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dc.contributor.authorSantana, Jorge André Vergueiro
dc.date.accessioned2023-12-22T03:08:30Z-
dc.date.available2023-12-22T03:08:30Z-
dc.date.issued2012-08-27
dc.identifier.citationSANTANA, Jorge André Vergueiro. Papel do exercício físico nas alterações comportamentais, na regulação hidroeletrolítica e no balanço simpato-vagal cardíaco no modelo de uso abusivo de esteróides anabolizantes em ratos. 2012. 98 f. Dissertação (Mestrado Multicêntrico em Ciências Fisiológicas) - Instituto de Ciências Biológicas e da Saúde, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2012 .por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/14932-
dc.description.abstractO abuso de esteróides anabólicos androgênicos (EAA), dentro e fora do cenário esportivo, se constitui atualmente em grande problema de saúde pública. Embora, estudos relativos a alterações comportamentais e hidroeletrolíticas induzidas por EAA sejam bem conhecidos, o mesmo já não se observa quando esses parâmetros são analisados em conjunto (no mesmo estudo). Além disso, alterações tardias (na fase adulta) induzidas pelo uso abusivo de EAA na adolescência são ainda mais raras. Assim, o principal objetivo deste estudo, foi avaliar possíveis alterações comportamentais, hidroeletrolíticas e autonômicas de ratos adultos sedentários ou fisicamente ativos submetidos ao tratamento com EAA na fase juvenil. O presente estudo foi submetido ao Comitê de Ética da Universidade Federal Rural do Rio de Janeiro (CEPBE/IB/UFRRJ-014/2008), e seguiu as normas propostas pelo “Guide for the Care and Use of Laboratory Animals” (Instituto Nacional de Saúde Norte Americano). Foram utilizados 40 ratos Wistar jovens (40 dias) e 10 casais de residentes (90 dias). Os animais foram divididos aleatoriamente nos seguintes grupos: tratados com proprionato de testosterona (Grupo PT) na dose de 5mg/kg/dia (i.m.) ou veículo (óleo de milho) no mesmo volume e via de administração (Grupo Controle, CTR) por 5 semanas ininterruptas. Ambos os grupos foram subdivididos em sedentários (PTsed ou CTRsed) e fisicamente ativos (PTexe ou CTRexe). Na 4a semana de administração (9 semanas de idade), os animais foram submetidos ao teste de agressividade e os resultados mostraram aumento significativo deste parâmetro (P < 0,05) no grupo PTsed em relação ao seu controle (CTRsed). Curiosamente, o aumento da agressividade foi amplamente inibido pelo exercício físico resistido, uma vez que não foram observadas diferenças significativas nos parâmetros que avaliam agressividade (ataques efetivos e ameaças) entre os grupos PTexe e CTRexe (P < 0,05) sendo ambos similares aos do grupo controle CTRsed. No teste do campo aberto houve aumento significativo tanto da exploração horizontal (número de quadrados percorridos/5 min.) como na vertical (número de rearings/5 min.) e diminuição no tempo de imobilidade no grupo PTsed comparado ao CTRsed (P < 0,05). Mais uma vez, o EFR foi capaz de reverter o efeito produzido pelo EAA, pois não houve diferença nestes parâmetros entre os grupos PTexe e CTRexe (P < 0,05) sendo ambos similares aos do grupo controle CTRsed. No teste do labirinto em cruz elevado não houve alteração significativa no tempo de permanência em nenhum dos braços entre os grupos, mas, as freqüências de entradas nos braços tiveram significativas diferenças por o grupo tratado PTsed ter maior número significativo que do seu respectivo controle CTRsed em ambos os braços, o que sugere inibição do efeito ansiolítico nos protocolos de administração de EAA e de EFR utilizados neste estudo. No estudo hidroeletrolítico houve aumento significativo (P < 0,05) na ingestão cumulativa de água e sódio no CTRexe, a partir de 60 minutos e assim por diante até o término do teste, em relação aos demais grupos em condições basais. O grupo tratado com EAA e que praticou exercício físico (PTexe) não apresentou este efeito, o que sugere que o PT foi capaz de prevenir as respostas adaptativas ao EFR. No estudo da variabilidade da frequência cardíaca observou-se que o tratamento com EAA aumentou a modulação simpática (diminuiu a parassimpática) no grupo sedentário tratado com PT e que este efeito, foi totalmente bloquedo pelo EFR, pois não houve diferença no balanço simpato-vagal cardíaco entre os grupos PTexe e CTRexe (P < 0,05) sendo ambos similares aos do grupo controle CTRsed. O tratamento com EAA na fase juvenil (adolescência) aumentou a agressividade e a atividade exploratória dos ratos na fase adulta e o protocolo de exercício utilizado foi efetivo em prevenir tais alterações. Além disso, as respostas hidroeletrolíticas adaptativas de aumento de ingestão de fluidos induzidos pelo exercício foram bloqueadas pelo uso de EAA na adolescência. É possível que este efeito mal adaptativo observado nos animais fisicamente ativos tratados com EAA, possa ser explicado, pelo menos em parte, pelo aumento da modulação simpática, conhecidamente retentora de sal e água observada na análise espectral. Apoio Financeiro: Conselho Nacional de Desenvolvimento Científico e Tecnológico e da Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro.por
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectexercício físicopor
dc.subjectuso abusivo de esteróides anabolizantespor
dc.subjectalterações fisiológicas em ratospor
dc.subjectexerciseeng
dc.subjectabuse of anabolic steroidseng
dc.subjectphysiological changes in ratseng
dc.titlePapel do exercício físico nas alterações comportamentais, na regulação hidroeletrolítica e no balanço simpato-vagal cardíaco no modelo de uso abusivo de esteróides anabolizantes em ratospor
dc.typeDissertaçãopor
dc.description.abstractOtherThe abuse of anabolic androgenic steroids (AAS), and off the sports scene, it is currently in big public health problem. Although studies on behavioral changes induced by AAS and electrolyte are well known, the same is not observed when these parameters are analyzed together (in the same study). In addition, late changes (in adulthood) induced by the use of AAS abuse in adolescence are even more rare. Thus, the main objective of this study was to assess possible behavioral changes, electrolyte and rat autonomic sedentary or physically active adults undergoing treatment with AAS in the juvenile phase. This study was submitted to the Ethics Committee of University Rural of Rio de Janeiro (CEPBE/IB/UFRRJ-014/2008), and followed the guidelines proposed by the "Guide for the Care and Use of Laboratory Animals" (National Institute of North American Health). A total of 40 young Wistar rats (40 days) and 10 pairs of residents (90 days). The animals were randomly divided into the following groups: proprionate treated with testosterone (PT) at a dose of 5mg/kg/day (im) or vehicle (corn oil) in the same volume and route of administration (control group, CTR) for 5 weeks uninterrupted. Both groups were subdivided into sedentary (or PTsed CTRsed) and physically active (or PTexe CTRexe). In the fourth week of administration (9 weeks of age), animals were tested for aggressiveness and the results showed a significant increase of this parameter (P <0.05) in PTsed in relation to its control (CTRsed). Interestingly, the increased aggressiveness was largely