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dc.contributor.authorCid, Gabriela de Carvalho
dc.date.accessioned2023-12-21T18:57:59Z-
dc.date.available2023-12-21T18:57:59Z-
dc.date.issued2020-02-04
dc.identifier.citationCID, Gabriela de Carvalho. Avaliações clínico-patológica e imunohistoquímica de lesões cardíacas em gatos (Felis catus) com doença renal crônica. 2020. 86 f. Tese (Doutorado em Medicina Veterinária) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/10149-
dc.description.abstractA doença renal crônica (DRC) é caracterizada por lesões morfoestruturais irreversíveis, que podem evoluir progressivamente para insuficiência renal crônica e falência renal. Sabe-se que o coração e os rins mantêm estreita relação e a comunicação entre esses órgãos ocorre por uma variedade de vias; alterações fisiológicas sutis em um desses órgãos nem sempre são compensadas pelo outro. A avaliação histopatológica cardíaca mediante a colorações rotineiras são limitadas para identificar lesões específicas ou discretas em cardiomiócitos. O presente trabalho teve como objetivos avaliar os níveis séricos de troponina em gatos com DRC, associados aos achados clínico-patológicos, bem como correlacionar as lesões cardíacas morfoestruturais, a fim de determinar a distribuição destas, por meio da avaliação macroscópica, histológica e imunohistoquímica com anti-cTnC. Neste estudo foram selecionados 20 gatos (18 diagnosticados com DRC e 2 animais controle). Para a aplicação da técnica de imunohistoquímica anti-troponina C humana, necropsias foram realizadas e cada coração coletado separadamente em 8 regiões. Fragmentos do coração de 2 gatos sem lesão cardíaca foram utilizados como controle. Em 11/18 animais (61,11%) a troponina sérica encontrava-se acima dos valores de referência e foram observadas diminuição da expressão para anticorpo-cTnC em cardiomiócitos individuais em 9/18 (50%). Notou-se que o número de regiões com diminuição da expressão para anticorpo-cTnC em cardiomiócitos está significativamente correlacionado com a troponina sérica. O anticorpo anti-TnC humano se mostrou eficaz para detectar lesões cardíacas e demonstrou diminuição da expressão nos cardiomiócitos de gatos com DRC. Houve correlação entre o aumento da CTnI sérica e perda da imunorretividade na avaliação imunohistoquímica com anticorpo anti-TnC em gatos com DRC o que comprova danos em cardiomiócitos secundários a doença renal.por
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectFelinopor
dc.subjectCardiologiapor
dc.subjectNefrologiapor
dc.subjectTroponinapor
dc.subjectFelineeng
dc.subjectCardiologyeng
dc.subjectNephrology,eng
dc.subjectTroponineng
dc.titleAvaliações clínico-patológica e imunohistoquímica de lesões cardíacas em gatos (Felis catus) com doença renal crônicapor
dc.title.alternativeClinical-pathological and immunohistochemical evaluations of cardiac lesions in cats (felis catus) with chronic renal diseaseeng
dc.typeTesepor
dc.description.abstractOtherChronic kidney disease (CKD) is characterized by irreversible morphostructural lesions, which may progressively progress to chronic renal failure (CKD) and renal failure. The heart and kidneys are known to be closely related, and communication between these organs occurs in a variety of ways; subtle physiological changes in one of these organs are offset by the other. On microscopic examination, routine histological staining is limited to identify specific or discrete lesions in cardiomyocytes. Many immunohistochemical techniques with high specificity and sensitivity have been developed in order to detect early lesions to cardiomyocytes. At time there are no studies evaluating immunohistochemistry with cardiac Troponin I (anti-cTnI) antibody in the detection of CKD-associated cardiac lesions in domestic cats. Thus, it aims to evaluate serum troponin levels in cats with CKD, associated with clinical-pathological findings, as