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DC Field | Value | Language |
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dc.contributor.author | Arruda, Bárbara Monteiro Coimbra Guimarães de | - |
dc.date.accessioned | 2024-02-15T23:56:17Z | - |
dc.date.available | 2024-02-15T23:56:17Z | - |
dc.date.issued | 2023-09-25 | - |
dc.identifier.citation | GUIMARÃES, Bárbara Monteiro Coimbra. Eficácia do Fluralaner Transdermal no tratamento de Lynxacarus radovskyi (ACARI: LISTROPHORIDAE) em gatos naturalmente infestados. 2023. 41 f. Dissertação (Mestrado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2023. | pt_BR |
dc.identifier.uri | https://rima.ufrrj.br/jspui/handle/20.500.14407/15846 | - |
dc.description.abstract | Os ácaros da espécie Lynxacarus radovskyi, comumente encontrados em gatos domésticos no Brasil, podem causar desconforto, prurido e alopecia. É necessário o desenvolvimento de novos tratamentos mais seguros e eficazes com amplo espectro de ação, incluindo o uso de isoxazolinas. O objetivo deste estudo foi avaliar a eficácia do fluralaner transdérmico em gatos domésticos naturalmente infestados com L. radovskyi. Vinte gatos foram avaliados por tricogramas e divididos em dois grupos de 10 animais. O grupo controle não foi tratado, enquanto o grupo tratado recebeu uma única dose tópica de fluralaner, conforme instruções do fabricante. Os gatos foram reavaliados quanto à presença de ovos e ácaros de L. radovskyi nos dias D+7, D+14, D+28, D+42, D+56, D+70, D+84 e D+98. A partir de D+42, todos os animais testaram negativo para ácaros e permaneceram livres do parasita até o final do estudo, enquanto o grupo controle apresentou resultado positivo durante todo o experimento. Pode-se concluir que uma única dose de fluralaner aplicada topicamente foi eficaz no tratamento de gatos naturalmente infestados com L. radovskyi. | pt_BR |
dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES | pt_BR |
dc.language | por | pt_BR |
dc.publisher | Universidade Federal Rural do Rio de Janeiro | pt_BR |
dc.subject | Linxacariose | pt_BR |
dc.subject | ectoparasiticida | pt_BR |
dc.subject | ácaros | pt_BR |
dc.subject | Lynxacariosis | pt_BR |
dc.subject | ectoparasiticid | pt_BR |
dc.subject | mite | pt_BR |
dc.title | Eficácia do Fluralaner Transdermal no tratamento de Lynxacarus radovskyi (ACARI: LISTROPHORIDAE) em gatos naturalmente infestados | pt_BR |
dc.title.alternative | Efficacy of Transdermal Fluralaner in the treatment of Lynxacarus radovskyi (ACARI: LISTROPHORIDAE) in naturally infested cats | en |
dc.type | Dissertação | pt_BR |
dc.description.abstractOther | Mites of the species Lynxacarus radovskyi, which are commonly found on domestic cats in Brazil, can cause discomfort, itching, and alopecia. The development of new, safer and more effective treatments with a broad spectrum of activity, including the use of isoxazolines, is needed. The purpose of this study was to assess the efficacy of transdermal fluralaner in domestic cats naturally infested with L. radovskyi. Twenty cats were evaluated by trichograms and divided into two groups of 10 animals. The control group was not treated, while the treated group was given a single topical dose of fluralaner, as per the manufacturer’s instructions. The cats were reassessed for the presence of L. radovskyieggs and mites on days D+7, D+14, D+28, D+42, D+56, D+70, D+84, and D+98. As of D+42, all the animals tested negative for mites (100%),and remained parasite-free until the end of the study, while the control group tested positive throughout the experiment. It can be concluded that a single dose of fluralaner applied topically was effective in treating cats naturally infested with L. radovskyi. | pt_BR |
