logo RIMA
logo UFRRJ

  1. Repositório de Múltiplos Acervos da UFRRJ
  2. Teses e Dissertações
  3. Programa de Pós-Graduação em Ciências Veterinárias
  4. Doutorado em Ciências Veterinárias
Please use this identifier to cite or link to this item: https://rima.ufrrj.br/jspui/handle/20.500.14407/9707
Full metadata record
DC FieldValueLanguage
dc.contributor.authorSantos, Tiago Marques dos
dc.date.accessioned2023-12-21T18:42:55Z-
dc.date.available2023-12-21T18:42:55Z-
dc.date.issued2011-03-01
dc.identifier.citationSantos, Tiago Marques dos. Agentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiro. 2011. 103 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2011.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/9707-
dc.description.abstractEste trabalho foi realizado nas microrregiões de Itaguaí e Serrana no estado do Rio de Janeiro para estudar os agentes da theileriose e da anaplasmose granulocítica equina. Amostras de soro e sangue foram submetidas à reação de imunofluorescência indireta (RIFI), reação em cadeia da polimerase em tempo real (RT-PCR) e a análise hematológica. A prevalência geral para T. equi foi de 81,09% (n=579), com maior prevalência (p<0,05) para microrregião de Itaguaí (85,43%), quando comparado a Serrana (76,92%). A região, altitude, nível da propriedade e origem dos equinos foram associados (p<0,05) com a soropositividade para T. equi. Equinos criados na microrregião de Itaguaí apresentaram 11% mais chance (RP=1,11; p=0,003) de terem contato com T. equi comparado aqueles criados na microrregião Serrana. Além disso, quando são criados a altitudes abaixo de 500m apresentaram 10% de chance a mais abaixo de 500m (RP=1.10; p=0,014) de se tornarem soropositivos. Equinos criados em propriedades de nível ruim (RP=1,13; p=0,018) e nascidos na propriedade (RP=1,10; p=0,008) apresentaram mais chance de terem contato com T. equi. A frequência de equinos soropositivos para A. phagocytophilum foi de 17% (n=17) das amostras examinadas no município de Seropédica. Apenas a idade apresentou associação (p=0,044) com a soropositividade dos equinos para A. phagocytophilum. Das 350 amostras avaliadas pela RT-PCR, 0,86% (n=3) apresentaram amplificação específica para o gene msp2. As amostras positivas apresentaram valores médios do CT de 35,09±1,48 ciclos e de Tm de 78,56±0,53ºC, semelhante a do controle positivo, de 78,45±0,32ºC. As microrregiões de Itaguaí e Serrana são endêmicas para theileriose equina e de estabilidade enzoótica para T. equi. Apenas os fatores relacionados à área de coleta influenciam a soropositividade dos equinos para T. equi nas microrregiões estudadas. A presença de anticorpos anti-A. phagocytophilum e a evidência molecular da infecção por esse agente em equinos do município de Seropédica, no estado do Rio de Janeiro, sugere a circulação de A. phagocytophilum nessa região.por
dc.description.sponsorshipFundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do RJ - FAPERJpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectEquídeospor
dc.subjectTheileria equipor
dc.subjectAnaplasma phagocytophilumpor
dc.subjectEpidemiologiapor
dc.subjectDiagnóstico sorológico e molecularpor
dc.subjectEquidseng
dc.subjectTheileria equieng
dc.subjectAnaplasma phagocytophilumeng
dc.subjectEpidemiologyeng
dc.subjectSorological and molecular diagnosis.eng
dc.titleAgentes da theileriose e da anaplasmose granulocítica em equídeos de microrregiões do estado do Rio de Janeiropor
dc.title.alternativeAgents of theileriosis and granulocytic anaplasmosis in equids of microregions in the State of Rio de Janeiroeng
dc.typeTesepor
dc.description.abstractOtherThis study was carried out in the microregions of Itaguaí and Serrana, State of Rio de Janeiro in order to study of granulocytic anaplasmosis and theileriosis equine agents. Blood and serum samples were subjected to indirect fluorescent antibody test (IFAT), real time polymerase chain reaction (RT-PCR) and hematological analysis. The overall prevalence for T. equi was 81.09% (n=579), with higher prevalence (p<0.05) for Itaguaí microregion (85.43%), when compared to Serrana (76.92%). The region, altitude, level of farm and origin of horses were associated (p<0.05) with seropositivity for T. equi. Horses reared in the Itaguaí microregion had 11% more likely (PR=1.11, p=0.003) of having contact with T. equi compared to those reared in the Serrana microregion. Moreover, when are raired at altitudes below 500m showed 10% chance less (PR=1.10; p=0,014) of becoming seropositive. Horses reared in poor level farms (PR=1.13, p=0.018) and born on the farm (PR=1.10, p=0.008) showed more chance of having contact with T. equi. The main ticks found attached in horses were Amblyomma cajennense and Dermacentor (Anocentor) nitens. The frequency of seropositive horses for A. phagocytophilum was 17% (n=17) of the samples tested in the Seropédica county. No association (p>0.05) was observed among the studied factors and seropositivity of horses to A. phagocytophilum. Of 350 samples tested by RT-PCR, 0.86% (n=3) showed specific amplification for msp2 gene. The positive samples showed average CT value of 35.09±1.48 cycles and Tm of 78.56±0.53°C, similar to the positive control, 78.45±0.32°C. The Itaguaí and Serrana microregions are endemic for equine theileriosis and of enzootic stability for T. equi. Only factors related to collection area influenced the seropositivity of horses for T. equi in the microregions studied. The presence of anti-A. phagocytophilum antibodies and molecular evidence of infection by this pathogen in horses of Seropédica municipality in the Rio de Janeiro state, suggests the circulation of A. phagocytophilum in this region.eng
