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  2. Teses e Dissertações
  3. Programa de Pós-Graduação em Engenharia Química
  4. Mestrado em Engenharia Química
Please use this identifier to cite or link to this item: https://rima.ufrrj.br/jspui/handle/20.500.14407/24323
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dc.contributor.authorQuina, Demetrio de Almeida-
dc.date.accessioned2025-12-10T16:11:44Z-
dc.date.available2025-12-10T16:11:44Z-
dc.date.issued2025-09-24-
dc.identifier.citationQUINA, Demetrio de Almeida. Encapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos. 2025. 82 f. Dissertação (Mestrado em Engenharia Química) - Instituto de Tecnologia, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2025.pt_BR
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/24323-
dc.description.abstractA esporotricose felina é uma micose subcutânea de relevância zoonótica crescente no Brasil, especialmente no estado do Rio de Janeiro. O tratamento com itraconazol, embora eficaz, apresenta baixa adesão por parte dos gatos, devido à rejeição ao sabor amargo e à dificuldade de administração forçada. Esta dissertação propõe a encapsulação do fármaco itraconazol em esferas de alginato de sódio saborizadas com extrato de carne, visando maior palatabilidade, adesão voluntária e eficácia terapêutica. As esferas foram produzidas por gelificação iônica e caracterizadas por FTIR (Fourier transform infrared spectroscopy), Raman, MEV (Microscopia Eletrônica de Varredura), HPLC (High Performance Liquid Chromatography) e ensaios de inibição fúngica. Os resultados confirmaram o encapsulamento, a interação entre fármaco e matriz, e a atividade antifúngica das formulações, especialmente na presença de proteínas do extrato de carne, sugerindo possível sinergia com o fármaco. A proposta apresenta viabilidade tecnológica e potencial aplicação no controle da esporotricose, oferecendo uma alternativa eficaz, acessível e adaptada ao comportamento alimentar felino.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectEsporotricose felinapt_BR
dc.subjectitraconazolpt_BR
dc.subjectAlginato de Sódiopt_BR
dc.subjectPalatabilidadept_BR
dc.subjectFeline sporotrichosispt_BR
dc.subjectItraconazolept_BR
dc.subjectSodium alginatept_BR
dc.subjectPalatabilitypt_BR
dc.titleEncapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.pt_BR
dc.title.alternativeEncapsulamento do fármaco itraconazol com alginato de sódio e sabor carne para tratamento da esporotricose em gatos.en
dc.typeDissertaçãopt_BR
dc.description.abstractOtherFeline sporotrichosis is a subcutaneous mycosis of increasing zoonotic relevance in Brazil, especially in the state of Rio de Janeiro. Although itraconazole is an effective treatment, it often shows low adherence by cats due to the drug's bitter taste and the difficulties of forced administration. This dissertation proposes the encapsulation of itraconazole in sodium alginate spheres flavored with meat extract, aiming to improve palatability, voluntary intake, and therapeutic efficacy. The spheres were produced by ionic gelation and characterized by FTIR, Raman spectroscopy, SEM, HPLC, and fungal growth inhibition assays. The results confirmed the encapsulation, interaction between the drug and the polymer matrix, and antifungal activity of the formulations, particularly in the presence of proteins from the meat extract, suggesting a possible synergistic effect. This approach demonstrates technological feasibility and potential application programs for controlling feline sporotrichosis, offering an effective, accessible, and behaviorally adapted alternative for veterinary treatment.en
dc.contributor.advisor1Oliveira, Renata Nunes-
dc.contributor.advisor1IDhttps://orcid.org/0000-0001-9782-269Xpt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/9026953896544145pt_BR
dc.contributor.referee1Oliveira, Renata Nunes-
dc.contributor.referee1IDhttps://orcid.org/0000-0001-9782-269Xpt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/9026953896544145pt_BR
dc.contributor.referee2Bonci, Mário Mendes-
dc.contributor.referee2IDhttps://orcid.org/0000-0002-3837-7378pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/6383796387620437pt_BR
dc.contributor.referee3Bigansolli, Antonio Renato-
dc.contributor.referee3IDhttps://orcid.org/0000-0002-0142-5989pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/5868109671445446pt_BR
dc.contributor.referee4Middea, Antonieta-
dc.contributor.referee4Latteshttp://lattes.cnpq.br/0641524479927336pt_BR
dc.creator.IDhttps://orcid.org/0009-0001-4963-5555pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/2381118930933698pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Tecnologiapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Engenharia Químicapt_BR
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