well as correlated as morphostructural cardiac lesions, in order to determine the daily distribution through macroscopic, histological and immunological evaluation. anti-cTnI histochemistry. The objective of this study was to evaluate serum troponin levels in cats with CKD associated with clinical and pathological findings, as well as to correlate the morphostructural cardiac lesions, in order to determine their distribution through macroscopic, histological and anti-cTnI histochemistry evaluation. In this study, 20 cats (Felis catus) diagnosed with CKD were selected. As inclusion criteria, the patients presented stable azotemic biochemical profile examination, were in stage II or higher of International Renal Interest Society (IRIS) and also had clinical signs and complementary exams consistent with the diagnosis of CKD. Necropsies of the 20 animals and fragments of all macroscopically evaluated organs were performed, as well as eight fragments of different regions of the heart (apex, interventricular septum, left ventricle, right ventricle, left papillary muscle, right papillary muscle, left atrium and right atrium) were collected in 10% formalin solution for 24h and routinely processed for histopathology. To perform the human anti-troponin C immunohistochemistry technique, serial sections were obtained from the eight regions of the heart. Serum troponin examination showed data above reference values in 11 animals (55%). In immunohistochemical examination, decreased expression of anti-cTnC was observed in individual cardiomyocytes (affected areas) of nine cats (45%), of which six (66.7%) had only one affected region and three (33.3%) had two affected regions. Of the eight areas observed, the most frequently affected heart region was the apex (41.7%), followed by left ventricle (25%), right papillary muscle (16.7%), left papillary muscle (8.3%). and right ventricle (8.3%). The number of regions with decreased expression for cTnC antibody in cardiomyocytes was found to be strongly and significantly correlated with serum Troponin dosage.eng
dc.contributor.advisor1Nogueira, Vivian de Assunção
dc.contributor.advisor1ID089.375.877-93por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6012855368365110por
dc.contributor.advisor-co1Souza, Heloisa Justen Moreira de
dc.contributor.advisor-co2Peixoto, Tiago da Cunha
dc.contributor.referee1Nogueira, Vivian de Assunção
dc.contributor.referee2Baldani, Cristiane Divan
dc.contributor.referee3Nascimento, Aparecida Alves do
dc.contributor.referee4Cerqueira, Valíria Duarte
dc.contributor.referee5Castro, Maria Cristina Nobre
dc.creator.ID124.460.277-92por
dc.creator.Latteshttp://lattes.cnpq.br/1474541499986492por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)por
dc.relation.referencesACIERNO, M.J.; LABATO, A. Hypertension in renal disease: diagnosis and treatment. Clinical Techniques in Small Animal Practice. 20:23-30, 2005. ADAMS, J.E.; ABENDSCHEIN, D.R.; JAFFE, A. S. Biochemical markers of myocardial injury. Is MB creatine kinase the choice for the 1990s? Circulation, v. 88, p. 750-763, 1993. AIRES, M.M. Excreção Renal de Solutos. In: AIRES, M.M. Fisiologia. 3ª ed. Rio de Janeiro. Guanabara Koogan, sec. 7, cap. 51, p. 730-747, 2008. ALFREY, A.C. The role of abnormal phosphorus metabolism in the progression of chronic kidney disease and metastatic calcification. Kidney International, v. 66, sup. 90, p. S13-S17, 2004. AMMANN, P.; MAGGIORINI, M.; BERTEL, O. Troponin as a risk factor for mortality in critically ill patients without acute coronary syndromes. Journal of the American College of Cardiology, 41:2004–2009, 2003. ANTMAN, E.M.; TANASIJEVIC, M.J.; THOMPSON, B.; SCHACTMAN, M.; MCCABE, C.H.; CANNON, C.P.; FISCHER, G.A.; FUNG, A.Y.; THOMPSON, C.; WYBENGA, D.; BRAUNWALD E. Cardiac specific troponin I levels to predict the risk of mortality in patients with acute coronary syndromes. New England Journal of