cirúrgica de segurança sem perda de função e / ou resultado estético aceitável pelos proprietários dos animais. Dados epidemiológicos são importantes para estabelecer um perfil da população afetada e estabelecer uma estratégia de tratamento precoce para cães que se enquadram na faixa de risco, buscando a cura ou proporcionando qualidade de vida quando o prognóstico é reservado. O melanoma na cavidade bucal é uma neoplasia extremamente agressiva, objeto de estudos em vários países, e ainda não estabeleceu protocolo de tratamento. O cão serve como modelo animal espontâneo desse neoplasma em humanos. Os dados epidemiológicos extraídos dos arquivos mostraram que dos 2832 casos de neoplasias tratadas no setor oncológico em um período de 7 anos (2011 a 2017), as neoplasias da cavidade bucal acometeram 176 animais (6,21%). Cães sem raça definida foram os mais afetados, a mediana de idade foi de 10 anos, o principal local acometido foi a maxila e o melanoma foi a neoplasia mais prevalente. No estudo multicêntrico de cães submetidos a diferentes terapias no tratamento do melanoma da cavidade bucal, observamos que durante a evolução da doença, os animais que apresentaram remissão completa apresentaram aumento da sobrevida em relação às demais evoluções clínicas. Animais que tinham margem cirúrgica livre sobreviveram mais tempo que aqueles que não obtiveram a margem livre da neoplasia. O presente estudo demonstrou que, no tratamento utilizado para combater o melanoma na cavidade bucal em cães, a quimioterapia com carboplatina, ao fazer parte do protocolo, aumentou a sobrevida dos pacientes quando comparados àqueles que não utilizavam o quimioterápico.por
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectMelanoma oralpor
dc.subjectCãespor
dc.subjectTerapia multimodalpor
dc.subjectOral melanomaeng
dc.subjectdogseng
dc.subjectmultimodal therapyeng
dc.titleAspectos clínicos epidemiológicos das neoplasias da cavidade oral de caninos e avaliação de diferentes protocolos no tratamento do melanoma oralpor
dc.title.alternativeEpidemiological clinical aspects of canine oral cavity neoplasms and evaluation of different protocols in the treatment of oral melanomaeng
dc.typeTesepor
dc.description.abstractOtherThe objectives of this study were to present the clinical epidemiological aspects of dogs treated with neoplasias in the oral cavity in the oncology sector of the Veterinary Hospital of the Federal Rural University of Rio de Janeiro between the years of 2011 and 2017 by means of a retrospective study of all medical records and a multicenter evaluation of several treatments in which 63 dogs diagnosed with melanoma in the oral cavity between 2012 and 2016 were submitted, analyzing the information obtained as age, race, sex, tumor size, tumor staging, clinical evolution, to establish a therapeutic protocol that is more appropriate for the treatment of this neoplasia. The neoplasias that affect the oral cavity of the dogs are quite heterogeneous. Those that have characteristics of malignancy have the unfavorable prognosis for tumor biology and the difficulty of establishing surgical margin of safety without loss of function and / or cosmetic result acceptable to the owners of the animals. Epidemiological data are important to establish a profile of the affected population and establish an early treatment strategy for dogs that fall within the risk range, seeking cure or providing quality of life when the prognosis is reserved. Melanoma in the oral cavity is an extremely aggressive neoplasm, object of studies in several countries, and has not yet established treatment protocol. The dog serves as the spontaneous animal model of this neoplasm in humans. The epidemiological data extracted from the archives showed that of the 2832 cases of neoplasms treated in the oncology sector in a period of 7 years (2011 to 2017), neoplasias of the oral cavity affected 176 animals (6.21%). Dogs with no defined breed were the most affected, mean age was 10 years, the main site affected was the maxilla and melanoma was the most prevalent neoplasia. In the multicentric study of dogs submitted to different therapies in the treatment of melanoma of the oral cavity, we observed that during the evolution of the disease, the animals that presented complete remission had an increase in survival compared to the other clinical evolutions. Animals that had a free surgical margin survived longer than those who did not obtain the free margin of the neoplasia. The present study demonstrated that in the treatment used to combat melanoma in the oral cavity in dogs, chemotherapy with carboplatin when being part of the protocol, increased the survival of the patients when compared with those who did not use the chemotherapeutic.eng
dc.contributor.advisor1Fernandes, Julio Israel
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/9221592908532393por
dc.contributor.referee1Fernandes, Julio Israel
dc.contributor.referee2Cirne, Lilian Cristina de Souza Oliveira Batista
dc.contributor.referee3Dutra, Ary Elias Aboud
dc.contributor.referee4Silva, Marta Fernanda Albuquerque da
dc.contributor.referee5Paiva, Jonimar Pereira
dc.creator.IDCPF: 080.545.357-16por
dc.creator.Latteshttp://lattes.cnpq.br/7104337583202748por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)por
dc.relation.referencesAMORY, J.T.; REETZ, J.A.; SÁNCHEZ, M.D.; BRADLEY, C.W.; LEWIS, J.R.; REITER A.M.; MAI, W. Computed tomographic characteristics of odontogenic neoplasms in dogs. Veterinary radiology & ultrasound, v. 55, n. 2, p. 147–158, 2014. AQUINO, J. U.; PINHEIRO, L. G. P.; VASQUES, P. H. D.; ROCHA, J. I. X.; CRUZ, D. A.; BESERRA, H. E. O.; CAVALCANTE, R. V. Modelo canino experimental para a pesquisa do linfonodo sentinela na vulva usando tecnécio e azul patente. Acta Cirurgica Brasileira, v.27, n. 2, p. 102-108, 2012. ARMBRUST, L. J.; BILLER, D, S,; BAMFORD, A.; CHUN, R.; GARRET, L. D.; SANDERSON, M. W. Comparison of three-view thoracic radiography and computed tomography for detection of pulmonary nodules in dogs with neoplasia. Journal of the American Veterinary Medical Association, v. 240, n. 9, p. 1088–1094, maio 2012. ARZI, B.; VERSTRAETE, F. J. M. Mandibular Rim Excision in Seven Dogs. Veterinary Surgery, v. 39, n. 2, p. 226–231, fev. 2010. ATHERTON, M. J.; MORRIS, J. S.; MCDERMOTT, M. R.; LICHTY, B. D. Cancer immunology and canine malignant melanoma: A comparative review. Veterinary Immunology and Immunopathology, v. 169, p. 15–26, jan. 2016. BABA, A. I.; CÂTOI, C. Tumors of the alimentary system. In: BABA, A. I.; CÂTOI, C. (Ed.). Comparative oncology. Bucharest: The Publishing House of the Romanian Academy, p. 1–787. 2007. BARTON, A. Handbook for good clinical research practice (GCP): guidance for implementation. Journal of Epidemiology & Community Health, v. 61, n. 6, p. 559–559, 1 jun. 2007. BARTTELBORT, S. W.; BAHN, S. L.; ARIYAN, S. Rim mandibulectomy for cancer of the oral cavity. The American Journal of Surgery, v. 154, n. 4, p. 423–428, out. 1987. BATEMAN, K. E.; CATTON, P. A.; PENNOCK, P. W.; KRUTH, S. A. Therapy for the palliation of advanced cancer in dogs. Journal of Veterinary Internal Medicine v.8; p. 394- 399. 1994. BASUKI, W.; WILSON, G. J.; DENNIS, M. Peripheral odontogenic fibroma and canine acanthomatous ameloblastoma: a review of nomenclature, diagnostic evaluation and case management. Australian Veterinary Practitioner, v. 43, n. 4, p. 534–539, 2013. BECK, E. R.; WITHROW, S. J. Canine tongue tumours: a retrospective review of 57 cases. Journal American Animal Hospital Association; v.22; n.4; p.525-532. 1986. BERG, J. Principles of oncologic orofacial surgery. Clinical Techniques in Small Animal Practice, v. 13, n. 1, p. 38–41, fev. 1998. 65 BERGMAN, P. J. Canine Oral Melanoma. Clinical Techniques in Small Animal Practice, v. 22, n. 2, p. 55–60, maio 2007. BERGMAN, P. J.; CAMPS-PALAU, M. A.; MCKNIGHT, J. A.; LEIBMAN, N. F.; CRAFT, D. M.; LEUNG, C.; LIAO, J.; RIVIERE, I.; SADELAIN, M.; HOHENHAUS, A. E.; GREGOR, P.; HOUGHTON, A. N.; PERALES, M. A.; WOLCHOK, J. D. Development of a xenogeneic DNA vaccine program for canine malignant melanoma at the Animal Medical Center. Vaccine, v. 24, n. 21, p. 4582–4585, 2006. BERGMAN, P. J.; MCKNIGHT, J.; NOVOSAD, A.; CHARNEY, S.; FARRELLY, J.; CRAFT, D.; WULDERK, M.; JEFFERS, Y.; SADELAIN, M.; HOHENHAUS, A. E.; SEGAL, N.; GREGOR, P.; ENGELHORN, M.; RIVIERE, I.; HOUGHTON, A. N.; WOLCHOK, J. D. Long-Term Survival of Dogs with Advanced Malignant Melanoma after DNA Vaccination with Xenogeneic Human Tyrosinase: A Phase I Trial. Clinical Cancer Research; v.9; n.4; p.1284-1290. 2003. BERTONE, E. R. Environmental Tobacco smoke and risk of malignant lymphoma in pet cats. American Journal of Epidemiology, v. 156, n. 3, p. 268–273, 2002. BERTONE, E. R.; SNYDER, L. A.; MOORE, A. S. Environmental and lifestyle risk factors for oral squamous cell carcinoma in domestic cats. Journal Veterinary Internal Medicine; v. 17; n. 4; p. 557-562. 