inhibited by resistive exercise, since there were no significant differences in parameters that assess aggression (actual attacks and threats) between the groups and PTexe CTRexe (P <0.05) and both are similar to CTRsed the control group. In the open field test showed a significant increase both the horizontal scanning (number of squares crossed / 5 min.) And vertical (number of rearings / 5 min.) And decrease in the immobility time compared to CTRsed PTsed group (P <0 , 05). Again, the EFR was able to reverse the effect produced by the AAS, as there was no difference in these parameters between groups and PTexe CTRexe (P <0.05) and both are similar to the control group CTRsed. In testing the elevated plus maze, no significant change in parameter the arms in any group and which probably indicates absence of anxiolytic in management protocols and EFR AAS used in this study. Electrolyte in the study increased significantly (p <0.05) in cumulative intake of water and sodium CTRexe from 60 minutes and so on until the end of the test, compared to other groups at baseline. The group treated with AAS and practiced physical exercise (PTexe) did not show this effect, suggesting that the PT was able to prevent the adaptive responses to the EFR. In the study of heart rate variability was observed that AAS treatment increased sympathetic modulation (decreased parasympathetic) in the sedentary group treated with PT and that this effect was totally blocked by EFR because there was no difference in cardiac vagal-sympathetic balance between groups and PTexe CTRexe (P <0.05) and both are similar to the control group CTRsed. The AAS treatment in the juvenile phase (adolescence) increased aggressiveness and exploratory activity of rats in adulthood and the exercise protocol used was effective in preventing such changes. Furthermore, the adaptive responses electrolyte of increased fluid intake induced by exercise have been blocked by the use of EAA in adolescence. It is possible that this effect maladaptive observed in animals treated with AAS physically active, may be explained at least in part, by increasing sympathetic modulation, known to salt and water retaining observed in the spectral analysis. Financial Support: National Council for Scientific and Technological Development and the Foundation for Research of the State of Rio de Janeiro.eng
dc.contributor.advisor1Olivares, Emerson Lopes
dc.contributor.advisor1ID027.886.707-37por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1361659701207857por
dc.contributor.advisor-co1Rocha, Fábio Fagundes da
dc.contributor.advisor-co1ID068.497.697-82por
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/3804957959723162por
dc.contributor.referee1Olivares, Emerson Lopes
dc.contributor.referee2Rocha, Fábio Fagundes da
dc.contributor.referee3Marassi, Michelle Porto
dc.contributor.referee4Fortunato, Rodrigo Soares
dc.creator.ID053.921.397-79por
dc.creator.Latteshttp://lattes.cnpq.br/0396494577534077por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Ciências Biológicas e da Saúdepor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicaspor
dc.relation.referencesAITKE, JM; LINDSAY, R.; HART, DM The redistribution of body sodium in women on long-term oestrogen therapy. Clin Sci Mol Med 47: 179-187; 1974. AKSELROD S., et al. Power spectrum analysis of heart rate fluctuation: a quantitative probe of beatto-beat cardiovascular control. Science Wash DC; v. 213, p. 220-222, 1981. AMARAL, S.L and MICHELINI, L.C. Sistema cardiovascular no exercício. In: Tirapegui J. Nutrição, metabolismo e suplementação na atividade física. São Paulo: Atheneu, p. 229-242, 2005. AMARAL, S.L, ZORN, T.M.T. and MICHELINI, L.C. Exercise training normalizes walltolumen ratio of the gracilis muscle arterioles and reduces pressure in spontaneously hypertensive rats. J hypertens, v. 18, p. 1563-1572, 2000. ANDERSON CM & SWANSON RA. Astrocyte glutamate transport: review of properties, regulation, and physiological functions. Glia 32:1–14, 2000. ANNITTO, W.J. & LAYMAN, W.A. Anabolic steroids and acute schizophrenic episode. J.Clin. Psychiat. 41:143-144, 1980. APOR, P, TIHANYI, J, BORKA, P. Improving of muscle mass and force in rehabilitation of heart-lung patients. Aerobic interval training, resistance-exercises, excentric exercises, vibration. Orv Hetil, v.146, n. 38, p. 1971-1975, 2005. ARCHER, J. 1973 Tests for emotionality in rats and mice: a review. Anim Behav. May; 21(2): 205-35, 1973. ASSUNÇÃO, S.S.M. Muscle dysmorphia. Rev.Bras.Psiquiatr. 24:80-84, 2002. AUBERT AE, SEPS B, BECKERS F. Heart rate variability in athletes. Sports Med. 33(12):889-919, 2003. 68 BADAUÊ-PASSOS, D. Jr.; VENTURA, R. R.; SILVA L. F. S.; OLIVARES, E. L. & REIS, L. C. Effect of brain serotoninergic stimulation on sodium appetite of euthyroid and hypothyroid rats. Exp Physiol, 88: 251-260, 2003. BAHRKE MS, YESALIS CE, KOPSTEIN AN, STEPHENS JA. Risk factors associated with anabolic-androgen steroid use among adolescents. Sports Med 29: 397–405, 2000. BAHRKE MS, YESALIS CE, BROWER KJ. Anabolic androgenic steroid abuse and performance-enhancing drugs among adolescents. Child Adolesc Phychiatr Clin N Am 7(4):821-38, 1998. BALDO-ENZI G, GIADA F, ZULIANI G, BARONI L, VITALE E, ENZI G et al. Lipid and apoprotein modifications in body builders during and after self administration of anabolic steroids. Metabol. 30(2):203-8, 1990. BANNERMAN DAVID M, ARIANPOUR ROOZBEH, DEACON ROBERT MJ, SEEBURG PETER H, SPRENGEL ROLF, RAWLINS J NP, AND SCHMITT WOLFRAM B. The role of hippocampal glutamate receptor-A-dependent synaptic plasticity in conditional learning: the importance of spatiotemporal discontiguity. J Neurosci, 24(33):7277-82. 2004. BARFIELD RJ, BUSCH DE & WALLEN K Gonadal influence on agonistic behavior in the male domestic rat. Horm Behav. Sep;3(3):247-59. 1972. BARROS, H.M.T. et al. The effects of GABAergic drugs on grooming behavior in the open field. Pharmacology e Toxicology. v. 74, p. 339-344. 1994. BASARIA et al. Anabolic-Androgenic Steroid Therapy in the Treatment of Chronic Diseases. J Clin Endocrinol Metab, November, 86(11):5108–5117, 2001. BAUMAN, D.H.; RICHERSON, J.T. and BRITT A.L. A comparison of body and organ weights, physiologic parameters, and pathologic changes in target organs of rats given 69 combinations of exercise, anabolic hormone, and protein supplementation. Am. J. Sports Med. 16, 397–402, 1988. BERTOGLIO, L. J., ANZINI, C., LINO DE OLIVEIRA, C. and CAROBREZ, A.P. Enhanced dorsolateral periaqueductal gray counteracts the anxiolytic response to midazolam on the elevated plus maze Trial 2 in rats. Behavioural Brain Research. 162, 99-107, 2005. BEUTEL, A.; BERGAMASCHI, C. T.; CAMPOS, R. B. Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats. Journal of Steroid Biochemistry & Molecular Biology. N. 93, p. 43–48. 2005. BEUTEL A, BERGAMASCHI CT, CAMPOS RR. Effects of chronic anabolic steroid treatment on tonic and reflex cardiovascular control in male rats. J Steroid Biochem Mol Biol. 93(1): 43, 2005. BIANCO AC, RABELO R. Introdução à fisiologia endócrina. In: Aires MM. Fisiologia. 