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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Cardoso, Verônica da Silva | |
| dc.date.accessioned | 2023-12-21T18:42:33Z | - |
| dc.date.available | 2023-12-21T18:42:33Z | - |
| dc.date.issued | 2011-04-28 | |
| dc.identifier.citation | CARDOSO, Verônica da Silva. Avaliação da capacidade protetora da piperina adicionada à ração contra os efeitos tóxicos da aflatoxina B1 em frangos de corte. 2011. 86 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica - RJ, 2011. | por |
| dc.identifier.uri | https://rima.ufrrj.br/jspui/handle/20.500.14407/9677 | - |
| dc.description.abstract | A interferência da piperina (amida extraída da pimenta do reino) adicionada à ração de frangos de corte intoxicados experimentalmente por aflatoxina B1 (micotoxina de grande relevância no setor avícola) e sua capacidade quimioprotetora foram o principal objetivo deste trabalho. O experimento foi dividido em dois ensaios: (i) O primeiro ensaio foi realizado para determinar os efeitos de diferentes concentrações de piperina (0, 60, 120 e 180 ppm) foram avaliados e sua possível toxicidade. Noventa e seis pintos (Cobb), com 7 dias de idade foram divididos aleatoriamente em 4 grupos (n=24), por 35 dias consecutivos. Os parâmetros avaliados foram: hematológicos, bioquímicos, histopatológicos (proventrículo, moela, fígado e rim), histomorfométrico (intestino delgado) e parâmetros zootécnicos. A concentração de 60 ppm de piperina adicionada à ração foi segura para frangos de corte, tendo ainda resultado em melhor desempenho dos frangos na fase final (36-42 dias de idade). A concentração de 180 ppm promoveu leucopenia e nas concentrações de 120 e 180 ppm foi observada diminuição do número de heterófilos e monócitos; hepatotoxicidade, com elevação da enzima AST e alterações histopatológicas em ambas as concentrações; diminuição da superfície de absorção nos segmentos (jejuno e íleo) do intestino delgado, porém, sem alteração dos parâmetros zootécnicos. (ii) Para o segundo ensaio com a concentração de 60ppm de piperina: 60 frangos com 9 dias de idade, foram divididos em 4 grupos (n=15): grupo controle, grupo aflatoxina B1 (0,5 mg aflatoxina B1.kg-1 de peso vivo por via oral), grupo piperina (60 ppm adicionada à ração) e grupo piperina associada a aflatoxina B1, determinando-se a capacidade quimioprotetora da piperina sendo avaliados os parâmetros zootécnicos, hematológicos, bioquímicos, histopatológicos, histomorfométricos, os efeitos genotóxicos da aflatoxina B1 pelo teste do cometa e do micronúcleo, presença de heterófilos tóxicos no sangue periférico. Os frangos intoxicados com aflatoxina B1 (0,5 mg de aflatoxina B1.Kg-1 de peso vivo) apresentaram: diminuição do ganho médio de peso e piora da conversão alimentar; diminuição do rendimento de carcaça e cortes; hepatotoxicidade, com aumento de peso relativo do fígado e coração, variações macroscópicas do parênquima hepático e elevação das enzimas hepáticas; aumento das enzimas renais, sem evidência de lesões macroscópicas e microscópicas no tecido renal; leucopenia, com diminuição significativa de linfócitos e heterófilos; diminuição da superfície de absorção em função da redução do comprimento e largura das vilosidades de todos os segmentos estudados do intestino delgado; presença de heterófilos tóxicos. Os efeitos citotóxicos e genotóxicos da aflatoxina B1 foram significativamente reduzidos ou ausentes no grupo piperina associada a aflatoxina B1, sem diferença significativa entre o grupo controle e piperina. A ração de frangos de corte com 60 ppm de piperina foi segura, promovendo efeito benéfico tanto nos parâmetros zootécnicos avaliados, como na sanidade avícola, por impedir os efeitos tóxicos da aflatoxina B1 em frangos de corte. | por |
| dc.description.sponsorship | Conselho Nacional de Desenvolvimento Científico e Tecnológico - CNPq | por |
| dc.format | application/pdf | * |
| dc.language | por | por |
| dc.publisher | Universidade Federal Rural do Rio de Janeiro | por |
| dc.rights | Acesso Aberto | por |
| dc.subject | Aflatoxin B1. Broiler chicken. Piperine | eng |
| dc.subject | Aflatoxina B1. Frangos de corte. Piperina | por |
| dc.title | Avaliação da capacidade protetora da piperina adicionada à ração contra os efeitos tóxicos da aflatoxina B1 em frangos de corte | por |
| dc.type | Tese | por |
| dc.description.abstractOther | Piperine interference (amide extracted from black pepper) added to the diet of broiler chickens experimentally intoxicated by aflatoxin B1 (mycotoxin of great importance in the poultry sector) and it´s chemoprotective capacity were the main goal of this work. The experiment was divided into two assays: (i) The first assay was carried out to determine the effects of different concentrations of piperine (0, 60, 120, 180 ppm) and it´s possible toxicity in broiler chickens diets. Ninety six male chicks (Cobb), seven days old were used, being randomly allocated into four experimental groups (n=24) during 35 consecutive days. The following parameters were evaluated: biochemical, hematological, histopathological (proventriculus, gizzard, liver, kidney), histomorphometric (small intestine) and zootecnic. The concentration of 60 ppm of piperine in the diet was safe for broilers, showing better performance of broilers on period from 36 to 42 days old. The concentration of 180 ppm caused leukopenia and concentrations of 120 and 180 ppm was observed decrease in the number of heterophils and monocytes. Hepatotoxicity was observed by elevated AST enzyme activity, histopathological changes and decreased absorption surface in the segments (jejunum and ileum) of small intestine were observed for both 120 and 180 ppm concentrations. (ii) In the second assay, 60 broilers with nine days old divided into four groups: control, piperine (60 ppm added to diet), aflatoxin B1 (0.5 mg of aflatoxin B1.Kg-1 of body weight, orally) and piperine associated aflatoxin B1, were evaluated by effect chemoprotector of piperine against toxics effects of aflatoxin B1 being evaluated for zootecnic, biochemical, histopathological and histomorphometric parameters, toxic heterophils in peripheral blood and genotoxic by comet assay and micronucleus were also determined. No changes in the performance parameters were observed after this experiment. Broiler