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dc.contributor.authorLima, Virgínia Conceição Tavares-
dc.date.accessioned2025-03-20T12:43:49Z-
dc.date.available2025-03-20T12:43:49Z-
dc.date.issued2020-02-18-
dc.identifier.citationLIMA, Virgínia Conceição Tavares. Comparação de protocolos de fluidoterapia pré-operatória associado a anestesia inalatória ou intravenosa total para procedimentos anestésicos em cães com sepse. 2020. 61 f. Dissertação (Mestrado em Medicina Veterinária – Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2020.pt_BR
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/20414-
dc.description.abstractA sepse é uma síndrome de disfunções orgânicas frente a uma resposta desregulada do organismo a uma infecção Certamente a disfunção cardiovascular se destaca em incidência e influência na morbidade do paciente desta forma, esse estudo clínico teve a proposição de avaliar diferentes protocolos de fluidoterapia associados à anestesia inalatória ou total intravenosa, na estabilidade hemodinâmica de cadelas com sepse, submetida a procedimento cirúrgico, para controle do foco infeccioso. Foram incluídas 32 cadelas, com diagnóstico de piometra e sepse (foco infeccioso mais uma disfunção orgânica), atendidas no HVPA – UFRRJ no período de 2018 a 2019. Após admissão, diagnóstico, avaliação clínica e laboratoriais, os pacientes foram distribuídos de maneira aleatória nos grupos Propofol 5 (P[5] - fluidoterapia restritiva pré-operatória na taxa de 5mL/kg/h e anestesia geral intravenosa), Propofol 10 (P[10]- fluidoterapia liberal pré-operatória na taxa de 10mL/kg/h e anestesia geral intravenosa) e Isofluorano 5 (I[5] – fluidoterapia restritiva pré-operatória na taxa de 5mL/kg/h e anestesia geral inalatória). Foram analisados os seguintes parâmetros: Lactato na admissão (LAC 1), pré cirúrgico (LAC 2) e na liberação (LAC 3) freqüência cardíaca (FC), freqüência respiratória (f), pressão arterial sistólica (PAS),temperatura retal (TEMP), saturação de oxigenio (SpO2) e taxa de extração de dióxido de carbono (ETCO2) nos seguintes momentos PRE, T10, T20, T30, T40, T50, TEXT e TLIB.A depuração de lactato ( LAC 3-LAC 1) ] foi positivo somente no grupo P[5], com o grupo P[10] tendo os melhores valores. Não houve diferença estatística no requerimento de vasopressores entre os grupos. A fluidoterapia liberal apresentou maior estabilidade cardiovascular quando comparado com a fluidoterapia restritiva no período perioperatório. Com relação a anestesia geral, o isoflurano apresentou maior estabilidade cardiorespiratória que o propofol na manutenção anestésica. Os resultados demonstraram que, apesar de todos os três protocolos propostos serem seguros e sem diferença em superioridade entre eles, algumas alterações observadas podem ser relevantes e ponderadas quando for possível a individualização da terapêutica no paciente.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectcadelaspt_BR
dc.subjectpiometrapt_BR
dc.subjectestabilidade cardiovascularpt_BR
dc.subjectdisfunção orgânicapt_BR
dc.subjecthipotensão arterialpt_BR
dc.subjectbitchespt_BR
dc.subjectpyometrapt_BR
dc.subjectcardiovascular stabilitypt_BR
dc.subjectorgan dysfunctionpt_BR
dc.subjectarterial hypotensionpt_BR
dc.titleComparação de protocolos de fluidoterapia pré- operatória associado a anestesia inalatória ou intravenosa total para procedimentos anestésicos em cães com sepsept_BR
dc.typeDissertaçãopt_BR
dc.description.abstractOtherSepsis is a syndrome of organic dysfunctions due to an unregulated response of the organism to an infection Certainly cardiovascular dysfunction stands out in incidence and influence on the patient's morbidity. Thus, this clinical study had the purpose of evaluating different fluid therapy protocols associated with anesthesia. inhalation or total intravenous, in the hemodynamic stability of bitches with sepsis, submitted to surgical procedure, to control the infectious focus. 32 bitches were included, diagnosed with pyometra and sepsis (infectious focus plus an organic dysfunction), attended at HVPA - UFRRJ in the period from 2018 to 2019. After admission, diagnosis, clinical and laboratory evaluation, patients were randomly assigned to groups Propofol 5 (P [5] - preoperative restrictive fluid therapy at a rate of 5mL / kg / h and intravenous general anesthesia), Propofol 10 (P [10] - preoperative liberal fluid therapy at a rate of 10mL / kg / h and general anesthesia intravenous) and Isofluorane 5 (I [5] - preoperative restrictive fluid therapy at a rate of 5mL / kg / h and general inhalation anesthesia). The following parameters were analyzed: Lactate at admission (LAC 1), pre- surgical (LAC 2) and at release (LAC 3) heart rate (HR), respiratory rate (f), systolic blood pressure (SBP), rectal temperature (TEMP ), oxygen saturation (SpO2) and carbon dioxide extraction rate (ETCO2) at the following moments PRE, T10, T20, T30, T40, T50, TEXT and TLIB. Lactate clearance (LAC 3-LAC 1)] it was positive only in group P [5], with group P [10] having the best values. There was no statistical difference in the requirement for vasopressors between the groups. Liberal fluid therapy showed greater cardiovascular stability when compared to restrictive fluid therapy in the perioperative period. Regarding general anesthesia, isoflurane showed greater cardiorespiratory stability than propofol in anesthetic maintenance. The results showed that, although all three protocols proposed are safe and with no difference in superiority between them, some observed changes can be relevant and considered when it is possible to individualize therapy in the patient.en
dc.contributor.advisor1Coelho, Cássia Maria Molinaro-
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-1205-8413pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1209397269710785pt_BR
dc.contributor.referee1Coelho, Cássia Maria Molinaro-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-1205-8413pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/1209397269710785pt_BR
dc.contributor.referee2Bendas, Alexandre José Rodrigues-
dc.contributor.referee2IDhttps://orcid.org/0000-0003-4320-9923pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/5357706483520041pt_BR
dc.contributor.referee3Miranda, Marcos Lopes de-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/1171233208858454pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/2261027132509433pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Veterináriapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)pt_BR
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WOLFF, C. B.; GREEN, D. W. Clarification of the circulatory patho-physiology of anaesthesia–implications for high-risk surgical patients. International journal of surgery, v. 12, n. 12, p. 1348-1356, 2014. YAMAZAKI, M.; Stekiel, T. A.; Bosnjak, Z. J.; Kampine, J. P.; Stekiel, W. J. Effects of volatile anesthetic agents on in situ vascular smooth muscle transmembrane potential in resistance- and capacitance-regulating blood vessels. Anesthesiology, vol. 88, n. 4, pp. 1085–95, 1999. YU, T. et al. Propofol increases preload dependency in septic shock patients. Journal Of Surgical Research, v. 193, n. 2, p. 849-855, 2015.pt_BR
dc.subject.cnpqMedicina Veterináriapt_BR
dc.subject.cnpqMedicina Veterináriapt_BR
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