2003. BLACKWOOD, L.; MURPHY, S.; BURACCO, P.; DE VOS, J. P.; DE FORNELTHIBAUD, P.; HIRSCHBERGER, J.; KESSLER, M.; PASTOR, J.; PONCE, F.; SAVARYBATAILLE, K.; ARGYLE, D. J. European consensus document on mast cell tumours in dogs and cats. Veterinary and Comparative Oncology, v. 10, n. 3, p. e1–e29, set. 2012. BLOOMFIELD, R. Stereotactic radiation therapy in veterinary medicine. The Canadian veterinary journal = La revue veterinaire canadienne, v. 56, n. 1, p. 95–7, jan. 2015. BLOT, W. J.; MCLAUGHLIN, J. K.; DEVESA, S. S; , FRAUMENI, J. F. Cancers of the oral cavity and pharynx. In: D. Schottenfeld and J. F. Fraumeni (Eds.) Cancer epidemiology and prevention. New York, Oxford University Press: p.666-680. 1996. BONFANTI, U.; BERTAZZOLO, W.; GRACIS, M.; ROCCABIANCA, P.; ROMANELLI, G.; PALERMO, G.; ZINI, E. Diagnostic value of cytological analysis of tumours and tumourlike lesions of the oral cavity in dogs and cats: A prospective study on 114 cases. The Veterinary Journal, v. 205, n. 2, p. 322–327, ago. 2015. BORIA, P. A.; MURRY, D. J.; BENNETT, P. F.; GLICKMAN, N. W.; SNYDER, P. W.; MERKEL, B. L.; SCHLITTLER, D. L.; MUTSAERS, A. J.; THOMAS, R. M.; ; KNAPP D. W.; Evaluation of cisplatin combined with piroxicam for the treatment of oral malignant melanoma and oral squamous cell carcinoma in dogs. Journal of the American Veterinary Medical Association, v. 224, n. 3, p. 388–394, fev. 2004. BORTHWICK, R.; ELSE, R. W.; HEAD, K. W. Neoplasia and allied conditions of the canine oropharynx. Veterinary Annals; v. 22, p. 248-269; 1982. 66 BOSTOCK, D. E. Classification and behaviour after surgery of canine “epulides.” Journal of Comparative Pathology, v. 97, p. 197–206, 1987. BOSTON, S. E.; LU, X.; CULP, W. T. N.; MONTINARO, V.; ROMANELLI, G.; DUDLEY, R. M.; LIPTAK, J. M.; MESTRINHO, L. A.; BURACCO P. Efficacy of systemic adjuvant therapies administered to dogs after excision of oral malignant melanomas: 151 cases (2001- 2012). Journal of the American Veterinary Medical Association, v. 245, n. 4, p. 401–407, 2014. BRACKER, K. E.; TROUT, N. J. Use of a free cortical ulnar autograft following en bloc resection of a mandibular tumor. Journal of the American Animal Hospital Association, v. 36, n. 1, p. 76–9, 2000. BRADLEY, R. L.; MACEWEN, E. G. Mandibular resection for removal of oral tumors in 30 dogs and six cats. Journal American Veterinary Medical Association; v.184; p. 460-463; 1984. BREGAZZI, V. S.; LARUE, S. M.; POWERS, B. E.; FETTMAN, M. J.; OGILVIE, G. K.; WITHROW, S. J. Response of feline oral squamous cell carcinoma to palliative radiation therapy. Veterinary Radiology Ultrasound; v.42; n.1; p. 77-79. 2001. BRENNAN, J. A., BOYLE, J. O., KOCH, W. M., GOODMAN, S. N., HRUBAN, R. H., EBY, Y. J., COUCH, M. J., FORASTIERE, A. A., SIDRANSKY, D. Association between cigarette smoking and mutation of the p53 gene in squamous-cell carcinoma of the head and neck. New England Journal Medicine; v.332; n.11; p. 712-717. 1995. BRISSOT, H. N.; EDERY, E. G. Use of indirect lymphography to identify sentinel lymph node in dogs: a pilot study in 30 tumours. Veterinary and Comparative Oncology, p. n/an/ a, fev. 2016. BRODEY, R. S. The use of naturally occurring cancer in domestic animals for research into human cancer: general considerations and a review of canine skeletal osteosarcoma. The Yale journal of biology and medicine, v. 52, n. 4, p. 345–61, 1979. BRØNDEN, L. B.; ERIKSEN, T.; KRISTENSEN, A. T. Oral malignant melanomas and other head and neck neoplasms in Danish dogs - data from the Danish Veterinary Cancer Registry. Acta Veterinaria Scandinavica, v. 51, n. 1, p. 54, 2009. BROCKLEY, L. K.; COOPER, M. A.; BENNETT, P. F. Malignant melanoma in 63 dogs (2001-2011): the effect of carboplatin chemotherapy on survival. New Zealand veterinary journal, v. 61, n. 1, p. 25–31, 2013. BROWN, J. S.; KALAVREZOS, N.; D’SOUZA, J.; LOWE, D.; MAGENNIS, P.; WOOLGAR, J. A. Factors that influence the method of mandibular resection in the management of oral squamous cell carcinoma. British Journal of Oral and Maxillofacial Surgery, v. 40, n. 4, p. 275–284, ago. 2002. BYRNE, C. M., THOMPSON, J. F., JOHNSTON, H. Treatment of metastatic melanoma using electroporation therapy with bleomycin (electrochemotherapy). Melanoma Research; v. 15; p. 45–51. 2005. 67 CADIEU, P. E.; DE BRITO, C.; GILLARD, M.; ABADIE, J.; VERGIER, B.; GUILLORY, A.; DEVAUCHELLE, P.; DEGORCE, F.; LAGOUTTE, L.; HÉDAN, B.; GALIBERT, M.; GALIBERT, F.; ANDRÉ, C. Analyse comparée des mélanomes chez le chien et l ’ homme. Bulletin de l’Academie Veterinaire de France, n. 2, p. 213–220, 2014. CAMARGO, L. P. DE; CONCEIÇÃO, L. G.; COSTA, P. R. D. S. Neoplasias melanocíticas cutâneas em cães: estudo retrospectivo de 68 casos (1996-2004). Brazilian journal veterinary research animal science, v. 45, n. 2, p. 138–152, 2008. CAMPOS, S. N.; MENEZES, R. S.; FERREIRA, A. M. R.; ALMEIDA, E. C. P. Estudo retrospectivo de neoplasias melanocíticas em cães e gatos. Congresso Medvep de Especialidades Veterinárias. Anais. 2010. CANCEDDA, S.; ROHRER, C.; BLEY; ARESU, L.; DACASTO, M.; LEONE, V. F.; PIZZONI, S.; GRACIS, M.; MARCONATO, L. Efficacy and side effects of radiation therapy in comparison with radiation therapy and temozolomide in the treatment of measurable canine malignant melanoma. Veterinary and Comparative Oncology, v. 14, n. 4, p. e146–e157, dez. 2016. CARPENTER, L. G., WITHROW, S. J., POWERS, B. E., OGILVIE, G. K. Squamous cell carcinoma of the tongue in 10 dogs. Journal of American Animal Hospital Association; v. 29; n. 1; p.17-24. 1993. CARVALHO, V. G. G. Cirurgia ortognática em cães: técnica intra-oral de osteotomia sagital da mandíbula para correção de prognatismo e retrognatismo. Estudo em cadáveres. [s.l.] Universidade de São Paulo, 2008. CATCHPOLE, B.; STELL, A. J.; DOBSON, J. M. Generation of Blood-derived Dendritic Cells in Dogs with Oral Malignant Melanoma. Journal of Comparative Pathology, v. 126, n. 2–3, p. 238–241, fev. 2002. CATCHPOLE, B.; GOULD, S. M.; KELLETT-GREGORY, L. M.; DOBSON, J. M. Development of a multiple-marker polymerase chain reaction assay for detection of metastatic melanoma in lymph node aspirates of dogs. American Journal of Veterinary Research, v. 64, n. 5, p. 544–549, 2003. CEMAZAR, M.; TAMZALI, Y.; SERSA, G.; TOZON, N.; MIR, L. M.; MIKLAVCIC, D.; LOWE, R.; TEISSIE, J. Electrochemotherapy in Veterinary Oncology. Journal of Veterinary Internal Medicine, v. 22, n. 4, p. 826–831, jul. 2008. CHAMBERLAIN, T. P.; LOMMER, M. J. Clinical behavior of odontogenic tumors. In: ARZI, B.; VERSTRAETE, F. J. M. (Ed.). Oral and maxillofacial surgery in dogs and cats. First ed. Pennsylvania: Elsevier Ltd, p. 403–410. 2012. CHATURVEDI, P. K.; BHUI, K.; SHUKLA, Y. Lupeol: Connotations for chemoprevention. Cancer Letters, v. 263, n. 1, p. 1–13, maio 2008. CHÉNIER, S.; DORÉ, M. Oral malignant melanoma with osteoid formation in a dog. Veterinary Pathology, v. 36, n. 1, p. 74–76,1999. 68 CHOISUNIRACHON, N.; JAROENSONG, T.; YOSHIDA, K.; SAEKI, K.; . MOCHIZUKI, M.; NISHIMURA, R.; SASAKI, N.; NAKAGAWA, T. Effects of low-dose cyclophosphamide with piroxicam on tumour neovascularization in a canine oral malignant melanoma-xenografted mouse model. Veterinary and Comparative Oncology, v. 13, n. 4, p. 424–432, dez. 2015. CIEKOT, P. A., POWERS, B. E., WITHROW, S. J., STRAW, R. C., OGILVIE, G. K., LARUE, S. M. Histologically low-grade, yet biologically high-grade, fibrosarcomas of the mandible and maxilla in dogs: 25 cases (1982-1991). Journal of American Veterinary Medical Association; v. 204, n. 4, p. 610-615. 1994. COHEN D., BRODEY, R.S., CHEN, S. M. “Epidemiologic aspects of oral and pharyngeal neoplasms of the dog.” American Journal Veterinary Research; v.25; p. 1776-1779. 1964 COOPER, S. M.; DAWBER, R. P. R. The history of cryosurgery. Journal of Royal Society of Medicine, v. 94, n.4, p. 196-201, 2001. COUTURE, C.; RAYBAUD-DIOGENE, H.; TETU, B.; BAIRATI, I.; MURRY, D.; ALLARD, J.; FORTIN, A. p53 and Ki-67 as markers of radioresistance in head and neck carcinoma. Cancer; v. 94, n. 3, p. 713-22. 2002. COSTA-CASAGRANDE, T. A. Avaliação de indicadores de prognóstico para mastocitoma canino : estereológico e de expressão gênica. [s.l.] Universidade de São paulo, 2010. COYLE, V. J.; GARRETT, L. D. Finding and treating oral melanoma, squamous cell carcinoma, and fibrosarcoma in dogs. Veterinary Medicine, v. 104, n. 6, p. 292–305, 2009. CULP, W. T. N.; EHRHART, N.; WITHROW, S. J.; REBHUN, R. B.; BOSTON, S.; BURACCO, P.; REITER, A. M.; SCHALLBERGER, S. P.; ALDRIDGE, C. F.; KENT, M. S.; MAYHEW, P. D. Results of surgical excision and evaluation of factors associated with survival time in dogs with lingual neoplasia: 97 cases (1995-2008). Journal of the American Veterinary Medical Association, v. 242, n. 10, p. 1392–1397, 2013. DAMY, S. B.; CAMARGO, R. S.; CHAMMAS, R.; DE FIGUEIREDO, L. F. P. Aspectos fundamentais da experimentação animal - aplicações em cirurgia experimental. Revista da Associação Médica Brasileira, v. 56, n. 1, p. 103–111, 2010. DANK, G.; RASSNICK, K. M.; SOKOLOVSKY, Y.; GARRETT, L. D.; POST, G. S.; KITCHELL, B. E.; SELLON, R. K.; KLEITER, M.; NORTHRUP, N.; SEGEV, G. Use of adjuvant carboplatin for treatment of dogs with oral malignant melanoma following surgical excision. Veterinary and Comparative Oncology, v. 12, n. 1, p. 78–84, mar. 2014. DASARI S.; TCHOUNWOU P. B. Cisplatin in cancert therapy: molecular mechanisms of action. European Journal Pharmacology. v.5, p. 364 – 378. 