dc.contributor.advisor1 | Fernandes, Julio Israel | - |
dc.contributor.advisor1ID | https://orcid.org/0000-0002-6936-1774 | pt_BR |
dc.contributor.advisor1Lattes | http://lattes.cnpq.br/9221592908532393 | pt_BR |
dc.contributor.referee1 | Fernandes, Julio Israel | - |
dc.contributor.referee2 | Bendas, Alexandre Jose Rodrigues | - |
dc.contributor.referee3 | Dutra, Ary Elias Aboud | - |
dc.creator.Lattes | http://lattes.cnpq.br/4367664187506580 | pt_BR |
dc.publisher.country | Brasil | pt_BR |
dc.publisher.department | Instituto de Veterinária | pt_BR |
dc.publisher.initials | UFRRJ | pt_BR |
dc.publisher.program | Programa de Pós-Graduação em Ciências Veterinárias | pt_BR |
dc.relation.references | Abbott WS. A Method of Computing the Effectiveness of an Insecticide, Journal of Economic Entomology, 1925 Volume 18, Issue 2, , Pages 265–267. Aguiar J, Machado MLS, Rodrigues RF, Stieven PH, Cunha AM, Zazycky RR. Infestação mista por Lynxacarus radovskyi e Felicola subrostratus em um gato na região de Porto Alegre, RS, Brasil. Acta Sci Vet. 2009;37:301–305. Akucewich, L.H.; Philman, K.; Clark, A.;Gillespie, J.;Kunkle, G.; Nicklin, C. F.; Greiner, E. C. Prevalence of ectoparasites in a population of feral cats from north central Florida during the summer. Veterinary Parasitology. v. 109, 2002, p. 129-139. Arruda, É.N, da Silva Marques, M., Galera, P. D., de Sousa Filho, R. P., & Monteiro, C. L. B. (2021). Gastric Obstruction by Tricobezoar in Cat Associated with Lynxacarus radovskyi: a Case Report. Brazilian Journal of Case Reports,1(2), 26-31. Beugnet, F.; Liebenberg, J.; Halos, L. Comparative efficacy of two oral treatments for dogs containing either afoxolaner or fluralaner against Rhipicephalus sanguineus sensu lato and Dermacentor reticulatus. Veterinary Parasitology, v. 209, n. 1-2, 142-145, 2015. Beugnet, F. et al. Efficacy of oral afoxolaner for the treatment of canine generalized demodicosis. Parasite, v. 23, 14, 2016. Becskei, C. et al. Efficacy of a new oral chewable tablet containing sarolaner, moxidectin and pyrantel (SimparicTrioTM) against induced ascarid infections in dogs. Parasites & Vectors, v. 13, n. 71, 2020. Boland, L.A., Angles, J.M., 2010. Feline permethrin toxicity: retrospective study of 42 cases. JFMS, 12, 2, 61-71. Campos, D.R., Chaves, J.K.O., Assis, R.C.P., Fernandes, J.I., Scott, F.B., 2020. Efficacy of oral sarolaner against Lynxacarus radovskyi in naturally infested cats. Vet Dermatol, 31, 5, e355-e392. Campos DR, Assis RCP, Chaves JKO, Almeida GPS, Lima EAS, Intrieri JM, et al. Furuncular myiasis caused by Dermatobia hominis in five cats and efficacy of topical fluralaner for its treatment. Vet Dermatol. 2021. Carithers, D. et al. Assessment of afoxolaner efficacy against Otodectes cynotis infestations of dogs. Parasites & Vectors, v. 9, 635, 2016. Carvalho, F. C. G. et al. Efficacy of oral sarolaner for the treatment of generalized demodicosis in dogs. Brazilian Journal of Veterinary Medicine, v. 41, e102219, 2019. Clare, F., Mello, R.M.L.C., Bastos, T.V., Lessa,C., Conceição, L. G., 2004. Use of fipronil for treatment of Lynxacarus radovskyi in outdoor cats in Rio de Janeiro (Brazil). Vet Dermatol, 15, Suppl. 