dc.contributor.advisor1Massard, Carlos Luiz
dc.contributor.advisor1ID257781297-34por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7743112049924654por
dc.contributor.advisor-co1Almeida, Fernando Queiroz de
dc.contributor.referee1Linhares, Guido Fontgalland Coelho
dc.contributor.referee2Leite, Romário Cerqueira
dc.contributor.referee3Faccini, João Luiz Horácio
dc.contributor.referee4Baldani, Cristiane Divan
dc.creator.ID830436081-00por
dc.creator.Latteshttp://lattes.cnpq.br/3348705741012678por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Ciências Veterináriaspor
dc.relation.referencesAGUERO-ROSENFELD, M. E.; KALANTARPOUR, F.; BALUCH, M.; HOROWITZ, H. W.; MCKENNA, D. F.; RAFFALLI, J. T.; HSIEH, T.-Z.; WU, J.; DUMLER J. S.; WORMSER, G.P. Serology of culture-confirmed cases of human granulocytic ehrlichiosis. Journal of Clinical Microbiology, v.38, n.2, p.635–638, 2000. AGUERO-ROSENFELD, M.F.; HOROWITZ, H.W.; WORMSER, G.P.; MCKENNA, D.F.; NOWAKOWSKI, J.; MUNOZ, J.; DUMLER, J.S. Human granulocytic ehrlichiosis: a case series from a medical center in New York State. Annais of Internal Medicine, v.125, n.11, p.904–908, 1996. ALBERDI, M.P.; WALKER, A.R.; PAXTON, E.A.; SUMPTION, K.J. Natural prevalence of infection with Ehrlichia (Cytoecetes) phagocytophila of Ixodes ricinus ticks in Scotland. Veterinary Parasitology, v.78, n.3, p.203–213, 1998. ALBERDI, M.P.; WALKER, A.R.; URQUHART, K.A. Field evidence that roe deer (Caprioles carpeolus) are natural host for Ehrlichia phagocytophila. Epidemiology and Infection, v.124, n.2, p,315–323, 2000. ALBERTI, A.; ADDIS, M.F.; SPARAGANO, O.; ZOBBA, R.; CHESSA, B.; CUBEDDU, T.; PARPAGLIA, M.L.P.; ARDU, M.; PITTAU, M. Anaplasma phagocytophilum, Sardinia, Italy. Emerging Infectious Diseases, v.11, n.8, p.1322–1323, 2005. ALEKSEEV, A.; DUBININA, H.; SCHOULS, L. First detection of Ehrlichia infected ticks among the primary vectors of the tick-borne encephalitis and borreliosis in the Russian Baltic region. Bulletin of the Scandinavian Society for Parasitology, v.8, p.88–91, 1998. ALEKSEEV, A.N.; DUBININA, H.V.; VAN DE POL, I.; SCHOULS, L.M. Identification of Ehrlichia and Borrelia burgdorferi species in Ixodes ticks in the Baltic regions of Russia. Journal Clinical Microbiology, v.39, n.6, p.2237–2242, 2001. AMUSATEGUI, I.; SAINZ, A.; TESOURO, M.A. Serological evaluation of Anaplasma phagocytophilum infection in livestock in northwestern Spain. Annals of the New York Academy of Science, v.1078, n.1, p.487-490, 2006. ARTURSSON, K.; GUNNARSSON, A.; WIKSTROM, U.B.; ENGVALL, E.O. A serological and clinical follow-up in horses with confirmed equine granulocytic ehrlichiosis. Equine Veterinary Journal, v.31, n.6, p.473–477, 1999. BAKKEN, J.S.; DUMLER, J.S. Human granulocytic ehrlichiosis. Clinical Infectious Diseases, v.31, n.2, p.554–560, 2000. BAKKEN, J.S.; DUMLER, J.S.; CHEN, S.M.; ECKMAN, M.R.; VAN ETTA, L.L.; WALKER, D.H. Human granulocytic ehrlichiosis in the upper Midwest. A new species emerging? Journal of American Medical Association, v.272, n.3, p.212–218, 1994. BAKKEN, J.S.; KREUTH, J.; WILSON-NORSKOG, C.; TILDEN, R.L.; ASANOVITCH, K.; DUMLER, J.S. Clinical and laboratory characteristics of human granulocytic ehrlichiosis. Journal of the American Medical Association, v.275, n.3, p.199–205, 1996. 74 BARLOUGH, J.; MADIGAN, J.; DEROCK, E.; DUMLER, J.S.; BAKKEN, J.S. Protection against Ehrlichia equi is conferred by prior infection with the human granulocytotropic ehrlichia (HGE agent). Journal of Clinical Microbiology, v.33, n.12, p.3333–3334, 1995. BARLOUGH, J.; MADIGAN, J.; KRAMER, V.; CLOVER, J.; HUI, L.; WEBB, J.; VREDEVOE, L. Ehrlichia phagocytophila genogroup rickettsiae in ixodid ticks from California collected in 1995 and 1996. Journal Clinical Microbiology, v.35, n.8, p.2018–2021, 1997. BARLOUGH, J.E.; MADIGAN, J.E.; DEROCK, E.; BIGORNIA, L. Nested polymerase chain reaction for detection of Ehrlichia equi genomic DNA in horses and ticks (Ixodes pacificus). Veterinary Parasitology, v.63, n.3-4, p.319-329, 1996. BARROS-BATTESTI, D.M.; ARZUA, M.; BECHARA, G.H. 2006. Carrapatos de Importância Médico-Veterinária da Região Neotropical: Um guia ilustrado para identificação de espécies. ed. VOX/ICTTD-3/BUTANTAN, 1th ed., pp. 223. São Paulo, SP. BELONGIA, E.A.; REED, K.D.; MITCHELL, P.D.; KOLBERT, C.P.; PERSING, D.H.; GILL, J.S.; KAZMIERCZAK, J.J. Prevalence of granulocytic Ehrlichia among white-tailed deer in Wisconsin. Journal of Clinical Microbiology, v.35, n.6, p.1465– 1468, 1997. BERMANN, F.; DAVOUST, B.; FOURNIER, P.E.; BRISOU-LAPOINTE, A.V.; BROUQUI, P. Ehrlichia equi (Anaplasma phagocytophila) infection in an adult horse in France. Veterinary Record, v.150, n.25, p.787–788, 2002. BJOERSDORFF, A.; BERGSTROM, S.; MASSUNG, R.F.; HAEMIG, P.D.; OLSEN, B. Ehrlichia-infected ticks on migrating birds. Emerging Infectious Diseases, v.7, n.5, p.877–879, 2001. BJÖERSDORFF, A.; BROUQUI, P.; ELIASSON, I.; MASSUNG, R.F.; WITTESJO, B.; BERGLUND, J.. Serological evidence of Ehrlichia infection in Swedish Lyme borreliosis patients. Scandinavian Journal of Infectious Diseases, v.31, n.1, p.51–55. 