Medicine, v. 335, n. 5, p. 1342-1349, 1996. ARKER, V.J.; GILOR, C; CHEW, D.J. Feline hyperparathyroidism: pathophysiology, diagnosis and treatment of primary and secondary disease. Journal of feline medicine and surgery, v. 17, n. 5, p. 427-439, 2015. ASPRONI, P. Amyloidosis in association with spontaneous feline immunodeficiency virus infection. Journal of feline medicine and surgery, v. 15, n. 4, p. 300-306, 2013. ATABEK, M.E.; PIRGON, O.; ORAN, B.; ERKUL, I.; KURTOGLU, S. Increased cardiac troponin I concentration in diabetic ketoacidosis. Journal Pediatric Endocrinology Metabolism, 17:1077–1082, 2004. BAGSHAW, S.M.; GEORGE, C.; DINU, I.; BELLOMO, R. A multi-centre evaluation of the RIFLE criteria for early acute kidney injury in critically ill patients. Nephrology Dialysis Transplantation, v. 23, p. 1203-1210, 2007. BAGSHAW, S.M.; HOSTE, E.A.; BRAAM, B.; BRIGUORI, C.; KELLUM, J.A.; MCCULLOUGH, P.A.; RONCO, C. Cardiorenal Syndrome Type 3: Pathophysiologic and Epidemiologic Considerations. Contributions to Nephrology, v. 182, p. 137-157, 2013. BANDINELLI, M.B.; BASSUINO, D.M.; FREDO, G.; MARI,C.; DRIEMEIER, D.; SONNE, L.; PAVARINI, S.P. Identificação e distribuição de lesões cardíacas em bovinos intoxicados por Amorimia exotropica. Pesquisa Veterinária Brasileira, v. 34, n. 9, p. 837-844, 2014. BOYCE, J.; DIBARTOLA, S.P.; CHEW, D.J. Familial renal amyloidosis in Abyssinian cats. Veterinary Pathology, 21:33–38, 1984. BROVIDA, C. Diagnóstico precoce de insuficiência renal crônica. Waltham: Revista Focus. Royal Canin, 2004. BROWN, S.A.; CROWELL, W.A., BROWN, J.A., BARSANTI, J.A.; FINCO, D.R. Pathophysiology and Management of Progressive Renal Disease. Vet. J. 154, 1997. BROWN, C.A. Chronic kidney disease in aged cats: clinical features, morphology, and proposed pathogeneses. Veterinary Pathology, v. 53, n. 2, p. 309-326, 2016. CAMPOBASSO, C.P.; DELL’ERBA, A.S.; ADDANTE, A.; ZOTTI, F.; MARZULLO, A.; COLONNA, M.F. Sudden cardiac death and myocardial ischemia indicators a comparative study of four immunohistochemical markers. The American Journal of Forensic Medicine and Pathology, v. 29, n. 2, p. 154-161, 2008. CARMO, P.M.S.; IRIGOYEN, L.F.; LUCENA, R.B.; FIGHERA, R.A.; KOMMERS, G.D.; BARROS, C.S.L. Spontaneous coffee senna poisoning in cattle: Report on 16 outbreaks. Pesquisa Veterinária Brasileira, v. 21, n.1, p. 139-146, 2011. CARDOSO, P.G.S.; PINTO, M.P.R.; MOROZ, L.R.; FONTES, T.N.; SANTOS, R.S.; FREITAS, J.L.; NOGUEIRA, V.A.; PEIXOTO, T.C. Dystrophic mineralization in uremic dogs: an update. Pesquisa Veterinária Brasileira, dados não publicados, 2019. CARRETÓN, E.; GRANDI, G.; MORCHÓN, R.; SIMÓN, F.; PASSERI, B.; CANTONI, A. M.; KRAMER, L.; MONTOYA-ALONSO, J.A. Myocardial damage in dogs affected by heartworm diseade (Dirofilaria immitis): Immunohistochemical study of cardiac myoglobin and troponin I in naturally infected dogs. Veterinary Parasitology, v. 189, p. 390-393, 2012. CARR, A. P.; EGNER B. Blood Pressure in Small Animals-Part 2: Hypertension-target organ damage, heart and kidney. European Journal of Companion Animal Practice, 19.1: 13-17, 2009. CHAKRABARTI, S.; SYME, HM.; BROWN, C.A. Histomorphometry of feline chronic kidney disease and correlation with markers of renal dysfunction. Veterinary Pathology, 50(1):147–155, 2013. CHANTRANUWAT, C.; QIAO, J.H.; KOBASHIGAWA, J.; HONG, L.; SHINTAKU, P.; FISHBEIN, M.C. Immunoperoxidase staining for C4d on paraffin-emmbedded tissue in cardiac allograft endomyocardial biopsies. Applied Immunohistochemistry & Molecular Morphology, v. 12, n. 2, p. 166-171, 2004. CHEW, D.J.; CAROTHERS, M. Hypercalcemia. Veterinary Clinics of North America, n.19, p.265-287, 1989. COSTA, S.Z.R.; PEIXOTO P.V.; D’AVILA, M.S.; SANTOS, A.M.; NOGUEIRA, V.A.; DRIEMEIER, D.; BRUST, L.A.C.; FRANÇA, T.N. Troponina C na detecção de alterações regressivas precoces no miocárdio de ovinos intoxicados naturalmente por Amaranthus spinosus (Amaranthaceae). Anais do VIII Encontro Nacional de Diagnóstico Veterinário. VIII ENDIVET, Cuiabá, MT, 2014. CÔTÉ, E. Congestive Heart Failure. In: CÔTÉ, E. et al. Feline cardiology. 