1, 50. Craig, T.M., Teel, P.D., Dubuisson, L. M., Dubuisson, R. K., 1993. Lynxacarus radovskyi in festation in a cat. J Am Vet Med Assoc, 202, 613-614. Curtis, C.F., Bourdeau, P.J., Barr, P.A., Mukherjee, R., 2019. Uso do novo ectoparasiticida fluralaner no tratamento da sarna sarcóptica felina. Vet Rec Case Rep. First published: 29 Janeiry 2019. Dongus, H.; Meyer, L.; Armstrong, R. Water immersion of dogs close to the time of topical fluralaner treatment does not reduce efficacy against a subsequent experimental challenge with Rhipicephalus sanguineus (sensulato). Parasites & Vectors, v. 10, n. 1, p. 1-3, 2017. Dumont, P. et al. Evaluation of the efficacy of afoxolaner against two European dog tick species: Dermacentor reticulatus and Ixodesricinus. Veterinary Parasitology, v. 201, n. 3-4, p. 216-219, 2014. Faccini, J. L. H., and V. Coutinho."Ocorrência de Lynxacarus radovskyi (Acari: Listrophoridae) em gatos domésticos no Brasil."Arquivos da Universidade Federal Rural do Rio de Janeiro. 9.1-2 (1986): 91-93. Faustino, M. A. G., Messias, J. B. & Romeiro, E. T. (2004). Infestação por Lynxacarus radovskyi (Tenório, 1974) em felinos – revisão. Clínica Veterinária, 53(1),52-56 Foley, R.H., 1991. An epizootic of a rare fur mite in an island’s cat population. Fel Pract,19, 17-19. Gassel M, Wolf C, Noack S, Williams H, Ilg T: The novel isoxazoline ectoparasiticide fluralaner: selective inhibition of arthropod γ-aminobutyric acid- and L-glutamate-gated chloride channels and insecticidal/acaricidal activity. Insect Biochemistry and Molecular Biology. 2014, 45: 111-124. Gopinath, D., Meyer, L., Smith, J. et al. Eficácia do fluralaner tópico ou oral contra a transmissão da pulga (Ctenocephalide sfelis) da infecção por Dipylidium caninum a cães. Parasites Vectors 11, 557 (2018). Greiner, E.C. Artrópodes de importância veterinária na América do Norte. In: SLOSS, M. W.; ZAJAC, A. M.; KEMP,R. L. Parasitologia clínica veterinária. 6. ed. São Paulo: Manole, 1999. Greve, J. H.; Gerrish, R. R. Fur mites (Lynxacarus) from cats in Florida. Feline Practice. v. 11, n. 6, p. 28-30, 1981. Halos, L. et al. Immediate efficacy and persistent speed of kill of a novel oral formulation of afoxolaner (NexGard®) against induced infestations with Ixodes ricinus ticks. Parasites & Vectors, v. 7, 452, 2014. Hampel, V. et al. Treatment of canine sarcoptic mange with afoxolaner (NexGard®) and afoxolaner plus milbemycin oxime (NexGard Spectra®) chewable tablets: efficacy under field conditions in Portugal and Germany. Parasite, v. 25, 2018. Han, H.S., Noli, C., Cena, T., 2016. Efficacy and duration of action of oral fluralaner and spot-on moxidectin/imidacloprid in cats infested with Lynxacarus radovskyi. Vet Dermatol, 27, 474–e127. Jacquot V, Buellet P, Letendre L, Tong W, Li H, Tielemans E. Pharmacokinetics of a novel endectoparasiticide topical formulation for cats, combining esafoxolaner, eprinomectin and praziquantel. Parasite. 