1999. BOOL, P.H.; REINDERS, J.S. Tick-borne fever in cattle in the Netherlands. Tijdschr Diergeneesk, v.89, n.1, p.1519–1527, 1964. BOWN, K.J.; BENNETT, M.; BEGON, M.; BIRTLES, R.J.; BURTHE, S.; LAMBIN, X.; TELFER, S.; WOLDEHIWET, Z.; OGDEN, N.H. Sympatric Ixodes trianguliceps and Ixodes ricinus ticks feeding on field voles (Microtus agrestis): potential for increased risk of Anaplasma phagocytophilum in the United Kingdom. Vector-Borne Zoonotic Diseases, v.6, n.4, p.404–410, 2006. BOWN, K.J.; BENNETT, M.; BEGON, M.; WOLDEHIWET, Z.; OGDEN, N.H. Seasonal dynamics of Anaplasma (formerly Ehrlichia) phagocytophila in a rodent–tick (Ixodes trianguliceps) system in the UK. Emerging Infectious Diseases, v.9, n.1, p.63–70, 2003. CAO, W.C.; ZHAO, Q.M.; ZHANG, P.H.; DUMLER, J.S.; ZHANG, X.T.; FANG, L.Q.; YANG, H. Granulocytic Ehrlichiae in Ixodes persulcatus ticks from an area in China where Lyme disease is endemic. Journal of Clinical Microbiology, v.38, n.11, p.4208–4210, 2000. CHANG, Y.F.; NOVOSEL, V.; DUBOVI, E.; WONG, S.J.; CHU, F.K.; CHANG, C.F.; DEL PIERO, F.; SHIN, S.; LEIN, D.H. Experimental infection of human granulocytic ehrlichiosis agent in horses. Veterinary Parasitology, v.78, n.2, p.137–145, 1998. 75 CHEN, S.M.; DUMLER, J.S.; BAKKEN, J.S.; WALKER, D.H. Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease. Journal of Clinical Microbiology, v.32, n.3, p.589–595, 1994. CINES, D.B.; POLLAK, E.S.; BUCK, C.A.; LOSCALZO, J.; ZIMMERMAN, G.A.; MCEVER, R.P.; POBER, J.S.; WICK, T.M.; KONKLE, B.A.; SCHWARTZ, B.S.; BARNATHAN, E.S.; MCCRAE, K.R.; HUG, B.A.; SCHMIDT, A.M.; STERN, D.M. Endothelial cells in physiology and the pathophysiology of vascular disorders. Blood, v.91, n.10, p.3527–3561, 1998. COLES, E.H. Patologia Clínica Veterinária. 3ª ed., Manole, São Paulo, 1984, 566p. COLLINS, J.D.; HANNAN, J.; FERGUSON, A.R.; WILSON, J.O. Tick-borne fever in Ireland. Irish Veterinary Journal, v.24, n.1, p.162–164, 1970. CUNHA, A.P.; BELLO, A.C.P.P.; LEITE, R.C.; MELO, M.M.; BRAZ, G.F.; RIBEIRO, A.C.C.L.; OLIVEIRA, P.R. Avaliação de parâmetros clínicos e hematológicos de eqüinos submetidos a um programa de controle estratégico de Amblyomma cajennense (Fabricius, 1787) (Acari: Ixodidae). Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.60, n.1, p.113- 120, 2008. DAGNONE, A.S.; SOUZA, A.I.; ANDRÉ, M.R.; MACHADO, R.Z. Molecular diagnosis of Anaplasmataceae organisms in dogs with clinical and microscopical signs of ehrlichiosis. Revista Brasileira de Parasitologia Veterinária, v.18, n.4, p.20-25, 2009. DANIELS, T.J.; BATTALY, G.R.; LIVERIS, D.; FALCO, R.C.; SCHWART, I. Avian reservoirs of the agent of human granulocytic ehrlichiosis. Emerging Infectious Diseases, v.8, n.12, p.1524–1525, 2002. DE LA FUENTE, J.; MASSUNG, R.F.; WONG, S.J.; CHU, F.K.; LUTZ, H.; MELI, M.; VON LOEWENICH, F.D.; GRZESZCZUK, A.; TORINA, A.; CARACAPPA, S.; MANGOLD, A.J.; NARANJO, V.; STUEN, S.; KOCAN, K.M. Sequence analysis of the msp4 gene in Anaplasma phagocytophilum strains. Journal of Clinical Microbiology, v.43, n.3, p.1309–1317, 2005. DE PAIVA DINIZ, PP.; SCHWARTZ, D.S.; DE MORAIS, H.S.; BREITSCHWERDT, E.B. Surveillance for zoonotic vector-borne infections using sick dogs from southeastern Brazil. Vector Borne Zoonotic Diseases, v.7, n.4, p.689–697, 2007. DENATALE, C.E.; BURKOT, T.R.; SCHNEIDER, B.S.; ZEIDNER, N.S. Novel potential reservoirs for Borrelia sp. and the agent of human granulocytic ehrlichiosis in Colorado. Journal of Wildlife Diseases, v.38, n.2, p.478–482, 2002. DIAS, E.; MARTINS, A.V. Spotted fever in Brazil. American Journal of Tropical Medicine, v.19, n.1, p.103–108, 1939. DRAZENOVICH, N.; FOLEY, J.; BROWN, R.N. Use of Real-Time Quantitative PCR Targeting the msp2 protein gene to identify cryptic Anaplasma phagocytophilum infections in wildlife and domestic animals. Vector-Borne and Zoonotic Diseases, v.6, n.1, p.83-90, 2006. DREHER, U.M.; DE LA FUENTE, J.; HOFMANN-LEHMANN, R.; MELI, M.L.; PUSTERLA, N.; KOCAN, K.M.; WOLDEHIWET, Z.; BRAUN, U.; REGULA, G.; STAERK K.D.C.; LUTZ, H. Serologic Cross-Reactivity between Anaplasma marginale and Anaplasma phagocytophilum. Clinical and Diagnostic Laboratory Immunology, v.12, n.10, p.1177–1183, 2005. 