chickens intoxicated with AFB1 (0.5 mg of aflatoxin B1.kg-1 of body weight ) showed: decreased body weight gain and increased feed conversion; reduced carcass and cuts yields; liver toxicity, with increased relative weight of the liver and heart, macroscopic variations of hepatic parenchyma and increase of liver enzymes activity; kidney enzymes increase without evidence of renal tissue damage macroscopic or microscopic; leukopenia with significant reduction of lymphocytes and heterophils; reduction in absorptive surface due to the reduction of the length and width of the villi of all studied segments of small intestine; presence of toxic heterophils. The cytotoxic and genotoxic effects of aflatoxin B1 described above were significantly reduced or absent in the group of broiler intoxicated with aflatoxin B1 and fed with with piperine. No significant difference between piperine associated aflatoxin B1 in control and piperine groups were observed. The addition of 60 ppm of piperine in the diet of broiler chickens was safe, promoting beneficial effect both in zootecnic parameters and in poultry health, preventing toxic effects of aflatoxin B1in broiler chickens. | por |
| dc.contributor.advisor1 | Danelli, Maria das Graças Miranda | |
| dc.contributor.advisor1Lattes | http://lattes.cnpq.br/7414712085904286 | por |
| dc.contributor.advisor-co1 | Direito, Gloria Maria | |
| dc.contributor.advisor-co1ID | 90709713720 | por |
| dc.contributor.advisor-co1Lattes | http://lattes.cnpq.br/7372929468876183 | por |
| dc.creator.ID | 8310213735 | por |
| dc.creator.Lattes | http://lattes.cnpq.br/0211928200714456 | por |
| dc.publisher.country | Brasil | por |
| dc.publisher.department | Instituto de Veterinária | por |
| dc.publisher.initials | UFRRJ | por |
| dc.publisher.program | Programa de Pós-Graduação em Ciências Veterinárias | por |
| dc.relation.references | ABDEL-WAHHAB, M. A.; ALY, S. E. Antioxidants and Radical Scavenging Properties of Vegetable Extracts in Rats Fed Aflatoxin-Contaminated Diet. Journal of Agriculture and Food Chemistry, v.51, p. 2409-2414, 2003. ALLAMEH, A.; SAXENA, M.; BISWAS, G.; RAI, H. G.; SINGH, J.; SRIVASTAVA, N. Piperine, a plant alkaloid of the piper species, enhances the bioavailability of aflatoxin B1 in rat tissue. Cancer Letters, v. 3, p. 195-199, 1992. AL-SABTI, K.; METCALFE, C. D. Fish micronuclei for assessing genotoxicity in water Mutation Research/Genetic Toxicology , v. 343, p. 121-135, 1995. ALTUG, T.; YOUSEF, A. E.; MARTH, E. H. Degradation of aflatoxin B1 in dried figs by sodium bisulfite with or without heat, ultraviolet energy or hydrogen peroxide Journal of food protection, v. 53, n.7, p. 581-582, 1990. AMMAR, R. B.; SGHAIER, M. B.; BOUBAKER, J.; BHOURI, W.; NAFFETI, A.; SKANDRANI, I.; BOUHLEL, I.; KILANI, S.; GHEDIRAA, K.; CHEKIR-GHEDIRAA, L. Antioxidant activity and inhibition of aflatoxin B1-, nifuroxazide-,and sodium azide-induced mutagenicity by extracts from Rhamnus alaternus L.Chemico-Biological Interactions, v.174, p. 1-10, 2008. ANDREATTI- FILHO, R. L. Doenças fúngicas. In: Andreatti Filho R.L. (Ed). Saúde Aviária e Doenças. São Paulo: Roca. p. 236-245, 2006. AOAC- ASSOCIATION OFFICIAL ANALYTICAL CHEMIST – In: Official Methods of Analysis of Official Analitycal Chemists, Washington, 2000. ARAUJO-JUNIOR, J. X.; DA CUNHA, E. V. L.; CHAVES, M. C.; GRAY, A. I.. Piperdardina, a piperidine alkaloid from Piper tuberculatum. Phytochemistry, v.44, n.3, p. 559-561, 1997. ARAVIND, K. L.; PATIL, V. S.; DEVEGOWDA, G.; UMAKANTHA, B.; GANPULE, S. P. Efficacy of esterified glucomannan to counteract mycotoxicosis in naturally contaminated feed on performance and serum biochemical, haematological parameters in broilers. Poultry Science, v. 82, p. 571–576, 2003. ASAO, T.; BUCHI, G.; ABDEL-KADER, M. M.; SHANG, S. B.; WICK, E. L,; WOGAN, G. N. Aflatoxin B and G. Journal of the American Chemistry Society, v. 85, p1706-1707, 1963. 68 ATAL, C. K.; DUBEY, R. K.; SINGH, J. Biochemical basis of enhanced drug bioavailability by piperine: evidence that piperine is a potent inhibitor of drug metabolism. Journal Pharmacology and Experimental Therapeutics, n. 232, p. 258-262, 1985. BADIALE-FURLONG, E. Toxicidade de micotoxinas: O conhecimento e sua aplicação, In: 14th National Mycotoxin Meeting, Abstract Book p.Santa Catarina, Florianópolis, p. 90, 2010. BADMAEV, V.; MAJEED, M.; NORKUS, E. Piperine, an alkaloid derived from black pepper increases serum response of beta-carotene during 14-days of oral beta-carotene supplemention. Nutrition Research, v. 19, n. 3, p. 381-388, 1999. BADMAEV, V.; MAJEED, M.; PRAKASH, L. Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation. Journal of Nutrition and Biochemistry, v.11, p. 109-113, 2000. BAE, G. S.; KIM, M. S.; JUNG, W. S; SEO, S. W.; YUN, S. W; KIM, S. G. Inhibition of lipopolysaccharide-induced inflammatory responses by piperine. European Journal of Pharmacology, v. 642, p. 154-162, 2010. BAILEY, G. S.; WILLIAMS, D. E.; WILCOX, J. S.; LOVELAND, P. M.; COULOMBE, R. A.; HENDRICKS, J. D. Aflatoxin B1 carcinogenesis and its relation to DNA adduct formation and adduct persistence in sensitive and resistant salmonid fish. Carcinogenesis, v. 9, p. 1919–1926, 1988. BAJAD, S.; JOHRI, R. K.; K.; SINGH, J.; BEDI, K. L. Simple high-performance liquid chromatographic method for the simultaneous determination of ketoconazole and piperine in rat plasma and hepatocyte culture Journal of Chromatography A, n. 949, p. 43-47, 2002. BALDISSERA, M. A.; SANTURIO, J. M.; SILVA, J. B.; ALMEIDA, C. A. A. Aflatoxinas, ocratoxina e zearalenona em grãos e rações para consumo animal no sul do Brasil. Ciência e Tecnologia de Alimentos, v. 12, n.1, p. 77-82, 1992. BANDO, E.; GONCALES, L. N.; TAMURA, N. K.; MACHINSKI, JR. M. Biomarcadores para avaliação da exposição humana às micotoxinas. Jornal Brasileiro de Patologia e Medicina Laboratorial, v.43, n.3, p. 175-180, 2007. BANO, G.; RAINA, R.K.; ZUTSHI, U., BEDI, K.L.; JOHRI, R.K.; SHARMA, S.C. The effect of piperine on bioavailability and pharmacokinetics of propranololol and theophylline in health volunteers European Journal of Clinical Pharmacology, v.41, p. 615-617, 1991. BELPAEME, K; COOREMAN, K.; KIRSCH-VOLDERS, M. Development and validation of the in vivo alkaline comet assay for detecting genomic damage in marine flatfish. Mutation