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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ribeiro, Wallace Martins Vianna | |
| dc.date.accessioned | 2023-12-22T01:52:18Z | - |
| dc.date.available | 2023-12-22T01:52:18Z | - |
| dc.date.issued | 2020-12-14 | |
| dc.identifier.citation | RIBEIRO, Wallace Martins Vianna. Efeito da terapia farmacológica e do treinamento resistido sobre respostas comportamentais no modelo experimental de TDAH. 2020. 50 f. Dissertação (Mestre em Ciências Fisiológicas, Fisiologia) - Instituto de Ciências Biológicas e da Saúde, Departamento de Ciências Fisiológicas, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2020. | por |
| dc.identifier.uri | https://rima.ufrrj.br/jspui/handle/20.500.14407/11401 | - |
| dc.description.abstract | Introdução: O TDAH é caracterizado como um distúrbio do neurodesenvolvimento com níveis prejudiciais de impulsividade, hiperatividade e desatenção, podendo também afetar a memória de trabalho ou de curto prazo. Objetivos: Na primeira etapa, foi verificado se os SHR da Universidade Federal Rural do Rio de Janeiro apresentam respostas comportamentais semelhantes ao TDAH e na segunda etapa foi investigado o papel do treinamento resistido de alta intensidade (TR), da terapia farmacológica (MP), e resposta combinada (treinamento associado ao fármaco) sobre as alterações comportamentais no modelo experimental de TDAH. Metodologia: Foi utilizado TR de alta intensidade (grupo TDAHtr; n=10), MP (grupo TDAHmp; n=10) e TR+MP (grupo TDAHtr+mp; n=10) comparados com grupo controle (TDAHct; n=10). Para avaliar as respostas comportamentais, foram utilizados o Teste do Campo Aberto (CA), Labirinto em Cruz Elevado (LCE), Labirinto de Barnes (LB) e Esquiva Passiva (EP). Resultados: No teste do Campo Aberto foi avaliada a hiperatividade através dos quadrantes totais percorridos, a exposição ao risco através do tempo em quadrante central e a impulsividade através do número de quadrantes centrais percorridos. Os grupos experimentais TDAHmp, TDAHtr e TDAHtr+mp apresentaram diferença significativa (p<0,05) com menor hiperatividade, menor tempo em exposição ao risco e menor impulsividade em comparação ao grupo controle, sem que houvesse diferenças significativas entre os grupos experimentais. No teste do Labirinto em Cruz Elevado, foi avaliada a hiperatividade através do número de transições entre os braços abertos e fechados o tempo em exposição ao risco através do tempo de permanência nos braços abertos, o tempo em avaliação de risco através da postura alongada (SAP) e a impulsividade através do número de entradas nos braços abertos. Os grupos experimentais TDAHmp, TDAHtr e TDAHtr+mp apresentaram diferenças sifnificativas (p<0,05) com menor hiperatividade, menor tempo em exposição ao risco, maior tempo em avaliação do risco, e menor impulsividade quando comparados ao grupo controle, sem que houvesse diferenças entre os grupos experimentais, exceto no tempo em avaliação de risco, no qual TDAHtr+mp apresentou resultados ainda melhores que TDAHmp e TDAHtr. Os resultados acerca da memória, obtidos através dos testes do Labirinto de Barnes e Esquiva Passiva demonstram que os grupos experimentais TDAHmp, TDAHtr e TDAHtr+mp obtiveram melhor desempenho em ambos os testes de memória, quando comparados ao grupo controle (p<0,05). Todavia, TDAHtr+mp apresentou melhor resultado que TDAHtr, indicando uma possível vantagem da resposta combinada neste parâmetro. Conclusão: O treinamento resistido e a terapia farmacológica, assim como a combinada, foram eficazes em reverter significativamente os principais sintomas análogos ao TDAH na maioria dos testes aplicados. | por |
| dc.description.sponsorship | CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior | por |
| dc.format | application/pdf | * |
| dc.language | por | por |
| dc.publisher | Universidade Federal Rural do Rio de Janeiro | por |
| dc.rights | Acesso Aberto | por |
| dc.subject | TDAH | por |
| dc.subject | Treinamento Resistido | por |
| dc.subject | Comportamento | por |
| dc.subject | ADHD | eng |
| dc.subject | Resistance Training | eng |
| dc.subject | Behavior | eng |
| dc.title | Efeito da terapia farmacológica e do treinamento resistido sobre respostas comportamentais no modelo experimental de TDAH | por |
