logo RIMA
logo UFRRJ

  1. Repositório de Múltiplos Acervos da UFRRJ
  2. Teses e Dissertações
  3. Programa de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)
  4. Mestrado em Medicina Veterinária (Patologia e Ciências Clínicas)
Please use this identifier to cite or link to this item: https://rima.ufrrj.br/jspui/handle/20.500.14407/14235
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMascarenhas, Mariana Bezerra
dc.date.accessioned2023-12-22T02:58:02Z-
dc.date.available2023-12-22T02:58:02Z-
dc.date.issued2014-02-14
dc.identifier.citationMASCARENHAS, Mariana Bezerra. Estudos imuno-histoquímico complementar e lectino-histoquímico do tumor venéreo transmissível canino no Brasil. 2014. 68 f. Dissertação (Mestrado em Medicina Veterinária, Patologia e Ciências Clínicas) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2014.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/14235-
dc.description.abstractCom a finalidade de aprofundar a investigação sobre a natureza (origem) do tumor venéreo transmissível canino (TVTC), bem como, fornecer subsídios para o estabelecimento do diagnóstico e diagnóstico diferencial, esse estudo complementar foi realizado por meio de avaliação imuno-histoquímica e lectino-histoquímica. A avaliação imuno-histoquímica foi feita em 10 TVTCs genitais e em 6 exclusivamente extragenitais previamente diagnosticados através da citologia e da histopatologia. Os TVTCs foram testados para reagentes específicos de antígenos de membrana e citoplasmáticos (anti-lisozima, anti-macrófago, anti-vimentina, anti-CD18, anti-CD3, anti-CD79, anti-CD117) com utilização da técnica complexo avidina-biotina-peroxidase. Adicionalmente, foram testadas as lectinas Con A, DBA, SBA, PNA, UEA-1, WGA, sWGA, GSL, SJA, PSA, PHA-L, PHA-E e RCA em quatro TVTCs genitais. Em 100% dos tumores testados (16/16) com anticorpo anti-vimentina houve forte imuno-reatividade. Os TVTCs também apresentaram forte marcação com o anticorpo anti-CD117 e anti-CD3. Não houve reatividade para os anticorpos anti-lisozima, anti-macrófago, anti-CD18 e anti-CD79a. Na avaliação lectino-histoquímica foi verificada forte marcação das células tumorais com Con-A, PHA-L e RCA. Não houve diferença histopatológica e de imuno-reatividade entre os TVTCs genitais e extragenitais. Estes achados não corroboram com a hipótese da origem histiocítica do TVTC (ausência de reatividade dos anticorpos anti-lisozima, anti-macrófago e anti-CD18), entretanto, indicam uma provável origem linfóide/mielóide deste tumor (reatividade para CD3, ConA, PHA-L e RCA).por
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectTVTCpor
dc.subjectimuno-histoquímicapor
dc.subjectlectino-histoquímicapor
dc.subjectcãopor
dc.subjectpatologiapor
dc.subjectimmunohistochemistryeng
dc.subjectlectin histochemistryeng
dc.subjectdogeng
dc.subjectpathologyeng
dc.titleEstudos imuno-histoquímico complementar e lectino-histoquímico do tumor venéreo transmissível canino no Brasilpor
dc.title.alternativeComplementary immunohistochemical studies and lectin histochemical of canine transmissible venereal tumor in Brazileng
dc.typeTesepor