2ª ed. Rio de Janeiro: Guanabara Koogan 65, p.741-65, 1999. BIGGER JT JR, et al. Frequency domain measures of heart period variability and mortality after myocardial infarction. Circulation, v.85, p. 164-171, 1992 BING O, HEILIG M, KAKOULIDIS P, SUNDBLAD C, WIKLUND L, ERIKSSON E. High doses of testosterone increase anticonflict behaviour in rat. Eur Neuropsychopharmacol. 321–3, 1998. BITRAN D, KELLOGG CK and HILVERS RJ. Treatment with an anabolicandrogenic steroid affects anxiety-related behavior and alters the sensitivity of cortical GABA A receptors in the rat. Horm Behav. 27:568–83, 1993. BLANCHARD, CAROLINE, D.; GRIEBEL, G.; BLANCHARD, ROBERT J. Mouse defensive behaviors: pharmacological and behavioral assays for anxiety and panic. Neuroscience and Biobehavioral Reviews. v.25, p. 205- 218. 2001. 70 BLANTZ RC, PETERSON OW, BLANTZ ER, WILSON CB. Sexual differences in glomerular ultrafiltration: effect of androgen administration in ovariectomized rats. Endocrinology. 122(3):767-73, 1988. BLAZER-YOST, BL & COX, M Insulin-like growth factor 1 stimulates renal epithelial Na+ transport. Am J Physiol 255: 413-417; 1988. BOOTH, R. E.; JOHNSON, J. P. & STOCKAND, J. D. Aldosterone. Adv Physiol Educ, 4: 8-20. 2002. BOWMAN, S. Anabolic steroids and infarction. BMJ. March 17; 300 (6726): 750, 1990. BREUER ME, MCGINNIS MY, LUMIA AR & POSSIDENTE BP. Aggression in male rats receiving anabolic androgenic steroids: effects of social and environmental provocation. Horm Behav. Nov;40(3):409-18. 2001. BRIDGES, MANN AND COPPETA. Hypothalamic Involvement in the Regulation of Maternal Behaviour in the Rat: Inhibitory Roles for the Ventromedial Hypothalamus and the Dorsal/Anterior Hypothalamic. Journal of Neuroendocrinology, 11: 259–266, 1999. BRONSON FH. Effects of prolonged exposure to anabolic steroids on the behavior of male and female mice. Pharmacol Biochem Behav 53(2):329–34, 1996. BROOKS JH and REDDON JR. Serum testosterone in violent and nonviolent young Offenders. J Clin Psychol 52:475–473, 1996. BROWER, K J. Anabolic steroids. Psychiatr Clin North Am. 16(1):97-103; 1993. BUCKLEY, WE; YESALIS, CE; FRIEDL, KE et al. Estimated prevalence of anabolic steroid use among high school seniors. JAMA . 260:3441-3445, 1988. 71 BUDDENBERG TE, KOMOROWSKI M, RUOCCO LA, SILVA MA, TOPIC B. Attenuating effects of testosterone on depressive-like behavior in the forced swim test in healthy male rats. Brain Res Bull. 79(3-4):182-6; 2009. BUONINCONTI, R. The juxtaglomerular apparatus: physiopathology and clinical aspects of renin-angiotensin system. Recenti Prog Med. Aug;41(2):81-165, 1966. BURGUERA, B., MURUAIS, C., PENALVA, A., DIEGUEZ, C., CASANUEVA, F. Dual and selective action of glucocorticoids upon basal and stimulated growth hormone release in man. Neuroendocrinology, v.51, p.51-8, 1990. CARLINI, E.A.; GALDURÓZ, J.C.; NOTO, A.R.; CARLINI, C.M.; OLIVEIRA, L.G.; NAPPO, S.A.; MOURA, Y.G.; SANCHEZ, Z.V.D.M. - II Levantamento domiciliar sobre o uso de drogas psicotrópicas no Brasil: estudo envolvendo as 108 maiores cidades do país. CEBRID v. 01. p. 472; 2005. CARSON, J.A. et al. Steroid receptor concentration in age rat hindlimb muscle: Effect of anabolic steroid administration. J. Applied Physiol. 93:242-250, 2002. CATLIN DH, MURRAY TH. Performance-enhancing drugs, fair competition and Olympic sport. JAMA 276:231-7, 1996. CAVALCANTE-LIMA, H. R.; BADAUÊ-PASSOS, D. Jr.; DE-LUCCA, J. R. W.; LIMA, H. R. C.; COSTA-e-SOUSA, R. H.; OLIVARES, E. L.; CEDRAZ-MERCEZ, P. L.; REIS, R. O; MEDEIROS, M. A.; CÔRTES, W. S. & REIS, L. C. Chronic excitotoxic lesion of dorsal raphe nucleus induces sodium appetite. Braz J Med Biol Res, 38: 1669-1675. 2005ª. CAVALCANTE-LIMA, H. R.; LIMA, H. R. C.; COSTA-e-SOUSA, R. H.; OLIVARES, E. L.; CEDRAZ-MERCEZ, P. L.; REIS, R. O.; BADAUÊ-PASSOS, D. Jr.; DE-LUCCA, J. R. W.; MEDEIROS, M. A.; CÔRTES, W. S. & REIS, L. C. Dipsogenic stimulation in ibotenic DRN-lesioned rats induces concomitant sodium appetite. Neurosci Lett, 374: 5-10, 2005b. 72 CEJUDO P et al. Exercise training in mitochondrial myopathy: a randomized controlled trial. Muscle Nerve. 32(3):342-50, 2005. CELOTTI F, CESI PN. Anabolic steroids: a review of their effects on the muscle, of their possible mechanisms of action and of their use in athletics. J Steroid Biochem Mol Biol. 43(5):469-77, 1992. CHESS GF, TAM RMK, CALARESU FR. Influence of cardiac neural inputs on rhythmic variations of heart period in the cat. AM J PHYSIOL 228:775–8, 1975. CHIN, E.; ZHOU, J.; BONDY, CA Renal growth hormone receptor gene expression: relationship to renal insulin-like growth factor system. Endocrinology 131:3061-3066; 1992. CHRISTIE MH & BARFIELD RJ.Effects of aromatizable androgens on aggressive behaviour among rats (rattus norvegicus). J Endocrinol. Oct;83(1):17-26. 1979. CHRISTIANSEN K. Behavioural effects of androgen in men and women. J Endocrinol. Jul; 170(1): 39-48, 2001. CLARK AS, HARROLD EV, FAST AS. Anabolic-androgenic steroid effects on the sexual behavior of intact male rats. Horm Behav 31:35–46; 1997. CLARK AS and FAST AS. Comparison of the effects of 17a-methyltestosterone, methandrostenolone, and nandrolone decanoate on the sexual behavior of castrated male rats. Behav Neurosci 110(6):1478–86, 1996. CLARK, S. & HENDERSON, L. Behavioral and physiological responses to anabolicandrogenic steroids. Neuroscience & Biobehavioral Reviews. Volume 27, Issue 5, August, Pages 413–436, 2003. CONCEIÇÃO CA, WANDER FS, MASSILI LP, VIANNA LAF, GONÇALVES DM, FOSSATI G. Uso de anabolizantes entre praticantes de musculação em academias. Revista Pesquisa Médica 33:103-16, 1999. COOPER, CJ et al. A high prevalence of abnormal personality traits in chronic users of anabolic-androgenic steroids. Br J Sports Med. 30(3):246-50. 1996. CORRIGAN B. Anabolic steroid and the mind. Med J Aust. 165:222-6, 1996. COSTA ROSA, L.F. Exercise as a time-conditioning effector in chronic disease: a complementary treatment strategy. Evid Based Complement Alternat Med 1:63–70, 2004. CRUZ, ANTÔNIO PEDRO DE MELLO; JÚNIOR, HÉLIO ZAGROSSI; GRAEFF, FREDERICO GUILHERME; LANDEIRA-FERNANDEZ, J. Modelos Animais de Ansiedade: Implicações Para a Seleção de Drogas Ansiolíticos. Psicologia: Teoria e Pesquisa. Vol.13 n3. p. 269-278. Set-Dez 1997 CUNHA TS, MOURA MJ, BERNARDES CF, TANNO AP, MARCONDES FK. Vascular sensitivity to phenylephrine in rats submitted to anaerobic training and nandrolone treatment. Hypertension 46(4):1010-5, 2005. CUNNINGHAM, RL and MCGINNIS, MY. Prepubertal social subjugation and anabolic androgenic steroid-induced aggression in male rats. J Neuroendocrinol. Aug;20(8):997- 1005, 2008. DANBOLT NC, HAZELL AS, RAO KV, POW DV & BUTTERWORTH RF. Selective down-regulation of the astrocyte glutamate transporters GLT-1 and GLAST within the medial thalamus in experimental Wernicke's encephalopathy. J Neurochem. Aug;78(3):560-8. 2001. DA SILVA PRP, CZEPIELEWSKI MA. Uso de agentes esteróides anabólicos, estimulantes, diuréticos, insulina e GH em amostra de praticantes de musculação de Porto Alegre. Revista Brasileira de Toxicologia14 (Supl):71, 2001. DAVIS, J. O. & FREEMAN, R. H. Mechanisms regulating renin release. Physiol Rev, 56:1- 56. 1976. 