1ªed, Chichester: Wiley-Blackwell, Cap.19 p. 257-302, 2011. COWGILL, L.; KALLET, A. Systemic hypertension, p.360-364.In: Kierk, R. Current veterinary therapy IX (ed.) Philadelphia: W. B. Saunders Company, 1986. CUNNINGHAM, J.G.; KLEIN, B.G. Fisiologia renal. Fisiologia dos animais Domésticos. 4ª ed. Rio de Janeiro. Elsevier Sauders, p. 527-547, 2008. DAMMAN, K.; NAVIS, G.; SMILDE, T.D.J.; VOORS, A.A.; BIJ, W.V.D.; VELDHUISEN, D.J.V.; HILLEGE, H.L. Decreased cardiac output, venous congestion and the association with renal impairment in patients with cardiac dysfunction. European Journal of Heart Failure, v.9, p. 872-878, 2007. DAMMAN, K.; VOORS, A.A.; HILLEGE, H.L.; NAVIS, G.; LECHAT, P.; VELDHUISEN. D.J.V.; DARGIE, H.J. Congestion in chronic systolic heart failure is related to renal dysfunction and increased mortality. European Journal of Heart Failure, n.12, p. 974-982, 2010. DANTAS, A.F.M.; KOMMERS, G.D. Lesões extra-renais de uremia em 72 cães. Ciência Rural, v. 27, n.2, p. 301-306, 1997. D'AVILA, M.S.; FRANCA, T.N.; PEIXOTO, P.F.V.; PEIXOTO, T.C.; SANTOS, A.M.; COSTA, S.Z.R.; SANTOS, R.S; GONCALVES, T.; NOGUEIRA, V.A. . Avaliações morfológica e imunohistoquímica (Troponina C) de lesões cardíacas em cães com doença renal crônica. Revista Brasileira de Medicina Veterinária, v. 38, p. 128-138, 2016. DE ZOYSA, J.R. Cardiac troponins and renal disease. Nephrology (Carlton), 9:83–88, 2004. DHONT, A.; VANHOLDER, R.; BIESEN, V.W; Lamiere, N. The removal of uremic toxins. Kidney International. S58:S47-S58. 2000. DORAN, J.P.; HOWIE, A. J.; TOWNEND, J. N.; BONSER, R. S. Detection of myocardial infarction by immunohistological staining for C9 on formalin fixed, paraffin wax embedded sections. Journal Clinical Pathology, v. 49, p. 34-37, 1996. DRIEHUYS, S.; VAN WINKLE, T.J.; SAMMARCO, C.D, DROBATZ, K.J. Myocardial infarction in dogs and cats: 37 cases (1985–1994). Journal of the American Veterinary Medical Association, 213:1444–1448, 1998. ETTINGER, S.J.; FELDMAN, E.C. Chronic Kidney Disease. Textbook of Veterinary Internal Medicine. 6ªed. St. Louis. Elsevier Saunders, vol. 2, cap. 260, p. 1756-1785, 2005. ESCALON, J.C.; WONG, S.S. False-positive cardiac troponin T levels in chronic hemodialysis patients. Cardiology, 87:268–9, 1996. FELDMAN, E.C. Disorders of the parathyroid glands. p.1437-1461. In: ETTINGER, S.J.; FELDMAN, E.C. Textbook of veterinary internal medicine. 4ªed. Philadelphia: W.B. Saunders.v.2, 1995. FONAROW, G.C.; UCLA. Cardiac Troponin I Assay Diagnostic Module. Clinical Practice Guideline, July, 1996. GLICK, A.D.; HORN, R.G.; HOLSCHER, M. Characterization of feline glomerulonephritis associated with viral-induced hematopoietic neoplasms. American Journal of Pathology, 92: 321–327, 1978. GODOY, M.F.; BRAILE, D.M.; NETO, J.P. A troponina como marcador de injúria celular miocárdica. Arquivos Brasileiros de Cardiologia, v. 71, n. 4, p. 629-633, 1998. GRIENDLING, K.K.; MINIERI, C.A.; OLLERENSHAW, J.D.; ALEXANDER, R.W. Angiotensin II Stimulates NADH and NADPH Oxidase Activity in Cultures Vascular Smooth Muscle Cells. Circulation Research, v. 74, n. 6, p. 1141-1148, 1994. HEYWOOD, J.T. The Cardiorenal Syndrome: Lessons from the ADHERE Database and Treatment Options. Heart Failure Reviews, v. 9, p. 195-201, 2004. HILLEGE, H.L.; NITSCH, D.; PFEFFER, M.A.; SWEDBERG, K.; MCMURRAY, J.J.V.; YUSUF, S.; GRANGER, C.B.; MICHELSON, E.L.; ÖSTERGREN, J.; CORNEL, J.H.; ZEEUW, D.; POCOCK, S.; VELDHUISEN, D.J. Renal Function as a Predictor of Outcome in a Broad Spectrum of Patients With Heart Failure. Circulation, v. 113, p. 671-678, 2006. HU, B.J.; CHEN, Y.C.; ZHU, J. Z. Immunohistochemical study of fibronectin for postmortem diagnosis of early myocardial infarction. Forensic Science