dc.description.abstractOtherTo further investigate the nature (origin) of the canine transmissible venereal tumor (CTVT), as well as provide support for establishing the diagnosis and differential diagnosis of this neoplasm, this complementary study was performed by means of immunohistochemistry and lectin histochemistry analysis. The immunohistochemical was performed on 10 genital TVTCs and on 6 exclusively extragenital TVTCs previously diagnosed by cytology and histopathology. CTVT samples were incubated with biotinylated antibodies raised against specific membrane and cytoplasmic antigens (anti-lysozyme, anti-macrophage, anti-vimentin, anti-CD18, anti-CD3, anti-CD79, anti-CD117) and subsequently developed using the avidin-biotin-peroxidase complex technique. Lectins Con A, DBA, SBA, PNA, UEA-1, WGA, sWGA, GSL, JSA, PSA, PHA-L, PHA-E and RCA were additionally tested in four genital TVTCs. A strong reactivity with the anti-vimentin antibody was found in 100% of the tumors tested (16/16). The CTVTs also showed strong staining with anti-CD117 and anti-CD3 antibody. There was no reactivity to anti-lysozyme, anti-macrophage, anti-CD18 and anti-CD79a antibodies. In lectin histochemical was observed strong staining of tumors to Con-A, PHA-L and RCA. There was no histopathological and immuno-reactivity difference among genital and extragenital CTVTs. These findings do not corroborate the hypothesis of histiocytic origin of CTVT (no reactivity to anti-lysozyme antibody, anti-macrophage and anti-CD18), however, they do indicate a probable lymphoid/myeloid origin of this tumor (reactivity for CD3, ConA, PHA -L and RCA).eng
dc.contributor.advisor1França, Ticiana do Nascimento
dc.contributor.advisor1ID027.897.197-05por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3545873525091315por
dc.contributor.advisor-co1Peixoto, Paulo de Vargas
dc.contributor.advisor-co1ID270.761.210-34por
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/3002512195318611por
dc.contributor.referee1Bezerra Junior, Pedro Soares
dc.contributor.referee2Cerqueira, Valíria Duarte
dc.contributor.referee3Peixoto, Tiago da Cunha
dc.contributor.referee4Ramadinha, Regina Helena Ruckert
dc.creator.ID055.187.017-64por
dc.creator.Latteshttp://lattes.cnpq.br/5125135856204760por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)por
dc.relation.referencesADAMS, E.W., SLAUGHTER, L.J. A canine venereal tumor with metastasis to the brain. Pathol.Vet., v. 7, p.498-502, 1970. AFFOLTER, V.K.; MOORE, P.F. Localized and disseminated histiocytic sarcoma of dendritic cell origin in dogs. Vet Pathol, v. 39, p. 74-83, 2002. ALMEIDA, J. R. C., PEDROSA, N. L., LEITE, J.B., FLEMING, T. R. P., CARVALHO, V. H., CARDOSO, A. A. A. Marcadores Tumorais: Revisão de Literatura. Revista Brasileira de Cancerologia, v. 53(3), p. 305-316, 2007. AMBER, E.I., ADEYANJU, J.B. Oronasal transmissible venereal tumor in a dog. Modern Vet Pract, v. 67, n. 12, p. 154, 1986. AMROLIA, P. J., REID S. D., GAO L., SCHULTHEIS, B., DOTTI, G., BRENNER M. K., MELO J. V., GOLDMAN, J. M., STAUSS, H. J. Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity. Blood, v. 101, p.1007-1014. 