Research, n. 415. p. 167-184, 1998. BENNETT, J. W.; KLICH, M. Mycotoxins Clinical Microbiology Reviews, v. 16, n. 3, p. 497-516 2003. BEZERRA D. P.; CASTRO, F. O.; ALVES, A. P. N. N.; PESSOA, C.; MORAES, M. O.; SILVEIRA, E. R.; LIMA, M. A. S.; ELMIRO, F. J. M.; COSTA-LOTUFO, L. V. In vivo 69 growth-inhibition of sarcoma 180 by piplartine and piperine, two alkaloid amides from Piper. Brazilian Journal of Medicine Biology and Research, v. 39, p. 801– 807, 2006. BHAT, G.; CHANDRASEKHARA, N. Metabolic disposition of piperine in the rat. Toxicology, v. 44, p. 99-106, 1987. BHAT, B. G.; CHANDRASEKHARA, N. Studies on the metabolism of piperine: absorption, tissue, distribution and excretion of urinary conjugates in rats. Toxicology, v.40, p. 83-92, 1986. BIANCHI, D. M.; OLIVEIRA, C. A. F.; ALBUQUERQUE, J. L.; GUERRA, S.; CORREA, B. Effects of prolonged oral administration of aflatoxin B1 and fumonisin B1 in broiler chickens. Poultry Science, v. 84, p. 1835-1840, 2005. BIAVATTI, M. W., BELLAVER, M. H., L. VOLPATO, C.; BELLAVER C. Preliminary studies of alternative feed additives for broilers: Alternanthera brasiliana extract, propolis extract and linseed oil. Revista Brasileira de Ciências Avícolas, v.5, :p.147-151, 2003. BIEHL, M. L.; BUCK, W. B. Chemical contaminants: their metabolism and their residues. Journal of Food Protection, v. 50, p. 1058-1075, 1987. BINDER, E. M.; TAN, L. M.; CHIN, L. J.; HANDL, J.; RICHARD, J. Worldwide occurrence of mycotoxins in commodities, feeds and feed ingredients. Animal Feed Science and Technology, v. 137, p.265–282, 2007. BINTVIHOK, A; KOSITCHAROENKUL, S. Effect of dietary calcium propionate on performance, hepatic enzyme activities and aflatoxin residues in broilers fed a diet containing low levels of aflatoxin B1. Toxicon, v. 47, p. 41–46, 2006. BONSI, P.; AUGUSTI-TOCCO, G.; PALMERY, M.; GIORGI, M. Aflatoxin B1 is an inhibitor of cyclic nucleotidephosphodiesterase activity, General Pharmacology, v. 32, p. 615-619, 1999. BORDIN, E. L. Aspectos patológicos das micotoxicoses em aves – Diagnóstico diferencial. In: I Simpósio Internacional sobre Micotoxinas e Micotoxicoses em Aves. p. 109-114, Curitiba , PR, 1995. BORSA, A.; LOPES, S.T.A.; SANTURIO, J.M. Enzimas de função hepática na aflatoxicose aguda experimental em frangos de corte. Ciência Rural, v.28, p.587-590, 1998. BRASIL, 1998. Portaria n.911, de 12 de novembro de 1998 – Dispõe sobre documentos necessários à instrução de pedidos de autorização para realização de pesquisa clínica. Secretaria Nacional de Vigilância Sanitária, Ministério da Saúde. BRASIL, 2000. Resolução-RDC n.17, de 24 de fevereiro de 2000 – Dispõe sobre registro de fitoterápicos. Secretaria Nacional de Vigilância Sanitária, Ministério da Saúde. BUENO, D. J.; SILVA, D. O.; OLIVER, G. Mycoflora in commercial pet foods. Journal of Food Protection, v.64, n.5, p.741-743, 2001. 70 BUSBY, J; NOTELOVITZ, M.; PUTNEY, K.; GROW, T. Exercise, high-density lipoprotein cholesterol and cardiovascular function in climacteric woman. South medicine Journal, v. 78, p. 769-763, 1985. CABASSI, E. The immune system and exposure to xenobiotics in animals. Veterinary Research Communications, v.31, p. 115-120, 2007. CALVO, A. M.; WILSON, R. A.; BOK, J. W.; KELLER, N. P. Relationship between secondary metabolism and fungal development. Microbiology and Molecular Biology Reviews, v.66, n.3, p. 447-459, 2002. CAMPANA, M. A.; PANZERI, A. M.; MORENO, V. J.; DULOUT, F. N.. Genotoxic evaluation of the pyrethroid lambda-cyhalothrin using the micronucleus test in erythrocytes of the fish Cheirodon interruptus interruptus. Mutation Research, nº438. p. 155-161, 1999. CAMPBELL, T. W.; DEIN, F. J. Avian Hematology. The Basics. Veterinary Clinics of North America Small Animal Practice, v. 14, n. 2, p. 223-248, 1984. CARDOSO, A. L. S. P.; TESSARI, E. N. C. Estudo dos parâmetros hematológicos em frangos de corte. Arquivo do Instituto Biológico, São Paulo, v.70, n.4, p. 419-424, 2003. CAMPBELL, T. W. Clinical Chemistry of birds. In: THRALL, M. A. Veterinary Hematology and Clinical Chemistry. Philadelphia: Lippincott, Willians and Wilkins, p. 479-492, 2004. CARDOSO, V. S. efeitos da piperina em frangos de corte (Gallus gallus) com intoxicação experimental por aflatoxinas, [Dissertação]. Microbiologia Veterinária, Universidade Federal Rural do Rio de Janeiro, 2007. CARDOSO, V. S.; LIMA, C. A. R.; LIMA, M. E. F.; DORNELES, L. E. G.; LEIRA FILHO, W. T; LISBOA, R. S.; GUEDES JUNIOR, D. S.; DIREITO, G. M.; DANELLI, M. G. M. Administração oral de piperina em frangos de corte. Ciência Rural, v. 39, p. 1521-1526, 2009. CAST. Mycotoxins: risks in plant, animal and humans. In Richard J.L, Payne, G.A. (Eds.), Council of Agricultural Science and Technology (CAST) Task Force Report No. 139, Ames, Iowa, p. 199, 2003. CHEN, J.; RAYMOND, K. The role of CYP3A4 and p-glycoprotein in food –drug and herb-drug interactions. Pharmacist, v. 25, n. 9, p. 732-738, 2006. CLIFORD, J. I.; REES, K. R. Aflatoxin in site of action in the rat liver cell. Nature, v. 209, p.312-313, 1996. COLES, E. H. Patologia Clínica Veterinária. 3ª edição, Editora Manole, São Paulo, 566p, 1984. COULOMBE, R.A. Aflatoxins. In: Sharma, R.P. & Salunkhe, D.K. Mycotoxins and Phytoallexins. BocaRaton: CRC Press, p.103-143, 1991. 71 CRUZ, L. C. H. 2010. Micologia Veterinária. Editora Revinter, 2ª edição, 2010. 348 p. CRUZ, L. C. H. Características gerais das micotoxinas e micotoxicoses: Reflexos na indústria avícola. In: I Simpósio Internacional sobre Micotoxinas e Micotoxicoses em Aves. p. 1-13, Curitiba , PR, 1995. CUCCIOLONI, M.; MOZZICAFREDDO, M.; BAROCCI, S.; CIUTI, F.; R. E., L.; ELEUTERI, A. M.; ANGELETTI, M. Aflatoxin B1 misregulates the activity of serine proteases: Possible implications in the toxicity of some mycotoxins. Toxicology in Vitro, v.23, n. 3, p. 393-399, 2009. DAFALLA, R.; YAGI, A. I.; ADAM, S. E. I. Experimental aflatoxicosis in hybro-type chicks; sequential changes in growth and serum constituents and histopathological changes. Veterinary and Human Toxicology, v.29, p.222–225, 1987. DALVI, R. R.; DALVI, P. S. Differences in the effects of piperine and piperonyl butoxide on hepatic drug-metabolizing enzyme system in rats, Drug Chemistry Toxicology, v. 14, p.219–229, 1991 DENLI, M.; OKAN, F. Efficacy of different adsorbents in reducing thetoxic effects of