International, v. 78, p. 209-217, 1996. IRIS 2019 Staging of CKD. Disponível em: <http://www.iris-kidney.com/> JACKSON, G.; GIBBS, C.R.; DAVIES, M.K.; LIP, G.Y.H. ABC of heart failure. Pathophysiology. British Medical Journal, v. 320, p. 167-170, 2000. JENKINS, C. P.; CARDONA, D. M.; BOWERS, J. N.; OLIAI, B. R.; ALLAN, R. W.; NORMANN, S. J. The utility of C4d, C9, and troponin T immunohistochemistry in acute myocardial infarction. Archives of Pathology & Laboratory Medicine, v. 134, p. 256-263, 2010. JONES, T.C.; HUNT, R.D.; KING, N.W. Depósitos minerais e pigmentos. In: JONES, T.C.; HUNT, R.D.; KING, N.W. Patologia Veterinária. 6ª ed. São Paulo. Manole, cap. 3, p. 63-87, 2000. JUNIOR, K.J.K; WILLIAMS, R.D. Exames laboratoriais em urologia. In: TANAGHO, E.A.; MCANINCH, J.W. Urologia Geral de Smith. Tradução da 17ªed. Rio Grande do Sul. AMGH, cap. 5, p. 46-57, 2010. KAWANO, H.; DO, Y.S.; KAWANO, Y.; STARNES, V.; BARR, M.; LAW, R.E.; HSUEH, W.A. Angiotensin II Has Multiple Profibrotic Effects in Human Cardiac Fibroblasts. Circulation, v. 101, p. 1130-1137, 2000. KELLER, S.P.; KOVACEVIC, A.; HOWARD, J. Evidence of cardiac injury and arrhythmias in dogs with acute kidney injury. Journal of Small Animal Practics, 57: 402–408, 2016. KENT, S.P. Diffusion of myoglobin in the diagnosis of early myocardial ischemia. Laboratory Investigation, v. 46, p. 265-270, 1982. KIDD, L.; STEPIEN, R.L.; AMRHEIW, D.P. Clinical findings and coronary artery disease in dogs and cats with acute and subacute myocardial necrosis: 28 cases. Journal of the American Animal Hospital Association, 36:199–208, 2000. KOGIKA, M.M. Avaliação do cálcio sérico ionizado em cães sadios e em cães com insuficiência renal crônica e acidose metabólica. 134f. Tese (Livre docência em clínica veterinária), Faculdade de Medicina Veterinária e Zootecnia, Universidade de São Paulo, 2002. LAMB, E.J.; WEBB, M.C.; ABBAS, N.A. The significance of serum troponin T in patients with kidney disease: a review of the literature. Annals of Clinical Biochemistry,41:1–9, 2004. LANGENDORF, R.; PIRANI, C.L. The Heart in Uremia - An Electrocardiographic and Pathologic Study. American Heart Journal, v. 33, n. 3, p. 282-307, 1947. LANGHORN, R;. OYAMA, M.A.; KING, L.G. Prognostic importance of myocardial injury in critically ill dogs with systemic inflammation. Journal Veterinary Internal Medicine, 27: 895–903, 2013. LANGHORN, R. & WILLESEN, J.L. Cardiac troponins in dogs and cats. Journal Veterinary Internal Medicine, 30: 36–50, 2016. LANGHORN, R.; JESSEN, L.R.; KLOSTER, A.S.; JENSEN, A.O.; KOCH, J. Cardiac troponin I in cats with compromised renal function. Journal of Feline Medicine and Surgery, p. 1098612X18813427, 2018. LAGRAND, W.K.; NIESSEN, H.W.; WOLBINK, G.J.; JASPARS, L.H.; VISSER, C.A.; VERHEUGT, F.W.A.; MEIJER, C.J.L.M.; HACK, C.E. C-Reactive Protein Co localizes With Complement in Human Hearts During Acute Myocardial Infarction. Circulation, v. 95, p. 97-103, 1997. LANGSTON, C. Managing fluid and electrolyte disorders in renal failure. Veterinary Clinics of North America: Small Animal Practice, v. 38, p. 677-697, 2008. LANGSTON, C.E. Acute renal failure. In: SILVERS, D.C.; E HOPPER, K. Small animal critical care medicine. Missouri. Saunders Elsevier, cap. 135, p. 590-593, 2009. LANGSTON, C.E. Urinary System. In: MORGAN, R.V. Small Animal Practice - Client Handouts. Missouri. Saunders Elsevier, sec. 7, p. 186- 216, 2011. LAZZERI, C.; BONIZZOLI, M.; CIANCHI, G.; GENSINI, G. F.; PERIS, A. troponin I in the intensive care unit setting: from the heart to the heart. Internal and Emergency Medicine, v. 3, p. 9-16, 2008. LEHNHARDT, A.; KEMPER, M.J. Pathogenesis, diagnosis and management of hyperkalemia. Pediatric Nephrology, v. 26, p. 377–384, 2011. LEVEY, A.S.; BETO, J.A.; CORONADO, B.E.; EKNOYAN, G.; FOLEY, R.N.; KASISKE, B.L.; KLAG, M.L.; MAILLOUX, L.U.; MANSKE, C.L.; MEYER, K.B.; PARFREY, P.S.; PFEFFER, M.A.; WENGER, N.K.; WILSON, P.W.F.; WRIGHT, J.T. Controlling