2003. FASSATI, A., MITCHISON, N. A. Testing the theory of immune selection in cancers that break the rules of transplantation. Cancer Immunol. Immunother. v.59, p. 643–651, 2010. BARRON, C., SAUNDERS, L.Z., SEIBOLD, H.R., et al. Intra-ocular tumors in animals. V. Transmissible venereal tumor of dogs. Am J Vet Res, v. 24, p. 1263-1269, 1963. BARROS, F.R.O. Identificação de marcadores de pluripotência em células tronco embrionárias e embriões de suínos, 2008, 86f. São Paulo- SP. Dissertação (Mestrado em reprodução animal) Universidade de São Paulo. Faculdade de de Medicina Veterinária e Zootecnia. BATAMUZI, E.K., BITTEGEKO, S.B.P. Anal and perianal transmissible venereal tumour in a bitch. Vet Rec, v. 129, p. 556, 1991. BLOOM, F., PAFF, G.H., NOBACK, C.R. The transmissible venereal tumor of the dog studies indicating that the tumor cells are mature end cells of reticulo-endothelial origin. Amer J Pathol, v. 27, p. 119-139, 1951. BOSCOS, C. Canine transmissible venereal tumor: clinical observations and treatment. Animal Famil., v. 3, p. 10-15, 1988. BRIGHT, R.M., GORMAN, N.T., PROBST, C.W., GORRING, R.L.. Transmissible venereal tumor of the soft palate in a dog. J Am Vet Med Assoc, v. 183, p. 893-895, 1983 BROWN, N.O., CALVERT, C., MACEWEN, E.G. Chemotherapeutic management of transmissible venereal tumour in 30 dogs. J. Am. Vet. Med.Assoc., v.176, p.983-6, 1980. CARLSON, J.A., ROGERS, B.B., SIFERS, R.N., HAWKINS, H.K., FINEGOLD, M.J., WOO, S.L.C. Multiple tissues express alpha-1-antitrypsin in transgenic mice and man. J. Clin. Invest., vol. 82, p. 26-36, 1988. 60 CHI-HO, YU1, DU-NA HWANG1, JI-YOUNG YHEE1, JONG-HYUK KIM1, KEUM-SOON IM1, WHAN-GOOK NHO2,YOUNG-SOO LYOO1, JUNG-HYANG SUR1 Comparative immunohistochemical characterization of canine seminomas and sertoli cell tumors. J. Vet. Sci., v. 10, p. 1-7, 2009. CHOI, Y.K., KIM, C.J. Sequence analysis of canine LINE-1 elements and p53 gene in canine transmissible venereal tumor. J. Vet. Sci.,v. 3, p. 285–92, 2002. COBBOLD, S.P., METCALF, S. Monoclonal antibodies that define canine homologies of human CD antigens: summary of the first international canine leukocyte antigen workshop (CLAW). Tissue Antigens, v. 43, p.137-154, 1994. COHEN, D. The canine transmissible venereal tumor: a unique result of tumor progression. Adv Cancer Res, v. 43, p. 75-112, 1985. COWELL, R.L., TYLER, R.D. Cytology of cutaneous lesions. Vet Clin of North America: Small Animal Practice, v. 19, n. 4, p. 769-794, 1989. DAS, U., DAS, A.K. Review of canine transmissible venereal sarcoma. Vet Res Commun, v. 24, n. 8, p. 545-556, 2000. DENADAI, M. V. A., SILVA, S. R. M., WAITZBERG, A. F. L., ARTIGIANI, R.; SAAD, S. S., MATOS, D. Estudo da relação entre a imunoexpressão das proteínas caderina-E e DCC com o grau de diferenciação celular e o estadiamento TNM do adenocarcinoma colorretal. J. Brás. Patol. Med. Lab., v. 43, n. 5, p. 355-361, 2007. DRABEROVA, L., DRABER, P. Thy-1 glycoprotein and src-like protein-tyrosine kinase p53/p56'Ynare associated in large detergent-resistant complexes in rat basophilic leukemia cells (tyrosine phosphorylation/mast cells/IgE receptor). Proc. Natl. Acad. Sci. v. 90, p. 3611-3615, 1993. DUNCAN, J.R., PRASSE, K.W. Cytology of canine cell tumors (Mast cell tumor, histiocytoma, lymphosarcoma and transmissible venereal tumor). Vet Pathol, v. 16, n. 4, p. 673-679, 1979. EPSTEIN, R.B., BENNETT, Histocompatibility typing and course of canine venereal tumors transplanted into unmodified random dogs. Cancer Res, vol. 34, p. 788-793, 1974. ESTEXHE, E. D, LESPAGNARD, L., EGEYTER, M. D,, EYMANN, R. H, COIGNOUL, F. Immunohistochemical identification of myoepithelial, epithelial, and connective tissue cells in canine mammary tumors. Vet Pathol, v. 30, p. 146-154, 1993. FASSATI, A., MITCHISON, A. Testing the theory of immune selection in cancers that breaks the rules of transplantation. Cancer Immunol. Immunother. v. 59, p. 643-651. FERNANDEZ, N. J., WEST, K.H., JACKSON, M.L., KIDNEY, B.A. Immunohistochemical and histochemical stains for differentiating canine round cell tumors. Vet Pathol, v. 42, p. 437-445, 2005. 