Avaliação da toxicidade e da hipersensibilidade induzida por doses diluídas de veneno de abelha em cães

Yasui, Anne Marie

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DC Field	Value	Language
dc.contributor.author	Yasui, Anne Marie
dc.date.accessioned	2023-12-22T02:58:12Z	-
dc.date.available	2023-12-22T02:58:12Z	-
dc.date.issued	2012-07-26
dc.identifier.citation	YASUI, Anne Marie. Avaliação da toxicidade e da hipersensibilidade induzida por doses diluídas de veneno de abelha em cães. 2012. 33 f. Dissertação (Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas) - Universidade Federal Rural do Rio de Janeiro, Seropédica.	por
dc.identifier.uri	https://rima.ufrrj.br/jspui/handle/20.500.14407/14245	-
dc.description.abstract	O veneno de abelhas (BV, do inglês beevenom), vem sendo usado com propósitos terapêuticos tanto em medicina humana quanto em medicina veterinária. A apipuntura é uma prática terapêutica da acupuntura, onde o veneno de abelhas é injetado empontos de acupuntura, através do próprio ferrão do inseto na pele ou de aplicação de injeções de veneno diluído. Apesar dos efeitos promissores do BV, o potencial tóxico do veneno de abelhas deve ser considerado. O objetivo deste estudo foi monitorar os possíveis efeitos tóxicos e a resposta cutânea local induzida pela injeção de doses diluídas em cães Beagles sadios. A resposta cutânea local foi mensurada através da distensão tecidual relativa onde a distensão da orelha esquerda, injetada com 0,1 ml de uma solução de BV diluído em salina nas doses de 0,3mg/kg (n=4), 0,043mg/kg (n=4) de BV/animal ou de salina (grupo controle, n=4) foi comparada com a distensão da orelha direita injetada com salina. A distensão tecidual relativa foi analisada nos tempos 5, 10, 15, 30 minutos, 1, 6, 12, 24, 48 e 72 horas pós inoculação do veneno. As alterações clínicas como freqüência cardíaca e respiratória, pressão arterial e temperatura; assim como as reações comportamentais; os perfis hematológico (hemograma) e renal (uréia, creatinina) e foram monitorados em diferentes tempos após a inoculação. O pico de distensão tecidual relativa ocorreu 6 horas após a inoculação do veneno, sendo a dose de 0,3mg/kg capaz de produzir distensão diferente do controle-salina nos tempos 1, 6 e 12 horas após inoculação. Não foram detectadas diferenças siginificativas entre os grupos nos demais parâmetros analisados. Estes resultados indicam que o veneno de abelhas em cães produz um pico dereação cutânea local 6 horas após a inoculação e que as doses de 0,3mg/kg e 0,043mg/kg não produzem alterações comportamentais ou autonômicas significaticas além de não produzir nefrotoxidade ou alterações no perfil hematológico de cães.	por
dc.format	application/pdf	*
dc.language	por	por
dc.publisher	Universidade Federal Rural do Rio de Janeiro	por
dc.rights	Acesso Aberto	por
dc.subject	veneno de abelha	por
dc.subject	apipuntura	por
dc.subject	cães	por
dc.subject	toxidade	por
dc.subject	reação cutânea local	por
dc.subject	beevenom	eng
dc.subject	apipuncture	eng
dc.subject	dogs	eng
dc.subject	toxicity	eng
dc.subject	cutaneous local reaction	eng
dc.title	Avaliação da toxicidade e da hipersensibilidade induzida por doses diluídas de veneno de abelha em cães	por
dc.title.alternative	Assessment of toxicity and hypersensitivity induced by diluted doses of bee venom in dogs	por
dc.type	Dissertação	por
dc.description.abstractOther	The bee venom (BV) has been used for therapeutic purposes in both human medicine and veterinary medicine. The apipuncture is a therapeutic practice of acupuncture, where the bee venom is injected into acupuncture points, by their own insect's sting into the skin or injections of diluted venom. Despite the promising effects of BV, the toxic and allergenic potential of bee venom should be considered. The aim of this study was to check the possible toxic effects and local cutaneous reaction of the injection of diluted doses in healthy dogs Beagles. The local cutaneous reaction was measured by relative tissue distension on where the distension of the left ear (injected with 0.1 ml of a solution BV diluted with saline in the doses of 0.3 mg / kg (n = 4), 0.043 mg / kg (n= 4) BV / animal or saline (control group, n = 4) was compared with the distension of the right ear, injected with saline. The tissue distension was analyzed on the times of 5, 10, 15, 30 minutes, 1, 6, 12, 24, 48 and 72 hours post inoculation. Clinical changes such as heart rate and respiratory rate, blood pressure and temperature as well as behavioral responses, the profiles hematologic (blood) and kidney (urea, creatinine and urinalysis) were monitored at different times after inoculation. The peak of tissue distension occurred 6 hours after venom inoculation and the dose of 0.3 mg/kg producedsignificant higher distension than the saline-control group one, 6 and 12 hours after inoculation. No siginicant differences were found between groups for the other parameters. These results indicate that the bee venom in dogs produced a peak of cutaneous distension 6 hours after inoculation and that the dosis of 0.3 mg / kg and 0.043 mg / kg did not produced significant behavioral or autonomic changes and did not produced nephrotoxicity or hematological changes in dogs.	eng
dc.contributor.advisor1	Medeiros, Magda Alves de
dc.contributor.advisor1ID	036.592.248-38	por
dc.contributor.advisor1Lattes	http://lattes.cnpq.br/6392136073564306	por
dc.contributor.referee1	Szabó, Márcia Valéria Rizzo Sconamillo
dc.contributor.referee2	Danelli, Maria das Graça
dc.contributor.referee3	Côrtes, Wellington
dc.creator.ID	187.546.348-81	por
dc.creator.Lattes	http://lattes.cnpq.br/9455113572562261	por
dc.publisher.country	Brasil	por
dc.publisher.department	Instituto de Veterinária	por
dc.publisher.initials	UFRRJ	por
dc.publisher.program	Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)	por
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dc.subject.cnpq	Medicina Veterinária	por
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dc.originais.uri	https://tede.ufrrj.br/jspui/handle/jspui/3653
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