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dc.contributor.authorSantos, Luan Valim dos-
dc.date.accessioned2026-02-06T17:31:38Z-
dc.date.available2026-02-06T17:31:38Z-
dc.date.issued2025-12-27-
dc.identifier.citationDOS SANTOS, Luan Valim. Efeitos do hidrato de morina sobre o desenvolvimento e metabolismo de Aedes aegypti. 2025. 206 f. Tese (Doutorado em Química) - Instituto de Química, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2025.pt_BR
dc.identifier.urihttp://rima110.im.ufrrj.br:8080/jspui/handle/20.500.14407/24504-
dc.description.abstractAedes aegypti é o principal vetor de arboviroses de grande impacto em saúde pública, como dengue, zika, chikungunya e febre Mayaro, sendo capaz de adaptar-se a diferentes ambientes e desenvolver resistência a inseticidas sintéticos. Nesse cenário, compostos naturais como os flavonoides como alternativas no manejo integrado de vetores. O hidrato de morina, flavonol de origem vegetal, tem sido estudado por suas propriedades farmacológicas, mas pouco se conhece sobre sua ação em insetos vetores. O objetivo deste trabalho foi avaliar de forma integrada os efeitos do hidrato de morina sobre o metabolismo energético e parâmetros biológicos de A. aegypti, com enfoque na sobrevivência, no desenvolvimento, na fertilidade e na suscetibilidade vetorial. Para isso, foram conduzidos ensaios laboratoriais com larvas expostas ao composto em diferentes concentrações e condições nutricionais, sendo avaliados crescimento, sobrevivência, reservas energéticas, perfil bioquímico e metabolômico, além de ensaios de infecção com vírus Mayaro e análises complementares de toxicidade em mamíferos. Os resultados mostraram que o hidrato de morina provoca mortalidade larval dependente da dose, retarda o desenvolvimento e reduz a fertilidade de fêmeas emergidas, mesmo quando a exposição ocorre apenas em estágios juvenis. Observou-se depleção significativa de lipídios, carboidratos e proteínas, associada a alterações em vias metabólicas e indução de estresse oxidativo, configurando um estado fisiológico semelhante ao jejum. Essa perturbação energética repercutiu na fase adulta, comprometendo a reprodução e reduzindo a suscetibilidade vetorial para o vírus Mayaro. Além disso, os testes em camundongos demonstraram ausência de efeitos tóxicos relevantes, reforçando o potencial seletivo e ambientalmente seguro do composto. Em conjunto, os achados revelam que o hidrato de morina atua como um modulador metabólico multifuncional, capaz de comprometer simultaneamente sobrevivência, metabolismo, desenvolvimento e reprodução de A. aegypti, configurando uma alternativa promissora para o desenvolvimento de novas estratégias de controle sustentáveis e seletivos.pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectflavonoidept_BR
dc.subjectcontrole biológicopt_BR
dc.subjectdesenvolvimentopt_BR
dc.subjectmetabolismo energéticopt_BR
dc.subjectsuscetibilidade vetorialpt_BR
dc.subjectflavonoidpt_BR
dc.subjectbiological controlpt_BR
dc.subjectlarval developmentpt_BR
dc.subjectenergy metabolismpt_BR
dc.subjectvector susceptibilitypt_BR
dc.titleEfeitos do hidrato de morina sobre o desenvolvimento e metabolismo de aedes aegypti.pt_BR
dc.title.alternativeEffects of morin hydrate on the development and metabolism of aedes aegypti.en
dc.typeTesept_BR
dc.description.abstractOtherAedes aegypti is the primary vector of arboviruses with major public health impact, such as dengue, Zika, chikungunya, and Mayaro fever, being capable of adapting to diverse environments and developing resistance to synthetic insecticides. In this context, natural compounds such as flavonoids as alternatives for integrated vector management. Morin hydrate, a plant-derived flavonol, has been investigated for its pharmacological properties, but its effects on insect vectors remain poorly understood. The aim of this study was to comprehensively evaluate the effects of morin hydrate on the energy metabolism and biological parameters of A. aegypti, with emphasis on survival, development, fertility, and vector competence. Laboratory assays were conducted using larvae exposed to the compound at different concentrations and under variable nutritional conditions. Growth, survival, energy reserves, biochemical and metabolomic profiles were assessed, in addition to infection assays with Mayaro virus and complementary toxicity analyses in non-target organisms. The results showed that morin hydrate induces dose-dependent larval mortality, delays development, and reduces female fertility, even when exposure occurs only at juvenile stages. Significant depletion of lipids, carbohydrates, and proteins was observed, associated with alterations in metabolic pathways and the induction of oxidative stress, establishing a physiological state similar to starvation. This energy imbalance persisted into adulthood, impairing reproduction and decreasing vector competence for Mayaro virus. Moreover, toxicity tests in mice revealed no relevant adverse effects, supporting the selective and environmentally safe potential of the compound. Collectively, the findings demonstrate that morin hydrate acts as a multifunctional metabolic modulator, simultaneously impairing survival, metabolism, development, and reproduction of A. aegypti, representing a promising alternative for the development of sustainable and selective vector control strategies.en
dc.contributor.advisor1Pontes, Emerson Guedes-
dc.contributor.advisor1IDhttps://orcid.org/0000-0002-2679-238Xpt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1562085358907265pt_BR
dc.contributor.referee1Pontes, Emerson Guedes-
dc.contributor.referee1IDhttps://orcid.org/0000-0002-2679-238Xpt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/1562085358907265pt_BR
dc.contributor.referee2Lima, Marco Edilson Freire de-
dc.contributor.referee2IDhttps://orcid.org/0000-0003-0563-3483pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/8392420706762318pt_BR
dc.contributor.referee3Chaves, Douglas Siqueira de Almeida-
dc.contributor.referee3IDhttps://orcid.org/0000-0002-0571-9538pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/1864237318361425pt_BR
dc.contributor.referee4Gondim, Katia Calp-
dc.contributor.referee4Latteshttp://lattes.cnpq.br/4058529639765821pt_BR
dc.contributor.referee5Martins Júnior, Ademir de Jesus-
dc.contributor.referee5Latteshttp://lattes.cnpq.br/0370224663642100pt_BR
dc.creator.IDhttps://orcid.org/0000-0002-2333-210Xpt_BR
dc.creator.Latteshttp://lattes.cnpq.br/1407400988697500pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Químicapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Químicapt_BR
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