61 FERRER L, FONDEVILA D, RABANAL R, TARRES J, RAMIS A. Immunohistochemical detection of CD3 antigen (pan T marker) in canine lymphomas. J Vet Diagn Invest., v. 5, p. 616-620, 1993. FULMER, A. K.; MAULDIN, G.E. Canine histiocytic neoplasia: an overview. Can Vet J., v. 48, n. 10, p. 1041-1450, 2007. GALLI, S. J.,BORREGAARD, N., WYNN, T. A. Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol., v. 12, n. 11, p. 1035–1044, 2011. GIMENO, E. J., MASSONE, A. R., MARINO, F. P., IDIART, J. R. Intermediate filament expression and lectin histochemical features of canine transmissible venereal tumour. APMIS. v. 103, p. 645-650, 1995. GOLDSCHMIDT, M. H., HENDRICK, M.J. Tumors of the skin and soft tissue. In: MEUTEN, D.J., Tumors in domestic animals. 4th ed. Blackwell Publishing Company, 2002, p. 45-117. GROSS, T. L., IRHKE, P.J., WALDER, E.J., AFFOLTER, V.K. Skin diseases of the dog and cat. Clinical and histopathologic diagnosis. 2nd ed. Blackwell Science, 2005. HAINES, D.M., CHELACK, B.J. Technical considerations for developing enzyme immunohistochemistry staining procedures on formaling-fixed paraffing-embedded tissues for diagnostic pathology. J Vet Diag Invest, vol. 3, p. 101-112, 1991. HOOGSTEDEN, H. C., VAN HAL, P. T., WIJKHUIJS, J. M., HOP, W., VERKAIK, A. P., HILVERING, C. Expression of the CD11/CD18 cell surface adhesion glycoprotein family on alveolar macrophages in smokers and nonsmokers. Chest, n.100; p.1567-1571, 1991. HSIAO, Y.W., LIAO, K.W., HUNG, S.W., CHU, R.M. Tumor-infiltrating lymphocyte secretion of IL-6 antagonizes tumor-derived TGF-beta 1 and restores the lymphokine-activated killing activity. J. Immunol., v. 172, p. 1508–14, 2004. HSIAO, Y.W., LIAO, K.W., CHUNG, T.F., LIU, C.H.,HSU, C.D., CHU, R.M. Interactions of host IL-6 and IFN-gamma and cancer-derived TGF-beta1 on MHC molecule expression during tumor spontaneous regression. Cancer Immunol. Immunother. v. 57, p. 1091-1104, 2008. ISAACSON, P., JONES, D.B., MILLWARD-SADLER, G.H., JUDD, M.A., PAYNE, S. Alpha-1-antitrypsin in human macrophages. J. Clin Pathol., vol. 34, p. 982-990, 1981. JUBB, K.F.V., KENNEDY, P.C., PALMER, P.C. Pathology of Domestic Animals. 5th ed., San Diego: Academic Press, 2007. JÚNIOR, D. M., ARAÚJO J. A. P., CATELAN T. T. T., SOUZA, A. W. S., CRUVINEL, W. M., ANDRADE, L. E.C., SILVA N. P. Sistema Imunitário – Parte II Fundamentos da resposta imunológica mediada por linfócitos T e B. Rev Bras Reumatol. v. 50(5), p.552-80, 2010. 