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dc.contributor.authorLopes, Cecília Azevedo Dias-
dc.date.accessioned2026-10-21T13:21:59Z-
dc.date.available2026-10-21T13:21:59Z-
dc.date.issued2025-12-03-
dc.identifier.citationLOPES, Cecília Azevedo Dias. Aplicação da densitometria óptica radiográfica na análise da densidade mineral óssea em cães com doença renal crônica. 2025. 42 f. Tese (Doutorado em Medicina Veterinária) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2025.pt_BR
dc.identifier.urihttp://rima.ufrrj.br/jspui/handle/20.500.14407/26739-
dc.description.abstractA doença renal crônica (DRC) é altamente prevalente em cães e frequentemente leva ao desenvolvimento de distúrbios do metabolismo mineral e ósseo, comprometendo a densidade mineral óssea (DMO) e a qualidade de vida dos animais. Na medicina veterinária, os métodos acessíveis e validados para o diagnóstico e monitoramento do distúrbio do metabolismo mineral e ósseo associado à DRC ainda são limitados. Este estudo avaliou a viabilidade da radiografia óptica digital como ferramenta para mensuração da DMO em cães com DRC, bem como sua correlação com biomarcadores séricos de remodelamento ósseo - fração óssea da fosfatase alcalina e fosfatase alcalina total - e com outros marcadores laboratoriais (ureia, creatinina, fósforo, cálcio total, cálcio iônico, proteínas totais e albumina). Radiografias digitais de mandíbula (alveolar e base do corpo), fêmur e segunda vértebra lombar foram analisadas por densitometria óptica digital, calibrada com penetrômetro (escalímetro) de alumínio. Foram incluídos no estudo 40 cães, sendo oito clinicamente saudáveis (grupo controle) e 32 com DRC, distribuídos igualmente entre os estádios 1 a 4, conforme as diretrizes da International Renal Interest Society (IRIS, 2023).pt_BR
dc.description.sponsorshipCoordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPESpt_BR
dc.languageporpt_BR
dc.publisherUniversidade Federal Rural do Rio de Janeiropt_BR
dc.subjectbiomarcadores de remodelação ósseapt_BR
dc.subjectdistúrbio mineral e ósseopt_BR
dc.subjectfração óssea da fosfatase alcalinapt_BR
dc.subjecthiperparatireoidismo secundário renalpt_BR
dc.subjectbone remodeling biomarkerspt_BR
dc.subjectbone-specific alkaline phosphatase fractionpt_BR
dc.subjectmineral and bone disorderpt_BR
dc.subjectrenal secondary hyperparathyroidismpt_BR
dc.titleAplicação da densitometria óptica radiográfica na análise da densidade mineral óssea em cães com doença renal crônicapt_BR
dc.title.alternativeApplication of radiographic optical densitometry in the analysis of bone mineral density in dogs with chronic kidney diseaseen
dc.typeTesept_BR
dc.description.abstractOtherChronic kidney disease (CKD) is highly prevalent in dogs and frequently leads to the development of mineral and bone metabolism disorders, compromising bone mineral density (BMD) and the animals' quality of life. In veterinary medicine, accessible and validated methods for the diagnosis and monitoring of CKD-associated mineral and bone disorder remain limited. This study evaluated the feasibility of digital optical radiography as a tool for BMD measurement in dogs with CKD, as well as its correlation with serum biomarkers of bone remodeling bone-specific alkaline phosphatase fraction and total alkaline phosphatase and other laboratory markers (urea, creatinine, phosphorus, total calcium, ionized calcium, total protein, and albumin). Digital radiographs of the mandible (alveolar region and body base), femur, and second lumbar vertebra were analyzed by digital optical densitometry, calibrated with an aluminum penetrometer (step wedge). Forty dogs were included in the study: eight clinically healthy (control group) and 32 with CKD, equally distributed across stages 1 to 4 according to the International Renal Interest Society (IRIS, 2023) guidelines.en
dc.contributor.advisor1Baldani, Cristiane Divan-
dc.contributor.advisor1IDhttps://orcid.org/0000-0002-4627-1362pt_BR
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/6210245465538447pt_BR
dc.contributor.advisor-co1Veiga, Cristiano Chaves Pessoa da-
dc.contributor.advisor-co1Latteshttp://lattes.cnpq.br/2990518541233552pt_BR
dc.contributor.referee1Baldani, Cristiane Divan-
dc.contributor.referee1IDhttps://orcid.org/0000-0002-4627-1362pt_BR
dc.contributor.referee1Latteshttp://lattes.cnpq.br/6210245465538447pt_BR
dc.contributor.referee2Bendas, Alexandre José Rodrigues-
dc.contributor.referee2IDhttps://orcid.org/0000-0003-4320-9923pt_BR
dc.contributor.referee2Latteshttp://lattes.cnpq.br/5357706483520041pt_BR
dc.contributor.referee3Silva, Bruno Ricardo Soares Alberigi da-
dc.contributor.referee3IDhttps://orcid.org/0000-0002-5707-2203pt_BR
dc.contributor.referee3Latteshttp://lattes.cnpq.br/5366748874483915pt_BR
dc.contributor.referee4Lanna, Leonardo Lara e-
dc.contributor.referee4Latteshttp://lattes.cnpq.br/6565670863098571pt_BR
dc.contributor.referee5Castro, Maria Cristina Nobre e-
dc.contributor.referee5IDhttps://orcid.org/0000-0003-2818-4318pt_BR
dc.contributor.referee5Latteshttp://lattes.cnpq.br/6404309516329167pt_BR
dc.creator.IDhttps://orcid.org/0009-0009-1887-5634pt_BR
dc.creator.Latteshttp://lattes.cnpq.br/4524740766757888pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentInstituto de Veterináriapt_BR
dc.publisher.initialsUFRRJpt_BR
dc.publisher.programPrograma de Pós-Graduação em Medicina Veterinária (Patologia e Ciências Clínicas)pt_BR
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The effect of naturally occurring chronic kidney disease on the micro- structural and mechanical properties of bone. PLoS ONE, v.9, n.10, 2014 SHIPOV, A. et al. The Influence of Chronic Kidney Disease on the Structural and Mechanical Properties of Canine Bone. Journal of Veterinary Internal Medicine, v.32, n.1, p.280 287, 2018 VULCANO, L. C.; SANTOS, F. A. M.; GODOY, C. L. B. Determination the bone mineral density of the distal extremity of the radius-ulna in cats: correlation between weight, sex and age. Ciência Rural, v.38, n.1, p.124-128, 2008 WIDMER, W. R.; THRALL, D. E. Radiation Protection and the Physics of Diagnostic Radiology. Em: SEILER, G. S.; THRALL, D. E. Textbook of Veterinary Diagnostic Radiology. 8 ed, St. Louis, Missouri: Saunders, 1024 p.2-22, 2024 WOODS, G.; ISRAELIANTZ, G. N.; HANDEL, I.; LIUTI, T.; MELLANBY, R. J.; SCHWARZ, T. Osteodensitometry for assessment of bone mineral density of the canine head: preliminary results. Animals, n. 11, v. 5, p. 1-12, 2021pt_BR
dc.subject.cnpqMedicina Veterináriapt_BR
Aparece nas coleções:Doutorado em Medicina Veterinária (Patologia e Ciências Clínicas)

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