76 DUGAN, V.G.; YABSLEY, M.J.; TATE, C.M.; MEAD, D.G.; MUNDERLOH, U.G.; HERRON, M.J.; STALLKNECHT, D.E.; LITTLE, S.E.; DAVIDSON, W.R. Evaluation of white-tailed deer (Odocoileus virginianus) as natural sentinels for Anaplasma phagocytophilum. Vector Borne Zoonotic Diseases, v.6, n.2, p.192–207, 2006. DUMLER, J. S.; ASANOVICH, K. M.; BAKKEN, J.S.; RICHTER, P.; KIMSEY, R.; MADIGAN, J.E. Serologic cross-reactions among Ehrlichia equi, Ehrlichia phagocytophila, and human granulocytic ehrlichia. Journal of Clinical Microbiology, v.33, n.5, p.1098–1103, 1995. DUMLER, J.S.; BARBET, A.F.; BEKKER, C.P.J.; DASCH, G.A.; PALMER, G.H.; RAY, S.C.; RIKIHISA, Y.; RURANGIRWA, F.R. Reorganization of genera in the families Rickettsiaceae and Anaplasmataceae in the order Rickettsiales; unification of some species of Ehrlichia with Anaplasma, Cowdria with Ehrlichia and Ehrlichia with Neorickettsia, descriptions of six new species combinations and designation of Ehrlichia equi and BHGE agent as subjective synonyms of Ehrlichia phagocytophila. International Journal of Systematic and Evolutionary Microbiology, v.51, n.6, p.2145–2165, 2001. DUMLER, J.S.; WALKER, D.H. Tick-borne ehrlichiosis. Lancet Infectious Diseases, v.4, n.1, p.21–28, 2001. EGENVALL, A.; FRANZEN, P.; GUNNARSSON, A.; ENGVALL, E.O.; VAGSHOLM, I.; WIKSTROM, U.B.; ARTURSSON, K. Cross-sectional study of the seroprevalence to Borrelia burgdorferi sensu lato and granulocytic Ehrlichia spp. and demographic, clinical and tickexposure factors in Swedish horses. Preventive Veterinary Medicine, v.49, n.3-4, p.191–208, 2001. EGENVALL, A.; LILLIEHÖÖK, I.; BJÖERSDORFF, A.; ENGVALL, E.O.; KARLSTAM, E.; ARTURSSON, K.; HELDTANDER, M.; GUNNARSSON, A. Detection of granulocytic Ehrlichia species DNA by PCR in persistently infected dogs. Veterinary Record, v.146, n.7, p.186–190, 2000. FACCINI, J.L.H.; PRATA, M.C.A.; DAEMON, E.; BARROS-BATTESTI, D.M. Características biológicas da fase não parasitária do Ixodes amarali (Acari: Ixodidae) em gambá (Didelphis sp.) no Estado do Rio de Janeiro. Arquivo Brasileiro de Medicina Veterinária e Zootecnia, v.51, n.3, p.267-270, 1999. FOGGIE, A. Studies on the infectious agent of tick-borne fever in sheep. Journal of Pathology and Bacteriology, v.63, n.1, p.1–15, 1951. FOGGIE, A. Studies on tick pyaemia and tick-borne fever. Symposia of the Zoological Society of London, v.6, p.51–58, 1962. FOGGIE, A.; ALLISON, C.J. A note on the occurrence of tick-borne fever in cattle in Scotland with comparative studies of bovine and ovine strains of the organism. Veterinary Record, v.72, n.1, p.767–770, 1960. FOLEY, J.E.; FOLEY, P.; BROWN, R.N.; LANE, R.S.; DUMLER, J.S.; MADIGAN, J.E. Ecology of granulocytic ehrlichiosis and Lyme disease in the western United States. Journal of Vector Ecology, v.29, n.1, p.41–50, 2004. FOLEY, J.E.; KRAMER, V.L.; WEBER, D. Experimental ehrlichiosis in dusky footed woodrats (Neotoma fuscipes). Journal of Wildlife Diseases, v.38, n.1, p.194–198, 2002. 77 FOLEY, J.E.; NIETO, N.C.; ADJEMIAN, J.; DABRITZ, H.; BROWN, R.N. Anaplasma phagocytophilum Infection in Small Mammal Hosts of Ixodes Ticks, Western United States. Emerging Infectious Diseases, v.14, n.7, p. 1147-1150, 2008. FONSECA, F. Inquérito sobre a fauna acarológica de parasitas no nordeste do Brasil. Memorial do Instituo Butantan, v.28, n.1, p.99-186, 1957. FOSTER, W.N.M.; GREIG, J.C. Isolation of tick-borne fever from feral goats in New Galloway. Veterinary Record, v.85, n.1, p.585–586, 1969. FRANZÉN, P.; ASPAN, A.; EGENVALL, A.; GUNNARSSON, A.; ABERG, L; PRINGLE, J. Acute clinical, hematologic, serologic, and polymerase chain reaction findings in horses experimentally infected with a European strain of Anaplasma phagocytophilum. Journal of Veterinary Internal Medicine, v.19, n.2, p.232–239, 2005. FRANZÉN, P.; ASPAN, A.; EGENVALL, A.; GUNNARSSON, A.; KARLSTAM, E.; PRINGLE, J. Molecular evidence for persistence of Anaplasma phagocytophilum in the absence of clinical abnormalities in horses after recovery from de acute experimental infection. Journal of Veterinary Internal Medicine, v.23, n.3, p.636-642, 2009. FRENCH, D.M.; BROWN, W.C.; PALMER, G.H. Emergence of Anaplasma marginale antigenic variants during persistent rickettsemia. Infection and Immunity, v.67,n.11, p.5834– 5840, 1999. GOODMAN, J.L.; NELSON, C.; VITALE, B.; MADIGAN, J.E.; DUMLER, J.S.; KURTTI, T.J.; MUNDERLOH, U.G. Direct cultivation of the causative agent of human granulocytic ehrlichiosis. New England Journal of Medicine, v.334, n.4, p.209-215, 1996. GORDON, W.S.; BROWNLEE, A.; WILSON, D.R. Studies on louping ill, tick-borne fever and scrapie. In: PROCEEDINGS OF THE THIRD INTERNATIONAL CONGRESS OF MICROBIOLOGY, New York, p.362-363, 1940. GRAY, D.; WEBSTER, K.; BERRY, J.E. Evidence of louping ill and tick-borne fever in goats. Veterinary Record, v.122, n.3, p.66, 1988. GREIG, B.; ASANOVICH, K.M.; ARMSTRONG, P.J. Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs. Journal of Clinical Microbiology, v.34, n.1, p.44–48, 1996 GRIBBLE, D.H. Equine ehrlichiosis. Journal of the American Veterinary Medical Association, v.155, n.1, p.462–469, 1969. GUEDES, E.; LEITE, R.C.; PRATA, M.C. A.; PACHECO, R.C.; WALKER, D.H.; LABRUNA, M.B. Detection of Rickettsia rickettsii in the tick Amblyomma cajennense in a new Brazilian spotted fever-endemic area in the state of Minas Gerais. Memórias do Instituto Oswaldo Cruz, v.100, n.8, p.841-845, 2005. GUY, E.S.; TASKER, S.; JOYNSON, D.H. Detection of the agent of human granulocytic ehrlichiosis (HE) in UK ticks using polymerase chain reaction. Epidemiology and Infection, v.121, n.3, p.681–683, 1998. 