2014. DE AGUIAR, A. F.; KOWALSKI, JR., L. P.; DE ALMEIDA, O. P. (2007). Clinicopathological and immunohistochemical evaluation of oral squamous cell carcinoma in patients with early local recurrence. Oral Oncology. v.43, n. 6, p. 593-601. 2007. 69 DE ALMEIDA, E. M. P.; PICHE, C.; SIROIS, J.; DORE, M. Expression of cyclo-oxygenase- 2 in naturally occurring squamous cell carcinomas in dogs. The Journal of Histochemistry and Cytochemistry, v. 49, n. 7, p. 867–875, 2001. DE MATOS, A. J.; LOPES, C. C.; FAUSTINO, A. M.; CARVALHEIRA, J. G.; DOS SANTOS, M. S.; RUTTEMAN, G. R.; GARTNER M. D. E. F. MIB-1 labelling indices according to clinico-pathological variables in canine mammary tumours: a multivariate study. Anticancer Research; v. 26, n. 3A, p. 1821-1826. 2006. DENNIS, M.; EHRHART, N.; DUNCAN.; C, BARNES.; A, EHRHART, E Frequency of and risk factors associated with lingual lesions in dogs: 1196 cases (1995-2004). Journal of the American Veterinary Medical Association, v. 228, n. 10, p. 1533–1537, 2006. DERVISIS, N. G. Introduction of veterinary oncology and diagnostic approach to the cancer patient. Proceedings, The 15th Congress of FAVA, 27-30 October, Bangkok, Thailand p.71- 74. 2008. DHALIWALL, R. S.; KITCHELL, B. E.; MARRETA, S. M. Oral tumors in dogs and cats. Part I. Diagnosis and clinical signs The Compendium Continuum Education Practice Veterinary. v. 20, n. 9, p. 1001-1024. 1998. DIBERNARDI, L.; DORE, M.; DAVIS, J. A.; OWENS, J. G.; MOHAMMED, S. I.;GUPTILL, C. F.; KNAPP, D. W. Study of feline oral squamous cell carcinoma: potential target for cyclooxygenase inhibitor treatment. Prostaglandins Leukotic Essential Fatty Acids. v. 76, n. 4, p. 245-50. 2007. DORN, C.; TAYLOR, D.; FLYE, F.; HIBBARD, H. Survey of animal neoplasms in Alameda and Contra Costa Counties, California. II. Cancer morbidity in dogs and cats from Alameda County. Journal of the National Cancer Institute, v. 40, n. 2, p. 307–318, fev. 1968. DORN, C. R.; PRIESTER, W. A. Epidemiologic analysis of oral and pharyngeal cancer in dogs, cats, horses, and cattle. Journal American Veterinary Medical Association; v. 169, n. 11, p. 1202-1206. 1976. DUBIELZIG, R. R.; THRALL, D. E. Ameloblastoma and Keratinizing Ameloblastoma in Dogs. Veterinary Pathology, v. 19, n. 6, p. 596–607, 1982. DUJARDIN, N.; STAES, E.; KALIA, Y.; CLARYS, P.; GUY, R.; PREAT, V. In vivo assessment of skin electroporation using square wave pulses. Journal Controlled Release. v. 79, v. 1, p. 219 – 227. 2002. DVORAK, L. D.; BEAVER, D. P.; ELLISON, G. W.; BELLAH, J. R.; MANN, F. A.; HENRY, C. J. Major glossectomy in dogs: a case series and proposed classification system. Journal of the American Animal Hospital Association, v. 40, n. 4, p. 331–7, 2004.. ELLIS, A. E.; HARMON, B. G.; MILLER, D. L.; NORTHUP, N. C.; LATIMER, K. S.; UHL, E. W. Gingival osteogenic melanoma in two dogs. Journal of veterinary diagnostic investigation, v. 22, n. 1, p. 147–151, 2010. 70 EMMS, S. G.; HARVEY, C. E. Preliminary results of maxillectomy in the dog and cat. Journal of Small Animal Practice, v. 27, n. 5, p. 291–306, maio 1986. ESPLIN, D. G. Survival of dogs following surgical excision of histologically welldifferentiated melanocytic neoplasms of the mucous membranes of the lips and oral cavity. Veterinary Pathology, v.45, n. 6, p. 889-96. 2008. STELL, G. G.; MCMILLAN, T. J.; PEACOCK, J. H. The 5Rs of radiobiology. Internacional Journal of Radiation Biology, v. 56, n. 6, p.1045-1048. 1989. EVANS, S. M.; SHOFER, F. Canine oral non-tonsillar squamous cell carcinoma. Prognostic factors for recurrence and survival following orthovoltage radiation therapy. Veterinary Radiology, v. 29, p. 133–137, 1988. EVERSOLE, L. R.; TOMICH, C. E.; CHERRICK, H. M. Histogenesis of odontogenic tumors. Oral surgery, oral medicine, and oral pathology, v. 32, n. 4, p. 569–81, 1971. FAN, S.; TANG, Q-L.; LIN, Y-J.; CHEN, W-L.; LI, J-S.; HUANG, Z-Q.; YANG, Z-H.; WANG, Y-Y.; ZHANG, D-M.; WANG, H-J.; DIAS-RIBEIRO, E.; CAI, Q.; WANG, L. A review of clinical and histological parameters associated with contralateral neck metastases in oral squamous cell carcinoma. International journal of oral science, v. 3, n. 4, p. 180–191, 2011. FARCAS, N.; ARZI, B.; VERSTRAETE, F. J. M. Oral and maxillofacial osteosarcoma in dogs: a review. Veterinary and Comparative Oncology, v. 12, n. 3, p. 169–180, set. 2014. FARRAR, M.; SANDISON, A.; PESTON, D.; GAILANI, M. Immunocytochemical analysis of AE1/AE3, CK 14, Ki-67 and p53 expression in benign, premalignant and malignant oral tissue to establish putative markers for progression of oral carcinoma. Brazilian Journal Biomedical Science, v. 61, n. 3, p. 117-24. 2004. FELIZZOLA, C. R.; STOPIGLIA, A. J.; DE ARAUJO, V. C.; DE ARAUJO, N. S. Evaluation of a modified hemimandibulectomy for treatment of oral neoplasms in dogs. Journal Veterinary Dentistry, v. 19; n. 3, p. 127-135. 2002. FELIZZOLA, C. R.; STOPIGLIA, A. J.; DE ARAÚJO, N. S. Oral Tumors in dogs. Clinical aspects, exfoliative cytology and histopathology. Ciência Rural, v. 29, n. 3, p. 499–506, 1999. FERRIS, D. G.; HO, J. J. Cryosurgery equipament: a critical review.The Journal of Family Practice, v. 35, n. 2, p. 185-193, 1992. FIANI, N.; VERSTRAETE, F. J. M.; KASS, P. H.; COX, D. P. Clinicopathologic characterization of odontogenic tumors and focal fibrous hyperplasia in dogs: 152 cases (1995-2005). Journal of the American Veterinary Medical Association, v.238, n.4, p.495- 500, 2011. FLICKINGER, I.; RÜTGEN, B. C.; GERNER, W.; CALICE, I.; TICHY, A.; SAALMÜLLER, A.; KLEITER, M. Radiation up-regulates the expression of VEGF in a canine oral melanoma cell line. Journal of Veterinary Science, v. 14, n. 2, p. 207, 2013. 71 FOX, L. E.; GEOGHEGAN, S. L.; DAVIS, L. H. Owner satisfaction with partial mandibulectomy or maxillectomy for treatment of oral tumors in 27 dogs. Journal American Animal Hospital Association; v. 33, n. 1, p. 25–31. 1997. FRANCESCHI, S.; LEVI, F.; CONTI, E.; TALAMINI, R.; NEGRI, E.; DAL MASO, L.; BOYLE, P.; DECARLI, A.; LA VECCHIA, C. Energy intake and dietary pattern in cancer of the oral cavity and pharynx. Cancer Causes Control, v.10, n. 5, p. 439-444. 1999. FULTON, A. J.; NEMEC, A.; MURPHY, M. G.; KASS, P. H.; VERSTRAETE, F. J. M. Risk factors associated with survival in dogs with nontonsillar oral squamous cell carcinoma 31 cases (1990–2010). Journal of the American Veterinary Medical Association, v. 243, n. 5, p. 696–702, set. 2013. GAO, Y. H.; YANG, L. J.; YAMAGUCHI, A. Immunohistochemical demonstration of bone morphogenetic protein in odontogenic tumors. Journal of Oral Pathology and Medicine, v. 26, n. 6, p. 273–277, 1997. GARDNER, D. G. Epulides in the dog: a review. Journal of Oral Pathology and Medicine, v. 25, n. 1, p. 32–37, 1996. GARDNER, D. G.; BAKER, D. C. The relationship of the canine acanthomatous epulis to ameloblastoma. Journal of Comparative Pathology, v. 108, n. 1, p. 47–55, 1993. GARDNER, H.; FIDEL, J.; HALDORSON, G.; DERNELL, W.; WHEELER, B. Canine oral fibrosarcomas: a retrospective analysis of 65 cases (1998-2010). Veterinary and Comparative Oncology, v. 13, n. 1, p. 40–47, mar. 2015. GAVER, R. C.; GEORGE, A. M.; DUNCAN G. F.; MORRIS, A. D.; DEEB, G.; FAULKNER, R. H.. The disposition of carboplatin in the beagle dog. Cancer Chemotherapy Pharmacology, v. 21, p. 197–202. 1988. GHIRELLI, C. D. O. Estudo radiográfico e por tomografia computadorizada das formações orais em cães. 2008. 121f. Dissertação (Mestrado em Ciências) - Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, São Paulo, 2008. GILLETTE, S. M.; GILLETTE E. L. Radiation therapy for head and neck cancers. Seminars in veterinary medicine and surgery (small animal), v. 10, n. 3, p. 168-72. 1995. GIUFFRIDA, M. A. Type II error and statistical power in reports of small animal clinical trials. Journal of the American Veterinary Medical Association, v. 244, n. 9, p. 1075–80, 1 maio 2014. GOLDSCHMIDT, M. H. Benign and malignant melanocytic neoplasms of domestic animals. American Journal Dermatopathology, v. 7 (Suppl), p. 203–212, 1985. GOLDSCHMIDT, M. H.; SHOFER, F. S. Skin tumors of the dog and cat. [s.l.] Pergamon Press, 1998. 