aflatoxin B1 in broiler diets. South African Journal of Animal Science, v. 36, p. 222–228, 2006. DEPLEDGE, M. H.; AAGAARD, A.; GYÖRKOS, R. Assessment of trace metal toxicity using molecular, physiological and behavioral biomarkers. Marine Pollution Bulletin, v. 31, p. 19-27, 1995. DOGRA, R. K.; KHANNA, S; SHANKER, R. Immunotoxicological effects of piperine in mice. Toxicology, v. 196, n. 3, p. 229-36, 2004. ESPADA, Y.; DOMINGO, M.; GOMEZ, J.; CALVO, M. A. Pathological lesions following an experimental intoxication with aflatoxin B1 in broiler chickens. Research in Veterinary Science, v.53, p. 275-279, 1992. ESTRELA, J. L. V.; GUEDES, R. N. C.; MALTHA, C. R. A.; FAZOLIN, M. Toxicidade de amidas análogas à piperina a larvas de Ascia monuste orseis Godart (Lepdopitera: Pieridae) e Spodoptera frugiperda (J. E. Smith) (Lepidóptera: Noctuidae). Neotropical Entomology, v. 32, n.2, 2003. FADLALLA, I. M. T.; MOHAMMED, B. H.; BAKHIET, A. O. Effect of Feeding Garlic on the Performance and Immunity of Broilers. Asian Journal Poultry Science, v. 4; p. 182-189, 2010. FAO- Food and Nutrition, paper 45. World Regulation for Mycotoxins, 1995. A compendium, Rome, 1996. FENECH, M. The in vitro micronucleus technique. Mutation Research, v. 455, p. 81-95, 2000. 72 FENECH, M.; CHENG, W.P.; KIRSCH-VOLDERS, M.; HOLLAND, N.; BONASSI, S.; ZEIGER, E. Humn project: detailed description of the scoring criteria for the cytokinesis-block micronucleus assay using isolated human lymphocyte cultures. Mutation Research. n. 534, p. 65-75p. 2003. FENECH, M.; HOLLAND, N.; CHANG. W. P.; ZEIGER, E.; BONASSI, S. The human micronucleus project-an international collaborative study on the use of the micronucleus technique for measuring DNA damage in humans. Mutation Research, v. 428, p. 271-283, 1999. FOSTER, P. L., EISENSTADT, E., MILLER, J. H. Base substitution mutations induced by metabolically activated aflatoxin B1. Proceedings of the National Academy of Sciences, U.S.A. v. 80, n. 9, 2645–2648, 1983. FUDGE, A. M; JOSEPH, V. Avian Complete Blood Count. In: FUDGE, A. M. Laboratory medicine –avian and exotic pets; W.B. SAUNDERS, p. 19-27, 2000. GAGINI, T. B.; SILVA, R. E.; CASTRO, I. S.; SOARES, B. A.; LIMA, M. E. F.; BRITO, M. F.; MAZUR, C.; DIREITO, G. M.; DANELLI, M. G. M. Oral adminstration of piperine for the control of aflatoxin intoxication in rats. Brazilian Journal of Microbiology, v.41, n.2, p. 345-348 2010. GALTIER, P. Biological fate of mycotoxins in animals, Revue. Médicine. Véterinaire. v.149, p. 549-554, 1998. GEYIKOGLU, F.; TURKEZ, H. Protective effect of sodium selenite on genotoxicity to human whole blood culture induced by aflatoxin B1. Brazilian Archives of Biology and Technology, v.48, n. 6, p. 905-910, 2006. GHANEM, I.; ORFI, M.; SHAMMA, M. Efeito da radiação gama na inativação de aflatoxina B1 em alimentos e ração. Brazilian Journal of Microbiology, v. 39, n. 4, p. 787-791, 2008. GHOSH, R. C.; CHAUHAN, H. V. S.; JHA, G. J. Suppression of cell-mediated immunity by purified aflatoxin B1 in broiler chicks. Veterinary Immunology and Immunopathology, v. 28, n.2, p.165-172, 1991. GHOSHAL, S.; KRISHNA, P. B. N.; LAKSHMI, V. Antiamoebic activity of Piper longum fruits against entamoeba histolytica in vitro and in vivo. Journal of Ethnopharmacology, n. 50, p. 167-170, 1996. GIACOMINI, L.; FICK, F. A.; DILKIN, P.; MALLMANN, C. A.; RAUBER, R. H.; ALMEIDA, C. Desempenho e plumagem de frangos de corte intoxicados por aflatoxinas. Ciência Rural. Ciência Rural, Santa Maria, v. 36, n. 1, p. 234-239, 2006. GRISOLIA, C. K. A comparison between mouse and fish micronucleus test using cyclophosphamide, mitomycin C and various pesticides. Mutation Research. n. 518, p. 145-150, 2002. 73 GROOPMAN, J. D.; KENSLER, T. W. The light and the end of the tunnel for chemical-specific biomarkers: daylight or headlight? Carcinogenese, v. 20, n. 1-11, 1999. GUO, B; CHEN, Z. Y.; LEE, R. D.; SCULLY, B. T. Drought Stress and Preharvest Aflatoxin Contamination in Agricultural Commodity: Genetics, Genomics and Proteomics. Journal of Integrative Plant Biology, v. 50, n.10, p. 1281–1291, 2008. HEDDLE, J. A.; CIMINO, M. C.; HAYASHI, M.; ROMAGNA, F.; SHELBY, M. D.; TUCKER , J. D.; VANPARYS, PH; MACGREGOR, J. T. Micronuclei as an index of cytogenetic damage: Past, present, and future. Environmental and Molecular Mutagenesis, v.18, p. 277 – 291, 1991. HOERR, F. J. Mycotoxins. In: CALNEK, B. W. Diseases of Poultry, Iowa: Iowa State University Press, n. 199, p. 884-915, 1991. HUFF, W. E.; WYATT, R. D.; HAMILTON, P. B. Effects of dietary aflatoxin on certain egg yolk parameters. Poultry Science, n. 54, p.2014-2018, 1975. HUSSEIN, H. S.; BRASEL, J. M. Toxicity, metabolism, and impact of mycotoxins on humans and animals. Toxicology, v.167, p.101-134, 2001. IAMARCOVAI, G.; BOTTA, A.; ORSIÉRE, T. Number of centromeric signals on micronuclei and mechanisms of aneuploidy. Toxicology Letter, v.166, p.1-10, 2007. IARC - INTERNATIONAL AGENCY FOR RESEARCH ON CANCER - Some Naturally Occurring Substances: food items and constituents, heterocyclic aromatic amines and mycotoxins. In: IARC Monographs on the carcinogenic risks to humans, IARC, Lyon, v.56, 1993. IARC - INTERNATIONAL AGENCY FOR RESEARCH ON CANCER- In: IARC Monographs on the evaluation of carcinogenic risks to humans, 2003. IKAN, R. In Natural Products. A Laboratory Guide 2ª. ed. New York Academic Press., p. 233-238, 1991. Image J, National Institute Mental of Health - http://rsb.info.nih.gov/ij/. JAIN, N. C. Essential of Veterinary Hematology, Lea & Febiger: Philadelphia, 1993, 417 p. JIANG, Y.; JOLLY, P. E.; ELLIS, W. O. J. S. WANG, PHILLIPS, T. D.; WILLIAMS, J. H. Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians International Immunology, v.17, n.6 p. 807-814, 2005. KANEKO, J. J. Appendixes. In: KANEKO, J. J. Clinical biochemistry of domestic animals. 4ª. ed. San Diego: Academic Press, 1989. p.877-901. 