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dc.contributor.authorCorreia, Carolina de Albuquerque
dc.date.accessioned2023-12-22T01:57:07Z-
dc.date.available2023-12-22T01:57:07Z-
dc.date.issued2020-02-17
dc.identifier.citationCORREIA, Carolina de Albuquerque. Influência de linfócitos B-1 na dinâmica de leucócitos de animais deficientes da Tirosina Quinase de Bruton (XID). 2020. 36 f. Dissertação (Mestrado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2020.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/11805-
dc.description.abstractA inflamação é uma reação fisiológica do organismo a um agente agressor e pode ser desencadeada por uma infecção e/ou por uma injúria. A fase aguda desse processo é uma resposta rápida e ocorre nos primeiros minutos e horas após o reconhecimento do patógeno. Sua resolução geralmente resulta na eliminação dos agentes infecciosos e reparo da arquitetura e função normais dos tecidos. A fase crônica se instaura quando as tentativas de restabelecimento da homeostase não são bem-sucedidas. Muitas vezes, apenas a ação dos fagócitos é suficiente para conter a inflamação, entretanto, se o estímulo nocivo perdurar, outros agentes do sistema imunológico são acionados, configurando a inflamação dentro da resposta adaptativa. As células dendríticas fazem a ligação entre a resposta imune inata e a adaptativa, pois são especializadas em processar e expor fragmentos dos antígenos para os linfócitos T. Esses, por sua vez, auxiliam na ativação de linfócitos B, que são células capazes de produzir e secretar anticorpos e formar células de memória. Os linfócitos B-1 constituem uma subpopulação de linfócitos B e têm como características a produção de anticorpos naturais, apresentação de antígenos aos linfócitos T e a liberação de várias citocinas, dentre elas a citocina anti-inflamatória IL-10. Assim, eles têm o potencial de modular a resposta inflamatória. Neste trabalho, nós avaliamos a dinâmica populacional dos leucócitos no sangue e na cavidade peritoneal de camundongos BALB/c e XID durante a resposta inflamatória aguda desencadeada por LPS. Para isso, usamos camundongos XID, cujo peritônio é um ambiente com pouquíssimos linfócitos B-1. Nossos resultados revelaram que os animais XID, espontaneamente, tem um número elevado de neutrófilos no sangue periférico e essa população fica ainda maior após a estimulação com LPS. Concomitantemente, altos níveis de IL-6 foram detectados. Além disso, a cavidade peritoneal desses animais também tem quantidade maior de neutrófilos, em comparação com camundongos BALB/c. Esse dado não sofre alteração após estimulação em nossas condições experimentais. Nos ensaios com fagócitos, observamos que o número de macrófagos capazes de fagocitar é estatisticamente igual entre BALB/c e XID, mas o número de leveduras internalizadas é menor no grupo XID LPS+IFN-γ. Isso sugere uma maior atividade microbicida dos macrófagos desses camundongos. Esse resultado é corroborado pela dosagem de nitrito no sobrenadante das culturas, na qual os macrófagos XID estimulados produziram mais óxido nítrico que o grupo controle. Nossos resultados, em conjunto, sugerem uma habilidade em desenvolver resposta inflamatória mais intensa nos camundongos XID em comparação com camundongos BALB/c, provavelmente devido a baixa produção da citocina anti-inflamatória IL-10. Logo, nossa análise reporta pela primeira vez que camundongos XID possuem número aumentado na população de neutrófilos no sangue e cavidade peritoneal, quando comparado com BALB/c, indicando a importância dos linfócitos B-1 na modulação da resposta inflamatória e sugerindo que esses possam ser futuros alvos de investigações em estratégias de imunoterapiapor
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.description.sponsorshipCNPQ - Conselho Nacional de Desenvolvimento Científico e Tecnológicopor
dc.description.sponsorshipFAPERJ - Fundação de Amparo à Pesquisa do Estado do Rio de Janeiropor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectLinfócitos B-1por
dc.subjectInflamaçãopor
dc.subjectModulaçãopor
dc.subjectB-1 lymphocyteseng
dc.subjectInflammationeng
dc.subjectModulationeng
dc.titleInfluência de linfócitos B-1 na dinâmica de leucócitos de animais deficientes da Tirosina Quinase de Bruton (XID)por
dc.title.alternativeInfluence of B-1 lymphocytes on the leucocyte dynamics of Bruton’s Tyrosine Kinase deficient animals (XID)eng
dc.typeDissertaçãopor