72 GOMES, C.; DE OLIVEIRA, L. O.; ELIZEIRE, M. B.; OLIVEIRA, M. B.; DE OLIVEIRA, R. T.; CONTESINI, E. A. Avaliação epidemiológica de cães com neoplasias orais atendidos no hospital de clínicas veterinárias da Universidade Federal do Rio Grande do Sul. Ciência Animal Brasileira, v. 10, n. 3, p. 835–839, 2009. GORDON, I.; PAOLONI, M.; MAZCKO, C.; KHANNA, C. The comparative oncology trials consortium: Using spontaneously occurring cancers in dogs to inform the cancer drug development pathway. PLoS Medicine, v. 6, n. 10, p. 2–6, 2009. GORREL, C.; PENMAN, S.; EMILY, P. Handbook of Small Animal Oral Emergencies. [s.l.] Elsevier, 1993. GOTHELF, A.; MIR, L. M.; GEHL, J. Electrochemotherapy: results of cancer treatment using enhanced delivery of bleomycin by electroporation. Cancer Treatment Review. V.29; n.5; p. 371-387; 2003. GRABENBAUER, G. G.; MUHLFRIEDEL, C.; RODEL, F.; NIEDOBITEK, G.; HORNUNG, J.; RODEL, C.; MARTUS, P.; IRO, H.; KIRCHNER, T.; STEININGER, H.; SAUER, R.; WEIDENBECHER, M.; DISTEL, L. Squamous cell carcinoma of the oropharynx: Ki-67 and p53 can identify patients at high risk for local recurrence after surgery and postoperative radiotherapy. International Journal Radiation Oncololgy Biology Physics, v. 48, n. 4, p. 1041-1050. 2000. GRAF, R.; GRUNTZIG, K.; HASSIG, M.; AXHAUSEN, K. W.; FABRIKANT, S.; WELLE, M.; MEIER, D.; GUSCETTI, F.; FOLKERS, G.; OTTO, V.; POSPISCHIL, A. Swiss Feline Cancer Registry: A Retrospective Study of the Occurrence of Tumours in Cats in Switzerland from 1965 to 2008. Journal of Comparative Pathology, v. 153, n. 4, p. 266–277, nov. 2015. GREEN, K.; BOSTON, S. E. Bilateral removal of the mandibular and medial retropharyngeal lymph nodes through a single ventral midline incision for staging of head and neck cancers in dogs: a description of surgical technique. Veterinary and Comparative Oncology, p. n/an/ a, maio 2015. GRIER, C. K.; MAYER, M. N. Radiation therapy of canine nontonsillar squamous cell carcinoma. Canadian Veterinary Journal, v. 48, n. 11, p. 1189-1191. 2007. GRIMES, J. A.; MATZ, B. M.; CHRISTOPHERSON, P. W.; KOEHLER, J. W.; CAPPELLE, K. K.; HLUSKO, K. C.; SMITH, A. Agreement Between Cytology and Histopathology for Regional Lymph Node Metastasis in Dogs With Melanocytic Neoplasms. Veterinary Pathology, v.54, n.4, p.579-587. mar. 2017. GROSENBAUGH, D. A.; LEARD, A. T.; BERGMAN, P. J.; KLEIN, M. K.; MELEO, K.; SUSANECK, S.; HESS, P. R.; JANKOWSKI, M. K.; JONES, P. D.; LEIBMAN, N. F.; JOHNSON, M. H.; KURZMAN, I. D.; WOLCHOK, J. D. Safety and efficacy of a xenogeneic DNA vaccine encoding for human tyrosinase as adjunctive treatment for oral malignant melanoma in dogs following surgical excision of the primary tumor. American Journal of Veterinary Research, v. 72, n. 12, p. 1631–1638, 2011. 73 GROSS, T. L.; IHRKE, P. J.; WALDER, E. J.; AFFOLTER, V. K. Skin diseases of the dog and cat. Oxford, UK: Blackwell Science Ltd, p. 1–944. 2005. GUERRA, J. L.; DAGLI, M. L.; GODOY, L. F.; BIRMAN, E. G. A retrospective study of oral neoplasms in dogs:a survey from 1941 to 1986. Revista da Faculdade de Medicina Veterinaria e Zootecnia da Universidade de Sao Paulo, v. 26, n. 2, p. 207–212, 1989. GULBAHAR, M. Y.; OZAK, A.; KABAK, Y. B.; KARAYIGIT, M. O.; GACAR, A. Oral metastatic melanoma with neurosarcomatous transformation in a dog. Veterinary Journal of Ankara University, v. 63, p. 89–92, 2016. HAFIAN, H.; VENTEO, L.; SUKHANOVA, A.; NABIEV, I.; LEFEVRE, B.; PLUOT, M. Immunohistochemical study of DNA topoisomerase I, DNA topoisomerase II alpha, p53, and Ki-67 in oral preneoplastic lesions and oral squamous cell carcinomas. Humane Pathology, v. 35, n. 6, p. 745-751. 2004. HAHN, K. A.; De NICOLA, D. B.; RICHARDSON, R. C.; HAHN, E. A. Canine oral malignant melanoma: Prognostic utility of an alternative staging system. Journal of Small Animal Practice, v. 35, n. 5, p. 251–256, maio 1994. HAMMER, A. S.; WEEREN, F. R.; WEISBRODE, S. E.; PADGETT, S. L. Prognostic factors in dogs with osteosarcomas of the flat or irregular bones.Journal American Animal Hospital Association, v. 31, n. 4, p. 321-326. 1995. HANSEN K.; KHANNA C. Spontaneous and genetically engineered animal models; use in preclinical cancer drug development. European Journal Cancer, v. 40, n. 6, p. 858-880. 2004. HART, A. K. E.; KARAKLA, D. W.; PITMAN, K. T.; ADAMS, J. F. Oral and oropharyngeal squamous cell carcinoma in young adults: A report on 13 cases and review of the literature. Otolaryngology Head Neck Surgery, v. 120, n. 6, p. 828-833. 1999. HARVEY, C. E. Oral surgery. Radical resection of maxillary and mandibular lesions. Veterinary Clinics North America Small Animal Practice, v. 16, n. 5, p. 983 - 993. 1986. HAWAI, S. M.; AL-ZAYER, M.; ALI, M. M.; NIU, Y.; ALAWAD, A.; ALJOFAN, M.; ALJARBOU, A.; ALTUWAIJRI, S. Dogs: Active Role Model for Cancer Studies—A Review. Journal of Cancer Therapy, v. 4, n. 5, p. 989–995, 2013. HAYES, A. M.; ADAMS, V. J.; SCASE, T. J.; MURPHY, S. Survival of 54 cats with oral squamous cell carcinoma in United Kingdom general practice. Journal Small Animal Practice, v. 48, n. 7, p. 394-399. 2007. HEAD, K. W.; ELSE, R. W.; DUBIELZIG, R. R.. Tumors of the alimentary tract. In: D. J. Meuten (Ed.). Tumors in Domestic Animals. Ames, Iowa, Iowa State Press: P. 401- 425. 2002. HERRING, E. S.; SMITH, M. M.; ROBERTSON, J. L. Lymph node staging of oral and maxillofacial neoplasms in 31 dogs and cats. Journal Veterinary Dentistry, v. 19, n. 3, p. 122-126. 2002. 74 HEYMAN, S. J.; DIEFENDERFER, D. L.; GOLDSCHMIDT, M. H.; NEWTON, C. D. Canine axial skeletal osteosarcoma. A retrospective study of 116 cases (1986 to 1989). Veterinary Surgery, v.21, n. 4, p. 304-310. 1992. HILLMAN, L. A.; GARRETT, L. D.; DE LORIMIER, L-P.; CHARNEY, S. C.; BORST, L. B.; FAN, T. M. Biological behavior of oral and perioral mast cell tumors in dogs: 44 cases (1996-2006). Journal of the American Veterinary Medical Association, v. 237, n. 8, p. 936–942, 2010. HOFFMAN, S. L.; KRESSIN, D. J.; VERSTRAETE, F. J. M. Myths and misconceptions in veterinary dentistry. Journal of the American Veterinary Medical Association, v. 231, n. 12, p. 1818–1824, 15 dez. 2007. HOLMBERG, D. L.; FRIES, C.; COCKSHUTT, J.; VAN PELT, D. Ventral Rhinotomy in the Dog and Cat. Veterinary Surgery, v. 18, n. 6, p. 446–449. 1989. HOLMBERG, D. L. Sequelae of ventral rhinotomy in dogs and cats with inflammatory and neoplastic nasal pathology: a retrospective study. The Canadian veterinary journal = La revue veterinaire canadienne, v. 37, n. 8, p. 483–5, ago. 1996. HORSTING, N.; A. VON REISWITZ, WOHLSEIN, P.; BULLERDIEK, J.; REIMANN, N.; NOLTE, I. Oropharyngeal tumors of dogs-a clinical study of 79 cases. Berl Munch Tierarztl Wochenschr, v.111, n. 7-8, p. 242-247. 1998. HSAN, K. M.; CHEN, C. C.; SHYUR, L. F. Current research and development of chemotherapeutic agents for melanoma. Cancers, v. 2, n. 2, p. 397–419, 9 abr. 2010. HUNTER, T. Oncoprotein networks. Cell, v. 88, p. 333-346. 1997. IHAN HREN, N.; MILJAVEC, M. Spontaneous bone healing of the large bone defects in the mandible. International Journal of Oral and Maxillofacial Surgery, v. 37, n. 12, p. 1111– 1116, dez. 2008. IMPELLIZERI, J.; AURISICCHIO, L.; FORDE, P.; SODEN, D. M. Electroporation in veterinary oncology. The Veterinary Journal, v. 217, p. 18–25, nov. 2016. IUSSICH, S.; MANISCALCO, L.; DI SCIUVA, A.; IOTTI, B.; MORELLO, E.; MARTANO, M.; GATTINO, F.; BURACCO, P.; DE MARIA, R. PDGFRs expression in dogs affected by malignant oral melanomas: correlation with prognosis. Veterinary and Comparative Oncology, v.15, n.2, p.462-469.2017. JUNQUEIRA, L. C. U.; CARNEIRO, J. Histologia básica. 11 ed. Rio de Janeiro: Guanabara Koogan, p. 1–524. 2008. KAPLAN, E. L.; MEIER, P. Nonparametric Estimation from Incomplete Observations. Journal of the American Statistical Association, v. 53, n. 282, p. 457–481, jun. 1958. 75 KAWABE, M.; BABA, Y.; TAMAI, R.; YAMAMOTO, R.; KOMORI, M.MORI, T.; TAKENAKA, S. Profiling of plasma metabolites in canine oral melanoma using gas chromatography-mass spectrometry. Journal of Veterinary Medical Science, v. 77, n. 8, p. 1025–1028, 2015. KAWABE, M.; MORI, T.; ITO, Y.; MURAKAMI, M.; SAKAI, H.; YANAI, T.; MARUO, K. Outcomes of dogs undergoing radiotherapy for treatment of oral malignant melanoma: 111 cases (2006–2012). Journal of the American Veterinary Medical Association, v. 247, n. 10, p. 1146–1153, 15 nov. 2015. KESDANGSAKONWUT, S.; CHANKOW, K.; RUNGSIPIPAT, A. Disseminated oral melanoma with brain and gastrointestinal tract involvements in a cocker spaniel: A case report. Thai Journal of Veterinary Medicine, v. 45, n. 1, p. 141–145, 2015. KESSLER, M. Mandibulectomy and maxillectomy as a treatment for bone invasive oral neoplasia in the dog – a retrospective analysis of 31 patients. European Journal Companion Animal Practice, v. 16, n. 1, p. 74-82, 2006. KILLICK, D. R.; STELL, A. J.; CATCHPOLE, B. Immunotherapy for canine cancer - Is it time to go back to the future? Journal of Small Animal Practice, v. 56, n. 4, p. 229–241, abr. 2015. KIMURA, K. C.; GÁRATE, A.P.; DAGLI, M. L. Z. Retrospective study of Neoplasms in Domestic Animals: a Survey Between 1993 and 2002 of the Service of Animal Pathology, Department of Pathology, School of Veterinary Medicine and Animal Science, University of Sao Paulo, Southeast Brazil. Brazilian Journal of Veterinary Pathology, V. 5, n. 2, p. 60 – 69. 