78 HANSEN, M.G.B.; CHRISTOFFERSEN, M.; THUESEN, L.R.; PETERSEN, M.R.; BOJESEN, A.M. Seroprevalence of Borrelia burgdorferi sensu lato and Anaplasma phagocytophilum in Danish horses. Acta Veterinaria Scandinavica, v.52, n.3, p.1-6, 2010. HARDALO, C.; QUAGLIARELLO, V.; DUMLER, J.S. Human granulocytic ehrlichiosis in Connecticut: report of a fatal case. Clinical Infectious Diseases, v.21, n.4, p.910–914, 1995. HEIMER, R.; VAN ANDEL, A.; WORMSER, G.P.; WILSON, M.L. Propagation of granulocytic Ehrlichia spp. from human and equine sources in HL-60 cells induced to differentiate into functional granulocytes. Journal of Clinical Microbiology, v.35, n.4, p.923– 927, 1997. HINAIDY, H.K. Zwei neue infektiose Blutkrankheiten des Rindes in Osterreich. Wiener Tierarztliche Monatsschrift, v.60, n.1, p.364–366, 1973. HUDSON, J.R. The recognition of tick-borne fever as a disease of cattle. British Veterinary Journal, v.106, n.1, p.3–17, 1950. JENKINS, A.; HANDELAND, K.; STUEN, S.; SCHOULS, L.; VAN DE POL, I.; MEEN, R.; KRISTIANSEN, B.E. Ehrlichiosis in a moose calf in Norway. Journal of Wildlife Diseases, v.37, n.1, p.201–203, 2001. JONGEJAN, F.; WASSINK, L.A.; THIELEMANS, M.J.C.; PERIE, N.M.; UILENBERG, G. Serotypes in Cowdria ruminantium and their relationship with Ehrlichia phagocytophila determined by immunofluorescence. Veterinary Microbiology, v.21, n.1, p.31–40, 1989. JUSTE, R.A.; SCOTT, G.R.; PAXTON, E.A.; GELABERT, J.L. Presence of Cytoecetes phagocytophila in an atypical disease of cattle in Spain. Veterinary Record, v.124, n.24, p.636, 1989. KORBUTIAK, E.; SCHNEIDERS, D.H. First confirmed case of equine ehrlichiosis in Great Britain. Equine Veterinary Education, v.6, n.6, p.303–304, 1994. LABRUNA, M.B.; KASAI, N.; FERREIRA, F.; FACCINI, J.L.H.; GENNARI, S.M. Seasonal dynamics of ticks (Acari: Ixodidae) on horses in the state of São Paulo, Brazil. Veterinary Parasitology, v.105, n.1, p.65-77, 2002. LARSSON, L.-G.; ASPAN, A.; BERGSTRÖM, K. Persistence of Anaplasma phagocytophilum in naturally infected Swedish cattle (in Swedish). Svensk Veterinärtidning, v.8–9, n.1, p.13–19, 2006. LEBLOND, A.; PRADIER, S.; PITEL, P.H.; FORTIER, G.; BOIREAU.; CHADOEUF, J.; SABATIER, P. An epidemiological survey of equine anaplasmosis (Anaplasma phagocytophilum) in southern France. Revue Scientifique et Technique, v.24, n.3, p.899-908, 2005. LEPIDI, H.; BUNNELL, J.E.; MARTIN, M.E.; MADIGAN, J.E.; STUEN, S.; DUMLER, J.S. Comparative pathology and immunohistology associated with clinical illness after Ehrlichia phagocytophila-group infections. American Journal of Tropical Medicine and Hygiene, v.62, n.1, p.29–37, 2000. 79 LEVIN, M.L.; FISH, D. Interference between the agents of Lyme disease and human granulocytic ehrlichiosis in a natural reservoir host. Vector-Borne and Zoonotic Diseases, v.1, n.2, p.139–148, 2001. LEVIN, M.L.; NICHOLSON, W.L.; MASSUNG, R.F.; SUMNER, J.W.; FISH, D. Comparison of the reservoir competence of medium-sized mammals and Peromyscus leucopus for Anaplasma phagocytophilum in Connecticut. Vector-Borne and Zoonotic Diseases, v.2, n.2, p.125–1136, 2002. LIZ, J.S.; ANDERES, L.; SUMNER, J.W.; MASSUNG, R.F.; GERN, L.; RUTTI. B.; BROSSARD, M. PCR detection of granulocytic ehrlichiae in Ixodes ricinus ticks and wild small mammals in western Switzerland. Journal of Clinical Microbiology, v.38, n.3, p.1002–1007, 2000. LIZ, J.S.; SUMNER, J.W.; PFISTER, K.; BROSSARD, M. PCR detection of and serological evidence of granulocytic Ehrlichia; infection in roe deer (Capreolus capreolus) and chamois (Rupicapra rupicapra). Journal of Clinical Microbiology, v.40, n.3, p.892–897, 2002. MAcLEOD, J. Preliminary studies in tick transmission of louping ill. II. A study of the reaction of sheep to tick infestation. Veterinary Journal, v.88, n.1, p.276-284, 1932. MAcLEOD, J. Studies on tick-borne fever of sheep. II. Experiment on transmission and distribution of the disease. Parasitology, v.28, n.1, p.320–329, 1936. MAcLEOD, J. Ticks and disease in domestic stocks in Great Britain. Symposium of the Zoological Society of London, v.6, n.1, p.29–50, 1962. MAcLEOD, J.; GORDON, W.S. Studies on tick-borne fever in sheep. I. Transmission by the tick Ixodes ricinus and description of the disease produced. Parasitology, v.25, n.1, p.273–283. 1933. MADEWELL, B.R.; GRIBBLE, D.H. Infection in two dogs with an agent resembling Ehrlichia equi. Journal of the American Veterinary Medical Association, v.180, n.5, p.512–514, 1982. MADIGAN, J. E.; RICHTER, P. J.; KIMSEY, R. B.; BARLOUGH, J. E.; BAKKEN, J. S.; DUMLER, J.S. Transmission and passage in horses of the agent of human granulocytic ehrlichiosis. Journal of Infectious Diseases, v.172, n.4, p.1141–1144, 1995. MADIGAN, J.E.; GRIBBLE, D. Equine ehrlichiosis in northern California: 49 cases (1968- 1981). Journal of the American Veterinary Medical Association, v.190, n.4, p.445-448, 1987. MADIGAN, J.E.; HIETALA, S.; CHALMERS, S.; DEROCK, E. Seroepidemiologic survey of antibodies to Ehrlichia equi in horses of Northern-California. Journal of the American Veterinary Medical Association, v.196, n.12, p.1962–1964, 1990. MADIGAN, JE. Equine ehrlichiosis. Veterinary Clinical North American Equine Practice, v.9, n.2, p.423–428, 1993. MASSUNG, R. F.; SLATER, K.G. Comparison of PCR assays for detection of the agent of human granulocytic ehrlichiosis, Anaplasma phagocytophilum. Journal of Clinical Microbiology, v.41, n.2, p.717–722, 2003. MASSUNG, R.F.; COURTNEY, J.W.; HIRTZAK, S.L.; PITZER, V.E.; SMITH, G.; DRYDEN, R.L. Anaplasma phagocytophilum in white-tailed deer. Emerging Infectious Diseases, v.11, n.10, p.1604–1606, 2005. 