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dc.contributor.authorMiranda, Fernando Rocha-
dc.date.accessioned2026-08-26T16:00:51Z-
dc.date.available2026-08-26T16:00:51Z-
dc.date.issued2026-02-09-
dc.identifier.citationMIRANDA, Fernando Rocha. Avaliação da eficácia clínica de uma formulação em spray contendo carvacrol e eugenol contra Rhipicephalus linnaei e Ctenocephalides felis felis em cães artificialmente infestados 2026. 69 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2026.pt_BR
dc.identifier.urihttp://rima.ufrrj.br/jspui/handle/20.500.14407/26189-
dc.description.abstractA estreita convivência entre humanos e animais de companhia aumenta a demanda por terapias seguras contra ectoparasitos de importância médico-veterinária, como Ctenocephalides felis felis e Rhipicephalus linnaei. O controle convencional, baseado em moléculas sintéticas, frequentemente associa-se a efeitos tóxicos e impacto ambiental deletério, incentivando a busca por alternativas naturais. Neste contexto, o presente estudo avaliou a eficácia in vivo de uma formulação em spray contendo eugenol e carvacrol, biocompostos com atividade sinérgica comprovada in vitro, para o controle desses ectoparasitos em cães da raça Beagle. Foram utilizados 16 cães Beagle do plantel do LQEPV. Todos os animais selecionados apresentavam infestações basais homogêneas e adequadas (>25% de recuperação), sem diferenças estatísticas entre si. Após esta verificação, os cães foram ranqueados e distribuídos nos grupos tratado (GT) e controle (GC). O grupo tratado recebeu a formulação no dia 0, com a eficácia avaliada aos +2, +7 e +14 dias, enquanto o controle permaneceu sem tratamento. A carga parasitária foi avaliada pela contagem dos ectoparasitos retidos após a infestação artificial de cada animal com 25 casais de R. linnaei e 50 casais de C. felis felis. Os valores de média geométrica no grupo controle (GC) mantiveram-se estáveis ao longo do período experimental, registrando 35,8 (D+2), 33,8 (D+7) e 35,0 (D+14) para R. linnaei, e 52,8 (D+2), 65,8 (D+7) e 80,8 (D+14) para C. felis felis. Em contraste, o grupo tratado (GT) apresentou uma redução significativa, com médias de 1,39 (D+2), 15,76 (D+7) e 32,64 (D+14) para R. linnaei, e 0,54 (D+2), 24,97 (D+7) e 50,09 (D+14) para C. felis felis. Com base nesses resultados, a eficácia acaricida da formulação foi calculada em 96,11% (D+2), 53,32% (D+7) e 6,77% (D+14) para R. linnaei, enquanto a eficácia pulgicida atingiu 98,97% (D+2), 62,05% (D+7) e 38,02% (D+14) para C. felis felis. O perfil de segurança mostrou-se satisfatório, uma vez que não foram observados sinais de toxicidade ou alterações hematológicas e bioquímicas significativas. Conclui-se que a associação em estudo configura uma alternativa natural, eficaz e segura para o controle estratégico desses ectoparasitospt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectBiocontrolept_BR
dc.subjectTerpenóidespt_BR
dc.subjectFenilpropanóidespt_BR
dc.subjectCarrapatospt_BR
dc.subjectPulgaspt_BR
dc.subjectBiocontrolpt_BR
dc.subjectTerpenoidspt_BR
dc.subjectPhenylpropanoidspt_BR
dc.subjectTickspt_BR
dc.subjectFleaspt_BR
dc.titleEnsaio clínico de formulação em spray contendo carvacrol e eugenol contra Rhipicephalus linnaei e Ctenocephalides felis felis em cães artificialmente infestadospt_BR
dc.title.alternativeAvaliação da eficácia clínica de uma formulação em spray contendo carvacrol e eugenol contra Rhipicephalus linnaei e Ctenocephalides felis felis em cães artificialmente infestadosen
dc.typeTesept_BR
dc.description.abstractOtherThe close coexistence between humans and companion animals increases the demand for safe therapies against ectoparasites of medical and veterinary importance, such as Ctenocephalides felis felis and Rhipicephalus linnaei. Conventional control, based on synthetic molecules, is often associated with toxic effects and deleterious environmental impact, encouraging the search for natural alternatives. In this context, the present study evaluated the in vivo efficacy of a spray formulation containing eugenol and carvacrol, biocompounds with proven synergistic activity in vitro, for the control of these ectoparasites in Beagle dogs. Sixteen Beagle dogs from the LQEPV colony were used. All selected animals presented homogeneous and adequate basal infestations (>25% recovery), with no statistical differences between them. After this verification, the dogs were ranked and distributed into treated (TG) and control (CG) groups. The treated group received the formulation on day 0, with efficacy evaluated on days +2, +7, and +14, while the control group remained untreated. Parasite load was assessed by counting retained ectoparasites after artificial infestation of each animal with 25 pairs of R. linnaei and 50 pairs of C. felis felis. Geometric mean values in the control group (CG) remained stable throughout the experimental period, recording 35.8 (D+2), 33.8 (D+7), and 35.0 (D+14) for R. linnaei, and 52.8 (D+2), 65.8 (D+7), and 80.8 (D+14) for C. felis felis. In contrast, the treated group (TG) showed a significant reduction, with means of 1.39 (D+2), 15.76 (D+7), and 32.64 (D+14) for R. linnaei, and 0.54 (D+2), 24.97 (D+7), and 50.09 (D+14) for C. felis felis. Based on these results, the acaricidal efficacy of the formulation was calculated as 96.11% (D+2), 53.32% (D+7), and 6.77% (D+14) for R. linnaei, while the fleacidal efficacy reached 98.97% (D+2), 62.05% (D+7), and 38.02% (D+14) for C. felis felis. The safety profile was satisfactory, as no signs of toxicity or significant hematological and biochemical alterations were observed. It is concluded that the studied association represents a natural, effective, and safe alternative for the strategic control of these ectoparasitesen
dc.contributor.advisor1Cid, Yara Peluso-
dc.contributor.advisor1IDhttps://orcid.org/0000-0003-0775-0704pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/0788912635109182pt_BR
dc.contributor.referee1Cid, Yara Peluso-
dc.contributor.referee1IDhttps://orcid.org/0000-0003-0775-0704pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/0788912635109182pt_BR
dc.contributor.referee2Costa Junior, Livio Martins-
dc.contributor.referee2IDhttps://orcid.org/0000-0002-1475-049Xpt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/6651961821189728pt_BR
dc.contributor.referee3Martins, Isabella Vilhena Freire-
dc.contributor.referee3IDhttps://orcid.org/0000-0002-8700-3065pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/6446528818006897pt_BR
dc.contributor.referee4Campos, Diefrey Ribeiro-
dc.contributor.referee4IDhttps://orcid.org/0000-0002-5434-1463pt_BR
dc.contributor.referee4Latteshttp://lattes.cnpq.br/8547992443497955pt_BR
dc.contributor.referee5Avelar, Barbara Rauta de-
dc.contributor.referee5Latteshttp://lattes.cnpq.br/0590740773474773pt_BR
dc.creator.IDhttps://orcid.org/0000-0003-2309-7231pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/1678690316561276pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Veterináriapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Ciências Veterináriaspt_BR
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