Please use this identifier to cite or link to this item: https://rima.ufrrj.br/jspui/handle/20.500.14407/9709
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dc.contributor.authorBorges, Debora Azevedo
dc.date.accessioned2023-12-21T18:42:57Z-
dc.date.available2023-12-21T18:42:57Z-
dc.date.issued2023-03-30
dc.identifier.citationBORGES, Debora Azevedo. Fluazuron no controle do carrapato Amblyomma sculptum: eficácia, farmacocinética e palatabilidade utilizando o porquinho-da-índia como modelo experimental. 2023. 115 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Departamento de Parasitologia Animal, Universidade Federal Rural do Rio de Janeiro, Seropédica, RJ, 2023.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/9709-
dc.description.abstractO carrapato Amblyomma sculptum é conhecido pelo fato de sua picada causar lesões extremamente pruriginosas e por ser a espécie transmissora da bactéria Rickettsia rickettsii, causadora da Febre Maculosa Brasileira no homem. Qualquer uma de suas fases parasitárias podem ser encontradas em animais domésticos, selvagens e até mesmo no homem, mas a capivara é um de seus hospedeiros preferenciais. Devido à semelhança da capivara com porquinhos-da-índia, esta segunda espécie foi utilizada para a execução desse trabalho em substituição à primeira. O objetivo geral desse trabalho foi avaliar a eficácia do fluazuron no controle do carrapato A. sculptum em porquinhos-da-índia infestados artificialmente com larvas do carrapato. Para isso, o trabalho foi dividido em seis etapas que ocorreram de forma cronológica (Estudo I ao VI). No Estudo I foi determinada a influência de três diferentes doses de fluazuron administrado por gavagem na concentração plasmática e na eficácia no controle de A. sculptum em porquinhos-da-índia. No Estudo II foi realizada a farmacocinética descritiva do fluazuron após sua administração por gavagem para porquinhos-da-índia. Com os resultados obtidos nos dois primeiros estudos, no Estudo III, foram desenvolvidas diferentes formulações em isca que passaram por avaliações das características organolépticas e de resistência à diferentes temperaturas e umidades. O fluazuron foi incorporado na formulação escolhida, que passou por testes de uniformidade de dose. Em seguida, foi realizado o Estudo IV para avaliar a palatabilidade da formulação desenvolvida para porquinhos-da-índia, onde foram oferecidas iscas contendo (grupo tratado) e não contendo (grupo placebo) fluazuron. No Estudo V as iscas foram administradas para porquinhos-da-índia para determinar a farmacocinética descritiva do fluazuron, seguindo a mesma metodologia aplicada no Estudo II. Por fim, a última etapa (Estudo VI), determinou a eficácia da isca contendo fluazuron administrada para porquinhos-da-índia no controle do carrapato A. sculptum. Nesta etapa, os animais foram divididos em grupos onde cada um recebeu a isca contendo fluazuron em dose única em dias experimentais pré-infestação distintos. No Estudo I, os resultados de eficácia mostraram que mesmo a dose mais baixa alcançou 100% de eficácia contra a muda das larvas ingurgitadas. Quanto a biodisponibilidade plasmática, ocorreu um aumento na concentração plasmática de fluazuron com o aumento da dose no dia +1. No entanto, do dia +4 até o último dia de avaliação (+21), as concentrações plasmáticas médias não diferiram significativamente entre os grupos. Nos Estudos II e V, as concentrações plasmáticas de fluazuron aumentaram rapidamente, indicando absorção rápida e eliminação lenta. Os resultados permitiram o desenvolvimento de uma isca resistente à diferentes temperaturas e umidade, a qual o fluazuron foi incorporado e aprovado nos testes de uniformidade de dose (Estudo III). No Estudo IV as iscas placebo e tratado foram palatáveis para porquinhos-da-índia em, pelo menos, 92% das vezes. A eficácia obtida das iscas foi 64,99% para os animais tratados 21 dias antes da infestação, de 61,88% para os animais tratados 14 dias antes da infestação e de 59,31% para os animais tratados 7 dias antes da infestação. O fluazuron foi eficaz no controle do carrapato A. sculptum em porquinhos-da-índia.por
dc.description.sponsorshipCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superiorpor
dc.description.sponsorshipCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológicopor
dc.description.sponsorshipFAPUR - Fundação de Apoio a Pesquisa da Universidade Ruralpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectControle de carrapatospor
dc.subjectcarrapato estrelapor
dc.subjectbenzoilfenil ureiaspor
dc.subjectTick controleng
dc.subjectstar tickeng
dc.subjectbenzoylphenylureaseng
dc.titleFluazuron no controle do carrapato Amblyomma sculptum: eficácia, farmacocinética e palatabilidade utilizando o porquinho-da-índia como modelo experimentalpor
dc.title.alternativeFluazuron in the control of Amblyomma sculptum tick: efficacy, pharmacokinetics and palatability using the guinea pig as an experimental modeleng
dc.typeTesepor
dc.description.abstractOtherThe tick Amblyomma sculptum is known for the fact that its bite causes extremely itchy lesions and for being the transmitting species of the bacterium Rickettsia rickettsii, which causes Brazilian Spotted Fever in humans. Any of its parasitic stages can be found in domestic and wild animals and even in humans, but the capybara is one of its preferred hosts. Due to the similarity between capybaras and guinea pigs, this second species was used to carry out this work, replacing the first one. The general objective of this work was to evaluate the efficacy of fluazuron in the control of the tick A. sculptum in guinea pigs artificially infested with larvae. The work was divided into six stages that occurred chronologically (Study I to VI). In Study I, the influence of three different doses of fluazuron administered by gavage on plasma concentration and efficacy in controlling A. sculptum in guinea pigs was determined. In Study II, the descriptive pharmacokinetics of fluazuron was performed after its administration by gavage to guinea pigs. With the results obtained in the first two studies, in Study III, different bait formulations were developed that underwent evaluations of organoleptic characteristics and resistance to different temperatures and humidity. Fluazuron was incorporated into the chosen formulation, which underwent dose uniformity tests. Subsequently, Study IV was conducted to assess the palatability of the formulation developed for guinea pigs, where baits containing fluazuron (treated group) and placebo group (not treated) were offered. In Study V the baits were administered to guinea pigs to complete the descriptive pharmacokinetics of fluazuron, following the same methodology applied in Study II. In this step, the animals were divided into groups where each received the bait containing fluazuron in a single dose on different pre-infestation experimental days. In Study I, the efficacy results showed that even the lowest dose achieved 100% efficacy against molting engorged larvae. As for plasma bioavailability, there was an increase in the plasma concentration of fluazuron with the increase in dose on day +1. However, from day +4 to the last day of evaluation (+21), mean plasma concentrations did not differ significantly between groups. In Studies II and V, fluazuron plasma concentrations increased rapidly, indicating rapid absorption and slow elimination. The results allowed the development of a bait resistant to different temperatures and humidity, which fluazuron was incorporated and approved in the dose uniformity tests (Study III). In Study IV the placebo and treated baits were palatable to guinea pigs at least 92% of the time. In Study VI, the efficacy obtained was 64.99% for the treated animals 21 days before the infestation, 61.88% for the animals treated 14 days before the infestation and 59.31% for the animals treated 7 days before the infestation. Fluazuron was effective in controlling the A. sculptum tick in guinea pigs.eng
dc.contributor.advisor1Scott, Fabio Barbour
dc.contributor.advisor1ID001.382.167-97por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/1217253540572819por
dc.contributor.advisor-co1Cid, Yara Peluso
dc.contributor.referee1Scott, Fabio Barbour
dc.contributor.referee2Azevedo, Thais Ribeiro Correia
dc.contributor.referee3Labarthe, Norma Vollmer
dc.contributor.referee4Reck, José
dc.contributor.referee5Albuquerque, George Rego
dc.creator.ID111.192.427-97por
dc.creator.Latteshttp://lattes.cnpq.br/4643004403221236por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Ciências Veterináriaspor
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