74 DE ANGELIS K, WICHI RB, JESUS WRA, MOREIRA ED, MORRIS M, KRIEGER EM, IRIGOYEN MC. Exercise training changes autonomic cardiovascular balance in mice. Journal of Applied Physiology, v.96, p.2174-2178, 2004. DE LEON, K.R., GRIMES, J.M., CONNOR, D.F., MELLONI, R.H. Adolescent cocaine exposure and offensive aggression: involvement of serotonin neural signaling and innervation in male Syrian hamsters. Behav. Brain Res. 133 (2), 211–220, 2002a. DE LEON, K.R., GRIMES, J.M., MELLONI, R.H. Repeated anabolic–androgenic steroid treatment during adolescence increase vasopressin V1A receptor binding in Syrian hamsters: correlation with offensive aggression. Horm. Behav. 42, 182–191, 2002b. DE ROSE EH, NÓBREGA ACL. Drogas lícitas e ilícitas. In: Ghorayeb N, Barros TO. Exercício. São Paulo: Atheneu, 395-405, 1999. DI BELO V, GIORGI D, BIANCHI M, BERTINI A, CAPUTO MT, VALENTI G, et al. Effects of anabolic-androgenic steroids on weight-lifters’ myocardium: an ultrasonic videodensitometric study. Med Sci Sports Exerc 31: 514-21, 1999. DOBS AS. Is there a role for androgenic anabolic steroids in medical practice? JAMA 281:1326-27, 1999. DOS REIS, AF et al. Disfunção Parassimpática, Variabilidade da Freqüência Cardíaca e Estimulação Colinérgica após Infarto Agudo do Miocárdico. Arq Bras Cardiol vol. 70, (nº 3), 1998. DUBEY, R. & JACKSON, E. Estrogen-induced cardiorenal protection: potential cellular, biochemical and molecular mechanisms. Am J Physiol Renal Physiol 280: 365–388, 2001. DUNCAN, N.D.; DAVID A. W.; GORDON, S. L. – Adaptations in rat skeletal muscle following long-term resistance exercise training. Eur J Appl Physiol 77:372-378,1998. 75 DURANT RH, ESCOBEDO LG, HEATH GW. Anabolic-steroid use, strength training, and multiple drugs use among adolescents in the United States. Pediatrics 96:23-8, 1995. ELLISON, KE; INGELFINGER, JR; PIVOR, M; DZAU, VJ. Androgen regulation of rat renal angiotensinogen messenger RNA expression. J Clin Invest 83: 1941-1945, 1989. EVANS NA. Current concepts in anabolic-androgenic steroids. Am J Sports Med. Mar;32(2):534-42, 2004. FAIGENBAUM AD, ZAICHOWSKY LD, GARDNER DE, MICHELI LJ. Anabolic steroid use by male and female middle school students. Pediatrics 101:1-6, 1998. FALKENBERG M, KARLSSON J, ÖRTENWALL P. Peripheral arterial thrombosis in two young men using anabolic steroids. Eur J Vasc Endovasc Surg 13:223-6, 1997. FARRELL SF & MCGINNIS MY. Long-term effects of pubertal anabolicandrogenic steroid exposure on reproductive and aggressive behaviors in male rats. Horm Behav. Aug;46(2):193-203, 2004. FERENCHICK GS. Anabolic/androgenic steroid abuse and thrombosis: is there a connection? Med Hypotheses 35:27-31, 1991. FERRARA, N. Vascular endothelial growth factor: molecular and biological aspects. Curr Top Microbiol Immunol, v. 237, p. 1-29, 1999. FERRERA PC, PUTNAM DL and VERDILE VP. Anabolic steroid use as the possible precipitant of dilated cardiomyopathy. Cardiology 88:218-20, 1997. FERRARI, C. Abuso de hormônios esteróides anabólicos: O que não contaram para você! SaBios: Rev. Saúde e Biol., v.6, n.3, p.59-69, set./dez., 2011. FISCHER, S.G., RICCI, L.A., & MELLONI, R.H. Repeated anabolic-androgenic steroid exposure during adolescence alters phosphate-activated glutamase and glutamate receptor 1 76 (GluR1) subunit immunoreactivity in hamster brain: Correlation with offensive aggression. Behavioral Brain Research. 180, 77-85, 2007. FITZSIMONS, J. T. Angiotensin, thirst, and sodium appetite. Physiol Rev, 78: 583-686, 1998. FITZSIMONS, J. T. Physiology and Pathology of thirst and sodium appetite. In: SELDIN DW; GIEBISCH G (Eds). The kidney: physiology and pathophysiology. New York: Raven Press, P 885-901,1985. FOSTER, M.T., SOLOMON, M.B., HUHMAN, K.L., BARTNESS, T.J., 2006 May. Social defeat increases food intake, body mass, and adiposity in Syrian hamsters. American Journal Physiology Regulation Integration and Comparative Physiology; n.290, v.5, p.1284-93. 2005. FRIEDLL, K.E. Effect of anabolic steroids on physical health. In: YESALIS, C.E. (Ed). Anabolic Steroids in Sports and Exercise, Champaign. p.175-225, 2000. FRIEDL, R.; BRUNNER, M.; MOESLINGER, T. and Spieckermann, PG. Life Sci 68: 417- 429, 2000. FRONTERA WR, MEREDITH CN, O'REILLY KP, KNUTTGEN HG, EVANS WJ.Strength conditioning in older men: skeletal muscle hypertrophy and improved function. J Appl Physiol. 64: 1038-1044, 1988. FURLAN et al. Continuous 24-hour assessment of the neural regulation of systemic arterial pressure and RR variabilities in ambulant subject. Circulation. Vol. 81:537-547, 1990. GALVÃO, D.A. and TAAFFE, D.R. Resistance exercise dosage in older adults: singleversus multiset effects on physical performance and body composition. J Am Geriatr Soc. 53(12):2090-7, 2005. 77 GANTEN. D. & STOCK, G. Humoral and neurohormonal aspects of blood pressure regulation: focus on angiotensin. Klin Wochenschr, 1:31-41. Review. 1978. GLAZER G. Atherogenic effects of anabolic steroids on serum lipid levels. Arch Internal Med. 151(10):1925-33, 1991. GONZALEZ BADILLO, I.J.; AYESTARÁN, E.S. Fundamentos do Treinamento de Força: aplicação ao alto rendimento desportivo. Artmed 94-98, 2001. GOODMAN & GILMAN. As Bases Farmacológicas da Terapêutica. Editora Artmed 9ª Edição. 1996. GRAEFF, F. G. AND GUIMARÃES, F. S. Fundamentos de Psicofarmacologia. 1° Edição. Editora Atheneu. São Paulo, pp: 123-160. 2000. GUISELINI, MAURO. Aptidão Física saúde bem- estar: Fundamentos teóricos e exercícios práticos. Phorte 2ª Ed. – São Paulo: 2006. GUYTON, Arthur C., HALL, John E..Tratado de Fisiologia Médica.10ª Ed. Rio de Janeiro: Guanabara. p. 312-318. 2002. GUZMAN et al. Treatment with anabolic steroids increases the activity of the mitochondrial outer carnatine palmitoyltransferase in rat liver fast twitch muscle. Biochemical Pharmacology 41 (5): 833-835, 1991. HALLBERG, M et al. Anabolic-androgenic steroids affect the content of substance P and substance P (1-7) in the rat brain. Peptides. 21(6):845-52, 2000. HALL, C.S. Temperament: A survey of animal studies. Psycholl Bull v.38 p.909-943, 1941. HALL, RYAN C. W.; HALL, RICHARD C. W.; CHAPMAN, MARCIA Psychiatric Complications of Anabolic Steroid Abuse. J.Psychosomatics: Journal of Consultation Liaison Psychiatry, Vol 46(4), Jul-Aug 2005 78 HANDLEY, S. L. AND S. MITHANI. Effects of alpha-adrenoceptor agonists and antagonists in a maze-exploration model of 'fear'-motivated behavior. Naunyn-Schmiedeberg's Archives of Pharmacology. n.327, v.1. p.1-5. 