2012. KINZEL, S., HEIN, S., STOPINSKI, T., KOCH, J., BUECKER, A., TREUSACHER, H. P., SCHMACHTENBERG, A., JANSEN, T., EBLE, M., KUPPER, W. Hypofractionated radiation therapy for the treatment of malignant melanoma and squamous cell carcinoma in dogs and cats. Berl Munch Tierarztl Wochenschr, v.116, n. 3-4, p. 134-8, 2003. KIRPENSTEIJN, J.; WITHROW, S.J.; STRAW, R.C. Combined resection of the nasal planum and premaxilla in three dogs. Veterinary Surgery ; v.23, n.5, p.341–346. 1994 KIUPEL, M., TESKE, E., BOSTOCK, D. Prognostic factors for treated canine malignant lymphoma. Veterinary Pathology, v.36, n. 4, p. 292-300, 1999. KLAHN, S. Chemotherapy Safety in Clinical Veterinary Oncology. Veterinary Clinics of North America: Small Animal Practice, v. 44, n. 5, p. 941–963, set. 2014. KLEIN, M. K. Multimodality therapy for head and neck cancer. Veterinary Clinical North America Small Animal Practice, v. 33, n. 3, p. 615-28, 2003. KLOPFLEISCH, R.; KOHN, B.; GRUBER, A. D. Mechanisms of tumour resistance against chemotherapeutic agents in veterinary oncology. The Veterinary Journal, v. 207, p. 63–72, jan. 2016. 76 KODRE, V.; CEMAZAR, M.; PECAR, J.; SERSA, G.; COR, A.; TOZON, N. Electrochemotherapy compared to surgery for treatment of canine mast cell tumours. In vivo (Athens, Greece), v. 23, n. 1, p. 55–62, 2009. KOSOVSKY, J. K., MATTHIESEN, D. T.; MARRETTA, S. M.; PATNAIK, A. K. Results of partial mandibulect;my for the treatment of oral tumors in 142 dogs. Veterinary Surgery v. 20, n. 6, p. 397- 401. 1991. KUBOTA Y.; TOMITA Y.; TSUKIGI M. A. case of perineal malignant melanoma successfully treated with electrochemotherapy. Melanoma Research. v. 15, p. 133–134, 2005. KUFLIK, E. G. Cryosurgery updated. Journal of American Academy of Dermatology, v. 31, n. 6, p. 925-944, 1994. KW, H. Tumors of the upper alimentary tract. Bulletin World Health Organization, v. 53, p. 145–167, 1976. LANG, J.; WORTMAN, J. A.; GLICKMAN, L. T.; BIERY, D. N.; RHODES, H. W. Sensitivity of radiographic detection of lung metastases in the dog. Veterinary Radiology, v. 27, n. 3, p. 74–78, maio 1986. LARUE, S. M.; GILLETTE E. L. Radiation therapy. In: S. J. Withrow and D. M. Vail (Eds.). Small Animal Clinical Oncology. Canada, Saunders Elsevier: p. 193-210, 2007. LARUE, S. M.; CUSTIS, J. T. Advances in Veterinary Radiation Therapy. Veterinary Clinics of North America: Small Animal Practice, v. 44, n. 5, p. 909–923, set. 2014. LASCELLES, B. D.; HENDERSON R. A.; SEGUIN B. Bilateral rostral maxillectomy and nasal planectomy for large rostral maxillofacial neoplasms in six dogs and one cat. Journal American Animal Hospital Association, v.40, n.2, p.137–146. 2004 . LASCELLES, B. D.; THOMSON, M. J.; DERNELL, W. S. Combined dorsolateral and intraoral approach for the resection of tumors of the maxilla in the dog. Journal American Animal Hospital Association, v. 39, n. 3, p. 294–305. 2003. LEVISON, D.A.; PARRAT, D. Skin Diseases of the Dog and Cat. Oxford, UK: Blackwell Science Ltd, v. 318; 2005. LEWIS, J. R. Therapeutic Decision Making and Planning in Veterinary Dentistry and Oral Surgery. Veterinary Clinics of North America: Small Animal Practice, v. 43, n. 3, p. 471– 487, maio 2013. LIPTAK, J. M.; WITHROW, S. J. Cancer of the Gastrointestinal Tract. In: WITHROW, S. J.; VAIL, D. M. (Ed.). Withrow and MacEwen’s Small Animal Clinical Oncology. 5th ed. St. Louis: Elsevier - Saunders. p. 381–431. 2012. 77 LU, B.; CAO, H.; CAO, J.; HUANG, S.; HU, Q.; LIU, D.; SHEN, R.; SHEN, X.; TAO, W.; WAN, H.; WANG, D.; YAN, Y.; YANG, L.; ZHANG, J.; ZHANG, L.; ZHANG, L.; ZHANG, M. Discovery of EBI-907: A highly potent and orally active B-RafV600E inhibitor for the treatment of melanoma and associated cancers. Bioorganic & Medicinal Chemistry Letters, v. 26, n. 3, p. 819–823, fev. 2016. MACEWEN, E. G. Spontaneous tumors in dogs and cats: models for the study of cancer biology and treatment. Cancer Metastasis Review. v. 9, n. 2, p. 125-136. 1990. MACEWEN, E. G.; PATNAIK, A. K.; HARVEY, H. J.; HAYES, A. A.; MATUS, R. Canine oral melanoma: comparison of surgery versus surgery plus Corynebacterium parvum. Cancer investigation, v. 4, n. 5, p. 397–402, 1986. MAEKAWA, N.; KONNAI, S.; OKAGAWA, T.; NISHIMORI, A.; IKEBUCHI, R.; IZUMI, Y.; TAKAGI, S.; KAGAWA, Y.; NAKAJIMA, C.; SUZUKI, Y.; KATO, Y.; MURATA, S.; OHASHI, K. Immunohistochemical Analysis of PD-L1 Expression in Canine Malignant Cancers and PD-1 Expression on Lymphocytes in Canine Oral Melanoma. PLOS ONE, v. 11, n. 6, p. 157-176, 8 jun. 2016. MARTY, M.; SERSA, G.; GARBAY, JR. Electrochemotherapy—An easy, highly effective and safe treatment of cutaneous and subcutaneous metastases: Results of ESOPE (European Standard Operating Procedures of Electrochemotherapy) study. European Journal Cancer , v. 4(Suppl); p. 3–13. 2006 . MAS, A.; BLACKWOOD, L.; CRIPPS, P.; MURPHY, S.; DE VOS, J.; DERVISIS, N.; MARTANO, M.; POLTON, G.A Canine tonsillar squamous cell carcinoma -- a multi-centre retrospective review of 44 clinical cases. The Journal of Small Animal Practice, v. 52, n. 7, p. 359–364, 2011. MASON, S. Palliative care in small animal oncology. In Practice, v. 38, n. 5, p. 203–217, 5 maio 2016. MATZ, B. M. Current Concepts in Oncologic Surgery in Small Animals. Veterinary Clinics of North America: Small Animal Practice, v. 45, n. 3, p. 437–449, maio 2015. MCCAW, D. L., POPE, E. R., PAYNE, J. T., WEST, M. K., TOMPSON, R. V., TATE, D.. Treatment of canine oral squamous cell carcinomas with photodynamic therapy. British Journal Cancer, v. 82, n. 7, p. 1297-1299, 2000. MCLEAN, J. L.; LOBETTI, R. G. Use of the melanoma vaccine in 38 dogs: The South African experience. Journal of the South African Veterinary Association, v. 86, n. 1, p. 1– 4, 25 mar. 2015. MCENTEE, M. C. Clinical behavior of nonodontogenic tumors. In: ARZI, B.; VERSTRAETE, F. J. M. (Ed.). Oral and maxillofacial surgery in dogs and cats. Pennsylvania: Elsevier, p. 387–402. 2012. MEIER, V.; GUSCETTI, F.; ROOS, M.; OHLERTH, S.; PRUSCHY, M.; BLEY, C. R. Hypoxia-Related Marker GLUT-1, CAIX, Proliferative Index and Microvessel Density in Canine Oral Malignant Neoplasia. PLOS ONE, v. 11, n. 2, e149993, 23 fev. 2016. 78 MENDONÇA, P. P. Perfil epidemiológico do câncer de boca em cães : estudo multicêntrico. Dissertação [s.l.] Universidade de São Paulo, 2015. MILLANTA, F.; FRATINI, F.; CORAZZA, M.; CASTAGNARO, M.; ZAPPULLI, V.; POLI, A. Proliferation activity in oral and cutaneous canine melanocytic tumours: correlation with histological parameters, location, and clinical behavior. Research Veterinary Science. v. 73, n. 1, p. 45- 51, 2002. MIR, L. M.; DEVAUCHELLE, P.; QUINTIN-COLONNA, F.; DELISLE, F.; DOLIGER, S.; FRADELIZI, D.; BEHRADEK, J.; ORLOWSKI, S. First clinical trial of cat soft-tissue sarcomas treatment by electrochemotherapy. British journal of cancer, v. 76, n. 12, p. 1617– 1622, 1997. MODIANO, J. F.; RITT M. G.; WOJCIESZYN, J. The molecular basis of canine melanoma: pathogenesis and trends in diagnosis and therapy. Journal Veterinary Internal Medicine v. 13, n. 3, p. 163-74, 1999. MOHAMMED, S. I.; KHAN, K. N. M.; SELLERS, R. S.; HAYEK, M. G.; DENICOLA, D. B.; WU, L.; BONNEY, P. L.; KNAPP, D. W. Expression of cyclooxygenase-1 and 2 in naturally-occurring canine cancer. Prostaglandins, leukotrienes, and essential fatty acids, v. 70, n. 5, p. 479–483, 2004. MORENO-LOPEZ, L. A.; ESPARZA-GOMEZ, G. C.; GONZALEZ-NAVARRO, A.; CERERO-LAPIEDRA, R.; GONZALEZ-HERNANDEZ, M. J.; DOMINGUEZ-ROJAS, V. Risk of oral cancer associated with tobacco smoking, alcohol consumption and oral hygiene: a case- control study in Madrid, Spain. Oral Oncolology, v. 36, n.2, p. 170-4, 2000. MORTON, L. D.; BARTON, C. L.; ELISSALDE, G. S.; WILSON, S. R. Oral Extramedullary Plasmacytomas in Two Dogs. Veterinary Pathology, v. 23, p. 637–639, 1986. MOULTON, J. E. Tumors in domestic animals. [s.l.] University of California Press, 1990. MUNDAY, J. S.; TUCKER, R. S.; KIUPEL, M.; HARVEY, C. J. Multiple oral carcinomas associated with a novel papillomavirus in a dog. Journal of Veterinary Diagnostic Investigation, v. 27, n. 2, p. 221–225, mar. 2015. MURAKAMI, Y., TATEYAMA, S., RUNGSIPIPAT, A., UCHIDA, K., YAMAGUCHI, R. (2000). "Immunohistochemical analysis of cyclin A, cyclin D1 and P53 in mammary tumors, squamous cell carcinomas and basal cell tumors of dogs and cats." Journal Veterinary Medical Science, v. 62, n. 7, p. 743-750, 2000. MURRAY, R. L.; AITKEN, M. L.; GOTTFRIED, S. D. The Use of Rim Excision as a Treatment for Canine Acanthomatous Ameloblastoma. Journal of the American Animal Hospital Association, v. 46, n. 2, p. 91–96, mar. 2010. MURPHY, S.; HAYES, A. M.; BLACKWOOD, L.; MAGLENNON, G.; PATTINSON, H.; SPARKES, A. H. Oral malignant melanoma - the effect of coarse fractionation radiotherapy alone or with adjuvant carboplatin therapy. Vetetinary Comparative Oncolology, v. 3, n. 4, p. 222-229, 2005. 