74 KARAN, R. S.; BHARGAVA, V. K.; GARG, S. K. Effect of trikatu, an Ayrvedic prescription on the pharmacokinetic profile of rifampicin in rabbits. Journal of Ethnopharmacolical, v. 64, p. 259-264, 1999. KHAJURIA, A.; THUSU, N.; ZUTSHI, U.; Piperine modulates permeability characteristics of intestine by inducing alterations in membrane dynamics: Influence on brush border membrane fluidity, ultrastructure and enzyme kinetics. Phytomedicine, v. 9, p. 224-231, 2002. KHAJURIA, A.; THUSU, N.; ZUTSHI, U.; BEDI, K. L. Piperine modulation of carcinogen induced oxidative stress in intestinal mucosa, Molecular Cellular Biochemitry, v.189, p. 113–118, 1998. KIM, J. E.; BAUER, M. M.; MENDOZA, K. M.; REED, K. M.; COULOMBE Jr. R. A. Comparative genomics identifies new alpha class genes within the avian glutathione S-transferase gene cluster. Gene, v. 452, p. 45-53, 2010. KIM, S. H.; LEE, Y. C. Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model. The Journal of Pharmacy and Pharmacology, v. 61, n. 3, p. 353-359, 2009. KIRSCH-VOLDERS, M.; FENECH, M. Inclusion of micronuclei in non-divided mononuclear lymphocytes and necrosis/apoptosis may provide a more comprehensive cytokinesis block micronucleus assay for biomonitoring purposes. Mutagenesis v. 16, p. 51-58, 2001. KOHLERT, C.; VAN RENSEN, I.; MARZ, R.; SHINDLER, G.; GRAEFE, E. U.;VEIT, M. Bioavailability and pharmokinetics of natural volaite terpenes in animal and humans. Planta Medica, v. 66, p. 495-505, 2000. KOBAYASHI, H.; SUGIYAMA, C.; MORIKAMA, Y.; HAYASHI, M.; SOFUNI, T. A comparaison between manual microscopic analysis and computerized image analysis in the cell gell electrophoresis. MMS Communications, v. 3, p. 103-115, 1995. KOHAYAGANA, A.; SAUKAS, T. N.; BORETTI, L. P.; BORSA, A.; KUIBIDA, K. Valores hematológicos em frangos de corte de criação industrial no Estado de São Paulo. Revista Brasileira de Ciência Avícola, Campinas: FACTA. Conferência APINCO de Ciência e Tecnologia Avícolas. Prêmio José Maria Lamas da Silva, supl. 3, p.82, 2001. KOUL, I. B.; KAPIL, A. Evaluation of the liver protective potential of piperine, an active principle of black and long peppers. Planta Medica, v.59, n.5, p. 413-417, 1993. 75 KUBENA, L. F.; HARVEY, R. B.; BAILEY, R. H.; BUCKLEY, S. A.; ROTTINGHAUS, G. E. Effects of hidrated sodium calcium aluminosilicate (T-BindTM) on mycotoxicosis in young broiler chichickens. Poultry Science, v.77, p. 1502-1509, 1998. KUBENA, L. F.; BAILEY, R. H.; BYRD, J. A.; YOUNG, C. R.; CORRIER, D. E.; STANKER, L. H.; ROTTINGHAUST, G. E. Cecal volatile fatty acids and broiler chick susceptibility to Salmonella typhimurium colonization as affected by aflatoxins an T-2 toxin. Poultry Science, v.80, p.411-417, 2001. KUMAR, M. S.; LU, J., KIM, L. M.; GOLUB, T. R.; JACKS, T. Impaired microRNA processing enhances cellular transformation and tumorigenesis. Nature Genetics, v. 39, p. 673 – 677, 2007. LEDOUX, D. R.; BERMUDEZ A.J.; ROTTINGHAUS G. E. Effects of feeding Fusarium moniliforme culture material,containing know levels of fumonisin B1, in young turkey poult. Poultry Science. v. 75, n.12, p.1472-8, 1996. LEE, C. S.; HAN, E. S.; KIM, Y. K. Piperine inhibition of 1-methyl-4-phenylpyridinium-induced mitochondrial dysfunction and cell death in PC12 cells. European Journal of Pharmacology, v.537, p.37–44, 2006. LEESON, S., DIAZ, G. J.; SUMMERS, J. D. Poultry Metabolic Disorders and Mytoxins. University Books, Guelph, Ontario. p. 249-280, 1995. LEGATOR, M. biological effects of aflatoxin in cell culture. Bacteriological Reviews, v. 30, n. 2, p. 471-477, 1966. LILLEHOJ, E. B. Feed sources and conditions conductive to production of aflatoxina, ochratoxin, fusarium toxins, and zearalenone. J. A. V. A., v. 163, n. 11, p. 1281-1284, 1973. LIN, W. C.; LIAO, Y. C.; LIAU, M. C.; LII, C. K.; SHEEN, L. Y. Inhibitory effect of cda-11, a urinary preparation, on aflatoxin B1- induced oxidative stress and DNA damage in primary cultured rat hepatocytes. Food Chemical Toxicology, v. 44, n. 4, p. 546-551, 2006. LODER, J. W.; MOORHOUSE, A.; RUSSELL, G. B. Tumor inhibitory plants: amides of pepper novaehollandiae, Australian Journal of Chemistry, v. 22, p.1531–1538, 1969. LUMEIJ, J. T. Avian Clinical Biochemistry. In: KANEKO, J. J.; HARVEY, J. W.; BRUSS , M. L. Clinical Biochemistry of Domestic Animals, 5th edition. San Diego, Academic Press, 1997. 932p. LUNA, L. G. Manual of histologic staining methods of the Armed Forces Institute of Pathology, 13. ed., New York: McGraw-hill, 258 p., 1968. MABROUK, S. S.; EL-SHAYEB, N. M. A. 1980. Inhibition of aflatoxin formation by some spices. In: Golob, P., Moss, C., Dales, M., Fidgen, A., Evans, J. & Gudrups, I. (eds.). The use of spices and medicinals as bioactive protectants for grains. FAO Agric. Serv. Bull., 137p. Lebensm. Unters. Forsch. v.171, p. 344-347, 1980. 76 MADHYASTHA, M. S.; BHAT, R. V. Aspergillus parasiticus growth and aflatoxin production on black and white pepper and the inhibitory action of their chemical constituints. Applied and Environmental Microbiology, v. 48, n. 2, 1984. MALINI, T.; MANIMARAN, R. R.; ARUNAKARAN, J.; ARULDHAS, M. M.; GOVINDARAJULU, P. Effects of piperine on testis of albino rats. Journal Ethnopharmacology, v. 64, p. 218-225, 1999. MALLMANN, C. A.; DILKIN, P.; GIACOMINI, L. Z.; RAUBER, R. H. Critérios para um bom sequestrante para micotoxinas. In: Anais da Conferência APINCO de Ciência e Tecnologia Avícolas, p. 213-224, 2006. MANOHARAN, S.; BALAKRISHNAN, S.; MENON, V. P.; ALIAS, L. M.; REENA, A. R. Chemopreventive efficacy of curcumin and piperine during 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis Medicine Journal, v. 50, n. 2, p.139, 2009. MARIANI, G. V. C. Efeito de aflatoxinas sobre o desempenho produtivo de frangos de corte em diferentes períodos de desenvolvimento corporal. [Dissertação]. Santa Maria, (RS): Universidade Federal de Santa Maria, 1998. MCCANN, J.; SPINGARN, N. E.; KOBORI, J.; AMES, B. N. Detection of carcinogens as mutagens: bacterial tester strains with R factor plasmids. Proceedings of the National Academy of Sciences. U.S.A., v. 72, p. 979-983, 1975. MEISSONNIER, G. M.; LAFFITTE, J.; LOISEAU, N.; BENOIT, E.; RAYMOND, I.; PINTON, P.; COSSALTER, A. M.; BERTIN, G.; OSWALD, I. P.; GALTIER, P.Selective impairment of drug-metabolizing enzymes in pig liver during subcronic dietary exposure to aflatoxin B1. Food Chemical Toxicology, v. 45, p. 2145–2154, 2007. MERKLEY, J. W.; MAXWELL, R. J.; PHILLIPS, J. G.; HUFF, W. E. Hepatic fatty acid profiles in aflatoxin-exposed broiler chickens, Poultry Science, v. 66, p. 59-64, 1987. MINAMI, L.; MEIRELLES, P. G.; HIROOKA, E. Y.; ONO, E. Y. S. Fumonisinas: efeitos toxicológicos, mecanismo de ação e biomarcadores para avaliação da exposição. Ciências Agrárias, v. 25, n. 3, p. 207-224, 2004. MITCHELMORE, C. L.; CHIPMAN, J. K. DNA strand breakage in aquatic organisms and the potential values of the comet assay in environmental monitoring. Mutatation Reserch n.399, p.135-147, 1998. MITTAL, R.; GUPTA, R. L. In vitro antioxidant activity of piperine. Methods and Findings in Experimental and Clinical Pharmacological, v. 122, p. 163-167, 2000. MIYAMAE, Y.; YAMAMOTO, M.; SASAKI, Y. F.; KOBAYASHI, H.; GARASHISOGA, M.; SHIMOI, K.; HAYASHI, M. Evaluation of a tissue homogenization technique that isolates nuclei for the in vivo single cell gel electrophoresis (comet) assay: a collaborative study by five laboratories. Mutation Research, v. 418, p. 131-140, 1998. 