1984. HARDMAN JG, GILMANN AG, LINBIRD LE, EDITORS. GODMAN AND GILMAN’S. The pharmacological basis of therapeutics. New York: McGraw-Hill, 1996. HARRISON G. POPE, JR Anabolic–Androgenic Steroids as a Gateway to Opioid Dependence N Engl J Med 342:15-32, 2000. HARTGENS F, RIETJENS G, KEIZER HA, KUIPERS H, WOLFFENBUTTEL BH. Effects of androgenic-anabolic steroids on apolipoproteins and lipoprotein (a). Br J Sports Med 38(3):253-9, 2004. HARTLEY JE AND FLETCHER A. The effects of WAY-100135 and 8-hydroxy-2-(di-npropylamino)tetralin on feeding in the rat. Eur J Pharmacol 252:329–332, 1994. HATFIELD, F. C. Esteróides anabólicos. Editora Sprint, v. 4, n. 6, p. 246 - 256, 1986. HEBERT A, HAUPT MD, GEORGE D, ROVERE M. Anabolic steroids: a review of the literature. Am J Sports Med. 12(6):469-84, 1984. HEYWARD V.H. Designing resistance training programs Advanced fitness assessment and exercise prescription. Human Kinetics 3.ed. Champaing, illinois,, p 121 – 144, 1998. HICKSON, RC and KUROWSKI, TG. Anabolic steroids and training. Clin Sports Med 5(3):461, 1986. HORNBERGER TA, MCLOUGHLIN TJ, LESZCZYNSKI JK, ARMSTRONG DD, JAMESON RR, BOWEN PE, HWANG ES, HOU H, MOUSTAFA ME, CARLSON BA, HATWELD DL, DIAMOND AM, ESSER KA. Selenoprotein-deWcient transgenic mice exhibit enhanced exercise-induced muscle growth. J Nutr 133:3091–3097, 2003. HUNTER, I., HOPKINS, J. and FELAND, J. "A comparison of four methods of calculating vertical stiffness in distance running." Medicine and Science in Sports and Exercise. Vol. 37. S-345, 2005. IKKOS, D.; LUFT, R.; SJÖGREN, B. Body water sodium in patients with acromegaly. J Clin Invest 33: 989-994; 1954. INGELFINGER, JR; ZUO, WM; FON, EA; ELLISON, KE; DZAU, VJ. In situ hybridization evidence for angiotensinogen messenger RNA in the rat proximal tubule. An hypothesis for the intrarenal rennin angiotensin system. J Clin Invest 85: 417-423, 1990. IRIART, JORGE ALBERTO BERNSTEIN; ANDRADE, TARCÍSIO MATOS. Bodybuilding, steroid use, and risk perception among young body-builders from a low-income neighborhood in the city of Salvador, Bahia State, Brazil. Cad. Saúde Pública, Rio de Janeiro, 18(5):1379-1387, set-out, 2002. JILL M. GRIMES, LESLEY A. RICCI, AND RICHARD H. MELLONI JR. Plasticity in Anterior Hypothalamic Vasopressin Correlates With Aggression During Anabolic– Androgenic Steroid Withdrawal in Hamsters. Behavioral Neuroscience. Vol. 120, No. 1, 115–124, 2006. JILL M. GRIMES and RICHARD H. MELLONI JR Prolonged Alterations in the Serotonin Neural System Following the Cessation of Adolescent Anabolic–Androgenic Steroid Exposure in Hamsters (Mesocricetus auratus). Behavioral Neuroscience. Vol. 120, No. 6, 1242–1251, 2006. JILL M. GRIMES and RICHARD H. MELLONI JR. Serotonin modulates offensive attack in adolescent anabolic steroid-treated hamsters. Pharmacology, Biochemistry and Behavior. 73: 713 – 721, 2002. JOHANSSON, C., AHLENIUS, S. Evidence for the involvement of 5-HT1A receptors in the mediation of exploratory locomotor activity (LMA) refers to the movement from place to place. In psychopharmacology, locomotor activity of lab animals is often monitored to assess 80 the behavioural effects of these drugs. in the rat. Journal. Psychopharmacology. n.3, p.32- 35. 1989. JORDAN, J.; SHANNON, J.R.; BLACK, B. K.; ALI, Y.; FARLEY, M.; COSTA, F.; DIEDRICH, A.; ROBERTSON, R.M.; BIAGGIONI, I.; ROBERTSON, D. The Pressor Response to Water Drinking in Humans: A Sympathetic Reflex? Circulation, 101:504-509; 2000. J. TORRES-CALLEJA, M. GONZÁLEZ-UNZAGA, R. DECELIS-CARRILLO, L. CALZADA-SÁNCHEZ AND N. PEDRÓN. Effect of androgenic anabolic steroids on sperm quality and serum hormone levels in adult male bodybuilders. Life Sciences. 68: 1769–1774, 2001. KACSOH, B., MEYERS, J.S., CROWLEY, W.R., GROSVENOR, C.E. Maternal modulation of growth hormone secretion in the neonatal rat: involvement of mother-infant interactions. Journal Endocrinology., v.40, p.224-33, 1990. KAWACO, Y.; SUDO, R.T.; FERRARO, C.M. Effects of chronic intraventricular sodium on blood pressure and fluid balance. Hypertension, 17, p. 28-35, 1992. KANAYAMA et al. Issues for DSM-V: Clarifying the Diagnostic Criteria for AnabolicAndrogenic Steroid Dependence. Am J Psychiatry 166: 642-645, 2009. KANAYAMA G, GRUBER AJ, POPE JR HG, BOROWIECKI JJ, HUDSON JI. Over the counter drug use in gymnasiums: an underrecognized substance abuse problem? Psychother Psychosom 70:137-40, 2001. KASHKIN, K.B. & KLEBER, H.D. Hooked on hormones? An anabolic steroid addiction hypothesis. J.Am.Med.Assoc 262: 3166-3170, 1989. KASIKCIOGLU E, OFLAZ H, ARSLAN A, TOPCU B, KASIKCIOGLU HA, UMMAN B et al. Aortic elastic properties in athletes using anabolic-androgenic steroids. Int J Cardiol. 114910;132-4, 2007. 81 KATER, C. E.; BIGLIERI, E. G.; BRUST, N.; CHANG, B. & HIRAI, J. Regulation of the mineralocorticoid hormones in adrenocortical disorders with adrenocorticotropin excess. Clin Exp Hypertens A. 10:1749-58. 1982. KATZ DL, POPE HG JR. Anabolic-androgenic steroid-induced mental status changes. NIDA Res Monogr. 102:215-23, 1990. KATZUNG, B.G. Farmacologia: básica e clínica. Guanabara Koogan 609-611, 2003. KAZLAUCKAs, V. et al. Distinctive effects of unpredictable subchronic stress on memory, serum corticosterone and hippocampal BDNF levels in high and low exploratory mice. Behavioural Brain Research. v. 218 pages 80-86, 2011. KELLEY, G.A, KELLEY, K.S, Z, Vu. Tran. Aerobic exercise, lipids and lipoproteins in overweight and obese adults: a meta-analysis of randomized controlled trials. Int J Obesity, v. 29, p. 881-893, 2005. KICMAN, AT. Pharmacology of anabolic steroids. Br J Pharnacol. 154 (3): 502-521. KINDLUNDH, AMS; LINDBLOM, J and NYBERG, F. Chronic administration with nandrolone decanoate induces alterations in the gene-transcript content of dopamine D(1)- and D(2)-receptors in the rat brain. Brain Res 979:37-42, 2003. KINDLUNDH, A.M.S.; JONAS, LINDBLOM; LENA, BERGSTRÖM; JARL, E. S. WIKBERG and FRED, NYBERG. The anabolic-androgenic steroid nandrolone decanoate affects the density of dopamine receptors in the male rat brain. The European journal of neuroscience. 13(2):291-6, 2001. KINDLUNDH AMS, ISACSON DGL, BERGLUND L, NYBERG F. Factors associated with adolescent use of doping agents: anabolic-androgenic steroids. Addiction 94:543-53, 1999. 82 KITNEY, R.I.; ROMPELMAN O. The Study of Heart Rate Variability. London: Oxford Clarendon; 457p. 1980. KLEIGER RE, MILLER JP, BIGGER JT JR AND MOSS, AJ. Decreased heart-ratevariability and its association with increased mortality after acute myocardialinfarction. Am J Cardiol 59: 256–262, 1987. KOCHAKIAN, CD. History, chemistry and pharmacodynamics of anabolic-androgenic steroids. Wien Med Wochenschr. 143(14-15):359-63, 1993. KOUVELAS, DIMITRIOS et al. Nandrolone abuse decreases anxiety and impairs memory in rats via central androgenic receptors. International Journal of Neuropsychopharmacology, v. 11, p. 925-934, 2008. KRISTINA MAGNUSSON et al. Nandrolone decanoate administration elevates hippocampal prodynorphin mRNA expression and impairs Morris water maze performance in male rats. Neuroscience Letters 467:189–193, 2009. KUHN CM. Anabolic steroids. Recent Prog Horm Res. 57:411-34, 2002. KUTSCHER et al. Anabolic Steroids. A Review for the Clinician. Sports Med 32 (5): 285- 296, 2002. KYROU, I., TSIGOS, C. Stress mechanisms and metabolic complications. Horm Metab Res., v.39, p.430-8, 2007. LABREE, M. A. A review of anabolic steroids: uses and effects. J Sport Med Phys Fit, v. 31, n. 4, p. 618 - 626, 1991. LE GREVÈS P, HUANG W, JOHANSSON P, THÖRNWALL M, ZHOU Q & NYBERG F. Effects of an anabolic-androgenic steroid on the regulation of the NMDA receptor NR1, NR2A and NR2B subunit mRNAs in brain regions of the male rat. Neurosci Lett. Apr 18;226(1):61-4. 1997. 83 LEWANDOWSKI, MAIELE BERTOLDO. Leptina: mecanismos de ação na obesidade. Centro Universitário Franciscano. Santa Maria, RS: 2006. Disponível em: <http://www.nutricaoativa.com.br/arquivos/monografia6.pdf> Acesso em: 30 março 2012. LIMA, F. F. T. Esteróides Anabolizantes. Centro de Estudos e Pesquisas da Psicologia do Esporte. Disponível em: <http://www.ceppe.com.br> Acesso em 30 de março de 2012. LINDQVIST, A. S. Anabolic androgenic steroid affects competitive behaviour, behavioural response to ethanol and brain serotonin levels. Behavioural Brain Research, 133: 21-29; 2001. LISE, MLZ et al. O abuso de esteróides anabólicos androgênicos em atletismo. Rev Ass Med Brasil. 