79 MUSCATELLO, L. V.; LENZI, R.; PELLINI, R.; GIUDICE, M.; SPRIANO, G. Marginal mandibulectomy in oral cancer surgery: a 13-year experience. European Archives of Oto- Rhino-Laryngology, v. 267, n. 5, p. 759–764, 17 maio 2010. MUSCATELLO, L. V.; AVALLONE, G.; BENAZZI, C.; SARLI, G.; PORCELLATO, I.; BRACHELENTE, C.; BRUNETTI, B. Oral Squamomelanocytic Tumour in a Dog: a Unique Biphasic Cancer. Journal of Comparative Pathology, v. 154, n. 2–3, p. 211–214, fev. 2016. NAKAICHI, M.; YUNUKI, T.; OKUDA, M.; UNE, S.; TAURA, Y. Activity of matrix metalloproteinase-2 in canine oronasal tumors. Research Veterinary Science v. 82, n. 2, p. 271-279. 2007. NAKHLEH, R. E.; WICK, M. R.; ROCAMORA, A.; SWANSON, P. E.; DEHNER, L. P Morphologic diversity in malignant melanomas. American journal of clinical pathology, v. 93, n. 6, p. 731–740, 1990. NEMEC, A.; ARZI, B.; MURPHY, B.; KASS, P. H.; VERSTRAETE, F. J. Prevalence and types of tooth resorption in dogs with oral tumors. American journal of veterinary research, v. 73, n. 7, p. 1057–66, jul. 2012. NEMEC, A.; MURPHY, B.; KASS, P. H.; VERSTRAETE, F. J. M. Histological subtypes of oral non-tonsillar squamous cell carcinoma in dogs. Journal of comparative pathology, v. 147, n. 2-3, p. 111–20, 2012. NGUYEN, S. M.; THAMM, D, H.; VAIL, D. M.; LONDON, C. A. Response evaluation criteria for solid tumours in dogs (v1.0): a Veterinary Cooperative Oncology Group (VCOG) consensus document. Veterinary and comparative oncology, v. 13, n. 3, p. 176–83, set. 2015. NISHIYA, A. T.; MASSOCO, C. O.; FELIZZOLA, C. R.; PERLMANN, E.; BATSCHINSKI, K.; TEDARDI, M. V.; GARCIA, J. S.; MENDONÇA, P. P.; TEIXEIRA, T. F.; ZAIDAN DAGLI, M. L. Comparative Aspects of Canine Melanoma. Veterinary Sciences, v. 3, n. 7. 2016. NORTHRUP, N. C.; SELTING, K. A.; RASSNICK, K. M.; KRISTAL, O.; O'BRIEN, M. G.; DANK, G.; DHALIWAL, R. S.; JAGANNATHA, S.; CORNELL, K. K.; GIEGER, T. L. Outcomes of cats with oral tumors treated with mandibulectomy: 42 cases. Journal American Animal Hospital Association, v. 42, n. 5, p. 350-360, 2006. OAKES, M. G.; LEWIS, D. D.; HEDLUND, C.S.; HOSGOOD, G. Canine oral neoplasia. Compendium Continuous Educational Practice Veterinary , v.15, n. 1, p. 15-29, 1993. O’BRIEN, M. G.; WITHROW, S. J.; STRAW, R. C. Total and partial orbitectomy for the treatment of periorbital tumors in 24 dogs and 6 cats: a retrospective study. Veterinary Surgery. v. 25, n. 6, p. 471–479. 1996. OGILVIE, G. K.; OBRADOVICH, J. E.; ELMSLIE, R. E.; VAIL, D. M.; MOORE, A. S.; STAW, R. C. Tumors of the Oral Cavity. In: G.K. Ogilvie and A.S. Moore (Eds.). Managing the Veterinary Cancer Patient, Veterinary Learning System, p. 327-348, 1995. 80 OKAMOTO, Y. Systemic and local injections of lupeol inhibit tumor growth in a melanoma‑bearing mouse model. Biomedical Reports, n. 16, p. 641–645, 28 maio 2013. OLIVEIRA FILHO, R. S.; SILVA, A. M.; HOCHMAN, B.; OLIVEIRA, R. L.; ARCUSCHIN, L.; WAGNER, J.; YAMAGA, L. Y.; FERREIRA, L. M. Vital dye is enough for inguinal sentinel lymph node biopsy in melanoma patients. Acta Cirurgica Brasileira, v.21, p. 12-15, 2006. OLIVEIRA, L. O.; OLIVEIRA, R. T. Associação de cirurgia e quimioterapia para tratamento de adenocarcinoma orofacial com linfonodo positivo em um cão. Acta Scientiae Veterinariae, v. 35, n. Supl 4, p. 1321–1322, 2007. OTTNOD, J. M.; SMEDLEY, R. C.; WALSHAW, R.; HAUPTMAN, J. G.; KIUPEL, M.; OBRADOVICH, J. E. A retrospective analysis of the efficacy of Oncept vaccine for the adjunct treatment of canine oral malignant melanoma. Veterinary and comparative oncology, v. 11, n. 3, p. 219–229, 2013. OWEN, L. TNM Classification of tumours in domestic animals. World Health Organisation, p. 46–47, 1980. PANG, L. Y.; ARGYLE, D. J. Using naturally occurring tumours in dogs and cats to study telomerase and cancer stem cell biology. Biochimica et biophysica acta, v. 1792, n. 4, p. 380–91, abr. 2009. PATNAIK, A. K.; EHLER, W. J.; MACEWEN, E. G. Canine cutaneous mast cell tumor: morphologic grading and survival time in 83 dogs. Veterinary Pathology. v. 21, n. 5, p. 469– 474, 1984. PATNAIK, A. K.; MOONEY, S. Feline melanoma: a comparative study of ocular, oral, and dermal neoplasms.. Veterinary Pathology. v. 25, n. 2, p. 105-112, 1988. PAULINO, P. G.; BARBALHO, C. M.; COSTA, T. S.; SILVA, M. A.; FERNANDES, J. I. Avaliação epidemiológica de neoplasias em cavidade oral de cães diagnosticados por exame citológico e/ou histopatológico no Hospital Veterinário da UFRRJ. In: Medvep Congresso de Especialidades Veterinárias, 2015, Curitiba. PEÑA, L. L.; NIETO, A. I.; PEREZ-ALENZA, D.; CUESTA, P.; CASTANO, M. Immunohistochemical detection of Ki-67 and PCNA in canine mammary tumors: relationship to clinical and pathologic variables. Journal Veterinary Diagnostical Investigation, v. 10, n. 3, p. 237-246, 1998. PENWICK, R. C.; NUNAMAKER, D. M. Rostral mandibulectomy: a treatment for oral neoplasia in the dog and cat. Journal American Animal Hospital Association, v. 23, p. 19- 25, 1987. PIFFKO, J.; BANKFALVI, A.; OFNER, D.; JOOS, U.; BOCKER, W.; SCHMID, K. W. Immunohistochemical detection of p53 protein in archival tissues from squamous cell carcinomas of the oral cavity using wet autoclave antigen retrieval. Journal Pathology. v. 176, n.1, p. 69-75, 1995. 81 PIRAS, L. A.; IUSSICH, S.; MANISCALCO, L.; GATTINO, F.; MARTANO, M.; MORELLO, E.; LORDA MAYAYO, S.; ROLIH, V.; CARAVAGLIA, F.; DE MARIA, R.; LARDONE, E.; COLLIVIGNARELLI, F.; MIGNACCA, D.; GIACOBINO, D.; FERRONE, S.; CAVALLO, F.; BURACCO, P. Prolongation of survival of dogs with oral malignant melanoma treated by en bloc surgical resection and adjuvant CSPG4-antigen electrovaccination. Veterinary and Comparative Oncology, v. 15, n. 3, p. 9913–1013, 2017. PIRES, I.; GARCIA, A.; PRADA, J.; QUEIROGA, F. L. COX-1 and COX-2 expression in canine cutaneous, oral and ocular melanocytic tumours. Journal of Comparative Pathology, v. 143, n. 2–3, p. 142–149, 2010. PHILIPSEN, H. P.; REICHART, P. A. Classification of odontogenic tumours . A historical review. journal oral pathological medical, v. 35, p. 525–529, 2006. PORRELO, A.; CARDELLI, P.; SPUGNINI, E. P. Pet Models in Cancer Research: General Principles. Experimental Clinical Cancer Research, v. 23, n. 2, p. 181–194, 2004. POULET, F. M.; VALENTINE, B. A.; SUMMERS, B. A. A Survey of Epithelial Odontogenic Tumors and Cysts in Dogs and Cats. Veterinary Pathology, v. 29, n. 5, p. 369– 380, 1992. PROULX, D. R.; RUSLANDER, D. M.; DODGE, R. K.; HAUCK, M. L.; WILLIAMS, L. E.; HORN, B.; PRICE, G. S.; THRALL, D. E. A retrospective analysis of 140 dogs with oral melanoma treated with external beam radiation. Veterinary Radiology Ultrasound. v. 44, n.3, p.352- 359, 2003. PRICE, G. S.; FRAZIER, D. L. Use of body surface area (BSA)-based dosages to calculate chemotherapeutic drug dose in dogs: I. Potential problems with current BSA formulae. Journal Veterinary Internal Medicine, v. 12; p. 267–271. 1998. PRZEŹDZIECKI, R.; CZOPOWICZ, M.; SAPIERZYŃSKI, R. Accuracy of routine cytology and immunocytochemistry in preoperative diagnosis of oral amelanotic melanomas in dogs. Veterinary Clinical Pathology, v. 44, n. 4, p. 597–604, dez. 2015. QUEIROGA F.; LOPES C. Tumores mamários caninos, pesquisa de novos factores de prognóstico. Revista Portuguesa Ciências Veterinárias, v. 97, n. 543, p. 119-127, 2002. RAGHAVAN, M.; KNAPP, D. W.; BONNEY, P. L.; DAWSON, M. H.; GLICKMAN, L. T. Topical flea and tick pesticides and the risk of transitional cell carcinoma of the urinary bladder in Scottish Terriers. Journal of the American Veterinary Medical Association, v. 225, n. 3, p. 389–394, 2004. RAMOS-VARA, J. A.; BEISSENHERZ, M. E.; MILLER, M. A.; JOHNSON, G. C.; PACE, L. W.; FARD, A.; KOTTLER, S. J. Retrospective study of 338 canine oral melanomas with clinical, histologic, and immunohistochemical review of 129 cases. Veterinary Pathology, v. 37, n. 6, p. 597-608, 2000. 82 RASSNICK, K. M.; RUSLANDER, D. M.; COTTER, S. M.; AL-SARRAF, R.; BRUYETE, D. S.; GAMBLIN, R. M.; MELEO, K. A.; MOORE, A. S. Use of carboplatin for treatment of dogs with malignant melanoma: 27 cases (1989–2000). Journal of American Veterinary association, v. 218, n. 9, p. 1444–1448, 2001. REGAN, R. C.; KAPLAN, M. S. W.; BAILEY, D. B. Diagnostic evaluation and treatment recommendations for dogs with substage-a high-grade multicentric lymphoma: Results of a survey of veterinarians. Veterinary and Comparative Oncology, v. 11, n. 4, p. 287–295, 2013 REGAN, D.; GUTH, A.; COY, J.; DOW, S. Cancer immunotherapy in veterinary medicine: Current options and new developments. The Veterinary Journal, v. 207, n. October 2014, p. 20–28, jan. 2016. REIF, J. S.; COHEN, D. The environmental distribution of canine respiratory tract neoplasms. Archives Environment Health, v. 22, n. 1. p. 136-40, 1971. REQUICHA, J. F. M. F. Neoplasias da Cavidade Oral do Cão Estudo Retrospectivo de 14 Anos. 2010. 