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dc.contributor.authorFonseca, Fabricia Viana
dc.date.accessioned2023-12-22T03:08:31Z-
dc.date.available2023-12-22T03:08:31Z-
dc.date.issued2011-03-25
dc.identifier.citationFONSECA, Fabricia Viana. Papel dos receptores 5-HT1A do núcleo dorsal da rafe no mecanismo de saciedade ao sódio em ratos WISTAR. 2011. 87 f. Dissertação (Programa Multicêntrico de Pós-Graduação em Ciências Fisiológicas) - Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/14938-
dc.description.abstractNós investigamos o possível papel dos autorreceptor somatodentritico 5-HT1A no núcleo dorsal da rafe (NDR) sobre a resposta do consumo de sal em condições basais e após desafios natriorexigênica induzido pela depleção de sódio em ratos. Ratos em condição basal, ratos submetidos a protocolos de depleção de sódio, onde os animais foram tratados com furosemida (20mg/kg, SC) ou protocolo FUROCAP, FUROCAP modificado, estimulação beta-adrenérgica ou modificação do protocolo de estimulação beta-adrenérgicos. Os animais que foram tratados com furosemida foram divididos em dois grupos de ratos: um sem acesso à água, e com água ad libitum. A cirurgia estereotáxica foi realizada para administração (7,5 nmol / rato) de 8-OH-DPAT e (2nmol / ratos) WAY100135 intra-DRN. Sistemicamente os animais receberam WAY100135 (5mg/kg, IP). Curiosamente, a microinjeção de 8-OH-DPAT no DRN promoveu um aumento suplementar de longa duração da ingestão de 0,3 M NaCl em ratos em condição basal, apesar de um elevado volume ingerido 30 minutos após a injeção central. Por outro lado, repetidas doses de microinjeção intra-DRN (7,5 nmol / rato) provocou uma diminuição significativa a longo prazo na ingestão de 0,3 M NaCl em ratos em condições basais e submetidos aos protocolo de depleção. Administração de WAY100135 não alteraram as respostas de ingestão de água ou NaCl 0,3 M no grupo sem acesso à água. Por outro lado, a administração sistêmica e intra-DRN de antagonista 5-HT1A promoveu redução intensa e prolongada na resposta natriorexigênica, no grupo que recebeu água ad libitum. A administração aguda de antagonistas 5-HT1A, diminuiu significativamente a ingestão de 0,3 M de NaCl nos protocolos de Furocap e Isoproterenol Modificado. Esta resposta, possivelmente, exigiu um aumento da atividade da 5-HT durante saciedade sal de sinalização ao longo da fase de consumação. Estes resultados mostram um claro envolvimento do 5-HT1A DRN na saciedade ao sódio em condições basais e durante a fase de do consumo de sal em ratos depletados.por
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico, CNPq, Brasilpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectserotoninapor
dc.subjectapetite por sódiopor
dc.subjectRatos Wistarpor
dc.subjectserotonineng
dc.subjectsodium appetiteeng
dc.subjectWistar Miceeng
dc.titlePapel dos receptores 5-HT1A do núcleo dorsal da rafe no mecanismo de saciedade ao sódio em ratos WISTARpor
dc.title.alternativeRole of 5-HT1A receptors in the dorsal raphe nucleus in the sodium satiety mechanism in WISTAR ratseng
dc.typeDissertaçãopor
dc.description.abstractOtherWe investigated the possible role of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus (DRN) on salt intake response during basal conditions and following natriorexigenic challenge aroused by sodium depletion in rats. Rats in condiction basal, rats submitted to protocols of sodium depletion, where the animals were treated with furosemide (20mg/kg, SC), protocol FUROCAP, modified FUROCAP, beta-adrenergic stimulated or modified beta-adrenergic protocols rats. Animals that were treated with furosemide were divided into two groups of rats with sodium depletion: one without access to water, and the other received water ad libitum. A stereotaxic surgery was realized for administering (7.5 nmol/rat) of 8-OH-DPAT and (2nmol/rats) WAY100135 intra- DRN. The animals received systemic WAY100135 (5 mg / kg, ip). Interestingly, microinjection of 8-OH-DPAT into the DRN raised an additional long-lasting increase of 0.3 M NaCl intake in sodium-depleted rats despite a high volume ingested 30 min after central injection. Conversely, repeated intra-DRN microinjection (7.5 nmol/rat) evoked a significant long-term decrease in 0.3 M NaCl intake in basal conditions and sodium-depleted rats. Administration of WAY100135 did not alter the responses of ingestion of water or 0.3 M NaCl in the group with no access to water. On the other hand, the 5-HT1A antagonist promoted intense and long-term reduction in the natriorexigenic response, in the group that received water ad libitum. Acute administration of 5-HT1A antagonist significantly decreased de 0.3 M NaCl ingestion in modified FUROCAP and modified beta-adrenergic protocols rats . This response possibly demanded an increased 5-HT activity during salt satiety signaling along the consummatory phase. These results show a clear-cut involvement of the DRN 5-HT1A somatodendritic autoreceptors in sodium satiety signaling under basal conditions and during the consummatory phase of salt intake in sodium-depleted rats.eng
dc.contributor.advisor1Reis, Luis Carlos
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/2679836949147357por
dc.contributor.referee1Carvalho, Denise Pires
dc.contributor.referee2Ventura, Renato Rizo
dc.contributor.referee3Olivares, Emerson Lopes
dc.creator.ID106.615.137-77por
dc.creator.Latteshttp://lattes.cnpq.br/9292722675695467por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Ciências Exataspor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma Multicêntrico de Pós-Graduação em Ciências Fisiológicaspor
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