45(4):364-370, 1999. LITWACK G, SCHIMIDT TJ. Biochemistry of hormones II: steroids hormones. In: Devlin TM, editor. Textbook of biochemistry with clinical correlations. New York: Wiley-Liss 893-918, 1997. LIU PY, DEATH AK, HANDELSMAN DJ Androgens and cardiovascular disease. Endocr Rev 24:313–340, (2003a). LIU PY, YEE BJ, WISHART SM, JIMENEZ M, JUNG DG, GRUNSTEIN RR, HANDELSMAN DJ The short-term effects of high dose testosterone on sleep, breathing and function in older men. J Clin Endocrinol Metab 88:3605–3613, (2003b). LUKAS SE.CNS effects and abuse liability of anabolic-androgenic steroids. Annu Rev Pharmacol Toxicol. 36:333-57. 1996. LUKE et al. Bioavailability assessment of cyclosporine in the rat. Influence of route of administration. Drug Metab Dispos March, 18:158-162, 1990. 84 LUMIA, A. R., THORNER, K. M., and McGINNIS, M. Y. Effects of chronically high doses of the anabolic androgenic steroid, testosterone, on intermale aggression and sexual behavior in male rats. Physiol. Behav. 55, 331–335, 1994. MACFARLAND,C., & W. G. REEDER. Cleaning symbiosisin volving Galapagost ortoisesa nd two species of Darwin's finches. Z. Tierpsychol. n.34, p.464-483. 1974. MALIK M, CAMM J - Components of heart rate variability - what they really mean and what we really measure. Am J Cardiol 72: 821-2, 1993. MANGER, T. A., & MOTTA, R. W. The impact of an exercise program on posttraumatic stress disorder, anxiety, and depression. International Journal of Emergency Mental Health, 7, 49 –57, 2005. MARAVELIAS, C., DONA, A., STEFANIDOU, M. & SPILIOPOULOU, C. Adverse effects of anabolic steroids in athletes: a constant threat. Toxicology Letters. 158, 2005. MARTIN JA, ELMER E. Battered children grown up: a follow-up study of individuals severely maltreated as children. Child Abuse Negl 16: 75–87, 1992. MARTÍNEZ-SANCHIS S, BRAIN PF, SALVADOR A, SIMON VM. Long-term chronic treatment with stanozolol lacks significant effects on aggression and activity in young and adult male laboratory mice. Gen Pharmacol 27(2):293–8, 1996. MARTÍNEZ-SANCHIS S, ARAGON CM, SALVADOR A. Cocaine-induced locomotor activity is enhanced by exogenous testosterone. Physiol Behav 2002;76:605–9. MCARDLE ED, KATCH FI, KATCH VL. Fisiologia do exercício: energia, nutrição e desempenho humano. 6ª ed. Rio de Janeiro. Guanabara Koogan, 2008. McCARTHY K, TANG ATM, DALRYMPLE-HAY MJR, HAW MP. Ventricular thrombosis and systemic embolism in bodybuilders: etiology and management. Ann Thorac Surg 70:658-60, 2000. MCGINNIS, MY. Anabolic androgenic steroids and aggression: studies using animal models. Ann N Y Acad Sci. 1036:399-415, 2004. MCGINNIS MY, LUMIA AR, BREUER ME & POSSIDENTE B. Physical provocation potentiates aggression in male rats receiving anabolic androgenic steroids. Horm Behav. Feb;41(1):101-10. 2002. McINTYRE, KL; PORTER, DM and HENDERSON, LP. Anabolic androgenic steroids induce age-, sex-, and dose-dependent changes in GABAA receptor subunit mRNAs in the mouse forebrain. Neuropharmacology 43:634–645, 2002. MELCHERT, RB & WELDER, AA. Cardiovascular effects of androgenic-anabolic steroids. Medicine and Science in Sports and Exercise 27(9):1252-62, 1995. MICHELAKIS, AM; YOSHIDA, H.; DORMOIS, JC Plasma rennin activity and plasma aldosterone during the normal menstrual cycle. Am J Obstet Gynecol 123: 724-726; 1975. MINKIN DM, MEYER ME, VAN HAAREN F. Behavioral effects of longterm administration of an anabolic steroid in intact and castrated male Wistar rats. Pharmacol Biochem Behav 44:959–63, 1993. MIRCOLI, L.; FEDELE, L.; BENETTI, M.; BOLLA, G. B.; RADAELLI, A.; PERLINI, S.; FERRARI, A. U. Preservation of the baroreceptor heart rate reflex by chemical sympathectomy in experimental heart failure. Circulation. v. 106, p. 866 - 872, 2002. MOLLER, J.; MOLLER, N.; FRANDSEN, E.; WOLTHERS,T.; JORGENSEN, JOL; CHRISTIANSEN, JS Blockade of the rennin-angiotensin-aldosterone system prevents growth hormone induced fluid retention in humans. Am J Physiol 272: 803-808; 1997. MOLLER, J.; JORGENSEN, JOL.; MARQVERSEN, J.; FRANDSEN, E.; CHRISTIANSEN, JS Insulin-like growth factor 1 administration induces fluid and sodium retention in healthy adults: possible involvement of rennin and atrial natriuretic factor. Clin Endocrinol 52:181- 186; 2000. 86 MONTGOMERY HE, CLARKSON P, DOLLERY CM, et al. Association of angiotensinconverting enzyme gene I/D polymorphism with change in left ventricular mass in response to physical training. Circulation 96:741–7, 1997. MONTGOMERY, K. C. The elevated pluz-maze. Pharmacol methodology Ethology and psychopharmacology s.1, v. 53, p. 334-342, 1958. MOODY, T.W., MERALI, Z., CRAWLEY, J.N. The effects of anxiolytics and other agents on rat grooming behavior. Annals of the New York Academy of Sciences. v.90, p.281-290. 1993. MUNIZ, M., AFONSO, R. & COSTA, V. R. Anabolizantes: bombas-relógio nos músculos. Ciência Hoje, RJ, 22(131), set. 1997. MURPHY TC, SAMSON WK. The novel vasoactive hormone, adrenomedullin, inhibits water drinking in the rat. Endocrinology. Jun;136 (6):2459-63, 1995. NAHAMA, PETIT et al. Girls are more successful than boys at the university: Gender group differences in models integrating motivational and aggressive components correlated with test-anxiety. Encephale. 30: 1-15, 2004. NAHAS, T.R. O Teste do Campo Aberto In: XAVIER, G.F. Técnicas para o Estudo do Sistema Nervoso. São Paulo: Ed. Plêiade, 1999. p.197-215. 1999. NEGRÃO, ANDRÉ B, LICINIO, JULIO. Leptina: o Diálogo entre Adipócitos e Neurônios.Arquivo Brasileiro de Endocrinologia e Metabologia. São Paulo, junho. 2000. Disponível em: http://www.rgnutri.com.br/sap/tr-cientificos/leptina.php. Acesso em: 30 de março de 2012. NELSON, R. J. and CHIAVEGATTO, S. Molecular basis of aggression. Trends Neurosci 24:713–719, 2001. 87 NEUGARTEN, J.; DING, Q.; FRIEDMAN, A.; LEI, J. and SILBIGER, S. J Am Soc Nephrol. 8: 1240-1246, 1997. NIU T, CHEN X & XU X. Angiotensin converting enzyme gene insertion/deletion polymorphism and cardiovascular disease: therapeutic implications. Drugs. 62(7):977-93, 2002. NOORAFSHAN, A; KARIMIPOOR, M; BAHMANPOOR, S.; DEHGHANI, F. The influence of exposure to stress of pregnant rats on the adrenal gland structure of their offspring. An unbiased stereological study. Scandinavian Journal of Laboratory Animal Science. Estocolmo, v.32, n.3, p.161-166, sept. 2005. OLIVARES, E. L.; COSTA-E-SOUSA, R. H.; CAVALCANTE-LIMA, H. R.; LIMA, H. R.; CEDRAZ-MERCEZ, P. L. & REIS, L.C. 2003. Effect of electrolytic lesion of the dorsal raphe nucleus on water intake and sodium appetite. Braz. J. Med. Biol. Res. 36, 1709–1716. 2003. PALMA, A. Exercício físico e saúde; sedentarismo e doença: epidemia, causalidade e moralidade. Motriz, Rio Claro, v.15, n.1, p.185-191, jan/mar, 2009. PARROTT AC, CHOI PY & DAVIES M. Anabolic steroid use by amateur athletes: effects upon psychological mood states J Sports Med Phys Fitness. 34(3):292-8. 