77 MORAES, L. B. Estabelecimento de escores histopatológicos de lesão hepática e determinação dos valores normais das Enzimas aspartatoaminotransferase e creatinina quinase em frangos de corte. [Dissetação]. Universidade Federal do Rio Grande do Sul, Porto Alegre, 2004. MOSS, M. O. Centenary Review. Micotoxins and Mycology Researsh, v. 100, n.5, p. 513-523, 1996. MOTTA, V. T. Enzimas. In: Bioquímica clínica para laboratório: princípios e interpretações. 4.ed. Porto Alegre: Editora Médica Missau, 2003. p. 90-120. MUJUMDAR, A. M.; DHULEY, J. N.; DESHMUKH, V. K., RAMAN, P. H. NAIK, S. R. Anti-inflammatory activity of piperine. Japonise Journal of Medical and Science Biology, v. 43, p. 95–100, 1990. NACCI, D. F.; CAYULA, S.; JACKIM, F. Detection of DNA damage in individual cells from marine organisms using the single cell gel assay. Aquatic Toxicology, v.35, p.197-210, 1996. NAIDU, K. A.; THIPPESWAMY, N. B. Inhibition of human low density lipoprotein oxidation by active principles from spices, Molecular Cellular Biochemistry,v.229, p. 9–23, 2002. NATT, M. P.; HERRICK, C. A. A New Blood Diluent for Counting the Erythrocytes and Leucocytes of the Chicken. Poultry Science, v. 31, p. 735-738, 1951. NESSLANY, F.; ZENNOUCHE, N.; SIMAR-NEINTIERES, S.; TALAHARI, I.; NKILI-MBOUI, E. N.; MARZIN, D. In vivo comet assay on isolated kidney cells to distinguish genotoxic carcinogens from epigenetic carcinogens or cytotoxic compounds, Mutation Research, p. 28–41, 2007. NORIEGA, M. L. V. C. Apuntes de hematología aviar: material didático para curso de hematologia aviária. Universidad Nacional Autónoma de México. Departamento de produccíon animal: Aves. México, 70 p., 2000. OLIVEIRA, M. C.; MARQUES, R. H.; GRAVENA, R. A.; MORAES, V. M. B. Morfometria do intestine delgado de frangos tratados com dietas adicionadas de mananoglicossacarídeo e complexo enzimático. Biotemas, v.21, n.3, p. 135-142, 2008. OGUZ, H.; KEÇECI, T.; BIRDANE, Y. O.; ÖNDER, F.; KURTOG, L. U. V. Effect of clinoptilolite on serum biochemical and haematological characters of broiler chickens during aflatoxicosis. Research in Veterinary Science, v. 69, p. 89–93, 2000. ONO, E. Y. S.; MENDES, A. M.; MEIRELLES P. G.; HIROOKA, E. Y.; ONO, M. A. Micotoxinas em alimentos. Biotecnologia Ciência e Desenvolvimento, n.32, 2004. 78 ORTATALI, M., OGUZ H.,. Ameliorative effects of dietary clinoptilolite on pathological on broiler chickens during aflatoxicosis. Research in Veterinary Science, v. 71, n. 1, p. 59-66, 2001. ORTATATLI, M.; OGUZ, H.; HATIPOGLU, F.; KARAMAN, M. Evaluation of pathological changes in broilers during chronic aflatoxin (50 and 100 ppb) and clinoptilolite exposure. Research in Veterinary Science, v.78, p. 61–68 2005. OSBORNE D. J.; HAMILTON, P. B. Decreased pancreatic digestive enzymes during aflatoxicosis. Poultry Science. v.60, p. 1818-1822, 1981. OSWALD, I. P.; MARIN, D. E.; BOUHET, S.; PINTON, P.; TARANU, I.; ACCENSI, F. Immunotoxicological risk of mycotoxins for domestic animals. Food Additives and Contaminants, v.22, n. 4, p. 354-360, 2005. ÖZEN, H.; KARAMAN, M.; ÇIGREMIS, Y.; TUZCU, M.; ÖZCAN, K.; ERDAG, D. Effectiveness of melatonin on aflatoxicosis in chicks. Research in Veterinary Science, v.86, p. 485–489, 2009. PARLAT, S.S. YILDIZ, A.O.; OGUZ, H. Effects of clinoptilolite on fattening performece of Japanese quail (Coturinix coturnix japonica) during experimental aflatoxicosis. British Poultry Science, v.40, p.495-500, 1999. PATHAK, N.; KHANDELWAL, S. Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice. Biomedical and Life Sciences, v. 21, n. 6 p. 649-661, 2008. PATHAK, N.; KHANDELWAL, S. Cytoprotective and immunomodulating properties of piperine on murine splenocytes: An in vitro study. European Journal of Pharmacology, v. 576, p.160-170, 2007. PATHAK, N.; KHANDELWAL, S. Immunomodulatory role of piperine in cadmium induced thymic atrophy and splenomegaly in mice. Environmental Toxicology and Pharmacology, v.28, p. 52–60, 2009. PATHAK, N.; KHANDELWAL, S. Modulation of cadmium induced alterations in murine thymocytes by piperine: Oxidative stress, apoptosis, phenotyping and blastogenesis. Biochemical Parmacology, v. 72, p. 486 – 497, 2006. PEI, Y. Q. A review of pharmacology and clinical use of piperine and its derivatives. Epilepsia, v.24, n.2, p.177-182, 1983. PEROZO, F.; FERRER, J.; ALVARADO, M.; RICÓN, H.; MAVAREZ, Y.; GIL, M. Valores hematológicos em pollos de engorde expuestos de forma continua a bajas dosis de aflatoxina B1 em el estado Zulia, Venezuela. Revista Cientifica, FCV-LUZ, v. 13, n. 1, p. 59-64, 2003. PINTO, L. R. F.; FELZENSZWALB, I. Genética do câncer humano. IN: RIBEIRO, L. R.; SALVATORI, D. M. F.; MARQUES, E. K. Mutagênese Ambiental, 1ª ed., 2003, 356p. 79 PITT, I. J. Toxigenic fungi and mycotoxins. British Medical Bulletin, v.56, n.1, p. 184-192, 2000. PÓVOA, H. C. C. Efeito da talidomida e da pentoxifilina na produção do fator de necrose tumoral alfa (TNF-α) e gama inteferon (INF-γ) na carcinogênese mamária em ratas wistar. [Dissertação] Universidade Federal Fluminense, Niterói 2008. 