Por favor, use este identificador para citar o enlazar este ítem:
https://rima.ufrrj.br/jspui/handle/20.500.14407/22026Registro completo de metadatos
| Campo DC | Valor | Lengua/Idioma |
|---|---|---|
| dc.contributor.author | Gonzaga, Gabriel Marchiori | - |
| dc.date.accessioned | 2025-05-30T13:45:30Z | - |
| dc.date.available | 2025-05-30T13:45:30Z | - |
| dc.date.issued | 2025-02-03 | - |
| dc.identifier.citation | GONZAGA, Gabriel Marchiori. Avaliação cardíaca multimodal em cães com parvovirose. 2025. 54 f. Dissertação (Mestrado em Medicina Veterinária - Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2025. | pt_BR |
| dc.identifier.uri | https://rima.ufrrj.br/jspui/handle/20.500.14407/22026 | - |
| dc.description.abstract | O estudo teve como objetivo avaliar alterações cardiovasculares em cães naturalmente infectados pelo parvovírus canino (CPV-2), utilizando exames clínicos, ecocardiográficos, eletrocardiográficos e biomarcadores cardíacos. Foram incluídos 29 cães, sendo 14 saudáveis e 15 doentes, diagnosticados por testes de imunocromatografia. Os cães passaram por avaliações clínicas detalhadas, incluindo aferição de pressão arterial, tempo de preenchimento capilar (TPC) e ausculta cardíaca. Exames eletrocardiográficos e ecocardiográficos foram realizados conforme protocolos padronizados, enquanto os biomarcadores cardíacos, troponina I e NT- proBNP, foram mensurados para análise comparativa. Os resultados demonstraram que os cães infectados apresentaram aumento significativo no TPC (p=0,006), alterações nos linfonodos (p=0,005) e na ausculta cardíaca (p=0,029). O ecocardiograma revelou comprometimento contrátil com redução da fração de encurtamento (p=0,016), redução no gradiente de pressão aórtico (p<0,001) e redução na velocidade do fluxo aórtico (p<0,001). O eletrocardiograma indicou prolongamento do intervalo QTc (p=0,033) e aumento na duração do QRS (p=0,004). A troponina I estava elevada no grupo doente (p=0,014), enquanto os níveis de NT-proBNP permaneceram dentro dos limites normais. Concluiu-se que a parvovirose canina pode causar alterações cardiovasculares significativas, como comprometimento contrátil, risco de arritmias e lesão miocárdica aguda, mesmo na ausência de insuficiência cardíaca avançada. Esses achados ressaltam a importância de integrar avaliações cardíacas no manejo clínico de cães com parvovirose, possibilitando a detecção precoce de complicações subclínicas e contribuindo para intervenções terapêuticas mais eficazes. | pt_BR |
| dc.description.sponsorship | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES | pt_BR |
| dc.language | por | pt_BR |
| dc.publisher | Universidade Federal Rural do Rio de Janeiro | pt_BR |
| dc.subject | Parvovírus | pt_BR |
| dc.subject | biomarcadores | pt_BR |
| dc.subject | ecodopplercardiograma | pt_BR |
| dc.subject | eletrocardiograma | pt_BR |
| dc.subject | Parvovírus | pt_BR |
| dc.subject | biomarkerks | pt_BR |
| dc.subject | echodopplercardiogram | pt_BR |
| dc.subject | electrocardiogram | pt_BR |
| dc.title | Avaliação cardíaca multimodal em cães com parvovirose | pt_BR |
| dc.title.alternative | Multimodal cardiac assessment in dogs with parvovirosis | en |
| dc.type | Dissertação | pt_BR |