2021;28:19. Jayanthy C, Nagarajan B, Latha BR. Cat fur mite Lynxacarus radovskyi in India. J Parasit Dis. 2017 Dec;41(4):1102-1104. Ketzis, J.K., Dundas, J., Shell, L.G., 2016. Lynxacarus radovskyi mites in feral cats: a study of diagnostic methods, preferential body locations, co‐infestations and prevalence. Vet Dermatol, 27, 5, 425-e108. Kilp, S., Ramirez, D., Allan, M.J. et al. Pharmacokinetics of fluralaner in dogs following a single oral or intravenous administration. Parasites Vectors7, 85 (2014). Kilp, S., Ramirez, D., Allan, M.J., Roepke, R.K., 2016. Comparative pharmacokinetics of fluralaner in dogs and cats following single topical or intravenous administration. Parasite & Vectors, 9, 1, 1-7. Lahm, G.P. et al. 4-Azolylphenyl isoxazoline insecticides acting at the GABA gated chloride channel. Bioorganic& Medicinal ChemistryLetters, v. 23, n. 10, 3001- 3006, 2013. Larsson, E.C.; Lucas, L. Tratado de Medicina Externa, Dermatologia veterinária. São Paulo: Interbook Editorial LTDA, 2016. Lasmar PVF, Murphy M, Drake J, Nanchen S. Laboratory evaluation of the efficacy of lotilaner (CredelioTM) Against Amblyomma cajennense sensulato infestations of dogs. Parasites & Vectors. 2018 (In press). Lavan RP, Tunceli K, Zhang D, Normile D, Armstrong R. Avaliação da adesão dos donos de cães às recomendações veterinárias de prevenção contra pulgas e carrapatos nos Estados Unidos usando uma pesquisa transversal Vetores Parasitários. 2017;10:284. Letendre, L. et al. The intravenous and oral pharmacokinetics of afoxolaner used as a monthly chewable antiparasitic for dogs. Veterinary Parasitology, v. 201, n. 3-4, 190-197, 2014. Lopes, Leide Maria Leão, Ana Cristina Macário Lopes and Nicolau Maués da Serra-Freire. “Registro de lynxacariose em Feliscatus domesticus na cidade de Jundiaí, Estado de São Paulo.” (1997). Meadows, C., Guerino, F. & Sun, F. Um estudo de campo randomizado, cego e controlado nos EUA para avaliar o uso da soluçãotópica de fluralaner no controle de infestações por pulgas felinas. Parasites Vectors 10, 37 (2017). Medleau, L; Hnilica, K. A. Ácaro de pêlos de gatos (Lynxacarus radovskyi).Dermatologia de pequenos animais: Atlas colorido e guia terapêutico. São Paulo: Roca, 2003. Merchant, S. R. The Skin: Parasitic Diseases. In: NORSWORTHY, G. D. Feline Practice. Philadelphia: J.B. Lippincott Company, 1993, p. 515-516. Packianathan, R. et al. Comparative speed of kill of sarolaner (Simparic®) and afoxolaner (NexGard®) against induced infestations of Ixodesholocyclus on dogs. Parasites & Vectors, v. 10, n. 1, p. 1-8, 2017. Pereira, M. C. P. (1996). The cat fur mite (Lynxacarus radovskyi) in Brazil. Feline Practice, 24(5),24-26. Ranjan, S., Young, D., Sun, F., 2018. A single topical fluralaner application to cats and to dogs controls fleas for 12 weeks in a simulated home environment. Parasit & Vectors, 11, 1, 1-6. Rocha, C.M., Granadeiro Farias, P.C., Gorza, L., Soares, F. E. F., Ferraz, C. M., Souza, R. L. O., Renon, L. B. S., Braga, F. R., 2019. Association between infestation by Lynxacarus radovskyi (Acari: Lystrophoridae) and the occurrence of Feline Eosinophilic Granuloma Complex. J Parasit Dis, 443, 726-729. Rodan, I., Sundahl, E., Carney, H., Gagnon, A.-C.,Heath, S., Landsberg, G.,Seksel, K., Yin, S., American Animal Hospital Association, 2011. AAFP and ISFM feline-friendly handling guidelines. JFMS, 13, 5, 364-375. Rohdich N, Roepke RKA, Zschiesche E: A randomized, blinded, controlled and multi-centered field study comparing the efficacy and safety of BravectoTM (fluralaner) against FrontlineTM (fipronil) in flea- and tick-infested dogs. Parasite & Vectors. 