| dc.title.alternative | Effect of pharmacological therapy and resistance training on behavioral responses in the experimental model of ADHD | eng |
| dc.type | Dissertação | por |
| dc.description.abstractOther | Introduction: ADHD is characterized as a neurodevelopmental disorder with harmful levels of impulsivity, hyperactivity and inattention, and can also affect working or short-term memory. Objectives: In the first stage, it was verified whether the SHR of the Federal Rural University of Rio de Janeiro have behavioral responses similar to ADHD and in the second stage, the role of high-intensity resistance training (RT), pharmacological therapy (MP), and combined response (drug-associated training) were investigated on behavioral changes in the experimental model of ADHD. Methods: High-intensity RT group (ADHDrt; n=10), MP group (ADHDmp group; n=10) and TR+MP group (ADHDrt+mp; n=10) were used compared to the control group (ADHDct; n=10). To assess behavioral responses, the Open Field Test (OF), Elevated Plus Maze (EPM), Barnes Maze (BM) and Avoidance Test (AT) were used. Results: In the Open Field test, hyperactivity was assessed through the total quadrants covered, exposure to risk over time in the central quadrant and impulsivity through the number of central quadrants covered. The experimental groups ADHDmp, ADHDtr and ADHDrt+mp showed a significant difference (p <0.05) with less hyperactivity, less time in exposure to risk and less impulsivity compared to the control group, without significant differences between the experimental groups. In the Labyrinth in Cross Elevated test, hyperactivity was assessed through the number of transitions between open and closed arms, the time in risk exposure through the time in the open arms, the time in risk assessment through extended posture (SAP) and impulsiveness through the number of open arms entries. The experimental groups ADHDmp, ADHDtr and ADHDrt+mp showed significant differences (p<0.05) with less hyperactivity, less time in risk exposure, more time in risk assessment, and less impulsiveness when compared to the control group, without any differences between the experimental groups, except for the time in risk assessment, in which ADHDrt+mp showed even better results than ADHDmp and ADHDtr. The results about memory, obtained through the Barnes Labyrinth and Passive Dodge tests demonstrate that the experimental groups ADHDmp, ADHDtr and ADHDrt+mp obtained better performance in both tests of memory, when compared to the control group (p<0.05). However, ADHDrt+mp showed better results than ADHDtr, indicating a possible advantage of the combined response in this parameter. Conclusion: Resistance training and pharmacological therapy, as well as combination therapy, were effective in significantly reversing the main symptoms similar to ADHD in most of the tests applied. | eng |
| dc.contributor.advisor1 | Silveira, Anderson Luiz Bezerra da | |
| dc.contributor.advisor1ID | 078.828.167-44 | por |
| dc.contributor.referee1 | Silveira, Anderson Luiz Bezerra da | |
| dc.contributor.referee2 | Giusti, Fabiana Cardoso Vilela | |
| dc.contributor.referee3 | Olivares, Emerson Lopes | |
| dc.creator.ID | 124.232.537-96 | por |
| dc.creator.Lattes | http://lattes.cnpq.br/5820622607230348 | por |
| dc.publisher.country | Brasil | por |
| dc.publisher.department | Instituto de Ciências Biológicas e da Saúde | por |
| dc.publisher.initials | UFRRJ | por |
| dc.publisher.program | Programa de Pós-Graduação em Ciências Fisiológicas | por |
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M.; ROBBINS, T. W. Behavioral models of impulsivity in relation to ADHD: Translation between clinical and preclinical studies. Clinical Psychology Review, v. 26, n. 4, p. 379–395, 2006. WOLRAICH, M. et al. ADHD: Clinical practice guideline for the diagnosis, evaluation, and treatment of attention-deficit/ hyperactivity disorder in children and adolescents. Pediatrics, v. 128, n. 5, p. 1007–1022, 2011. YUEN, E. Y. et al. Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex. Neuron, v. 73, n. 5, p. 962–977, 2012. | por |
| dc.subject.cnpq | Fisiologia | por |
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| dc.originais.uri | https://tede.ufrrj.br/jspui/handle/jspui/5746 | |
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