68f. Dissertação (Mestre Ciências Veterinárias) - Escola de Ciências Agrárias e Veterinárias, Universidade de Trás-Os-Montes e Alto Douro, 2010. REQUICHA, J. F. M. F.; PIRES, M. A.; ALBUQUERQUE, C. M.; VIEGAS, C. A. Neoplasias Da Cavidade Oral Do Cão : Uma Revisão. Revista Brasileira de Medicina Veterinária, v. 37, n. 1, p. 22–30, 2015. RIBAS, C. R.; PRADO, A. M. B.; CAPRIGLIONE, L. G. A.; FRIESEN, R.; CEREDA, A. H. S.; FRANÇA, J. F.; DORNBUSCH, P.T. Aspectos clínicos e fatores prognósticos do melanoma oral de quatro cães. Ciência Animal. v. 25, n. 2, p.07-12, 2015. RICCARDO, F.; IUSSICH, S.; MANISCALCO, L.; LORDA MAYAYO, S.; LA ROSA, G.; ARIGONI, M.; DE MARIA, R.; GATTINO, F.; LANZARDO, F.; LARDONE, E.; MARTANO, M.; MORELLO, E.; PRESTIGIO, S.; FIORE, A.; QUAGLINO, E.; ZABARINO, S.; FERRONE, S.; BURACCO, P.; CAVALLO, F. CSPG4-specific immunity and survival prolongation in dogs with oral malignant melanoma immunized with human CSPG4 DNA. Clinical Cancer Research, v. 20, n. 14, p. 3753–3762, 2014. ROBINSON, N. G. Complementary and Alternative Medicine for Cancer: The Good, the Bad, and the Dangerous. In: WITHROW, S. J.; VAIL, D. M. (Eds.). Withrow and MacEwen’s small animal clinical oncology. 5th ed. St. Louis: Elsevier - Saunders. p. 280– 292. 2012. RODRIGUEZ, F.; CASTRO, P.; RAMIREZ, G. A. Collision Tumour of Squamous Cell Carcinoma and Malignant Melanoma in the Oral Cavity of a Dog. Journal of Comparative Pathology, v. 154, p. 314–318, 2016. ROELS, S.; TILMANT, K.; DUCATELLE, R. PCNA and Ki67 Proliferation Markers as Criteria for Prediction of Clinical Behaviour of Melanocytic Tumours in Cats and Dogs. Journal of Comparative Pathology, v. 121, n. 1, p. 13–24, jul. 1999. 83 ROLIM, V. M.; CASAGRANDE, R. A.; WATANABE, T. T.; WOUTERS, A. T.; WOUTERS, F.; SONNE, L.; DRIEMEIER, D. Melanoma amelanótico em cães: estudo retrospectivo de 35 casos (2004-2010) e caracterização imuno-histoquímica. Pesquisa Veterinária Brasileira, v. 32, n. 4, p. 340–346, 2012. ROSSETTO, V. J. V.; MORENO, K.; GROTTI, C. B.; REIS, A. C. F.; BRACARENSE, A. P. F. R. L. Frequencia de neoplasmas em cães diagnosticados por exame citolígico: estudo retrospectivo em um hospital-escola. Semina:Ciencias Agrarias, v. 30, n. 1, p. 189–200, 2009. RUIZ, F. S.; ALESSI, A. C.; CHAGAS, C. A.; PINTO, G. A.; VASSALLO, J. Immunohistochemistry in veterinary pathology: a critical review. Journal Brazilian Pathology Medical Laboratory, v. 41, n. 4, p. 263-270, 2005. SAAR, L. I.; GETTY, G. R. Lymphatic system of the carnivore. In: G. R. Getty (Ed.). Sisson and Grossman’s The anatomy of the domestic animals. WB Saunders, Philadelphia 2 ed. p. 1551-1566. 1986. SALEEM, M. Lupeol, a novel anti-inflammatory and anti-cancer dietary triterpene. Cancer Letters, v. 285, n. 2, p. 109–115, nov. 2009. SALISBURY, S.K. Aggressive cancer surgery and aftercare. In: W.B. Morrison (Ed.). Cancer in dogs and cats: medical and surgical management. Teton New Media, Jackson, Wyoming. p. 249-301. 2002. SALISBURY, S. K.; RICHARDSON, D. C.; LANTZ, G. C. Partial maxillectomy and premaxillectomy in the treatment of oral neoplasia in the dog and cat. Veterinary Surgery v.15, n.1, p.16–26. 1986. SALISBURY, S. K.; THACKER, H. L.; PANTZER, E. E. Partial maxillectomy in the dog. Comparison of suture material and closure techniques. Veterinary Surgery, v. 14, n. 4, p. 265–276. 1985. SARBU, L.; KITCHELL, B. E.; BERGMAN, P. J. Safety of administering the canine melanoma DNA vaccine (Oncept) to cats with malignant melanoma – a retrospective study. Journal of Feline Medicine and Surgery, v. 19, n. 2, p. 224–230, fev. 2017. SCOTT, D. W.; MILLER, W. H.; GRIFFIN, C. E. Structure and Function of the Skin. In: SCOTT, D. W.; MILLER, W. H.; GRIFFIN, C. E. (Eds.). Muller & Kirk’s small animal dermatology. 6th. ed. Philadelphia: Elsevier, p. 1–70. 2001. SCHMIDT, A.; KESSLER, M.; TASSANI-PRELL, M. Computed tomographic characteristics of canine acanthomatous ameloblastoma - a retrospective study in 52 dogs. Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere, v. 40, n. 3, p. 155–160, 2012. SCHMIDT, A.; KESSLER, M.; TASSANI-PRELL, M. Evaluation of piroxicam for the treatment of oral squamous cell carcinoma in dogs. Journal of the American Veterinary Medical Association, v. 218, n. 11, p. 1783–1786, 2001. 84 SCHRENZEL, M. D.; NAYDAN, D. K.; MOORE, P. F. Leukocyte differentiation antigens in canine cutaneous and oral plasmacytomas. Veterinary Dermatology, v. 9, n. 1, p. 33–41, 1998. SERSA, G. The state-of-the-art of electrochemotherapy before the ESOPE study: Advantages and clinical uses. European Journal Cancer, v. 4 (Suppl); p. 52–59. 2006. SERSA, G.; MIKLAVCIC, D.; CEMAZAR, M. Electrochemotherapy in treatment of tumours. European Journal of Surgical Oncology. v.34; p.232–240. 2008. SILVA, K.L.F. Estudo da proliferação celular em tumores melanocíticos caninos. [s.l.] Universidade de Trás-os-Montes e Alto Douro, 2013. SILVEIRA, L. M. G.; BRUNNER, C. H. M.; CUNHA, F. M.; FUTEMA, F.; CALDERARO, F. F.; KOZLOWSKI, D. Utilização de eletroquimioterapia em neoplasias de origem epitelial ou mesenquimal localizadas em pele ou mucosas de cães. Brazilian Journal of Veterinary Research and Animal Science, v. 47, n. 1, p. 55–66, 2010. SMEDLEY, R. C.; SPANGLER, W. L.; ESPLIN, D. G.; KITCHELL, B. E.; BERGMAN, P. J.; HO, H. Y.; BERGIN, I. L.; KIUPEL, M. Prognostic markers for canine melanocytic neoplasms: a comparative review of the litera- ture and goals for future investigation. Veterinary Pathology, v.48, p. 54–72. 2011. SMITH, S. H.; GOLDSCHMIDT, M. H.; MCMANUS, P. M. A Comparative Review of Melanocytic Neoplasms. Veterinary Pathology, v. 39, n. 6, p. 651–678, 2002. SMITH, S. H.; GOLDSCHMIDT, M. H.; McMANUS, P. M. Multicentric Oral Plasmacytoma in 3 Dogs. Journal of veterinary dentistry, v. 29, n. 2, p. 96–110, 2012. STOPIGLIA, A. J.; FELIZZOLA, C. R.; DAGLI, M. L. Z.; XAVIER, J. G.; GUERRA, J. L.; BIRMAN, E. Estudo clínico e anátomo-patológico das formações neoplásicas e não neoplásicas da cavidade bucal de cães. Comunicações Científicas da Faculdade de Medicina Veterinária e Zootecnia da USP, v. 16, n. 1/2, p. 33–39, 1992. SIMONS, K. W. J. Oral tumours in dogs: a retrospective study of 110 cases (2002-2014), 2015. Mestrado. Faculdade de Medicina Veterinária. Universidade de Utrecht. Disponível em: <https://dspace.library.uu.nl/handle/1874/312606>. Acesso em: 13 fev. 2017. SIMPSON, R. M.; BASTIAN, B. C.; MICHAEL, H. T.; WEBSTER, J. D.; PRASAD, M. L.; CONWAY, C. M.; PRIETO, V. M.; GARY, J. M.; GOLDSCHIMIDT, M. H.; ESPLIN, D. G.; SMEDLEY, R. C.; PIRIS, A.; MEUTEN, D. J.; KLUPEL, M.; LEE, C. C.; WARD, J. M.; DWYER, J. E.; DAVIS, B. J.; ANVER, M. R.; MOLINOLO, A. A.; HOOVER, S. B.; RODRIGUEZ-CANALES, J.; HEWITT, S. M. Sporadic naturally occurring melanoma in dogs as a preclinical model for human melanoma. Pigment Cell & Melanoma Research, v. 27, n. 1, p. 37–47, jan. 2014. SKINNER, O. T.; BOSTON, S. E.; SOUZA, C. H. D. M. Patterns of lymph node metastasis identified following bilateral mandibular and medial retropharyngeal lymphadenectomy in 31 dogs with malignancies of the head. Veterinary and Comparative Oncology, p. 1–9, maio 2016. 85 SNOJ, M.; RUDOLF, Z.; CEMAZAR, M. Successful sphincter-saving treatment of anorectal malignant melanoma with electrochemotherapy, local excision and adjuvant brachytherapy. Anticancer Drugs, v. 16, p. 345–348. 2005. SOBCZYŃSKA-RAK, A.; POLKOWSKA, I.; SILMANOWICZ, P. Elevated Vascular Endothelial Growth Factor (VEGF) levels in the blood serum of dogs with malignant neoplasms of the oral cavity. Acta Veterinaria Hungarica, v. 62, n. 3, p. 362–371, set. 2014. SOLTERO-RIVERA, M.; ENGILES, J. B.; REITER, A. M.; REETZ, J.; LEWIS, J. R.; SANCHEZ, M. D. Benign and Malignant Proliferative Fibro-osseous and Osseous Lesions of the Oral Cavity of Dogs. Veterinary Pathology, v. 52, n. 5, p. 894–902, set. 2015. SNOJ, M. Electrochemotherapy of tumors. Current Oncology, v. 16, n. 2, p. 34–35, 2009. SMEDLEY, R. C.; SPANGLER, W. L.; ESPLIN, D. G.; KITCHELL, B. E.; BERGMAN, P. J.; HO, H. Y.; BERGIN, I. L.; KIUPEL, M. Prognostic Markers for Canine Melanocytic Neoplasms: A Comparative Review of the Literature and Goals for Future Investigation. Veterinary Pathology, v. 48, n. 1, p. 54–72, 1 jan. 2011. SMITH, S. H.; GOLDSCHMIDT, M. H.; MCMANUS, P. M. A comparative review of melanocytic neoplasms. Veterinary pathology, v. 39, n. 6, p. 651–678, 2002. SPUGNINI, E. P.; BALDI, A.; VINCENZI, B.; BONGIORNI, F.; BELLELLI, C.; CITRO, G.; PORRELLO, A. Intraoperative versus postoperative electrochemotherapy in high grade soft tissue sarcomas: a preliminary study in a spontaneous feline model. Cancer Chemotherapy and Pharmacology, v. 59, n. 3, p. 375–381, 20 dez. 2006. SPUGNINI, E. P.; FANCIULLI, M.; CITRO, G.; BALDI, A. Preclinical models in electrochemotherapy: the role of veterinary patients. Future Oncology, v. 8, n. 7, p. 829–837, jul. 2012. SPUGNINI, E. P.; VINCENZI, B.; BALDI, F.; CITRO, G.; BALDI, A. Adjuvant electrochemotherapy for the treatment of incompletely resected canine mast cell tumors. Anticancer Research, v. 26, n. 6 B, p. 4585–4589, 2006. SPUGNINI, E.; AZZARITO, T.; FAIS, S.; FANCIULLI, M.; BALDI, A. Electrochemotherapy as First Line Cancer Treatment: Experiences from Veterinary Medicine in Developing Novel Protocols. Current Cancer Drug Targets, v. 16, n. 1, p. 43–52, 18 dez. 2015. SPUGNINI, E. P.; BALDI, F.; MELLONE, P.; FEROCE, F.; DÁVINO, A.; BONETTO, F.; VINCENZI, B.; CITRO, G.; BALDI, A. Patterns of tumor response in canine and feline cancer patients treated with electrochemotherapy: preclinical data for the standardization of this treatment in pets and humans. Journal of translational medicine, v. 5, p. 48, 2007. SPUGNINI, E. P.; VINCENZI, B.; CITRO, G.; SANTINI, D.; DOTSINSNK, I.; MUDROV, N.; MONTESARCHIO, V.; LAIETA, M. T.; ESPOSITO, V.; BALDI, A. Adjuvant electrochemotherapy for the treatment of incompletely excised spontaneous canine sarcomas. In Vivo, v. 21, n. 5, p. 819–822, 2007. 