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dc.contributor.authorSantos, Bartolomeu Benedito Neves dos
dc.date.accessioned2023-12-22T02:57:02Z-
dc.date.available2023-12-22T02:57:02Z-
dc.date.issued2020-02-19
dc.identifier.citationSANTOS, Bartolomeu Benedito Neves. Imunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cães. 2020. 56 f. Dissertação (Mestrado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2020.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/14169-
dc.description.abstractA literatura sobre plasmocitomas extramedulares caninos (PEMCs) é ampla e com informações divergentes. Devido sua grande variação morfológica, essa neoplasia é comumente confundida com outros tumores benignos e malignos na rotina de diagnóstico histopatológico; principalmente com o histiocitoma cutâneo canino (HCC), o sarcoma histiocítico canino (SHC) e o linfoma canino (LC). Com o objetivo de fornecer informações adicionais sobre a imunofenotipagem dos PEMCs, testes de imuno-histoquímica foram realizados em microarranjo de tecidos (TMA) com cores de 2mm, usando os marcadores convencionais CD79a (em duplicata), CD3 (em duplicata), MUM1 (em duplicata), Iba1 e cadeias leves λ e κ de imunoglobulina em amostras de 39 PEMCs, 27 HCCs e 8 LCs. Para fins de comparação e controle, o estudo também incluiu amostras de 2 SHCs, 2 mastocitomas cutâneos (MCC), 2 melanomas orais, 1 mieloma múltiplo e espécimes de linfonodo, baço, medula óssea e pele caninos. Além disso, foi feita uma investigação inédita com o anticorpo monoclonal antireceptor α da interleucina 3 (CD123) aplicado a cães. O CD123 tem sido amplamente estudado na medicina humana como eficiente marcador de algumas neoplasias linfoides, de mastócitos e de células dendríticas plasmocitoides blásticas, mas é praticamente inexplorado na medicina veterinária. Com o objetivo de avaliar a eficiência do microarranjo de tecidos (TMA) para alguns dos marcadores, realizou-se um estudo imuno-histoquímico piloto nas seções histológicas convencionais com MUM1 e CD79a em 27 amostras de PEMCs e 10 de HCCs, com os anticorpos anti-CD3 e CD79a em 8 amostras de LCs (5 cutâneos e 3 nodais) e com o anti-CD123 em amostras de 7 PEMCs e 2 HCCs. As conclusões mais importantes foram: 1) MUM1 é muito sensível (89,7%) para detectar PEMCs e eficiente para diferenciar os PEMCs de neoplasias histiocíticas. 2) Linfomas de células T podem expressar MUM1. 3) O CD123 é expresso por PEMCs, MCCs e SHCs, além de plasmócitos normais, endotélio e possivelmente por células dendríticas plasmocitoides caninas. 4) A expressão do antígeno CD123 em neoplasias malignas como MCC e SHC deve ser melhor investigada. 5) O anticorpo Iba1 teve 100% de sensibilidade para detectar HCCs e SHCs e, é muito específico para essas neoplasias.por
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectPlasmocitoma caninopor
dc.subjectCélula dendrítica plasmocitoidepor
dc.subjectCD123por
dc.subjectCanine plasmacytomaeng
dc.subjectPlasmacytoid dendritic celleng
dc.titleImunofenotipagem comparada dos plasmocitomas extramedulares, histiocitomas e linfomas cutâneos em cãespor
dc.title.alternativeCompared immunophenotyping of extramedullary plasmacytomas, histiocytomas and cutaneous lymphomas in dogseng
dc.typeDissertaçãopor
dc.description.abstractOtherThe literature about canine extramedullary plasmacytoma (CEP) is wide and contradictory. Due its great morphological variety, this neoplasm is commonly confused with others benign and malignant tumors in histopathologic diagnostic routine; mainly with Canine Cutaneous Histiocytoma (CCH), Canine Histiocytic Sarcoma (CHS) and Canine Lymphoma (CL). Aiming to compile information to investigate and clarify aspects regarding the immunophenotyping of CEPs, immunohistochemistry tests were performed in tissue microarray (TMA) with 2mm colors, using the conventional markers CD79a (in duplicate), CD3 (in duplicate), MUM1 (in duplicate), Iba1 and immunoglobulin λ and κ light chains in 39 CEPs, 27 CCHs and 8 CLs. For comparison and control purposes, the study also included samples from 2 CHSs, 2 cutaneous mast cell tumors (MCT), 2 oral melanomas and 1 multiple myeloma; in addition to normal and reactive tissues from canine lymph nodes, spleen, bone marrow and skin. Furthermore, an analysis unprecedented was carried out with the antibody anti- Interleukin 3 alpha receptor (CD123) applied in dogs. The CD123 has been widely studied in human medicine as an efficient marker of some lymphoid neoplasms, mast cells and blastic plasmacytoid dendritic cells, but it is practically unexplored in medicine veterinary. To evaluate the efficiency of the tissue microarray (TMA) for some markers used, a pilot immunohistochemical study was carried out in the conventional histological sections with MUM1 and CD79a in 27 samples of CEPs and 10 of CCHs, with antibodies anti-CD3 and CD79a in 8 samples of CLs (5 cutaneous and 3 nodal) and with anti-CD123 in samples of 7 CEPs and 2 CCHs. The mainly conclusions found out were: 1) MUM1 is very sensitive (89.7%) to detect CEPs and efficient to differentiate CEPs from histiocytic neoplasms; 2) T-cell lymphomas can to express MUM1; 3) CD123 is expressed in CEPs, MCCs and CHSs, in addition to normal plasmocytes, endothelium and possibly by canine plasmacytoid dendritic cells; 4) CD123 antigen expressions in malignant neoplasms such as MCC and CHS must be further investigated; 5) The Iba1 antibody had 100% sensitivity to detect CCHs and CHSs, being very specific for these neoplasms.eng
dc.contributor.advisor1França, Ticiana do Nascimento
dc.contributor.advisor1ID027.897.197-05por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3545873525091315por
dc.contributor.advisor-co1Hassan, Claudia Esther Alicia Rocio
dc.contributor.advisor-co1ID053.521.647-56por
dc.contributor.referee1França, Ticiana do Nascimento
dc.contributor.referee2Nascimento, Aparecida Alves do
dc.contributor.referee3Nogueira, Vivian de Assunção
dc.contributor.referee4Driemeier, David
dc.creator.ID037.024.961-57por
dc.creator.IDhttps://orcid.org/0000-0002-6147-319Xpor
dc.creator.Latteshttp://lattes.cnpq.br/0596268295640239por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)por
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