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dc.contributor.authorFernandes, Maria Eduarda dos Santos Lopes-
dc.date.accessioned2024-10-30T12:35:45Z-
dc.date.available2024-10-30T12:35:45Z-
dc.date.issued2023-12-07-
dc.identifier.citationFERNANDES, Maria Eduarda dos Santos Lopes. Influência do enxerto omental livre sem microanastomose vascular na integração de enxertos cutâneos em malha aplicados em ferida experimental de coelhos. 2023. 81 f. Tese (Doutorado em Medicina Veterinária) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica,2023.pt_BR
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/18887-
dc.description.abstractDiante dos desafios no uso de enxertos cutâneos autólogos na cirurgia veterinária, cresce progressivamente a busca de alternativas no enriquecimento do processo de reparo. Objetivou- se avaliar a influência do enxerto omental livre sem microanastomose vascular (LSMAV) na implantação de enxertos cutâneos em malha aplicados sobre feridas experimentalmente em coelhos. Vinte e quatro coelhos submetidos à celiotomia longitudinal mediana para coleta de fragmento omental (4cm2 ) foram utilizados. Após a celiorrafia foram produzidas, duas feridas quadradas de 4cm2 na região torácica dorsal, de forma que cada segmento de pele removido serviu de enxerto cutâneo em malha na ferida contralateral. Nas feridas controle (FC) o enxerto de pele foi suturado ao leito receptor utilizando-se pontos simples separados com fio poliamida 4-0, sem o fragmento omental entre o enxerto e leito receptor. Nas feridas tratadas (FO) o fragmento de omento foi implantado no leito receptor com oito pontos simples separados com fio de polidioxanona 4-0 em suas extremidades, com posterior sutura do enxerto de pele, conforme descrito anteriormente. No pós-operatório instituiu-se terapia com antibiótico e analgésicos, curativo do tipo tie over com gel lubrificante hidrossolúvel, trocado aproximadamente a cada 3 dias, além de colar protetor e botas esparadrapadas. As feridas foram clinicamente avaliadas nos dias 3, 7, 10, 14, 17, 21 e 28 pós-operatórios. Oitos animais foram mantidos diferentes períodos (7, 14 e 28 dias) e submetidos à eutanásia para avaliação anatomopatológica (macro e microscópica). Clinicamente destacou-se o aumento de volume nas FO, que se manteve por mais tempo e de forma mais intensa, sobretudo com consistência firme, na lateral dos enxertos a partir do terceiro dia de pós-operatório. Além disso, observou- se também nas FO produção de exsudato inflamatório por período mais prolongado, com evolução mais rápida dos enxertos para colorações escuras com aspecto ressecado e desvitalizado ao longo dos momentos de avaliação, não havendo integração do enxerto cutâneo em nenhum animal desse grupo. A avaliação macroscópica post-mortem evidenciou reação inflamatória mais intensa nas FO em todos os momentos de avaliação, porém com abrandamento dessas reações e evolução para reparo tecidual ao longo do tempo em ambos os grupos. Na microscopia observaram-se também inflamação mais intensa, com maior número de células polimorfonucleares, mononucleares e células gigantes nos dias 14 e 28 de pós- operatório, maior intensidade de úlceras epidérmicas no 28o dia e menos reepitelização nos 14o e 28o dias nas FO quando comparado às FC. Conclui-se que o enxerto omental LSMAV, apesar de ter se mantido viável e sem efeitos deletérios locais (leito receptor), não exerceu influência positiva na integração dos enxertos cutâneos em malha aplicados em feridas experimentais de coelhos.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectCicatrizaçãopt_BR
dc.subjectCirurgia Reconstrutivapt_BR
dc.subjectOryctolagus cuniculuspt_BR
dc.subjectOryctolagus cuniculuspt_BR
dc.subjectReconstructive Surgerypt_BR
dc.subjectWound Healingpt_BR
dc.titleInfluência do enxerto omental livre sem microanastomose vascular na integração de enxertos cutâneos em malha aplicados em ferida experimental de coelhospt_BR
dc.title.alternativeInfluence of free omental graft without microvascular anastomosis on the integration of mesh skin grafts applied in experimental wounds in rabbitsen