62 KANELLOPOULOS, J.M., PETRIS, S., LECA, G., CRUMPTON M. J. The mitogenic lectin from Phaseolus vulgaris does not recognize the T3 antigen of human T lymphocytes. Eur. J. Immunol. v.15, p. 457-486, 1985. KENNEDY, J.R., YANG, T-J., ALLEN, P.L. Canine transmissible venereal sarcoma: electron microscopic changes with time after transplantation. Br. J. Cancer. v.36, p. 375-385, 1977. KIM, JONG-HYUK, YU, CHI-HO, YHEE, JI-YOUNG, IM, KEUM-SOON, KIM, NA-HYUN, SUR, JUNG-HYANG. Canine classical seminoma: a specific malignant type with human classifications is highly correlated with tumor angiogenesis. BMC Cancer. v. 10, p. 243, 2010. KIUPEL, M., WEBSTER, J. D., KANEENE, J. B., MILLER, R., YUZBASIYAN-GURKAN, V. The Use of KIT and Tryptase Expression Patterns as Prognostic Tools for Canine Cutaneous Mast Cell Tumors. Vet. Pathol. v. 41, p. 371–377, 2004. KREISS, A., TOVAR, C., OBENDORF, D. L., DUN, K.,. WOODS, G. M. A Murine Xenograft Model for a Transmissible Cancer in Tasmanian Devils. Vet Pathol . v. 48, p. 475-481, 2011. LEROY, X., AUGUSTO, D., LETEURTRE, E., GOSSELIN, B. CD30 and CD117 (c-kit) used in combination are useful for distinguishing embryonal carcinoma from seminoma. J Histochem Cytochem. v. 50(2), p. 283-285, 2002. LIAO, K.W., LIN, Z.Y., PAO, H.N., KAM, S.Y.,WANG, F.I., CHU, R.M. Identification of canine transmissible venereal tumor cells using in situ polymerase chain reaction and the stable sequence of the long interspersed nuclear element J. Vet.Diag. Invest., v.15, p.399-406, 2003. LILIENBAUM, A., LEGAGNEUX, V., PORTIER, M-M., DELLAGI, K., PAULIN, D. Vimentm gene: expression in human lymphocytes and in Burkitt's lymphoma cells. EMBO J., v.5, n. 11, p.2809 -2814, 1986. LOORINGH VAN BEECK, F. A., ZAJONC, D. M., MOORE, P. F., SCHLOTTER, Y. M., BROERE, F., RUTTEN, V. P. M. G., WILLEMSE, T., RHIJN, I. V. Two canine CD1a proteins are differentially expressed in skin. Immunogenetics., v. 60, p. 315–324. 2008. LORIMIER, L.P., FAN, T. M. Canine Transmissible Venereal Tumor. In: WITHROW, S.J., MacEWEN, E.G. Small animal clinical oncology. 2nd. ed. Philadelphia, W.B. Saunders, 2007. MAKINO, S. Some epidemiologic aspects of venereal tumors of dogs as revealed by chromosome and DNA studies. Ann.N.Y. Acad. Sci. v. 108, p. 1106-1122, 1963. MARCHAL, T., CHABANNE, L., KAPLANSKI, C., RIGAL, D., MAGNOL, J.P. Immunophenotype of the canine transmissible venereal tumor. Vet Immunol Immunopathol, v. 57, n. 1-2, p. 1-11, 1997. MASCARENHAS, M.B. Estudo imuno-histoquímico e diagnóstico diferencial de formas genitais e extragenitais do tumor venéreo transmissível canino no Brasil. 2010, 78p. 63 Seropédica – RJ. Dissertação (Mestrado em Patologia Veterinária) - Curso de Pós-graduação em Medicina Veterinária, Universidade Federal Rural do Rio de Janeiro, 2010. MASON, D. Y., CORDELL, J. L., BROWN, M. H., BORST, J., JONES, M., PULFORD, K., JAFFE, E., RALFKIAER, E., DALLENBACH, F., STEIN, H., PILERI, S., GATTER, K. C. CD79a: A Novel Marker for B-Cell Neoplasms in Routinely Processed Tissue Samples. Blood. v. 86, n. 4, p. 1453-1459, 1995. MIETTINEM, M., LASOTA, J. KIT (CD117): A review on expression in normal and neoplastic tissues, and mutations and their clinicopathologic correlation. Appl. Immunohistochem. Mol. Morphol. v. 13, n. 3, p. 205-219, 2005. MOISAN, E., GIRARD, D. Cell surface expression of intermediate filament proteins vimentin and lamin B1 in human neutrophil spontaneous apoptosis. J. Leuk. Bio., v. 79, p. 489-498, 2006. MOORE, P.F., ROSIN, A. Malignant histiocytosis of Bersnese mountain dogs. Vet Pathol., v. 23, p. l-10, 1986. MOORE, P.F. Utilization of citoplasmic lysozyme as a histiocytic marker in canine histiocytic disorders. Vet. Pathol., v. 23, p. 757-762, 1986b. MOORE, P. F., AFFOLTER, V. K., VERNAU, W. Canine Hemophagocytic Histiocytic