the epidemic of cardiovascular disease in chronic renal disease: What do we know? What do we need to learn? Where do we go from here? American Journal of Kidney Diseases, v. 32, n. 5, p. 853–906, 1998. LEVIN, A.; SINGER, J.; THOMPSON, C.R.; ROSS, H.; LEWIS, M. Prevalent Left Ventricular Hypertrophy in the Predialysis Population: Identifying Opportunities for Intervention. American Journal of Kidney Diseases, v. 27, n.3, p. 347-354,1996. LIBBY, P.; RIDKER, P.M.; MASERI, A. Inflammation and atherosclerosis. Circulation, v. 105, n. 9, p. 1135-1143, 2002. LOCATELLI, F.; CANAUD, B.; ECKARDT, K.U.; STENVINKEL, P.; WANNER, C.; ZOCCALI, C. Oxidative stress in end-stage renal disease: an emerging threat to patient outcome. Nephrology Dialysis Transplantation, v. 18, p. 1271-1280, 2003. LONGENECKER, J.C.; CORESH, J.; POWE, N.R.; LEVEY, A.S.; FINK, N.E.; MARTIN, A.; KLAG, M.J. Traditional Cardiovascular Disease Risk Factors in Dialysis Patients Compared with the General Population: The CHOICE Study. Journal of the American Society of Nephrology, v. 13, p. 1918-1927, 2002. LUCKE, V.M. Renal disease in the domestic cat. Journal of Patholology and Bacteriology, 95(1): 67–91, 1968. LUNN, K. F. The kidney in critically ill small animals. Veterinary Clinics of North America Small Animal Practice, v. 41, p. 727-744, 2011. MARKOU N, GREGORAKOS L AND MYRIANTHEFS P. Increased blood troponin levels in ICU patients. Curr Opin Crit Care; 17: 454–463, 2011. MARTIN, L.C.; FRANCO, R.J. A Doença Renal Como Fator de Risco Cardiovascular. Arquivo Brasileiro de Cardiologia, v. 85, n. 6, p. 432-436, 2005. MARTINS, H.; PEDRO, N.; CASTELLANO, M.; MONTEIRO, P.; MOURA, J.J.; PROVIDÊNCIA, L.A. Síndrome Cardio-Renal: Os Desafios no Tratamento da Insuficiência Cardíaca. Acta Médica Portuguesa, v. 24, p. 285-292, 2011. MAXIE, M.G.; NEWMAN S.J. Urinary system. In: Jubb, Kennedy, and Palmer's Pathology of Domestic Animals.5th ed. Philadelphia. Elsevier Saunders, chapter 4, volume 2, p. 426-522, 2007. MAXIE, M.G.; ROBINSON, W.F. Cardiovascular system. In: Jubb, Kennedy, and Palmer's Pathology of Domestic Animals.5ªed. Philadelphia. Elsevier Saunders, chapter 1, volume 3, p. 02-105, 2007. MCLAURIN, M.D.; APPLE, F.S.; VOSS, E.M.; HERZOG, C.A.; SHARKEY, S.W. Cardiac troponin I, cardiac troponin T, and creatine kinase MB in dialysis patients without ischemic heart disease: evidence of cardiac troponin T expression in skeletal muscle. Clinical Chemistry, v. 43, n. 6, p. 976-982, 1997. MCCULLOUGH, P.A. Why Is Chronic Kidney Disease the "Spoiler" for Cardiovascular Outcomes? Journal of the American College of Cardiology, v. 41, n. 5, p. 725-728, 2003. MCCULLOUGH, P.A. Cardiorenal Intersection: Crossroads to the Future. Arquivo Brasileiro de Cardiologia, v. 88, n.1, p. 100-108, 2007. MCLELAND, S.M.; CIANCIOLO, R.E.; DUNCAN, C.G.; QUIMBY, J.M. A comparison of biochemical and histopathologic staging in cats with chronic kidney disease. Veterinary Pathology, 52(3), 524-534, 2015. MCGROTTY, Y. Diagnosis and management of chronic kidney disease in dogs and cats. In practice, v. 30, n. 9, p. 502-507, 2008. NASH, A.; WRIGHT, N.; SPENCER, A. Membranous nephropathy in the cat: a clinical and pathlological study. Veterinary Record, 105:71–77, 1979. NELSON, O.L.; THOMPSON, P.A.; Cardiovascular dysfunction in dogs associated with critical illnesses. Journal of the American Animal Hospital Association, 42:344–349, 2006. NEWMAN, S.J.; CONFER, A.W.; PANCIERA, R.J. Sistema urinário. In: MCGAVIN, M.D. e ZACHARY, J.F. Bases da Patologia em Veterinária. Tradução da 4ª ed. Rio de Janeiro. Elsevier, sec. II, cap. 11, p. 613-692, 2009. NOHRIA, A.; HASSELBLAD, V.; STEBBINS, A.; PAULY, D.F.; FONAROW, G.C.; SHAH, M.; YANCY, C.W.; CALIFF, R.M.; STEVENSON, L.W.; HILL, J.A. Cardiorenal Interactions - Insights From the ESCAPE Trial. Journal of the American College of Cardiology, v. 51, n. 