1994. PAVLATOS, A. M. et al. Review of oxymetholone: a 17 -alkylates an abolicandrogenic steroids. Clin Ther, v. 23, n. 6, p. 789 - 801, 2001. PEART, W. S. Renin 1978. Johns Hopkins Med J, 143:193-206, 1978. PELLOW S, CHOPIN P, FILE SE, BRILEY M Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat. J Neurosci Methods 14:149-167, 1985. 88 PEREIRA JR PP, CHAVES EA, COSTA E SOUSA RH, MASUDA MO, CARVALHO AC, NASCIMENTO JH. Cardiac autonomic dysfunction in rats chronically treated with anabolic steroid. Eur J Applied Physiol. 96(5):487-94, 2006. PESCATELLO, L.S. et al. American College of Sports Medicine Position Stand. Exercise and Hypertension. Med Sci Sports Exerc, v.36, n.3, p. 533-53; 2004. PHILLIS, B. D.; PHILLIS, B. D.; ABEYWARDENA, M. Y.; ADAMS, M. J.; KENNEDY, J. A.; IRVINE, R. J. Nandrolone potentiates arrhythmogenic effects of cardiac ischemia in the rat. Toxicological Sciences. n. 99, v. 2, p. 605–611. 2007. POLLOCK M.L. et al. Resistance exercise in individuals with and without cardiovascular disease. Benefits, rationale, safety, and prescription. An advisory from the committee on exercise, rehabilitation, and prevention, Council on clinical cardiology, American Heart Association. Circulation 101: 828 – 833, 2000. POPE HG JR & KATZ DL. Psychiatric and medical effects of anabolic-androgenic steroid use. A controlled study of 160 athletes. Arch Gen Psychiatry. May;51(5):375-82, 1994. PORTES LA, TUCCI PJ [Swim training attenuates myocardial remodeling and the pulmonary congestion in wistar rats with secondary heart failure to myocardial infarction]. Arq Bras Cardiol 87:54-59, 2006. POULSEN J. Ototoxic effect of readily soluble acetylsalicylic acid Ugeskr Laeger. 132(51):2435-7, 1970. PRICKAERTS J, RAAIJMAKERS W, BLOKLAND A Effects of myocardial infarction and captopril therapy on anxiety-related behaviors in the rat. Physiol Behav 60:43-50, 1996. QUINKLER, M.; IJB, KAUR K, HUGHES, SV.; HEWISON, M.; STEWART, PM. Testosterone enhances renal expression of the subunit of the epithelial sodium channel 89 (ENaC). Program of the 86th Annual Meeting of the Endocrine Society, New Orleans, LA, p. 150, 2004. RACCA, L et al. Hearing loss and depressive symptoms in elderly patients. Geriatr Gerontol Int. 12(3):440-5, 2012. RAMOS A, BERTON O, MORMEDE P, CHAOULOFF F. Behavioural Brain Research, 85: 57-69, 1997. RAMOS A, PEREIRA E, MARTINS GC, WEHRMEISTER TD, IZIDIO GS. Integrating the open field, elevated plus maze and light/dark box to assess different types of emotional behaviors in one single trial. Behav Brain Res 193:277–88, 2008. RANGH, P., DALE, M. M. & PITTER, J. M. Farmacologia. 4 ed. Rio de Janeiro: Guanabara Koogan, 2001. REIS, LUÍS C. et al. A reassessment of the role of serotonergic system in the control of feeding behavior. An. Acad. Bras. Ciênc. vol.77 no.1;2005 REIS, LUÍS C. Role of the serotoninergic system in the sodium appetite control. An Acad Bras Cienc 79: 261-283. 2007. REX. A.; SONDERN, U.; VOIGT, J.P.; FRANCK, S.; FINK, H. Strain differences in fearmotivaded behavior of rats. Pharmacology, Biochemistry and Behavior, v. 54, n.1, p. 107-111, 1996. RIBEIRO FILHO, FERNANDO F. et al . Gordura visceral e síndrome metabólica: mais que uma simples associação.Arquivo Brasileiro Endocrinologia Metabologia, São Paulo, v. 50, n.2, 2006. 90 RICCI LA, RASAKHAM K, GRIMES JM, MELLONI RH JR. Serotonin-1A receptor activity and expression modulate adolescent anabolic/androgenic steroid-induced aggression in hamsters. Pharmacol Biochem Behav. 85(1):1-11, 2006. RIKLI, RE. Reliability, validity and methodological issues in assessing physical activity in older adults. Res. Q. Exerc. Sport. 71 (2) 89-96: 2000. R.L. CUNNINGHAM AND M.Y. MCGINNIS Prepubertal Social Subjugation and Anabolic Androgenic Steroid-Induced Aggression in Male Rats. Journal of Neuroendocrinology, 20, 997-1005, 2008. ROCHA, F.L. et al Esteróides anabolizantes: mecanismos de ação e efeitos sobre o sistema cardiovascular. O mundo da saúde out/dez 31(4): 470-477, 2007. RODGERS, R.J., COLE, J.C. An ethological analysis of chlordiazepoxide and bretazenil (Ro16-6028) in the murine elevated plus-maze. Behavior Pharmacology. v.4, p.573–580. 1993. RODGERS, R. J. et al. Animal models of anxiety: an ethological perspective. Brazilian Journal of Medical and Biological Research, 30: 289-304, 1997. RODGERS, R.J., HALLER, J., HOLMES, A., HALASZ, J., WALTON, T.J., BRAIN, P.F. Corticosterone response to the plus-maze: high correlation with risk assessment in rats and mice. Physiology Behavior. v.68, p. 47–53. 1999. ROSSBACH UL, STEENSLAND P, NYBERG F, LE GREVÈS P. Nandrolone-induced hippocampal phosphorylation of NMDA receptor subunits and ERKs. Biochem Biophys Res Commun. Jun 15;357(4):1028-33. Epub Apr 17, 2007. ROUAH-ROSILIO M, OROSCO M, NICOLAIDIS S. Serotoninergic modulation of sodium appetite in the rat. Physiol Behav. 55(5):811-6, 1994. 91 RUWHOF et al. Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts. Molecular and cellular biochemistry Volume 208, Numbers 1-2, 89-98, 2000. RYAN, AJ. Anabolic steroids are fool's gold. Fed Proc. Oct;40 (12):2682-8, 1981. RYDER, J.W, CHIBALIN, A.V, ZIERATH, J.R. Intracellular mechanisms underlying increases in glucose uptake in response to insulin or exercise in skeletal muscle. Acta Physiol Scand, v.171, n.3, p. 249-57, 2001. SADER MA, GRIFFITHS KA, MCCREDIE RJ, HANDELSMAN DJ, CELERMAJER DS. Androgenic anabolic steroids and arterial structure and function in male bodybuilders. J Am Coll Cardiol 37(1):224-30, 2001. SADOWSKA & KOCHANOWSKA. A review of the present knowledge of the reninangiotensin-aldosterone system. Endokrynol Pol. 17(4):423-31,1966. SAKAI, R.R.; Ma, L.Y.; ZHANG, D. M.; McEWEN, B. S. FLUHARTY, S.J. Intracerebral administration of mineralocorticoid receptor antisense oligonucleotides attenuate adrenal steroid-induced salt appetite in rats. Neuroendocrinology, 64:425-429. 1996. SALAS-RAMIREZ, KALIRIS Y. et al. Anabolic steroids have long-lasting effects on male social behaviors. Behavioural Brain Research, 2008. 8 p. (a) SALAS-RAMIREZ, KALIRIS Y. et al. Anabolic androgenic steroids differentially affect social behaviors in adolescent and adult male Syrian hamsters. Hormones and Behavior, v. 53, p. 378-385, 2008. (b) SAMSON WK, SKALA KD, HUANG FL. CNP-22 stimulates, rather than inhibits, water drinking in the rat: evidence for a unique biological action of the C-type natriuretic peptides. Brain Res. 24;568(1-2):285-8, 1991. 92 SÁNCHEZ-OSORIO M, DUARTE-ROJO A, MARTÍNEZ-BENÍTEZ B, TORRE A, URIBE M. Anabolic-androgenic steroids and liver injury. Liver Int. 28(2):278-82, 2008. SAUL, JP. Beat-to-Beat Variationsof Heart Rate Reflect Modulation of Cardiac Autonomic Outflow. NIPS Volume 5/February 1990 SCHRIER, RW. Water and sodium retention in edematous disorders: role of vasopressin and aldosterone. Am J Med. Suppl. 1: 547-553, 2006. SEJERSTED OM, MEDBØ JI, HERMANSEN L. Metabolic acidosis and changes in water and electrolyte balance after maximal exercise. Ciba Found Symp. 87:153-67, 1982. SHAHIDI NT. A review of the chemistry, biological action, and clinical applications of anabolic-androgenic steroids. Clin Ther. 23(9):1355-90, 2001. SHAJI, A.V. and KULKARNI, S.K. Evidence of GABAergic modulation in melatonininduced short-term memory deficits and food consumotion. Methods Find. Exp. Clin. Pharmacol. v. 20 p. 311-319, 1998. SHEFFIELD-MOORE, M.; URBAN, R. G. An overviwen of endocrinology of skeletal muscle. Trends in endocrinology and metabolism, v. 15, p. 110-115, 2004. SHELLI, L. Autonomic nervous system pharmacogenomics: A progress report. Pharmacological Reviews. n. 56, p. 31–52. 