94p. PRADEEP, C. R.; KUTTAN, G. Effect of piperine on the inhibition of lung metastasis induced by B16F-10 melanoma cells in mice. Clinical and Experimental Metastasis, v. 19, p. 703-708, 2002. PRASAD, N. S.; RAGHAVENDRA, R.; LOKESH B. R.; AKHILENDER NAIDU, K.A. K. Spice phenolics inhibit human PMNL5-lipoxygenase. Prostaglandins, Leukotrienes. Essential Fatty Acids, v. 70, p. 521–528, 2004. QUEZADA, T.; CUÉLLAR, H.; JARAMILLO-JUÁREZ, F.; VALDIVIA, A. G.; REYES, J. L. Effects of aflatoxin B1 on the liver and kidney of broiler chickens during development. Comparative Biochemistry and Physiology Part C: Pharmacology, Toxicology and Endocrinology v. 125, p. 265-272, 2000. RAUBER, R. H.; DILKIN, P.; GIACOMINI, L.Z.; ARAUJO DE ALMEIDA, C. A.; MALLMANN, C. A. Performance of turkey poults fed different doses of aflatoxins in the diet. Poultry Science, v. 86, p. 1620–1624, 2007. RAUSCHER, F. M.; SANDERS, R. A.; WATKINS, J. B. Effects of piperine on antioxidant pathways in tissues from normal and streptozotocin-induced diabetic rats. Journal Biochemistry and. Molecular Toxicology, v. 14, p. 329–334, 2000. RAWAL, S.; KIM, J. E.; COULOMBE Jr., R. Aflatoxin B1 in poultry: Toxicology, metabolism and prevention. Research in Veterinary Science, In Press, Corrected Proof, Available online 11 May 2010. REDDY, L.; ODHAV, B.; BHOOLA, K. Aflatoxin B1-induced toxicity in HepG2 cells inhibited by carotenoids: morphology, apoptosis and DNA damage. Biology Chemistry, v. 387, n.1, p. 87-93, 2006. REEN, K. R.; WIEBEL, J. F.; SINGH, J. Piperine inhibits aflatoxin B1-induced cytotoxicity and and genotoxicity in V79 Chinese hamster cells genenetically engineered to express rat cytochrome P4502B1. Journal of Ethnopharmacology. v.58, p.165-173, 1997. REEN, R. K.; JAMWAL, D. S.; TANEJA, S. C.; KOUL, J. L.; DUBEY, R. K.; WIEBEL, F. J.; SINGH, J. Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine, Biochemical Pharmacology, v.46, p.229–238, 1993. 80 REEN, R. K.; SINGH, J. In vitro and in vivo inhibition of pulmonary cytochrome P450 activities by piperine, a major ingredient of piper species, Indian Journal of Experimental Biology, v. 29: p.568–573,1991. REEN, R. K.; ROESCH, S. F.; KIEFER, F.; WIEBEL, F. J.; SINGH J. Piperine Impairs Cytochrome P4501A1 Activity by Direct Interaction with the Enzyme and Not by Down Regulation of CYP1A1 Gene Expression in the Rat Hepatoma 5L Cell Line. Biochemical and Biophysical Research Communications, v. 218, p. 562–569, 1996. RIBEIRO, L. R.; SALVADORI, D. M. F.; MARQUES, E. K. In: Mutagênese Ambiental. Editora da ULBRA. Canoas-RS., p. 247-271, 2003, 356p. RIBEIRO, T. S.; LIMA, L. F.; PREVIATO, J. O.; PREVIATO, L. M.; HEISE, N.; LIMA, M. L. F. Toxic effects of natural piperine and its derivatives on epimastigotes and amastigotes of Trypanosoma cruzi. Bioorganic and Medicinal Chemistry, v. 14, p. 3555-3558, 2004. RODRIGUEZ-AMAYA, D. B.; SABINO, M. Micotoxin research in Brazil: the decade in review. Brazilian Journal of Microbiology, v. 33, p. 1-11, 2002. ROSMANINHO, J. F., OLIVEIRA, C. A. F., BITTENCOURT, A. B. F. Efeitos das Micotoxicoses Crônicas na Produção Avícola. Arquivo do Instituto Biológico, São Paulo, v.68, n.2, p.107-114, jul./dez., 2001. ROSTAGNO, H. S. Tabelas Brasileiras para Aves e Suínos. Composição de alimentos e exigências nutricionais. 2ª ed. Viçosa, Minas Gerais – Brasil, 2005. RUSTOM, I. Y. S. Aflatoxin in food and feed: occurrence, legislation and inactivation by physical methods. Food Chemistry, v. 59, n. 1, p. 57-67, 1997. SABINA, E. P.; NAGAR, S.; RASOOL, M. A role of piperine on monosodium urate crystal-induced inflammation-an experimental model of gouty arthritis. Inflammation, Asian Pacific Journal of Tropical Medicine, p.971-976, 2010. SABINO, M. Aflatoxinas B1, M1 e Aflatoxicol: extração, caracterização em tecidos e urina, [Tese]. Ciências do Alimento, Faculdade de Ciências Farmacêuticas, Universidade de São Paulo, 1990. SABINO, M. Variações de níveis de aflatoxina B1 em alimentos, rações animais no período de 1971 a 1979. Instituto Adolfo Lutz, v. 40, n.2, p. 153-158, 1980. SALWA, A. A.; ANWER, W. Effect of naturally contaminated feed with aflatoxins on performance of laying hens and the carryover of aflatoxin B1 residues in table eggs. Pakistan Journal of Nutrition, v. 8, p.181-186, 2009. SANTIN, E. Micotoxicoses. In: BERCHIERI JÚNIOR, A.; MACARI, M. Doenças das aves. Campinas: FACTA, p. 379-388, 2000. 81 SANTURIO, J. M. Micotoxicoses e micotoxinas na avicultur. Revista Brasileira de Ciência Avícola, v.2, n. 1, p. 1-12, 2000. SCHAEFFER, J. L.; HAMILTON, P. B. Interations of mycotoxins with feed ingredients. Do safe levels exist? In: SMITH, J. E.; HENDENSON, R. S., Mycotoxins and Animal Foods. CRC Press, Boca Raton, Fl, p.827-43, 1991. SCHMITD, E. M. S.; LOCATELLI-DITTRICH, R.; SANTIN, E.; PAULILO, A. C. Patologia clínica em aves de produção- uma ferramenta para monitorar a sanidade avícola-Revisão. Archives of Veterinary Science, v. 12, n. 3, p. 9-20, 2007. SELVENDIRAN, K.; BANU, S. M.; SAKTHISEKARAN, D. Protective effect of piperine on benzo(a)pyrene-induced lung carcinogenesis in Swiss albino mice. Clinica Chimica Acta, v. 350, p. 73–78, 2004. SELVENDIRAN, K.; SAKTHISEKARAN, D. Chemopreventive effect of piperine on modulating lipid peroxidation and membrane bound enzymes in benzo(a)pyrene induced lung carcinogenesis. Biomedicine and Pharmacotherapy, v. 58, p. 264–267, 2004. SELVENDIRAN, K.; BANU, S. M.; SAKTHISEKARAN, D. Oral supplementation of piperine leads to altered phase II enzymes and reduced DNA damage and DNA-protein cross links in benzo(a)pyrene induced experimaental lung carcinogenesis. Molecular and Cellular Biochemistry, v.268, n.1-2, p.141-147, 2005a. SELVENDIRAN, K.; THIRUNAVUKKARASU, C.; SINGH, J. P.; PADMAVATHI, R.; SAKTHISEKARAN, D. Chemopreventive effect of piperine on mitochondrial TCA cycles and phase-I and GSH-metabolizing enzymes in benzo(a)pyrene induced lung carcinogenesis in Swiss albino mice. Molecular and Cellular Biochemistry. v. 271, n. 1-2, p. 101-106, 2005 b. SHEN, H.; SHI, C.; SHEN, Y.; ONG, C. Detection of elevated reactive oxygen species level in cultured rat hepatocytes treated with aflatoxin B1. Free Radical Biology and Medicine, v. 21, n. 2, p.139-146, 1996. SHOBA, G.; JOY, D.; JOSEPH, T.; MAJEED, M.; RAJENDRAN, R.; SRINIVAS, P.S.S.R. Influence of piperine on pharmacokinetics of curcumin in animals and human volunteers. Planta Medica, v. 64, p. 353-356, 1998. SIDDIQUI, B. S. et al. An amide from fruits of Piper nigrum. Phytochemistry, v.45, v.8, p. 1617-1619, 1997 SINGH, J.; DUBEY, R. K.; ATAL, C. K. Piperine-mediated inhibition of glucuronidation activity in isolated epithelial cells of the guinea-pig small intestine: evidence that piperine lowers the endogeneous UDP-glucuronic acid content. Journal of Pharmacology and Experimental Therapeutics, v. 236, p.488–493, 1986. SINGH, J.; REEN, R. K.; WIEBEL, F. J. Piperine, a major ingredient of black and long pepper, protects against AFB1-induced cytotoxity and micronuclei formation in H4IIEC3 rat hepatoma cells. Cancer Letter, v. 86, n.2, p. 195-200, 1994. 