Sarcoma: A Proliferative Disorder of CD11d+ Macrophages. Vet. Pathol., n. 43, p. 632-645, 2006. MOORE, P.F. Homepage. Disponível em: http://www.histiocytosis.ucdavis.edu/ Acesso em 22 de junho de 2011. MOR-VAKNIN, N., PUNTURIERI, A., SITWALA, K., MARKOVITZ, D. M. Vimentin is secreted by activated macrophages. Nat. Cell Biol., v. 5, p. 59–63, 2003. MORINI, M., BETTINI, G., PREZIOSI, R., MANDRIOLI, L. C-Kit gene product (CD 117) immunoreactivity in canine and feline paraffin sections. J. Histochem. Cytochem. v. 52, p. 705-708, 2004. MORO, J.V., TINUCCI-COSTA, M., SILVEIRA, A.C.T., GERALDI, D.G., ALESSI, A.C. Reactivity of p53 protein in canine transmissible venereal tumor. Arq. Bras. Med. Vet. Zootec., v.62, 2, p.318-23, 2010. MORRISON, W.B. Cancer in dogs and cats: medical and surgical management. Baltimore, Williams & Wilkins Co. 1998, p. 795. MOURA, A.R., LAUSMANN, C.W. Tratamento quimioterápico de tumor (TVT) venéreo transmissível em caninos. A Hora Veterinária, v. 78, p. 16-18, 1994. MOZOS, E., MÉNDEZ, A., GÓMEZ-VILLAMANDOS, J.C., MARTÍN DE LAS MULAS, J., PÉREZ, J. Immunohistochemical characterization of canine transmissible venereal tumor. Vet Pathol, v. 33, p. 257-263, 1996. 64 MUKARATIRWA, S., GRUYS, E. Canine transmissible venereal tumour: cytogenetic origin, immunophenotype, and immunobiology. A review. Vet. Q., v.25, p.101-11, 2004. MURCHISON, E.P. Clonally transmissible cancers in dogs and Tasmanian devils. Review. Oncogene, v. 27, p. S19-S30.48, 2009. MURCHISON, E.P., TOVAR, C., HSU, A., BENDER, H.S., KHERADPOUR, P.,REBBECK, C.A., OBENDOR, D., COLAN,C., BAHLO,M. et al. The Tasmanian devil transcriptome reveals Schwann cell origins of a clonally transmissible cancer. Science.v. 327, p. 84-87, 2010. MURGIA, C., PRITCHARD, K.J., KIM, S., FASSATI, A., WEISS, A.R. Clonal origin and evolution of a transmissible cancer. Cell, v.126,p. 447-87, 2006. MURRAY, M.M., JAMES, Z.H., MARTIN, W.B. A study of the cytology and caryotype of the canine transmissible venereal tumor. Res Vet Sci, v. 10, p. 565-568, 1969. NDIRITU, C.G., MBOGWA, S.W., SAYER, P.D. Extragenitally located transmissible venereal tumor in dogs. Mod Vet Pract, v. 58 p. 940-946, 1977. NEUPATIMAGEM-UNICAMP web site. Disponível em: http://anatpat.unicamp.br/nptgerminoma3b.html. Acesso em 18 de outubro de 2011. NIELSEN, S.W., KENNEDY, P.C. Tumor of the genital systems: transmissible venereal tumors of the dog. In: MOULTON, J.E., Tumors in domestic animals. Berkeley Calif Press, 1990, p. 498-502. OGILVIE, G.K.; MOORE, A.S. Managing the veterinary patient – a practice manual. New Jersey, Veterinary Learning systems. 1995. p. 415-421. OWSTON, M.A, RAMOS-VARA, J.A. Histologic and immunohistochemical characterization of a testicular mixed germ cell sex cord-stromal tumor and a leydig cell tumor in a dog. Vet. Pathol. v. 44, n.6, p. 936-943, 2007. PATNAIK, A. K., MOSTOFI, F. K. A clinicopathologic, histologic, and immunohistochemical study of mixed germ cell-stromal tumors of the testis in 16 dogs. Vet. Pathol. v. 30, p. 287-295, 1993. PAPAZOGLOU, L.G., KOUTINAS, A.F., PLEVRAKI, A.G., TONTIS, D. Primary intranasal transmissible venereal tumor in the dog: a retrospective study of six cases. J Vet Med A Physiol Pathol Clin Med, v. 48, n. 7, p. 391-400, 2001. PEREZ, J., DAY, M.J., MOZOS, E. Immunohistochemical study of the local inflammatory infiltrate in spontaneous canine transmissible venereal tumour at different stages of growth. Vet. Immunol. Immunopathol., v .64,p.133–47, 1998. RAMADINHA, R.R., RAMADINHA, L.S., KUNER, A. Tumor venéreo transmissível canino em cavidade oral sem lesão genital. XV Congresso Brasileiro da Associação Nacional de Clínicos Veterinários de Pequenos Animais (Anais), Rio de Janeiro, 1993. 