2004. SHOJI, V.M. and FORJAZ, C.L. de M. Treinamento físico na Hipertensão Arterial. Rev Soc Cardiol. Estado de São Paulo, v.10, n.6, supl A, p. 7-14, 2000. SILVA et al 2007. Prevalência do Uso de Agentes Anabólicos em Praticantes de Musculação de Porto Alegre. Arq Bras Endocrinol Metab 51/1, 2007. SILVA, P.R.P et al. Anabolic steroids in sports. Rev.Bras.Med.Esp 8: 235-243, 2002. 93 SJAASTAD, I.; SJERSTED, O. M.; ILEBEKK, A.; BJORNERHEIM, R. Echocardiographic criteria for detection of postinfarction congestive heart failure in rats. J Appl Physiol. v. 89, p. 1445 - 1454, 2000. SMITH JC et al. Impaired vasoreactivity in bodybuilders using androgenic anabolic steroids. Eur J Clin Invest. 36(7):483-8, 2006. SOE, K.L.; SOE, M.; GLUUD, C.N. Liver pathology associated with anabolic-androgenic steroids. Ugeskr Laeger, v.156, p.2585-2588, 1994. SPRUIJT, B.M. et al. Ethology and Neurobiology of grooming behavior. Physiol Rev 72 (3): 825-852, 1992. STANDAERT DG, NEEDLEMAN P, DAY ML, WEIGAND R, KRAUSE JE. Expression of the gene for preproatriopeptin in the central nervous system of the rat. Brain Res. 464(1):7- 13, 1988. STACHENFELD, NS; DI PETRO, L.; PALTER, SF; NADEL, ER Estrogen influences osmotic secretion of AVP and body water balance in postmenopausal women. Am J Physiol 274: 187-195; 1998. SU et al. Neuropsychiatric Effects of Anabolic Steroids in Male Normal Volunteers JAMA. 269(21):2760-2764. 1993. SULLIVAN ML, MARTINEZ CM, GENNIS P, GALLAGHER EJ. The cardiac toxicity of anabolic steroids. Progr Cardiovasc Disease 41(1):1-15, 1998. SVARE BB. Anabolic steroids and behavior: a preclinical research prospectus. NIDA Res Monogr. 102:224-41, 1990. 94 SWANSON DA, SUI X, BRAMLETT KS, JORGE MC, VON ESCHENBACH AC & JENSTER G. Specific androgen receptor activation by an artificial coactivator. J Biol Chem. Apr 2;274(14):9449-54. 1999. TAKAHASHI M, TATSUGI Y, KOHNO T. Endocrinological and pathological effects of anabolic-androgenic steroid in male rats. Endocr J. 51(4):425-34, 2004. TANAKA, M. et al. Dopamine autoreceptors in rat nucleus accumbens modulate prepulse inhibition of acoustic startle. Pharmacology, Biochemistry, and Behavior, 60, 803-808, 1998. TERADA, S. et al. Effects of high-intensity swimming training on GLUT-4 and glucose transport activity in rat skeletal muscle. J Appl Physiol, v.90, p. 2019-2024, 2001. THIBLIN I et al. Anabolic androgenic steroids and suicide. Ann Clin Psychiatry. 11(4):223- 31, 1999. TIGERSTEDT R& P.BERGMAN: Niere und Kreislauf. Arch Physiol 8, 223-271, 1998. TREIT, D.; MENARD, J.; ROYAN, C. Anxiogenic stimuli in the elevated plus-maze. Pharmacology, Biochemistry and Behavior, 44: 463-469, 1993. TRICKER, R., CASABURI, R. STORER, T.W., CLEVENGER, B., BERMAN, N., SHIRAZI, A., & BHASIN, S. The effects of supraphysiological doses of testosterone on angry behavior in healthy eugonadal males - a clinical research center study. Journal of Clinical Endocrinology & Metabolism, 81, 3754-58, 1996. TRIFUNOVIC B, NORTON GR, DUFFIELD MJ, AVRAAM P, WOODIWISS AJ. An androgenic steroid decreases left ventricular compliance in rats. Am Journal of Physiology, v.268, n.3, Pt2, p.H1096-1105, 1995. TOMANARI, GV, PINEAS SILVA MTA, Ratos Wistar sob regimes rotineiros de restrição hídrica e alimentar. Rev Bras Ter Comp Cogn.V(1)57-71,2003. 95 UHLÉN S, LINDBLOM J, KINDLUNDH A, MUGISHA P, NYBERG F. Nandrolone treatment decreases the level of rat kidney alpha (1B)-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol. 2003. URHAUSEN A, ALBERS T, KINDERMANN W. Are the cardiac effects of anabolic steroid abuse in strength athletes reversible? Heart 90(5):496-501, 2004. UZYCH, L. Physicians and the treatment of domestic violence. J Am Med Womens Assoc. 47(6):239-40, 1992. VIAU, V.; SORIANO, L.; DALLMAN, MF. Androgens alter corticotropin releasing hormone and arginine vasopressin mRNA within forebrain sites known to regulate activity in the hypothalamic-pituitary-adrenal axis. J Neuroendocrinol, 13(5): 442-452, 2001. VELAZQUEZ, I. and ALTER, B.P. Androgens and liver tumors: Fanconi´s conditions. Am.J.Hematol, v.77, p.257-67, 2004. VERHOEVEN, G.; SWINNEN, J. V. Indirect mechanisms and cascades of androgen action. Molecular and Cellular Endocrinology, v. 151, p. 205-212, 1999. VOLAVKA, J., BILDER, R., & NOLAN, K. Catecholamines and aggression: The role of COMT and MAO polymorphisms. Annals of the New York Academy of Sciences, 1036, 393–398, 2004. WANG MG, YESALIS CE and FITZHYGH EC. Desire for weight gain and potential risks of adolescent males using anabolic steroids. Percept Hot Skills. 78:267, 1994. WATANABE, S. and KOBAYASHI, Y. Exogenous hormones and human cancer. J.Clin.Oncol, v.23, p.1-13, 1993. WEBER, MD & BRILLA, G. Remodeling and reparation of the cardiovascular system. Journal of the American College of Cardilogy. Volume 20, Issue 1, Pages 3-16, July, 1992. 96 WEISINGER RS, DENTON DA, MCKINLEY MJ, MULLER AF, TARJAN E. Cerebrospinal fluid sodium concentration and salt appetite. Brain Res. 326(1):95-105, 1985. WEISSBERGER, AJ & HO, KK. Activation of the somatropic axis by testosterone in adult males: evidence for the role of aromatization. J Clin Endocrinol Metab 76: 1407-1412; 1993. WICKLMAYR M, DIETZE G, BRUNNBAUER H, RETT K & MEHNERT H. Dosedependent effect of bradykinin on muscular blood flow and glucose uptake in man. Hoppe Seylers Z Physiol Chem. Jul;364(7):831-3, 1983. WILSON et al. The Rat Androgen Receptor: Primary Structure, Autoregulation of its Messenger Ribonucleic Acid, and Immunocytochemical Localization of the Receptor Protein. Molecular Endocrinology. 2: 1276-1285, 1988. WILSON, CM & MCPHAUL, MJ A and B forms of the androgen receptor are expressed in variety of human tissues. Mol Cell Endocrinol 120: 51-57, 1996. WU, F. & VON ECKARDSTEIN, A. Androgens and coronary artery disease. Endocrine Reviews 24 (2):183-217, 2003. WU, F. C. W. Endocrine aspects of anabolic steroids. Clin Chemistry. 43(7):1289-92, 1997. YANG, G; MERRILL, DC; THOMPSON, MW; ROBILLARD, JE; SIGMUND, CD. Functional expression of the human angiotensinogen gene in transgenic mice. J Biol Chem 269: 32497-32502, 1994. YANG, P et al. Mechanisms of anabolic androgenic steroid modulation of a1b3g2L GABAA receptors. Neuropharmacology. 43(4):619–33, 2002. 97 YARASHESKI KE, ZACHWIEJA JJ & BIER DM. Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women. Am J Physiol Endocrinol Metab 265, E210–E214, 1993. YESALIS CE et al. Indications of psychological dependence among anabolic-androgenic steroid abusers. NIDA Res Monogr. 102:196-214, 1990. YESALIS CE, KENNEDY NJ, KOPSTEIN NA, BAHRKE MS. Anabolic androgenic steroid use in the United States. JAMA 270:1217-21, 1993. YESALIS, CE & BAHRKE, MS. Anabolic-androgenic steroids. Current issues. Sports Med 19:326–340, 1995. ZLEBNIK NE, ANKER JJ, CARROLL ME. Exercise to reduce the escalation of cocaine self-administration in adolescent and adult rats. Psychopharmacology.2012.por
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