82 SINGH, N. P.; MCCOY, M. T.; TICE, R. R.; SCHNEIDER, E. L. A simple technique for quantitation of low levels of DNA damage in individual cells. Experimental Cell Research, n. 175. p. 184-191. 1988. SINGH, Y. N. Kava an overview. Journal of Ethnopharmacology, v. 37, p.18-45, 1992. SOARES, L. M. V.; RODRIGUEZ-AMAYA, D. B. survey of aflatoxins, ochratoxins A, zearalenona and sterigmatocystin in some Brazilian foods by multitoxin thin layer chromatographic method. Journal of the Association of Analytical Chemists, v. 72, p. 22-26, 1989. SOTOMAYOR, R. E.; WASHINGTON, M.; NGUYEN, L.; NYANG’ANYI, R.; HINTON, D. M.; CHOU, M. Effects of Intermittent Exposure to Aflatoxin B1 on DNA and RNA Adduct Formation in Rat Liver: Dose-Response and Temporal Patterns. Toxicological Sciences, v.73, p. 329–338, 2003. SOUZA, T. S.; FONTANETTI, C. S. Micronuleus test and observation of nuclear alterations in erythrocytes of Nile tilapia exposed to waters affected by refinery effluent. Mutation Research, p. 87-93, v. 605, 2006. SRINIVASAN, K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Critical Reviews in Food Science and Nutrition, v. 47, p. 735–748, 2007. STICH, H. F.; SAN, R. H.; ROSIN, M. P. Adaptation of the DNA-repair and micronuleus test to human cell suspensions and exfoliated cells. American New York Academic Science, 407, p. 93-105, 1983. SUNILA, E. S.; KUTTAN, G. Immunomodulatory and antitumor activity of Piper longum Linn.and piperine. Journal of Ethnopharmacology, v.90, p 339–346, 2004. SURESH, D.; SRINIVASAN, K. Tissue distribution and elimination of capsaicin, piperine and curcumin following oral intake in rats. Journal of Medicine Research, v. 131, p. 682-691, 2010. TESSARI, E. N. C; CARDOSO, A. L. S. P. Aflatoxina em frangos de corte. 2008. Artigo em Hypertexto. Disponível em: <http://www.infobibos.com/Artigos/2008_3/aflatoxina/index.htm>. TESSARI, E. N. C.; OLIVEIRA C. A. F.; CARDOSO, A. L. S. P.; LEDOUX, D. R.; ROTTINGHAUS, G. E. Parâmetros hematológicos de frangos de corte alimentados com ração contendo aflatoxina B1 e fumonisina B1. Ciência Rural, v. 36, n. 3, Santa Maria, June, 2006. 83 TESSARI, E. N. C.; OLIVEIRA, C. A. F.; CARDOSO, A. L. S. P.; LEDOUX, D. R.; ROTTINGHAUS, G.E. Efeitos da aflatoxina B1 e fumonisina B1 sobre os níveis séricos de Aspartato amino-transferase e proteína total de frangos de corte. Arquivos do Instituto de Biologia, São Paulo, v.72, n.2, p.185-189, 2005. THRALL, M. A.; BAKER, D.C.; CAMPBELL, T. W.; DENICOLA, D.; FETTMAN, M.J.; LASSEN, E. D.; REBAR, A.; WEISER, G. Hematologia e Bioquímica Veterinária, 1ª edição, Editora ROCA, 2007. 592p. THRALL, M. A. Veterinary Hematology and Clinical Chemistry. Philadelphia, Lippincott, Williams and Wilkins, 2004. 518p. TICE, R. R.; AGURELL, E.; ANDERSON, D.; BURLINSON, B.; HARTMANN, A.; KOBAYASHI, H.; MIYAMAE, Y.; ROJAS, E.; RYU, J. C.; SASAKI, Y.F. Single cell gel/Comet Assay: guidelines for in vitro and in vivo genetic toxicology testing. Environmental and Molecular Mutagenesis, n. 35, p. 206-21, 2000. TUNG, H. T.; COOK, F. W.; WYATT, R. D.: HAMILTON, P. B. The anemia caused by aflatoxin. Poultry Science, v. 54, p. 1962-1969, 1975. UDROIU, I. The micronucleus test in piscine erythrocytes. Aquatic Toxicology, v. 79, p. 201–204, 2006. UNNIKRISHNAN, M. C.; KUTTAN, R. Tumor reducing and anticarcinogenic activity of selected spices, Cancer Letters, v.51, p.85–89, 1990. VAN DER OOST, R.; BEYER, J.; VERMEULEN, N. P. E., Review article Fish bioaccumulation and biomarkers in environmental risk assessment: a review, Environmental Toxicology Pharmacology, Amsterdam, v. 13, p. 57-149, 2003. VIJAYAKUMAR, R. S.; SURYA, D.; NALINI, N. Antioxidant efficacy of black pepper (Piper nigrum L.) and piperine in rats with high fat diet induced oxidative stress, Redox Report, v. 9, p. 105–110, 2004. VIRINDER, S. P.; SUBASH, C. J.; KIRPAL, S. B.; RAJANI, J. Phytochemistry of genus Piper. Phytochemistry, v. 46, p.597-673, 1997. WANG, J.; GROOPMAN, J.D. DNA damage by mycotoxins. Mutation Research, v.424, p.167-181, 1999. WILD, C. O.; TURNER, P. C. The toxicology of aflatoxins as a basis for public health decisions. Mutagenese, v. 17, n. 6, p. 471-481, 2002. WILD, C. P.; Dietary intake of aflatoxins and the level of albumin-bound aflatoxin in peritpheral blood in The Gambia, West. Africa. Cancer Epidemiology Biomarkers Previews, v. 1, n. 3, p. 229-234, 1992. 84 WILLIAMS, J. H.; PHILLIPS, T. D.; JOLLY, P. E.; STILES, J. K.; JOLLY, C. M.; AGGARWAL, D. Human aflatoxicosis in developing countries: a review of toxicology, exposure, potencial health consequences, and interventions. American Journal of Clinical Nutrition, v. 80, n.5, p. 1106-1122, 2004. WINTROBE, M. M. Variations in the size and hemoglobin content of eritrocytes in the blood of various vertebrates. Folia Haematologica. Internationales Magazin fur Slutforschung, Leipzig, v. 51, p. 31, 1933. WOLF, T; LUEPKE, N. P. Formation of micronuclei inincubated hen’s eggs as a measure of Genotoxicity, Mutation Research, v.394, p 163–175,1997. WYATT, R. D. Poultry. In: SMITH, J. E.;HENDENSON R.S., ed. Mycotoxins and Animal Foods. CRC Press, Boca Raton, Fl., p. 553-605 1991. YENER, Z.; CELIK, I.; ILHAN, F.; BAL, R. Effects of Urtica dioica L. seed on lipid peroxidation, antioxidants and liver pathology in aflatoxin-induced tissue injury in rats. Food and Chemical Toxicology, v. 47, p. 418–424, 2009. YOO, S. A.; YOON, H. J;; KIM, H. S.; CHAE, C.B.; FALCO, S.; CHO, C. S.; KIM, W. U. Role of placenta growth factor and its receptor flt-1 in rheumatoid inflammation: A link between angiogenesis and inflammation. Arthritis and Rheumatism, v.60, p. 345-354, 2009. YU, J.; CLEVELAND, T. E.; NIEMAN, W. C.; BENNETT, J. W. Aspergillus flavusgenomics: gateway to human and animal health, food safety, and crop resistance to diseases Revista Iberoamericana de Micologia v. 22, p.194-202, 2005. ZIRINGUE-JUNIOR, H. J.; BHATNAGAR, D.; CLEVELAND, T. E. C15H24 volatile comounds unique to aflatoxigenic strains of Aspergillus flavus. Applied Environmental Microbiology, v. 59, p. 2264-2270, 1993. | por |
| dc.subject.cnpq | Medicina Veterinária | por |
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