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  4. Mestrado em Ciências Veterinárias
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dc.contributor.authorNascimento, Paloma Mathias do-
dc.date.accessioned2024-09-26T15:50:54Z-
dc.date.available2024-09-26T15:50:54Z-
dc.date.issued2022-03-04-
dc.identifier.citationNASCIMENTO, Paloma Mathias. Triagem de Fitoinsumos com Potencial Anti-helmíntico Utilizando o Modelo de Organismo Caenorhabditis elegans. 2022. 72 f. Dissertação (Mestrado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2022.pt_BR
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/18255-
dc.description.abstractA produtividade da pecuária pode ser significativamente diminuída pelos efeitos do parasitismo gastrointestinal. Assim como, pode impactar cães e gatos e, consequentemente, seres humanos devido ao potencial zoonótico. A necessidade de alimentos sem resíduos de pesticidas, melhores condições de trabalho e aumento de casos de resistência anti-helmíntica abre um caminho para alternativas sustentáveis no controle de helmintíases, como os óleos essenciais. Neste contexto, Caenorhabditis elegans é utilizado para pesquisar fitoinsumos com atividade anti-helmíntica em diversos estágios de desenvolvimento através da avaliação toxicológica em diferentes cepas de C. elegans. Neste contexto, objetivo deste trabalho foi investigar os efeitos dos diferentes fitoinsumos no desenvolvimento do ciclo de vida de C. elegans; determinar as CL50 ou CI50 e CL90 ou CI90 dos fitoinsumos com atividade antihelmíntica; determinar o fator de resistência utilizando diferentes cepas resistentes às principais classes de antiparasitários de C. elegans; e propor uma linha analítica de testes capaz de triar fitoinsumos com possível atividade anti-helmíntica. Foram utilizados os seguintes óleos essenciais (OEs): Cymbopogon flexuosus, Eugenia caryophyllus, Illicium verum, Mentha piperita, Mentha spicata, Pelargonium graveolens e Thymus vulgaris. Estes foram solubilizados em DMSO. Foram realizados testes in vitro de letalidade em adultos de cepa selvagem (N2) e cepas resistentes à ivermectina, albendazol e levamisol, eclodibilidade de ovos e postura de ovos. O OE de I. verum resultou em melhor atividade nematicida em adultos N2. Já o OE de P. graveolens exibiu melhor inibição de eclodibilidade de ovos. Quanto à inibição da ovoposição, os OEs de C. flexuosus, E. caryophyllus, I. verum e T. vulgaris apresentaram taxa semelhante, enquanto o OE de P. graveolens não resultou atividade. Os indivíduos adultos de C. elegans resistentes à ivermectina (DA1316) mostraram-se susceptíveis aos OEs de I. verum e T. vulgaris, entretanto demonstraram resistência cruzada ao OE de P. graveolens. Os indivíduos adultos de C. elegans resistentes ao albendazol (CB3474) mostraram-se susceptíveis aos OEs de P. graveolens e T. vulgaris, entretanto demonstraram resistência cruzada ao OE de I. verum. Já os indivíduos adultos de C. elegans resistentes levamisol (CB211) demonstraram resistência cruzada a todos os OEs testados.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectÓleos essenciaispt_BR
dc.subjectAntiparasitáriospt_BR
dc.subjectSeleçãopt_BR
dc.subjectEssential oilspt_BR
dc.subjectAntiparasiticspt_BR
dc.subjectSelectionpt_BR
dc.titleTriagem de Fitoinsumos com Potencial Anti-helmíntico Utilizando o Modelo de Organismo Caenorhabditis eleganspt_BR
dc.title.alternativeScreening of Active Phytopharmaceutical Ingredient with Anthelmintic Potential Using Caenorhabditis elegans Modelen
dc.typeDissertaçãopt_BR
dc.description.abstractOtherThe profitability of livestock activities can be significantly diminished by the effects of gastrointestinal parasitism. As well, it can also impact serious conditions in dogs and cats and, with a number of them also affecting the human population, due to their zoonotic potential. The demand for food without pesticide residues, safer working conditions and the increase cases of anthelmintic resistance opens a new pathway for sustainable alternatives in the control of helminthiases, such as essential oils. In this context, Caenorhabditis elegans is used to research phytoinputs with anthelmintic activity at different stages of development through toxicological evaluation in different strains of C. elegans. The aim of this study was to investigate the effects of different essential oils (EO) on the development of the life cycle of C. elegans; determine the LC50 or IC50 and LC90 or IC90 of essential oilswith anthelmintic activity; determine the resistance factor using different strains resistant to the main classes of C. elegans antiparasitics; and to propose an analytical line of tests capable of screening essential oils with possible anthelmintic activity. The following EOs were used: Cymbopogon flexuosus, Eugenia caryophyllus, Illicium verum, Mentha piperita, Mentha spicata, Pelargonium graveolens and Thymus vulgaris. All EOs were solubilized in DMSO. In vitro lethality tests were performed on adults of wild strain (N2) and strains resistant to ivermectin, albendazole and levamisole, egg hatchability and egg laying. I. verum EO showed better nematicidal activity in N2 adults. For oviposition inhibition, the C. flexuosus, E. caryophyllus, I. verum and T. vulgaris EOs showed a similar rate, while the P. graveolens EO did not result in activity. On the other hand, P. graveolens EO exhibited better inhibition of egg hatching. Adults ivermectin-resistant strain of C. elegans (DA1316) were shown to be susceptible to I. verum and T. vulgaris EOs, however they demonstrated cross-resistance to P. graveolens EO. Adults albendazole-resistant strain of C. elegans (CB3474) were shown to be susceptible to P. graveolens and T. vulgaris EOs, however they showed cross-resistance to I. verum EO. Adults levamisole-resistant strain of C. elegans (CB211) demonstrated cross-resistance to all tested EOs.en
dc.contributor.advisor1Scott, Fabio Barbour-
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-1683-8724pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1217253540572819pt_BR
dc.contributor.advisor-co1Magalhães, Viviane de Souza-
dc.contributor.advisor-co1IDhttps://orcid.org/0000-0002-8313-1246pt_BR
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/1129995417777144pt_BR
dc.contributor.referee1Scott, Fabio Barbour-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-1683-8724pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/1217253540572819pt_BR
dc.contributor.referee2Klafke, Guilherme Marcondes-
dc.contributor.referee2IDhttps://orcid.org/0000-0002-5620-2483pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/4799380226074807pt_BR
dc.contributor.referee3Monteiro, Caio Marcio de Oliveira-
dc.contributor.referee3IDhttps://orcid.org/0000-0001-5253-5451pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/2496419306394657pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/5935288138917748pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Veterináriapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Ciências Veterináriaspt_BR
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