| dc.description.abstractOther | The study aimed to evaluate cardiovascular alterations in dogs naturally infected with canine parvovirus (CPV-2) using clinical, echocardiographic, electrocardiographic, and cardiac biomarker assessments. A total of 29 dogs were included, with 14 healthy and 15 infected, diagnosed through immunochromatographic tests. The dogs underwent detailed clinical evaluations, including blood pressure measurement, capillary refill time (CRT), and cardiac auscultation. Electrocardiographic and echocardiographic exams were performed following standardized protocols, and cardiac biomarkers, troponin I and NT-proBNP, were measured for comparative analysis. The results showed that infected dogs had a significant increase in CRT (p=0.006), lymph node alterations (p=0.005), and cardiac auscultation abnormalities (p=0.029). Echocardiography revealed impaired contractility with reduced fractional shortening (p=0.016), decreased aortic pressure gradient (p<0.001), and decreased aortic flow velocity (p<0.001). Electrocardiography indicated QTc interval prolongation (p=0.033) and increased QRS duration (p=0.004). Troponin I levels were elevated in the infected group (p=0.014), while NT-proBNP levels remained within normal limits. The study concluded that canine parvovirus infection can cause significant cardiovascular alterations, including impaired contractility, increased risk of arrhythmias, and acute myocardial injury, even in the absence of advanced heart failure. These findings highlight the importance of integrating cardiac assessments into the clinical management of dogs with parvovirus, enabling early detection of subclinical complications and contributing to more effective therapeutic interventions. | en |
| dc.contributor.advisor1 | Silva, Bruno Ricardo Soares Alberigi da | - |
| dc.contributor.advisor1ID | https://orcid.org/0000-0002-5707-2203 | pt_BR |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/5366748874483915 | pt_BR |
| dc.contributor.advisor-co1 | Baldani, Cristiane Divan | - |
| dc.contributor.advisor-co1ID | https://orcid.org/0000-0002-4627-1362 | pt_BR |
| dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/6210245465538447 | pt_BR |
| dc.contributor.referee1 | Silva, Bruno Ricardo Soares Alberigi da | - |
| dc.contributor.referee1ID | https://orcid.org/0000-0002-5707-2203 | pt_BR |
| dc.contributor.referee1Lattes | http://lattes.cnpq.br/5366748874483915 | pt_BR |
| dc.contributor.referee2 | Bendas, Alexandre José Rodrigues | - |
| dc.contributor.referee2ID | https://orcid.org/0000-0003-4320-9923 | pt_BR |
| dc.contributor.referee2Lattes | http://lattes.cnpq.br/5357706483520041 | pt_BR |
| dc.contributor.referee3 | Lanna, Leonardo Lara e | - |
| dc.contributor.referee3Lattes | http://lattes.cnpq.br/6565670863098571 | pt_BR |
| dc.creator.ID | https://orcid.org/0000-0003-0723-3600 | pt_BR |
| dc.creator.Lattes | http://lattes.cnpq.br/0474625693387439 | pt_BR |
| dc.publisher.country | Brasil | pt_BR |
| dc.publisher.department | Instituto de Veterinária | pt_BR |
| dc.publisher.initials | UFRRJ | pt_BR |
| dc.publisher.program | Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas) | pt_BR |
| dc.relation.references | 1. Chetboul, V. and Bussadori, C. (2017) 'Doppler echocardiography in veterinary cardiology: Principles and clinical applications', Veterinary Journal, 223, pp. 1–11. Available at: https://doi.org/10.1016/j.tvjl.2016.10.007. 2. Connolly, D.J., Soares Magalhães, R.J., Fuentes, V.L. and Boswood, A. (2016) 'Prospective observational study of NT-proBNP measurement in the management of canine degenerative mitral valve disease', Journal of Veterinary Internal Medicine, 30(4), pp. 1118–1128. Available at: https://doi.org/10.1111/jvim.13972. 3. Decaro, N. and Buonavoglia, C. (2012) 'Canine parvovirus: Molecular and pathogenetic insights', Veterinary Microbiology, 155(1–2), pp. 1–12. Available at: https://doi.org/10.1016/j.vetmic.2011.09.018. 