2014, 7: 83. Romeiro, E.T; Alves, L.C.; Soares, Y.M.V.; Matoso, U.N.V.; Faustino, M.A.G. Infestação por Lynxacarus radovskyi (Tenorio, 1974) em gatos domésticos procedentes da região metropolitana do Recife, Pernambuco, Brasil. Revista Brasileira de Parasitologia Veterinária, v. 16, n. 3, p. 159-162, 2007. Romeiro, E.T., Alves, L.C., Faustino, M.A.G., 2010. Preliminary studies for evaluation of Lynxacarus radovskyi survival capacity (Tenorio, 1974) away from the host. CiêncAnim Bras, 11, 3, 629-636. Saridomichelakis MN (2008) Skin citology and examinations for ectoparasites. In: Proceedings 6th world congress of veterinary dermatology, Hong Kong, pp 14–21 Scott, D.A.; Miller, W.H.; JR.; Griffin, C. E. Parasitic Skin Disease. Muller & Kirk’s small animal dermatology. 6. ed. Philadelphia: W.B.Saunders Company, 2001, p. 446-447. Serra-Freire, N.M.; Benigno, R.N.M.; Oliveira, S.A.; Galvão, G. Lynxacarus radovskyi- diagnóstico e tratamento em felinos de Belém-Pará. Revista Universidade Rural, Série. Ciências de Vida, v. 22, n. 1, p. 57-60, 2002. Shoop, W.L. et al. Discovery and mode of action of afoxolaner, a new isoxazoline parasiticide for dogs. Veterinary Parasitology, v. 201, n. 3-4, p. 179-189, 2014. Six, R.H. et al. Comparative speed of kill of sarolaner (SimparicTM) and afoxolaner (NexGard®) against induced infestations of Amblyomma americanum on dogs. Parasites & Vectors, v. 9, n. 98, 2016. Snyder, D.E., Wiseman, S.; Liebenberg, J.E. Efficacy of lotilaner, a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp. Parasites & Vectors, v. 10, n. 532, 2017. Snyder, D.E., Wiseman, S.; Liebenberg, J.E. Efficacy of lotilaner , a novel oral isoxazoline against naturally occurring mange mite infestations in dogs caused by Demodex spp. Parasites & Vectors, v. 10, n. 532, 2017. Sojka, P. A. Isoxazolines. Journal of Exotic Pet Medicine, 27(2), 118 122, 2018. Taenzler, J., Liebenberg, J., Mienie, M. et al. Eficácia da solução spot-on de fluralaner contra infestações induzidas por Rhipicephalus sanguineus em cães. Parasites Vectors 9, 276 (2016). Taenzler, J., De Vos, C., Roepke, R.K.A., Frénais, R., Heckeroth, A.R., 2017. Efficacy of fluralaner against Otodectes cynotis infestations in dogs and cats. ParasitVectors, 10, 1, 1-6. Tamam, O.A., Omar, H.M (2009). Um novo recorde para o Lynxacarus na Toupeira Cega Menor egípcia (SpalaxleucodonEgyptiacus). European Journal of Scientific Research, 33(3), 509-514. Tenorio, J.M. A new species of Lynxacarus (Acarina: Astigmata: Listrophoridae) from Felis catus in the Hawaiian Islands. Journal of Medical Entomology, v. 11, p. 599-604, 1974. Toutain, C.E.; Seewald, W.; JUNG, M. Pharmacokinetics of lotilaner following a single oral or intravenous administration in cats. Parasites & Vectors, v. 11, n. 412, 1-7, 2018. Toutain, C.E.; Seewald, W.; Jung, M. The intravenous and oral pharmacokinetics of lotilaner in dogs. Parasites &Vectors, v. 10, n. 522, 2017. Weber, T.; Selzer, R, P.M. Isoxazolines: A novel Chemotype Highly Effective on Ectoparasites. In: Drug Discovery Against Moving Targets v.8, p.243-258, 2018. Wilkinson, G.T.; Harvey, R.G. Doenças Parasitárias. In: WILKINSON, G. T.; HARVEY, R.G. Atlas colorido de dermatologia dos pequenos animais: guia para o diagnóstico. 2. ed. São Paulo: Manole, 1996. Wismer, T.; Means, C. Toxicology of newer insecticides in small animals. Veterinary Clinics: Small Animal Practice, v. 48, n. 6, p. 1013-1026, 2018 Zhou, X.,Hohman, A.E.,Hsu, W.H., 2021. Current review of isoxazoline ectoparasiticides used in Veterinary medicine. J VetPharmacolTherap, 00, 1-15. | pt_BR |
dc.subject.cnpq | Medicina Veterinária | pt_BR |
Appears in Collections: | Mestrado em Ciências Veterinárias |
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