65 RAMADINHA, R.R., VIANNA, L.F.C.G., RAMADINHA, L.S. Tumor venéreo transmissível com metástases múltiplas: descrição de um caso. Rev Bras Med Vet, v. 145, n. 6, p. 178-180, 1985. RAMOS-VARA, J. A., KIUPEL, M., BASZLER, T.; BLIVEN, L., BRODERSEN, B., CHELACK, B., CZUB, S., PIERO, F.D., DIAL, S., EHRHART, E.J., GRAHAN, T., MANNING, L., PAULSEN, D., VALLI, V.E., WEST, K. Suggested guidelines for immunohistochemical techniques in veterinary diagnostic laboratories. J Vet Diagn Invest, v. 20, p. 393-413, 2008. RAMOS-VARA, J.A. Homepage. Disponível em: <http://web.ics.purdue.edu/~jramosva/index.htm> Acesso em 1 de junho 2012. REBBECK, C.A., THOMAS, R., BREEN, M., LEROI, A.M., BURT, A. Origins and evolution of a transmissible cancer. Evolution. v. 63, p. 2340–2349, 2009. RODRIGUES, M.G.J., RAMADINHA, R.H.R., PEREIRA, J.T. Tratamento do tumor venéreo transmissível canino com vincristina associada a prednisona. Arquivos da Universidade Rural, Rio de Janeiro, v. 15, n. 2, p. 175-179, 1992. ROGERS, K.S. Transmissible venereal tumor. Comp Cont Educ for Practicing Veterinaries, v. 19, n. 9, p. 1036-1045, 1997. SÁNCHEZ-SERVÍN A., MARTÍNEZ S.,CÓRDOVA-ALARCON E., FAJARDO R. TP53 Polymorphisms allow for genetic sub-grouping of the canine transmissible venereal tumor. J.Vet. Sci., v.10, 4, p.353-5, 2009. SANDUSKY, G.E., CARLTON, W.W., WIGHTMAN, K.A. Diagnostic Immunohistochemistry of Canine Round Cell Tumors. Vet Pathol., v. 24, p. 495-499, 1987. SANTOS, F.G.A., VASCONCELOS, A.G., NUNES, J.E.S., CASSALI, G.D., PAIXÃO, T.A., MORO, L. O tumor venéreo transmissível canino – aspectos gerais e abordagens moleculares (revisão de literatura). Biosci. J., v. 21, n. 3, p. 41-53, 2005. SCOTT, D.W., MILLER, W.H., GRIFFIN, C.E. Muller e Kirk’s Small Animal Dermatology. 6 ed. Philadelphia, W.B. Saunders, 2001. p. 1365-1369. SELL, A. M., COSTA, C. P. Atividades biológicas das lectinas PHA, WGA, jacalina e artocarpina. Acta Scientiarum. v. 22(2), p. 297-303, 2000. SINGH, T.P., PANGAWKAR, G.R. Hemostatic disorders in dogs infected with transmissible venereal tumor. Indian. Vet. J., n 75, p. 879, 1998. SODRÉ, L.P. Validação de anticorpo monoclonal anti-CD45 obtido in house para utilização em citometria de fluxo e imuno-histoquímica. 2009. Boucatu –S.P. Dissertação Universidade Estadual Paulista – Faculdade de Medicina de Botucatu, 2009. STOCKMANN, D., FERRARI, H.F., ANDRADE, A.L., CARDOSO, T.C., LUVIZOTTO, M.C. Detection of the tumour suppressor gene TP53 and expression of p53, Bcl-2 and p63 proteins in canine transmissible venereal tumor. Vet. Comp. Oncol., p 9, 2011. 66 TASHBAEVA, R. E., HWANG, D.N., SONG, G.-S., CHOI, N.-H., LEE, J.-H., LYOO, Y.-S., LEE, S.-J., JUNG, D.-I., KIM, H.-Y., SUR J.-H. Endothelium-Associated Antigens in Canine Hepatocellular Carcinoma and Cirrhotic Liver Cellular Characterization of Multidrug Resistance P-glycoprotein, Alpha Fetoprotein, and Neovascular. Vet Pathol. v. 44, p.600-606, 2007. THRALL, M.A. Diagnostic cytology in clinical oncology. In: WITHROW, S.J., MacEWEN, E.G. Small animal clinical oncology. 