4. Decaro, N., Desario, C., Addie, D.D., Martella, V., Vieira, M.J., Elia, G., Zicola, A., Davis, C., Thompson, G. and Buonavoglia, C. (2012) 'Molecular epidemiology of canine parvovirus, Europe', Emerging Infectious Diseases, 18(3), pp. 423–431. Available at: https://doi.org/10.3201/eid1803.111571. 5. Decaro, N. et al. (2020) 'Canine parvovirus evolution and vaccination implications', Veterinary Microbiology, 247, p. 108760. Available at: https://doi.org/10.1016/j.vetmic.2020.108760. 6. Diniz, A.N., Ferreira, F. and Silva, R. (2018) 'Troponina I como biomarcador de lesão cardíaca em cães com sepse', Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 70(6), pp. 1621–1628. Available at: https://doi.org/10.1590/1678-4162- 10012. 7. Ford, R., Bramble, M. and Short, M. (2017) 'Diagnostic significance of QT interval changes in dogs with systemic disease', Journal of Veterinary Cardiology, 19(4), pp. 250–257. Available at: https://doi.org/10.1016/j.jvc.2017.04.005. 8. Goddard, A., Leise, B. and Rosenthal, K. (2008) 'Evaluation of anemia in dogs with canine parvoviral enteritis', Journal of Veterinary Emergency and Critical Care, 18(4), pp. 425–432. Available at: https://doi.org/10.1111/j.1476-4431.2008.00330.x. 9. Godoy, K.C., Assis, A.R., da Silva Godoy, K.C., Antunes, T.R., Braz, P.H., de Oliveira, G.G., da Silva, P.M.P. and de Souza, A.I. (2017) 'Troponina, biomarcador de injúria cardíaca, na medicina veterinária: Revisão', Pubvet, 11(9), pp. 928–934. Available at: https://doi.org/10.22256/PUBVET.V11N9.928-934. 45 10. Goggs, R., Boag, A. K., Chan, D. L. and Allenspach, K. (2009). ‘Incidence, outcome, and risk factors for sepsis in dogs with severe parvoviral enteritis.’ Journal of Veterinary Internal Medicine, 23(5), pp.1046-1053. https://doi.org/10.1111/j.1939- 1676.2009.0383.x 11. Hall, E.J., Carter, A.J. and Chambers, J.N. (2016) 'Inflammatory markers in canine critical care', Veterinary Clinics of North America: Small Animal Practice, 46(4), pp. 721–734. Available at: https://doi.org/10.1016/j.cvsm.2016.03.009. 12. Haukoos, J. S., & Lewis, R. J. (2005). ‘Advanced statistics: Bootstrapping confidence intervals for statistics with “difficult” distributions’. Academic Emergency Medicine, 12(4), 360-365. doi:10.1197/j.aem.2004.11.018 13. Judge, P.J. (2015) 'Electrocardiographic findings in canine myocarditis', Veterinary Clinics of North America: Small Animal Practice, 45(4), pp. 697–711. Available at: https://doi.org/10.1016/j.cvsm.2015.03.004. 14. MacLachlan, N.J. and Dubovi, E.J. (2016) Fenner's Veterinary Virology. 5th ed. San Diego: Academic Press. 15. Meurs, K.M., Stern, J.A. and Adin, D. (2019) 'Fibrosis in canine dilated cardiomyopathy: A histological and genetic evaluation', Veterinary Pathology, 56(4), pp. 589–597. Available at: https://doi.org/10.1177/0300985819830971. 16. Miranda, C. and Thompson, G. (2016) 'Insights into canine parvovirus: A clinical update', Veterinary Medicine and Science, 2(3), pp. 134–140. Available at: https://doi.org/10.1002/vms3.35. 17. Moïse, N.S., Teply, L.J. and Diamond, L. (2017) 'Ventricular arrhythmias and their relation to myocardial damage in canine diseases', Journal of Veterinary Internal Medicine, 31(6), pp. 1720–1728. Available at: https://doi.org/10.1111/jvim.14821. 18. Oliveira, M.S., Larsson, M.H.M.A., and Yamaki, F.L. (2018) 'Echocardiographic findings in dogs with myocarditis: A review of clinical and diagnostic aspects', Journal of Veterinary Cardiology, 20(5), pp. 305–312. Available at: https://doi.org/10.1016/j.jvc.2018.01.012. 