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dc.contributor.authorLima, Lin Machado de
dc.date.accessioned2023-12-22T03:03:24Z-
dc.date.available2023-12-22T03:03:24Z-
dc.date.issued2019-07-01
dc.identifier.citationLIMA, Lin Machado de. Estudo da inibição da monoamina oxidase por novos compostos sintéticos derivados de cumarina. 2019. 33 f. Dissertação (Mestrado em Quí­mica) - Instituto de Quí­mica, Departamento de Bioquí­mica, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2019.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/14601-
dc.description.abstractA monoamina oxidase [EC 1.4.3.4 (MAO)] é uma enzima localizada na membrana externa da mitocôndria que usa a flavina adenina dinucleotídeo (FAD) como cofator enzimático para catalisar a conversão oxidante de uma amina em seu aldeído correspondente, produzindo também amônia e peróxido de hidrogênio. A atividade das monoamina oxidases regula os níveis de aminas biogênicas presentes nos tecidos, principalmente no cérebro. Monoamina oxidases existem como duas proteínas: MAO-A e MAO-B. Estas isoformas foram definidas primariamente pelas afinidades por substratos e sensibilidade aos inibidores. Assim, a MAO-A oxida preferencialmente serotonina, melatonina, noradrenalina e adrenalina. A MAO-B oxida preferencialmente a feniletilamina, um alcaloide do metabolismo da fenilalanina. A ingestão de feniletilamina promove a liberação de dopamina que atua no cérebro estimulando euforia. Com relação aos inibidores, a MAO-A é inibida preferencialmente por clorgilina. MAO-B é inibida por deprenil e por pargilina. Esses inibidores podem ser usados para o tratamento das doenças degenerativas do cérebro. Desde que estudos têm mostrado que moléculas derivadas de cumarinas obtiveram excelentes resultados como inibidoras destas enzimas, muitas drogas novas derivadas da cumarina vêm sendo sintetizadas, das quais algumas são muito promissoras para o tratamento das doenças de Alzheimer e Parkinson. O alvo desse trabalho foi promover testes de inibição in vitro da MAO da fração mitocondrial de cérebro de rato Wistar com novos produtos derivados da cumarina. Dentre os compostos testados, dois deles se mostraram promissores como inibidores da MAO de fração mitocondrial de cérebro de rato wistar, atingindo mais de 60% de inibição da atividade da monoamina oxidase.por
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectMonoamina oxidasepor
dc.subjectCumarinapor
dc.subjectInibidores de enzimaspor
dc.subjectMonoamine oxidaseeng
dc.subjectCoumarineng
dc.subjectEnzymes Inhibitorseng
dc.titleEstudo da inibição da monoamina oxidase por novos compostos sintéticos derivados de cumarinapor
dc.title.alternativeStudy of the inhibition of monoamine oxidase by new synthetic compounds derived from coumarineng
dc.typeDissertaçãopor
dc.description.abstractOtherMonoamine oxidase [EC 1.4.3.4 (MAO)] is an enzyme located in the outer membrane of the mitochondria, which uses flavin adenine dinucleotide (FAD) as a cofactor to catalyze the oxidant conversion of an amine in its corresponding aldehyde, also producing ammonia and hydrogen peroxide. MAO activity regulates the levels of biogenic amines present in tissues, especially in the brain. MAO exists as two proteins: MAO-A and MAO-B. These isoforms were defined primarily by substrate affinities and inhibitor sensitivity. Accordingly, MAO-A oxidizes, preferably, serotonin, melatonin, noradrenaline and adrenaline. MAO-B preferably oxidizes phenylethylamine, an alkaloid from the metabolism of phenylalanine. The ingestion of phenylethylamine promotes the release of dopamine that acts in the brain stimulating euphoria. Concerning the inhibitors, MAO-A is preferentially inhibited by clorgiline. MAO-B is inhibited by deprenyl and pargyline. These inhibitors can be used in the treatment of degenerative brain diseases. Since studies have shown that molecules derived from coumarins achieved excellent results as inhibitors of these enzymes, several new drugs derived from coumarin have been synthesized, which a few are very promising in the treatment of Alzheimer's and Parkinson's diseases. This study aimed to promote in vitro inhibition tests of MAO with new substances derived from coumarin. Among the compounds tested, two of them were shown to be promising as MAO inhibitors of mitochondrial fraction of wistar rat brain, reaching more than 60% inhibition of monoamine oxidase activity.eng
dc.contributor.advisor1Salles, Cristiane Martins Cardoso de
dc.contributor.advisor1IDCPF: 035.399.287-90por
dc.contributor.advisor-co1Bastos, Frederico Freire
dc.contributor.advisor-co1IDCPF: 082.617.467-76por
dc.contributor.referee1Vieira, André Luiz Gomes
dc.contributor.referee2Fernandes, Daniele Corrêa
dc.contributor.referee3Santos, André Marques dos
dc.contributor.referee4Bastos Neto, Jayme da Cunha
dc.creator.IDCPF: 805.264.627-87por
dc.creator.Latteshttp://lattes.cnpq.br/4443098894988565por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Químicapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Químicapor
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dc.subject.cnpqQuímicapor
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/67901/2019%20-%20Lin%20Machado%20de%20Lima.pdf.jpg*
dc.originais.urihttps://tede.ufrrj.br/jspui/handle/jspui/5322
dc.originais.provenanceSubmitted by Jorge Silva (jorgelmsilva@ufrrj.br) on 2022-01-19T18:51:44Z No. of bitstreams: 1 2019 - Lin Machado de Lima.pdf: 931751 bytes, checksum: b85decb15478a60703cdbcccab374702 (MD5)eng
dc.originais.provenanceMade available in DSpace on 2022-01-19T18:51:45Z (GMT). No. of bitstreams: 1 2019 - Lin Machado de Lima.pdf: 931751 bytes, checksum: b85decb15478a60703cdbcccab374702 (MD5) Previous issue date: 2019-07-01eng
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