2nd. ed. Philadelphia, W.B. Saunders, 2007. TRAIL, P.A., YANG, T.J. Canine transmissible venereal sarcoma: quantitation of T-limphocyte subpopulations during progressive growth and spontaneous tumor regression. Jpn Natl Cancer Inst, v. 74, p. 461-467, 1985. THEILEN, G.H., MADEWELL, B.R. Clinical applications of cancer chemotherapy. Veterinary cancer medicine. 2 ed. Philadelphia: Lea & Febiger, 1987. p. 183-196. VERMOOTEN, M.I. Canine transmissible venereal tumor (TVT) - a review. J South African Vet Assoc, v. 58, p. 147, 1987. WEBER, W.T., NOWELL, P.C., HARE, W.C. Chromosome studies of a transplanted and a primary canine venereal sarcoma. J. Natl. Cancer Inst., v.35, p.537-47, 1965. WEBSTER, J. D., YUZBASIYAN-GURKAN, V., MILLER, R. A., KANEENE, J. B., KIUPEL M. The role of c-KIT in tumorigenesis: Evaluation in canine cutaneous mast cell tumors. Neoplasia. v. 8, n. 2, p. 104-111, 2006. WEBSTER, J. D., YUZBASIYAN-GURKAN, V., MILLER, R. A., KANEENE, J. B., KIUPEL M. Cellular Proliferation in Canine Cutaneous Mast Cell Tumors: Associations with c-KIT and Its Role in Prognostication. Vet. Pathol. v. 44, p.298–308, 2007. WELSH, J.S. Contagious cancer. The Oncologist. v. 16, p. 1- 4, 2011. WHITE, R.A. Manual of small animal oncology. British Small Animal Veterinary Assoc ed, Londres, 1991, p. 380. WITHROW, S.J., MacEWEN, E.G. Small animal clinical oncology. 2nd. ed. Philadelphia, W.B. Saunders, 2007, p. 87. YANG, T.J., PALKER, T.J., HARDING, M.W. Tumor size, leukocyte adhence inhibition and serum levels of tumor antigen in dogs with canine transmissible venereal sarcoma. Cancer Immunol. Immunother., vol. 33, p. 255-262, 1991.por
dc.subject.cnpqMedicina Veterináriapor
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/12909/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/17314/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/23632/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/30010/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/36384/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/42762/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/49142/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.thumbnail.urlhttps://tede.ufrrj.br/retrieve/55588/2014%20-%20Mariana%20Bezerra%20Mascarenhas.pdf.jpg*
dc.originais.urihttps://tede.ufrrj.br/jspui/handle/jspui/3332
dc.originais.provenanceSubmitted by Celso Magalhaes (celsomagalhaes@ufrrj.br) on 2020-02-19T12:27:27Z No. of bitstreams: 1 2014 - Mariana Bezerra Mascarenhas.pdf: 9183051 bytes, checksum: ed6cf8cae14230a1d260ffa07e0028d9 (MD5)eng
dc.originais.provenanceMade available in DSpace on 2020-02-19T12:27:28Z (GMT). No. of bitstreams: 1 2014 - Mariana Bezerra Mascarenhas.pdf: 9183051 bytes, checksum: ed6cf8cae14230a1d260ffa07e0028d9 (MD5) Previous issue date: 2014-02-14eng
Appears in Collections:Mestrado em Medicina Veterinária (Patologia e Ciências Clínicas)

Se for cadastrado no RIMA, poderá receber informações por email.
Se ainda não tem uma conta, cadastre-se aqui!

Files in This Item:
File Description SizeFormat 
2014 - Mariana Bezerra Mascarenhas.pdf4.07 MBAdobe PDFThumbnail
View/Open
Show simple item record


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.