dc.description.abstractOtherInflammation is a physiological reaction of the body to an offending agent and can be triggered by infection and/or injury. The acute phase of this process is a rapid response and occurs in the first minutes and hours after pathogen recognition. Its resolution usually results in the elimination of infectious agents and repair of the normal tissue architecture and function. The chronic phase begins when attempts to restore homeostasis are unsuccessful. Often, the action of phagocytes is sufficient to contain inflammation, however, if the harmful stimulus lasts, other agents of the immune system are activated, configuring the inflammation within the adaptive response. Dendritic cells make the connection between the innate and adaptive immune responses, as they are specialized in processing and exposing fragments of antigens to T lymphocytes. These, in turn, assist in the activation of B-lymphocytes, which are cells capable of producing and secrete antibodies and form memory cells. B-1 lymphocytes are a subpopulation of B-lymphocytes, characterized by the production of natural antibodies, presentation of antigens to T lymphocytes and the release of various cytokines, including the anti-inflammatory cytokine IL-10. Thus, they have the potential to modulate the inflammatory response. In this work, we evaluated the population dynamics of leukocytes in the blood and in the peritoneal cavity of BALB/c and XID mice during the acute inflammatory response, triggered by LPS. Thus, we used XID mice, whose peritoneum is an environment with very few B-1 lymphocytes. Our results revealed that XID animals spontaneously have a high number of neutrophils in peripheral blood and this population is even greater after stimulation with LPS. Concomitantly, high levels of IL-6 were detected. In addition, the peritoneal cavity of these animals also has a greater amount of neutrophils, compared to BALB/c mice. This data does not change after stimulation in our experimental conditions. In phagocyte assays, we found out that the number of macrophages capable of phagocyting is statistically equal between BALB/c and XID, but the number of internalized yeasts is lower in the XID LPS+IFN-γ group. This suggests an increased microbicidal activity of the macrophages of these mice. This result is corroborated by the dosage of nitrite in the culture supernatant, in which the stimulated XID macrophages produced more nitric oxide than the control group. Our results together suggest an ability to develop a more intense inflammatory response in XID mice compared to BALB/c mice, probably due to the impairment in the production of the anti-inflammatory cytokine IL-10. Therefore, our analysis reports for the first time that XID mice have an increased number of neutrophil populations in the blood and peritoneal cavity when compared to BALB/c, indicating the importance of B-1 lymphocytes in modulating the inflammatory response and suggesting that these may be future targets of investigations in immunotherapy strategieseng
dc.contributor.advisor1Lima, Debora Decote Ricardo de
dc.contributor.advisor1ID875.362.007-06por
dc.contributor.advisor1IDhttps://orcid.org/0000-0001-8761-7641por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3572066508469025por
dc.contributor.advisor-co1Lima, Célio Geraldo Freire de
dc.contributor.advisor-co1ID002.031.157-59por
dc.contributor.advisor-co1IDhttps://orcid.org/0000-0002-4148-3657por
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/9591632153788667por
dc.contributor.referee1Lima, Debora Decote Ricardo de
dc.contributor.referee1ID875.362.007-06por
dc.contributor.referee1IDhttps://orcid.org/0000-0001-8761-7641por
dc.contributor.referee1Latteshttp://lattes.cnpq.br/3572066508469025por
dc.contributor.referee2Nascimento, Danielle de Oliveira
dc.contributor.referee2Latteshttp://lattes.cnpq.br/7254526945220214por
dc.contributor.referee3Fonseca, Leonardo Marques da
dc.contributor.referee3Latteshttp://lattes.cnpq.br/2723305557021149por
dc.contributor.referee4Silva, Lucia Helena Pinto da
dc.contributor.referee4IDhttps://orcid.org/0000-0002-7085-8649por
dc.contributor.referee4Latteshttp://lattes.cnpq.br/0013386072339397por
dc.contributor.referee5Guedes, Herbert Leonel de Matos
dc.contributor.referee5IDhttps://orcid.org/0000-0002-3819-3069por
dc.contributor.referee5Latteshttp://lattes.cnpq.br/7011121250058339por
dc.creator.ID121.231.357-71por
dc.creator.Latteshttp://lattes.cnpq.br/7916288755236610por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Ciências Veterináriaspor
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dc.subject.cnpqMedicina Veterináriapor
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