19. Oliveira, M.S., Moura, A.C. and Pinto, T. (2019) 'Electrocardiographic changes and their association with myocardial damage in dogs with parvoviral enteritis', Veterinary Research Communications, 43(3), pp. 237–245. Available at: https://doi.org/10.1007/s11259-019-09753-5. 20. Otto, C.M., Dingman, K. and Dow, S.W. (2017) 'Inflammatory response and cardiovascular changes in dogs with parvoviral enteritis', Journal of Veterinary Internal Medicine, 31(4), pp. 1035–1042. Available at: https://doi.org/10.1111/jvim.14754. 21. Oyama, M.A., Singletary, G.E., Tise, M.G. and Solter, P.F. (2017) 'Cardiac troponin I concentrations in dogs with cardiac disease', Journal of Veterinary Internal Medicine, 31(4), pp. 1147–1153. Available at: https://doi.org/10.1111/jvim.14650. 22. Pallás-Alonso, C.R., Martin, D.L., Crespo, M.L. and Muñoz, C. (2020) 'Cardiac involvement in canine parvovirus infections: An update on clinical and pathological findings', Journal of Veterinary Internal Medicine, 34(4), pp. 1200–1208. Available at: https://doi.org/10.1111/jvim.15764. 23. Pereira, G.G., Larsson, M.H.M.A. and Fighera, R.A. (2018) 'Avaliação dos níveis plasmáticos de NT-proBNP em cães de raça Poodle com doença valvar crônica mitral', Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 70(2), pp. 450–458. Available at: https://doi.org/10.1590/1678-4162-10012. 24. Santilli, R.A., Moïse, N.S., Pariaut, R. and Perego, M. (2019) Electrocardiography of the Dog and Cat: Diagnosis of Arrhythmias. 2nd ed. Hoboken, NJ: Wiley-Blackwell. 46 25. Santilli, R.A., Di Marcotullio, L. and Canelli, E. (2010) 'Ventricular arrhythmias in dogs: Clinical and electrocardiographic findings', Journal of Veterinary Cardiology, 12(4), pp. 217–230. Available at: https://doi.org/10.1016/j.jvc.2010.09.001. 26. Schober, K.E., Maerz, I. and Ricco, C. (2010) 'Echocardiographic and clinical features of myocarditis in dogs with confirmed or suspected inflammatory myocardial disease', Journal of Veterinary Internal Medicine, 24(5), pp. 1058–1064. Available at: https://doi.org/10.1111/j.1939-1676.2010.0552.x. 27. Schober, K.E. (2013) 'Echocardiographic assessment of myocardial function in small animals', Veterinary Clinics of North America: Small Animal Practice, 43(4), pp. 899–915. Available at: https://doi.org/10.1016/j.cvsm.2013.03.001. 28. Silverstein, D.C. and Hopper, K. (2015) Small Animal Critical Care Medicine. 2nd ed. St. Louis: Elsevier. 29. Tidholm, A., Häggström, J., Borgarelli, M. and Tarducci, A. (2005) 'Causes of fibrosis in canine myocardium: A histopathological study', Journal of Veterinary Cardiology, 7(2), pp. 75–84. Available at: https://doi.org/10.1016/j.jvc.2005.01.003. 30. Tidholm, A., Häggström, J., Borgarelli, M. and Tarducci, A. (2015) 'Causes of myocardial fibrosis and its implications in dogs: A review', Journal of Veterinary Cardiology, 17(2), pp. 129–141. Available at: https://doi.org/10.1016/j.jvc.2015.05.003. | pt_BR |
| dc.subject.cnpq | Medicina Veterinária | pt_BR |
| Aparece en las colecciones: | Mestrado em Medicina Veterinária (Patologia e Ciências Clínicas) | |
Se for cadastrado no RIMA, poderá receber informações por email.
Se ainda não tem uma conta, cadastre-se aqui!
Ficheros en este ítem:
| Fichero | Descripción | Tamaño | Formato | |
|---|---|---|---|---|
| GABRIEL MARCHIORI GONZAGA.pdf | 1.77 MB | Adobe PDF |  Visualizar/Abrir |
Los ítems de DSpace están protegidos por copyright, con todos los derechos reservados, a menos que se indique lo contrario.