80 MASSUNG, R.F.; MAUREL, M.J.; OWEN, J.H.; ALAN, N.; COURTNEY, J.W.; STAFFORD, K.C.; MATHER, T.N. Genetic variants of Ehrlichia phagocytophila: Rhode Island and Connecticut. Emerging Infectious Diseases, v.8, n.5, p.462–472, 2002. MASSUNG, R.F.; PRIESTLEY, R.A.; MILLER, N.J.; MATHER, T.N.; LEVIN, M.L. Inability of a variant strain of Anaplasma phagocytophilum to infect mice. Journal of Infectious Diseases, v.188, n.11, p.1757–1763, 2003. MASSUNG, R.F.; SLATER, K.; OWENS, J.H.; NICHOLSON, W.L.; MATHER, T.N.; SOLBERG, V.B.; OLSON, J.G. Nested PCR assay for detection of granulocytic ehrlichiae. Journal of Clinical Microbiology, v.36, n.4, p.1090–1095, 1998. McDIARMID, A. Modern trends in animal health and husbandry. Some infectious diseases of free-living wild-life. British Veterinary Journal, v.121, n.3, p.245–257, 1965. MUNDERLOH, U.G.; JAURON, S.D.; FINGERLE, V.; LEITRITZ, L.; HAYES, S.F.; HAUTMAN, J.M.; NELSON, C.M.; HUBERTY, B.W.; KURTTI, T.J.; AHLSTRAND, G.G.; GREIG, B.; MELLENCAMP, M.A.; GOODMAN, J.L. Invasion and intracellular development of the human granulocytic ehrlichiosis agent in tick cell culture. Journal of Clinical Microbiology, v.37, n.8, p.2518–2524, 1999. MUNDERLOH, U.G.; LYNCH, M.J.; HERRON, M.J.; PALMER, A.T.; KURTTI, T.; NELSON, R.D.; GOODMAN, J.L. Infection of endothelial cells with Anaplasma marginale and A. phagocytophilum. Veterinary Microbiology, v.101, n.1, p.53–64, 2004. MUNDERLOH, U.G.; MADIGAN, J.E.; DUMLER, J.S.; GOODMAN, J.L.; HAYES, S.F.; BARLOUGH, J.E.; NELSON, C.M.; KURTTI, T.J. Isolation of the equine granulocytic ehrlichiosis agent, Ehrlichia equi, in tick cell culture. Journal of Clinical Microbiology, v.34, n.3, p.664–670, 1996. MUNRO, R.; HUNTER, A.R.; MACKENZIE, G.; MCMARTIN, D.A. Pulmonary lesions in sheep following experimental infection by Ehrlichia phagocytophila and Chlamydia psittaci. Journal of Comparative Pathology, v.92, n.1, p.117–129, 1982. NICHOLSON, W.L.; CASTRO, M.B.; KRAMER, V.L.; SUMNER, J.W.; CHILDS, J.E. Duskyfooted wood rats (Neotoma fuscipes) as reservoirs of granulocytic ehrlichiae (Rickettsiales: Ehrlichieae) in northern California. Journal of Clinical Microbiology, v.37, n.10, p.3323–3327, 1999. NICHOLSON, W.L.; MUIR, J.W.; SUMNER, J.W.; CHILDS, J.E. Serologic evidence of infection with Ehrlichia spp in wild rodents (Muridae: Sigmodontinae) in the United States. Journal of Clinical Microbiology, v.36, n.3, p.695–700, 1998. NYINDO, M.B.A.; RISTIC, M.; LEWIS, G.E.; HUXSOLL, D.L.; STEPHENSON, E.H. Immune responses of ponies to experimental infection with Ehrlichia equi. American Journal of Veterinary Medical Association, v.180, n.1, p.512–514, 1978. OGDEN, N.H.; BOWN, K.; HORROCKS, B.K.; WOLDEHIWET, Z.; BENNETT, M. Granulocytic Ehrlichia infection in ixodid ticks and mammals in woodlands and uplands of the UK. Medical and Veterinary Entomology, v.12, n.4, p.423–429, 1998a. 81 OGDEN, N.H.; CASEY, A.N.J.; FRENCH, N.P.; BOWN, K.J.; ADAMS, J.D.W.; WOLDEHIWET, Z. Natural Ehrlichia phagocytophila transmission coefficients from sheep ‘carriers’ to Ixodes ricinus ticks vary with the numbers of feeding ticks. Parasitology, v.124, n.2, p.127–136, 2002a. OGDEN, N.H.; CASEY, A.N.J.; FRENCH, N.P.; WOLDEHIWET, Z. A review of studies on the transmission of Anaplasma phagocytophilum from sheep: implications for the force of infection in endemic cycles. Experimental Applied Acarology, v.28, p.195–202, n.1-4, 2002b. OGDEN, N.H.; WOLDEHIWET, Z.; HART, C.A. Granulocytic Ehrlichiosis: an emerging or rediscovered tick-borne disease. Journal of Medical Microbiology, v.47, n.6, p.475–482, 1998b. OHASHI, N.; INAYOSHI, M.; KITAMURA, K.; KAWAMORI, F.; KAWAGUCHI, D.; NISHIMURA, Y.; NAITOU, H.; HIROI, M.; MASUZAWA, T. Anaplasma phagocytophiluminfected ticks, Japan. Emerging Infectious Diseases, v.11, n.11, p.1780-1783, 2005. OVERAS, J. Tick-borne fever (sjodogg) hos storfe. Norsk Veterinaertisskrift, v.14, n.1, p.631– 641, 1962. PASSAMONTI, F.; FABRIZIA, V.; KATIA, C.; STEFANO, C.; GIACOMO, C.; LUISA, M.M.; DANIELA, P.;F.; ANDREA, V.S.; MAURO, C. Anaplasma phagocytophilum in horses and ticks: A preliminary survey of central Italy. Comparative Immunology, Microbiology and Infectious Diseases, v.33, n.1, p.73-83, 2010. PEEL, M.C.; FINLAYSON, B.L.; MCMAHON, T.A. "Updated world map of the Köppen- Geiger climate classification". Hydrology and Earth System Sciences, v.11, n.5, p.1633–1644, 2007. PETROVEC, M.; BIDOVEC, A.; AVSIC-ZUPANC, T.; KOREN, S.; SUMNER, J.W.; NOCHOLSON, W.L.; CHILDS, J.E. Infection with Anaplasma phagocytophila in cervids from Slovenia: evidence of two genotypic lineages. Wiener Klinische Wochenschrift, v.114, n.13-14, p.641–647, 2002. PFISTER, K.; ROESTI, A.; BOSS, P.H.; BALSIGER, B. Ehrlichia phagocytophila als