86 SPUGNINI, E. P.; DOTSINSNK, I.; MUDROV, N. ; BUFALINI, M.; GIANNINI, G.; CITRO, G.; FEROCE, F.; BALDI, A. Adjuvant electrochemotherapy for incompletely excised anal sac carcinoma in a dog. In vivo, v. 22, n. 1, p. 47–9, 2008. SPUGNINI, E. P.; MENICAGLI, F.; PETTORALI, M.; BALDI, A. Ultrasound guided electrochemotherapy for the treatment of a clear cell thymoma in a cat. Open Veterinary Journal, v. 7, n. 1, p. 57–60, 2017. SULAIMON, S. S.; KITCHELL, B. E. The biology of melanocytes. Veterinary Dermatology, v. 14, n. 2, p. 57–65, abr. 2003. SUZUKI, D. O. H.; BERKENBROCK, J. A.; DE OLIVEIRA, K. D.; FREYTAG, J. O.; RANGEL, M. M. M. Novel application for electrochemotherapy: Immersion of nasal cavity in dog. Artificial Organs, v. 41, n. 8, p. 767-773, dez. 2016. TEIXEIRA, T. F. Melanomas melânicos e amelânicos da cavidade bucal de cães : aspectos epidemiológicos , morfológicos e moleculares. [s.l.] Universidade de São Paulo, 2011. TEIXEIRA, T. F. Retrospective study of melanocytic neoplasms in dogs and cats. Brazilian Journal of Veterinary Pathology, v. 3, n. 2, p. 100–104, 2010. TEIXEIRA, F. V.; SANTOS, R. R. DOS; DINIZ, D. G. A. Estudo da cinética de liberação in vitro de nanocápsulas revestidas com quitosana contendo lupeol associado à paclitaxel. Revista de Biotecnologia & Ciência, v. 1, n. 2, 2013. THÉON, A. P.; RODRIGUEZ, C.; GRIFFEY, S.; MADEWELL, B. R. Analysis of prognostic factors and patterns of failure in dogs with periodontal tumors treated with megavoltage irradiation. Journal of the American Veterinary Medical Association, v. 210, n. 6, p. 785– 788, 1997. TIEMESSEN, I. Thoracic metastases of canine mammary gland tumors. Veterinary Radiology, v. 30, n. 6, p. 249–252, nov. 1989. TODOROFF, R. J.; BRODEY, R. S. Oral and pharyngeal neoplasia in the dog: a retrospective survey of 361 cases. Journal American Veterinary Medical Association, v. 175, n. 6, p. 567–571, 1979. TOLLETT, M. A.; DUDA, L.; BROWN, D. C.; KRICK, E. L. Palliative radiation therapy for solid tumors in dogs: 103 cases (2007-2011). American Veterinary Medical Association, v. 248, n. 1, p. 72–82, 2016. TOZON, N.; LAMPREHT TRATAR, U.; ZNIDAR, K.; SERSA, G.; TEISSIE, J.; CEMAZAR, M. Operating Procedures of the Electrochemotherapy for Treatment of Tumor in Dogs and Cats. Journal of Visualized Experiments, n. 116, p. 1–7, 24 out. 2016. TREGGIARI, E.; GRANT, J. P.; NORTH, S. M. A retrospective review of outcome and survival following surgery and adjuvant xenogeneic DNA vaccination in 32 dogs with oral malignant melanoma. The Journal of veterinary medical science, v. 78, n. 5, p. 845–50, 1 jun. 2016. 87 TUOHY, J. L.; MILGRAM, J.; WORLEY, D. R.; DERNELL, W. S. A review of sentinel lymph node evaluation and the need for its incorporation into veterinary oncology. Veterinary and Comparative Oncology, v. 7, n. 2, p. 81–91, jun. 2009. TUOHY, J. L.; SELMIC, L. E.; WORLEY, D. R.; EHRHART, N. P.; WITHROW, S. J. Outcome following curative-intent surgery for oral melanoma in dogs: 70 cases (1998-2011). Journal of the American Veterinary Medical Association, v. 245, n. 11, p. 1266–73, 2014. UMPHLET, R. C.; JOHNSON, A. L.; EURELL, J. C. The effect of partial rostral hemimandibulectomy on mandibular mobility and temporomandibular joint morphology in the dog. Veterinary Surgery, v.17, n. 4, p. 186 – 193. 1988. VAIL, D. M. Hematopoietic Tumors - Section D - Myeloma-Related Disorders. In: WITHROW, S. J.; VAIL, D. M. (Eds.). Withrow & MacEwen’s small animal clinical oncology. 5th ed. St. Louis: Elsevier – Saunders. p. 665–678. 2012. VAIL, D. M.; MACEWEN, E. G. Spontaneously Occurring Tumors of Companion Animals as Models for Human Cancer. Cancer Investigation, v. 18, n. 8, p. 781–792, 11 jan. 2000. VERGANTI, S.; BERLATO, D.; BLACKWOOD, L.; AMORES-FUSTER, I.; POLTON, G. A.; ELDERS, R.; DOYLE, R. TAYLOR, A.; MURPHY, S. Use of Oncept melanoma vaccine in 69 canine oral malignant melanomas in the UK. Journal of Small Animal Practice, v. 58, n. January, p. 10–16, jan. 2017. VERSTRAETE F. J. M. Mandibulectomy and Maxilectomy. Veterinary Clinics Small Animal Practice. V.35; p. 1009 -1039; 2005. VERSTRAETE, F. J. M. Oral pathology. In: SLATTER, D. H. (Ed.). Textbook of small animal surgery. 3rd. ed. Philadelphia: WB Saunders Co. p. 2638–2651. 2003. VERSTRAETE, F. J. M.; LIGTHELMF, A. J.; WEBERT, A. The histological nature of epulides in dogs. Journal of Coomparative Pathology, v. 106, p. 169–182, 1992. VETERINARY CO-OPERATIVE ONCOLOGY GROUP (VCOG). Veterinary Co-operative Oncology Group - Common Terminology Criteria for Adverse Events (VCOG-CTCAE) following chemotherapy or biological antineoplastic therapy in dogs and cats v1.0. Veterinary and comparative oncology, v. 2, n. 4, p. 195–213, dez. 2004. VOLKER, M. K.; LUSKIN, I. R. Oral osteoma in 6 dogs. Journal of veterinary dentistry, v. 31, n. 2, p. 88–91, jun. 2014. VOS, J. H.; VAN DER GAAG, I. Canine and feline oral-pharyngeal tumours. Zentralblatt für Veterinärmedizin. Reihe A, v. 34, n. 6, p. 420–427, 1987. WALLACE, J.; MATTHIESEN, D. T.; PATNAIK, A.K. Hemimaxillectomy for the treatment of oral tumors in 69 dogs. Veterinary Surgery. v.21, n.5, p.337–341. 1992. 88 WEBSTER, J. D.; DENNIS, M. M.; DERVISIS, N.; HELLER, J.; BACON, N. J.; BERGMAN, P. J.; BIENZLE, D.; CASSALI, G.; CASTAGNARO, M.; CULLEN, J.; ESPLIN, D. G.; PEÑA, L.; GOLDSCHMIDT, M. H.; HAHN, K. A.; HENRY, C. J.; HELLMÉN, E.; KAMSTOCK, D.; KILPENSTEIJN, K.; KITCHELL, B. E.; AMORIM, R. L.; LENZ, S. D.; LIPSCOMB, T. P.; MCENTEE, M.; MCGILL, L. D.; MCKNIGHT, C. A.; MCMANUS, P. M.; MOORE, A. S.; MOORE, P. F.; MOROFF, S. D.; NAKAYAMA, H.; NORTHRUP, N. C.; SARLI, G.; SCASE, T.; SORENMO, K.; SCHULMAN, F. Y.; SHOIEB, A. M.; SMEDLEY, R. C.; SPANGLER, W. L.; TESKE, E.; THAMM, D. H.; VALLI, V. E.; VERNAU, W.; VON EULER, H.; WITHROW, S. J.; WEISBRODE, S. E.; YAGER, J.; KIUPEL, M. Recommended guidelines for the conduct and evaluation of prognostic studies in veterinary oncology. Veterinary pathology, v. 48, n. 1, p. 7–18, jan. 2011. WILLIAMS, L. E.; PACKER, R. A. Association between lymph node size and metastasis in dogs with oral malignant melanoma: 100 cases (1987 – 2001). Journal of American Veterinary Medical Association. v. 222, n. 9, p. 1234-1236, 2003. WHITE, R. A. S. Mandibulectomy and maxillectomy in the dog: long term survival in 100 cases. Journal of Small Animal Practice, v. 32, n. 2, p. 69–74, 1991. WHITE, R. A. S. Mast cell tumors. In: DOBSON, J. M.; LASCELLES, B. D. X. (Ed.). BSAVA: manual of canine and feline oncology. Gloucester: BSAVA. p. 161–167. 2003. WHITE, R. A. S.; JEFFERIES, A. R.; FREEDMAN, L. S. Clinical staging for oropharyngeal malignancies in the dog. Journal of Small Animal Practice, v. 26, n. 10, p. 581–594, 1985. WITHERS, H. R. The four R’s of radiotherapy. Advances in Radiation Biology. v.5, p.241- 271; 1975. WOODWARD, T. M. Recurrent ossifying epulis in a dog. Journal of veterinary dentistry, v. 19, n. 2, p. 82–85, 2002. WRIGHT, Z. M.; ROGERS, K. S.; MANSELL, J. Survival data for canine oral extramedullary plasmacytomas: a retrospective analysis (1996-2006). Journal of the American Animal Hospital Association, v. 44, n. 2, p. 75–81, 2008. YANG, L. X.; DOUPLE, E. B.; O ́HARA, J. A.; WANG, H. J. Production of DNA double– strand breaks by interactions between carboplatin and radiation: a potential mechanism for radiopotentiation. Radiation research. v.143; n.3; p. 309-315. 1995. YEATES, J. W. Ethical principles for novel therapies in veterinary practice. Journal of Small Animal Practice, v. 57, n. 2, p. 67–73, fev. 2016. YOKOE, I.; AZUMA, K.; HATA, K.; MUKAIYAMA, T.; GOTO, T.; TSUKA, T.; IMAGAWA, T.; ITOH, N.; MURAHATA, Y.; OSAKI, T.; MINAMI, S.; OKAMOTO, Y.. Clinical systemic lupeol administration for canine oral malignant melanoma. Molecular and Clinical Oncology, p. 89–92, 30 out. 2014. 89 YOSHIDA, K.; YANAI, T.; IWASAKI, T.; SAKAI, H.; OHTA, J.; KATI, S.; MIKAMI, T. A.; LACKNER, A.; MASEGI, T. Clinicopathological study of canine oral epulides. Journal of Veterinary Medical Science, v. 61, n. 8, p. 897–902, 1999. ZOUBOULIS, C. C. Cryosurgery in dermatology. European Journal of Dermatology, v. 8, n.7, p. 466-474, 1998.por
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