3, p. 1268-1274, 2008. OFFERMAN, S.R.R.; LEERS, M.P.G.; SUYLEN, R.J.V.; NAP, M.; DAEMEN, M.J.A.P.; THEUNISSEN, P.H.M.H. Evaluation of the membrane attack complex of complement for the detection of a recent myocardial infarction in man. The Journal of Pathology, v. 191, p. 48-53, 2000. ORTMANN, C.; PFEIFFER, H.; BRINKMANN, B. A comparative study on the immunohistochemical detection of early myocardial damage. International Journal of Legal Medicine, v. 113, p. 215–220, 2000a. ORTMANN, C.; PFEIFFER, H.; BRINKMANN, B. Demonstration of myocardial necrosis in the presence of advanced putrefaction. International Journal of Legal Medicine, v. 113, p. 215–220, 2000b. OSBORNE, C. A.; STEVENS, J.B.; LULICH, J.P. A clinician´s analysis of urinalysis p.136- 205. In: OSBORNE, C. A.; FINCO, D.R. (ed.) Canine and Feline Nephrology and Urology. 2th. Philadelphia: Willimas & Willkins, 93-109, 1995. PATEINAKIS, P.; PAPAGIANNI, A. Cardiorenal Syndrome Type 4 - Cardiovascular Disease in Patients with Chronic Kidney Disease: Epidemiology, Pathogenesis, and Management. International Journal of Nephrology, v. 2011, p. 1-8, 2011. PAVARINI, S.P.; BANDINELLI, M.B.; JUFFO, G.D.; SOUZA, S.O.; DRIEMEIER, D.; CRUZ, C.E.F. Decreased expression of cardiac troponin C is associated with cardiac lesions in Amorimia exotropica poisoned cattle. Pesquisa Veterinária Brasileira, v. 32, n. 10, p. 1005-1008, 2012. PELANDER, L.; HÄGGSTRÖM, J.; LEY, C.J. Cardiac troponin I and amino-terminal pro B-type natriuretic peptide in dogs with stable chronic kidney disease. Journal of Veterinary Internal Medicine, 31: 805–813, 2017. PEMBERTON, C.J.; JOHNSON, M.L.; YANDLE, T.G.; ESPINER, E.A. Deconvolution analysis of cardiac natriuretic peptides during acute volume overload. Hypertension, v. 36, n. 3, p.355-359, 2000. POLZIN, D.J.; OSBORNE, C.A.; ROSS, S. Chronic Kidney Disease. In: ETTINGER, S.J.; FELDMAN, E.C. Textbook of Veterinary Internal Medicine. 6ªed. St. Louis. Elsevier Saunders, vol. 2, cap. 260, p. 1756-1785, 2004. PORCIELLO, F.; RISHNIW, M.; HERNDON, W.E.; BIRETTONI, F.; ANTOGNONI, M.T.; SIMPSON, K.W. Cardiac troponin I is elevated in dogs and cats with azotemia renal failure and in dogs with non‐cardiac systemic disease. Australian Veterinary Journal, https://doi.org/10.1111/j.1751-0813.2008.00345.x, 2008. POUCHELON, J. L.; ATKINS, C.E.; BUSSADORI, C.; OYAMA, M.A.; VADEN, S. L.; BONAGURA, J.D.;VAN ISRAËL, N. Cardiovascular–renal axis disorders in the domestic dog and cat: a veterinary consensus statement. Journal of Small Animal Practice, v. 56, n. 9, p. 537-552, 2015. 86, n. 10, p. 390-394, 2015. REID, I.A. Interactions between ANG II, sympathetic nervous system and baroreceptor reflexes in regulation of blood pressure. American Journal of Physiology, v. 262, n. 6, p. E763-E778, 1992. RIBEIRO, R.C.H.M.; OLIVEIRA, G.A.S.A.; RIBEIRO, D.F.; BERTOLIN, D.C.; CESARINO, C.B.; LIMA, L.C.E.Q.; OLIVEIRA, S.M. Caracterização e etiologia da insuficiência renal crônica em unidade de nefrologia do interior do Estado de São Paulo. Acta Paulista de Enfermagem, v. 21, n. especial, 2008. RISHNIW, M.; THOMAS, W.P. Dynamic right ventricular outflow obstruction: a new cause of systolic murmurs in cats. Journal of Veterinary Internal Medicine,16:547–552, 2002. RONCO, C. Cardiorenal and renocardiac syndromes: Clinical disorders in search of a systematic definition. The International Journal of Artificial Organs, v. 31, n. 1, p. 1-2, 2008a. RONCO, C.; HOUSE, A.A.; HAAPIO, M. Cardiorenal syndrome: refining the definition of a complex symbiosis gone wrong. Intensive Care Medicine, v. 34, p. 957-962, 2008b. RONCO, C.; HAAPIO, M.; HOUSE, A.A.; ANAVEKAR, N.; BELLOMO, R. Cardiorenal Syndrome. Journal of the American College of Cardiology, v. 52, n. 19, p. 1527- 1539, 2008c. RONCO, C. & DI LULLO L. Cardiorenal syndrome. Heart Failure Clinics, 10: 251–280, 2014. ROSS, L. Hypertension and chronic renal failure. Seminars in