dc.typeTesept_BR
dc.description.abstractOtherIn the face of challenges in the use of autologous skin grafts in veterinary surgery, there is a growing search for alternatives to enhance the repair process. The aim was to evaluate the influence of free omental graft without vascular microanastomosis (FOGWMA) on the integration of meshed skin grafts applied to wounds experimentally created in rabbits. Twenty- four rabbits subjected to median longitudinal celiotomy for omental fragment collection (4cm2 ) were used. After celiorrhaphy, two square wounds of 4cm2 each were created on the dorsal thoracic region, with each removed skin segment serving as a meshed skin graft on the contralateral wound. In control wounds (CW), the skin graft was sutured to the recipient bed using separate simple stitches with 4-0 polyamide thread, without the omental fragment between the graft and recipient bed. In omental wounds (OW), the omentum fragment was implanted in the recipient bed with eight separate simple stitches using 4-0 polydioxanone thread at its ends, followed by suturing of the skin graft, as described earlier. Postoperatively, antibiotic, and analgesic therapy was initiated, and tie-over dressings with water-soluble lubricant gel were applied, changed approximately every 3 days, in addition to protective collars and adhesive boots. The wounds were clinically evaluated on days 3, 7, 10, 14, 17, 21, and 28 postoperatively. Eight animals were euthanized at different intervals (7, 14, and 28 days) for macroscopic and microscopic pathological evaluation. Clinically, there was a noticeable increase in volume in OW, which persisted for a longer and more intense period, especially with a firm consistency on the lateral aspects of the grafts from the third postoperative day. Additionally, OW exhibited prolonged inflammatory exudate production, rapid evolution of grafts to dark discoloration with a dry and devitalized appearance during the evaluation periods, with no integration of the skin graft in any animal in this group. Post-mortem macroscopic evaluation revealed a more intense inflammatory reaction in OW at all evaluation times, but with attenuation of these reactions and progression to tissue repair over time in both groups. Microscopically, OW showed more intense inflammation, with a higher number of polymorphonuclear cells, mononuclear cells, and giant cells on days 14 and 28 postoperatively, greater intensity of epidermal ulcers on the 28th day, and less reepithelialization on the 14th and 28th days compared to CW. In conclusion, despite maintaining viability and having no local deleterious effects on the recipient bed, the FOGWMA graft did not exert a positive influence on the integration of meshed skin grafts applied to experimental rabbit wounds.en
dc.contributor.advisor1Carvalho, Vivian de Assunção Nogueira-
dc.contributor.advisor1IDhttps://orcid.org/0000-0002-4034-9675pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6012855368365110pt_BR
dc.contributor.advisor-co1Silva, Marta Fernanda Albuquerque da-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/0544591266946007pt_BR
dc.contributor.referee1Silva, Marta Fernanda Albuquerque da-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/0544591266946007pt_BR
dc.contributor.referee2França, Ticiana do Nascimento-
dc.contributor.referee2IDhttps://orcid.org/0000-0002-7365-2697pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/3545873525091315pt_BR
dc.contributor.referee3Nardi, Andrigo Barboza De-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/5256503293611165pt_BR
dc.contributor.referee4Peixoto, Tiago da Cunha-
dc.contributor.referee4Latteshttp://lattes.cnpq.br/2092167505993680pt_BR
dc.contributor.referee5Pippi, Ney Luis-
dc.contributor.referee5Latteshttp://lattes.cnpq.br/7254479300721225pt_BR
dc.creator.IDhttps://orcid.org/0000-0003-1414-2475pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/9974066735850760pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Veterináriapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)pt_BR
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