Erreger des ‘‘Weidefiebers im Berner Oberland. Schweizer Archiv für Tierheilkund, v.129, n.3, p.343– 347, 1987. POITOUT, F.M.; SHINOZAKI, J.K.; STOCKWELL, P.J.; SHUKLA, S.K. Journal of Clinical Microbiology, v.43, n.2, p.796–801, 2005. POLIN, H.; HUFNAGL, P.; HAUNSCHMID, R.; GRUBER, F.; LADURNER, G. Molecular evidence of Anaplasma phagocytophilum in Ixodes ricinus ticks and wild animals in Austria. Journal of Clinical Microbiology, v.42, n.5, p.2285–2286, 2004. POPOV, V.L.; HAN, V.C.; CHEN, S.M.; DUMLER, J.S.; FENG, H.M.; ANDREADIS, T.G.; TESH, R.B.; WALKER, D.H. Ultrastructural differentiation of the genogroups in the genus Ehrlichia. Journal of Medical Microbiology, v.47, n.3, p.235–251, 1998. PUSTERLA, N.; ANDERSON, R.J.; HOUSE, J.K.; PUSTERLA, J.B.; DEROCK, E.; MADIGAN, J.E. Susceptibility of cattle to infection with Ehrlichia equi and the agent of human granulocytic ehrlichiosis. Journal of the American Veterinary Medical Association, v.218, n.7, p.1160–1162, 2001. 82 PUSTERLA, N.; LEUTENEGGER, C.M.; CHAE, J.S; LUTZ, H.; KIMSEY, R.B.; DUMLER, J.S.; MADIGAN, J.E. Quantitative evaluation of ehrlichial burden in horses after experimental transmission of human granulocytic Ehrlichia agent by intravenous inoculation with infected leukocytes and by infected ticks. Journal of Clinical Microbiology, v.37, n.12, p.4042–4044, 1999. RAIDAL, S.L.; BAILEY, G.D.; LOVE, D.N. Effect of transportation on lower respiratory tract contamination and peripheral blood neutrophils function. Australian Veterinary Journal, v.75, n.6, p.433–438, 1997 REUBEL, G.H.; BARLOUGH, J.E.; MADIGAN, J.E. Experimental Transmission of Ehrlichia equi to Horses through Naturally Infected Ticks (Ixodes pacificus) from Northern California. Journal of Clinical Microbiology, v.36, n.7, p.2131-2134, 1998. RICHTER, P.J. Jr.; KIMSEY, R.B.; MADIGAN, J.E.; BARLOUGH, J.E.; DUMLER, J.S.; BROOKS, D.L. Ixodes pacificus (Acari:Ixodidae) as a vector of Ehrlichia equi (Rickettsiales: Ehrlichiae). Journal of Medical Entomology, v.33, n.1, p.1–5, 1996. RIKIHISA, Y. The tribe Ehrlichiae and ehrlichial diseases. Clinical Microbiology Reviews, v.4, n.3, p.286–308, 1991. RISTIC, M.; HUXSOLL, D.L. Tribe II. Ehrlichieae Philip 1957, 948A1. In: KRIEG, N.R.; HOLT, J.G. (Eds.), Bergey’s Manual of Systematic Bacteriology, vol. I. Williams & Wilkins, Baltimore, USA, p.704–711, 1984. SALVAGNI, C.A.; DAGNONE, A.S.; GOMES, T.S.; MOTA, J.S.; ANDRADE, G.M.; BALDANI, C.D.; MACHADO, R.Z. Serologic evidence of equine granulocytic anaplasmosis in horses from Central West Brazil. Revista Brasileira de Parasitologia Veterinária, v.19, n.3, p.135-140, 2010. SAMPAIO, I. B. M. Estatística aplicada à experimentação animal. 2ª ed. Belo Horizonte: Editora, FEPMVZ, 2002. 265 p. SANTOS, H.A.; PIRES, M.S.; SANTOS, T.M.; FACCINI, J.L.H.; BALDANI, C.D.; THOMÉ, S.M.; SANAVRIA, A.; MASSARD, C.L. Detection of Anaplasma phagocytophilum in dogs from Brazil detected by real-time polymerase chain reaction. Journal of Veterinary Diagnostic Investigation, v.23, n.4, In Press, 2011. SCHALM, O.W.; WEISS, D.J.; WARDROP, K.J. (eds.) Veterinary Hematology, 6th ed. Blackwell Publishing. Iowa, 2010. 1206p. SELLON, C.D.; LONG, M.T. Equine Infection Disease. St. Luis Missouri: Saunders; 2007. SMITH, A. Neutrophils, host defense, and inflammation: a double-edged sword. Journal of Leukocyte Biology, v.56, n.6, p.672–686, 1994. STAFFORD, K.C.; MASSUNG, R.F.; MAGNARELLI, L.A.; IJDO, J.W.; ANDERSON, J.F.; Infection with agents of human granulocytic ehrlichiosis, Lyme disease and babesiosis in wild white-footed mice (Peromyscus leucopus) in Connecticut. Journal of Clinical Microbiology, v.37, n.9, p.2887–2892. 1999. 83 STANNARD, A.A.; GRIBBLE, D.H.; SMITH, R.S. Equine ehrlichiosis, a disease with similarities to tick-borne fever and bovine petechial fever. Veterinary Record, v.84, n.6, p.149– 150, 1969. STUEN, S. Anaplasma phagocytophilum – the most widespread tick-borne infection in animals in Europe. Veterinary Research Communications, v.31, suppl.1, p.79-84, 2007. STUEN, S.; ENGVALL, E.O.; VAN DE POL, I.; SCHOULS, L.M. Granulocytic ehrlichiosis in a roe deer calf in Norway. Journal of Wildlife Diseases, v.37, p.614–616, 2001. STUEN, S.; VAN DE POL, I.; BERGSTROM, K.; SCHOULS, L.M. Identification of Anaplasma phagocytophila (formerly Ehrlichia phagocytophila) variants in blood from sheep in Norway. Journal of Clinical Microbiology, v.40, n.9, p.3192–3197, 2002. SUMNER, J.W.; NICHOLSON, W.L.; MASSUNG, R.F. PCR amplification and comparison of nucleotide sequences from the groESL heat shock operon of Ehrlichia species. Journal of Clinical Microbiology, v.35, n.8, p.2087–2092, 1997 TEGLAS, M.; MATERN, E.; LEIN, S.; FOLEY, P.; MAHAN, S.M.; FOLEY, J. Ticks and tickborne disease in Guatemalan cattle and horses. Veterinary Parasitology, v.131, n.1-2, p.119– 127, 2005. TEGLAS, M.B.; FOLEY, J. Differences in the transmissibility of two Anaplasma phagocytophilum strains by the North American tick vector species, Ixodes pacificus and Ixodes scapularis (Acari: Ixodidae). Experimental Applied Acarology, v.38, n.1, p.47–58, 2006. TELFORD, S.; DAWSON, J.; KATAVOLOS, P.; WARNER, C.; KOLBERT, C.; PERSING, D. Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle. Proceedings of the National Academy of Sciences of the United State of American, v.93, n.12 p.6209–6214, 1996. TUOMI, J. Experimental studies on bovine tick-borne fever. 1. Clinical and haematological data, some properties of the causative agent, and homologous immunity. Acta Pathol. Microbiol. Scand. v.70, n.3, p.429–445, 1967a. TUOMI, J. Experimental studies on bovine tick-borne fever. 3. Immunological strain differences. Acta Pathologica Microbiologica Scandinavica, v.71, n.1, p.89–100, 1967c. TUOMI, J.; VON BONSDORFF, C.H. Electron microscopy of tick-borne fever agent in bovine and ovine phagocytizing leukocytes. Journal of Bacteriology, v.92, n.5, p.1478–1492, 1966. TYZZER, E.E. Cytoecetes microti, N.G.H. Sp., a parasite developing in granulocytes and infective for small rodents. Parasitology, v.30, n.1, p.242–257, 1938. VAN ANDEL, A.E.; MAGNARELLI, L.A.; HEIMER, R.; WILSON, M.L. Development and duration of antibody response against Ehrlichia equi in horses. Journal of the American Veterinary Medical Association, v.212, n.12, p.1910–1914, 1998. VON STEDINGK, L.V.; GURTELSCHMIDT, M.; HANSON, H.S.; GISTAFSON, R.; DOTEVAKK, L.; ENGVALL, E.O.; GRANSTROM, M. The human granulocytic ehrlichiosis agent in Swedish ticks. Clinical Microbiology and Infection, v.3, n.5, p.573–574, 1997. 84 VREDEVOE, L.K.; RICHTER Jr, P.J.; MADIGAN, J.E.; KIMSEY, R.B. Association of Ixodes pacificus (Acari: Ixodidae) with the spatial and temporal distribution of equine granulocytic ehrlichiosis in California. Journal of Medical Entomology, v.36, n.5, p.551–561, 1999. WALKER DH.; DUMLER JS. Emergence of the ehrlichiosis as human health problems. Emerging Infectious and Diseases, v.2, n.1, p.1–16, 1996. WALKER DH.; DUMLER JS. Human monocytic and granulocytic ehrlichioses. Discovery and diagnosis of emerging tickborne infections and the critical role of the pathologist. Archives of Pathology & Laboratory Medicine, v.121, n.8, p.785–791, 1997. WEISS, S.J. Tissue destruction by neutrophils. New England Journal of Medicine, v.320, n.6, p. 365–376. 1989. WOLDEHIWET, Z. The effects of tick-borne fever on some functions of polymorphonuclear cells of sheep. Journal of Comparative Pathology, v.97, n.4, p.481–485, 1987a. WOLDEHIWET, Z. The natural history of Anaplasma phagocytophilum. Veterinary Parasitology, v.167, n.2-4, p.108–122, 2010. WOLDEHIWET, Z. Tick-borne fever: a review. Veterinary Research Communications, v.6, n.3, p.163-175, 1983. WOLDEHIWET, Z.; HORROCKS, B.K. Antigenicity of ovine strains of Anaplasma phagocytophilum grown in tick cells and ovine granulocytes. Journal of Comparative Pathology, v.132, n.4, p.322–328, 2005. WOLDEHIWET, Z.; HORROCKS, B.K.; SCAIFE, H.; ROSS, G.; MUNDERLOH, U.G.; BOWN, K.; EDWARDS, S.W.; HART, C.A. Cultivation of an ovine strain of Ehrlichia phagocytophila in tick cell culture. Journal of Comparative Pathology, v.127, n.2-3, p.142– 147, 2002. WOLDEHIWET, Z.; SCOTT, G.R. Corticosteroid therapy of tick-borne fever. Veterinary Record, v.110, n.7, p.151–152, 1982c. WOLDEHIWET, Z.; SCOTT, G.R. Stages in the development of Cytoecetes phagocytophila, the causative agent of tick-borne fever in sheep. Journal of Comparative Pathology, v.92, n.3, p.469–474, 1982a. ZEIDNER, N.S.; BURKOT, T.R.; MASSUNG, R.; NICHOLSON, W.L.; DOLAN, M.C.; RUTHERFORD, J.S.; BIGGERSTAFF, B.J.; MAUPIN, G.O. Transmission of the agent of human granulocytic ehrlichiosis by Ixodes spinipalpis ticks: evidence of an enzootic cycle of dual infection with Borrelia burgdorferi in Northern Colorado. Journal of Infectous Diseases, v.182, n.2, p.616–619, 2000. ZHI, N.; OHASHI, N.; RIKIHISA, Y. Multiple p44 genes encoding major outer membrane proteins are expressed in the human granulocytic ehrlichiosis agent. Jounal of Biological Chemistry. v.274, n.25, p.17828–17836, 1999. ZHI, N.; RIKIHISA, Y.; KIM, H.Y.; WORMSER, G.P.; HOROWITZ, H.W. Comparison of major antigenic proteins of six strains of the human granulocytic ehrlichiosis agent by Western immunoblot analysis. Journal of Clinical Microbiology, v.35, n.10, p.2606–2611, 1997.por
dc.subject.cnpqMedicina Veterináriapor
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/54202/2011%20-%20Tiago%20Marques%20dos%20Santos.pdf.jpg*
dc.originais.urihttps://tede.ufrrj.br/jspui/handle/jspui/2739
dc.originais.provenanceSubmitted by Sandra Pereira (srpereira@ufrrj.br) on 2019-06-11T16:47:44Z No. of bitstreams: 1 2011 - Tiago Marques dos Santos.pdf: 3461896 bytes, checksum: ec8177b9ae48982ca835665110176395 (MD5)eng
dc.originais.provenanceMade available in DSpace on 2019-06-11T16:47:44Z (GMT). No. of bitstreams: 1 2011 - Tiago Marques dos Santos.pdf: 3461896 bytes, checksum: ec8177b9ae48982ca835665110176395 (MD5) Previous issue date: 2011-03-01eng
Appears in Collections:Doutorado em Ciências Veterinárias

Se for cadastrado no RIMA, poderá receber informações por email.
Se ainda não tem uma conta, cadastre-se aqui!

Files in This Item:
File Description SizeFormat 
2011 - Tiago Marques dos Santos.pdf2011 - Tiago Marques dos Santos3.38 MBAdobe PDFThumbnail
View/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.