Veterinary Medicine and Surgery. n.7, p.221-226, 1992. RUIZ-ORTEGA, M.; LORENZO, O.; EGIDO, J. Angiotensin III increases MCP-1 and activates NF-kB and AP-1 in cultured mesangial and mononuclear cells. Kidney International, v. 56, p. 2285-2298, 2000. SAMPEDRANO. Systolic and diastolic myocardial dysfunction in cats with hypertrophic cardiomyopathy or systemic hypertension. Journal of veterinary internal medicine, v. 20, n. 5, p. 1106-1115, 2006. SANTOS, A.M., PEIXOTO, P.V., D'ÁVILA, M.S., PEIXOTO, T.C., FRANÇA, T.N., COSTA, S.Z., CID, G.C. & NOGUEIRA, V. A. Troponin C in immunohistochemical detection of early regressive myocardial lesions in cattle and sheep poisoned with sodium monofluoroacetate. Pesquisa Veterinária Brasileira. 36(2):67-72. 2016. SANTOS, A.M.; D'AVILA, M.S.; COSTA, S.Z.R.; PEIXOTO, T.C.; NOGUEIRA, V.A.; FRANÇA, T.N.; PEIXOTO, P.V. Troponina C na detecção imunohistoquímica de alterações regressivas precoces no miocárdio de bovinos e ovinos intoxicados por monofluoroacetato de sódio. Anais do VIII Encontro Nacional de Diagnóstico Veterinário. VIII ENDIVET, Cuiabá, MT, 2014. SCHIFFRIN, E.L.; LIPMAN, M.L.; MANN, J.F.E. Chronic Kidney Disease. Circulation Research.n.116, p.85-97, 2007. SCHRIER, R.W. Cardiorenal versus renocardiac syndrome: is there a difference? Nature Clinical Practice Nephrology, v. 3, p. 637, 2007. SILVA, A.R.; MARTIN, C.C.S.; ROSSI, M.A. Is immunohistochemistry a useful in the postmorten recognition of myocardial hypoxia in human tissue with no morphological evidence of necrosis? The American Journal of Forensic Medicine and Pathology, v. 23, n. 1, 2002. SINGH, A.P.; MUTHURAMAN, A.; JAGGI, A.S.; SINGH, N.; GROVER, K.; DHAWAN, R. Animal models of acute renal failure. Pharmacological Reports, v. 64, p 31-44, 2012. SLEEPER, M.M.; CLIFFORD, C.A.; LASTER, L.L. Cardiac Troponin I in the Normal Dog and Cat. Journal of Veterinary Internal Medicine, v. 15, p. 501-503, 2001. STIGGER, A.L.; BARROS, C.S.L.; LANGOHR, I.M.; BARROS, S.S. Intoxicação experimental por Ateleia glazioviana (Leg.Papilionoideae) em ovinos. Pesquisa Veterinária Brasileira, v.21, n.3, p.98- 108, 2001. SUTTON, R.A.L.; DIRKS, J.H. Disturbances of calcium and magnesium metabolism p.1038-1085. In: BRENNER, B. M.; RECTOR, F.C. The Kidney. 5ªed. Philadelphia: W.B. Saunders, 1996. VAN KIMMENADE, R.R.J. & JANUZZI, J.L. The evolution of the natriuretic peptides current applications in human and animal medicine. Journal of Veterinary Cardiology, v. 11, p.9-21, 2009. VANHOLDER, R.; SMET, R. Pathophysiologic effect of uremic retention solutes. Journal of American Society and Nephrology. n.10, p.1815-1823, 1999. VANHOLDER, R.; LAECKE, S.V. What is new in uremic toxicity?. Pediatric Nephrology, n.23, p.1211-1221, 2008. VERLANDER, J.W. Fisiologia renal. In: CUNNINGHAM, J.G.; KLEIN, B.G. Fisiologia dos animais Domésticos. 4ª ed. Rio de Janeiro. Elsevier Sauders, p. 527-547, 2008. VISWANATHAN, G.; GILBERT, S. The Cardiorenal Syndrome: Making the Connection. International Journal of Nephrology, v. 2011, p. 1-10, 2011. WOOD, G.N.; KEEVIL, B.; GUPTA, J. Serum troponin T measurement in patients with chronic renal impairment predicts survival and vascular disease: a 2 year prospective study. Nephrology Dialysis Transplantion,18:1610–1615, 2003. WURTINGER, G.; HENRICH, E.; HILDEBRANDT, N.; WIEDEMANN, N.; SCHNEIDER, M.; HASSDENTEUFEL, E. Assessment of a bedside test for N-terminal pro B-type natriuretic peptide (NT-proBNP) to differentiate cardiac from non-cardiac causes of pleural effusion in cats. Bmc Veterinary Research, v. 13, n. 1, p.394, 2017. YASOJIMA, K.; SCHWAB, C.; MCGEER, P.L. Human heart generates complement proteins that are upregulated and activated after myocardial infarction. Circulation Research, v. 83, n. 8, p. 860-869, 1998. ZOYSA, J.R.D. Cardiac troponins and renal disease. Nephrology, v. 9, p. 83-88, 2004.por
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