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dc.contributor.authorAnjos, Bruno Leite dos
dc.date.accessioned2023-12-21T18:43:05Z-
dc.date.available2023-12-21T18:43:05Z-
dc.date.issued2010-08-17
dc.identifier.citationAnjos, Bruno Leite dos. Doença do armazenamento lisossomal causada pela ingestão espontânea de Sida carpinifolia em cervos Sambar (Cervus unicolor) cativos no Rio de Janeiro.. 2010. 76 f. Tese (Doutorado em Ciências Veterinárias) - Instituto de Veterinária, Universidade Federal Rural do Rio de Janeiro, Seropédica, 2010.por
dc.identifier.urihttps://rima.ufrrj.br/jspui/handle/20.500.14407/9719-
dc.description.abstractCasos de doenças induzidas por plantas tóxicas em herbívoros domésticos são bastante relatados por todo o mundo e vêm sendo estudados também no Brasil. Pouco se sabe, contudo, sobre os aspectos epidemiológicos e patológicos dessas condições em animais selvagens de vida livre ou criados em cativeiro. Os riscos de desenvolvimento dessas toxicoses em cativeiros vêm aumentando, conforme os habitats naturais são destruídos pela ação humana, e mais centros de conservação de vida silvestre e zoológicos são criados. Nesse estudo são descritos os aspectos epidemiológicos, biológicos e clinicopatológicos, lectinohistoquímicos e ultraestruturais de um surto de doença do armazenamento lisossomal de oligossacarídeos induzido pela ingestão de Sida carpinifolia em cervos Sambar jovens (Cervus unicolor) no zoológico da Fundação Rio-Zoo no Estado do Rio de Janeiro. Nove cervos apresentaram sinais clínicos neurológicos caracterizados por déficits proprioceptivo e motor. Os sinais neurológicos incluíram principalmente depressão, incoordenação, dismetria, ataxia, membros em base ampla, tremores musculares, perda do tônus lingual, quedas frequentes e morte. Macroscopicamente foram observados hematomas, secundários a traumas provocados por machos dominantes do rebanho, e estriações esbranquiçadas, principalmente no córtex renal. As lesões histológicas incluíam acentuada tumefação/vacuolização citoplasmática especialmente em neurônios, pâncreas exócrino, células foliculares da tireoides e do epitélio renal, necrose neuronal com evolução para lise e esferoides axonais. Pelo exame lectino-histoquímico os vacúolos eram formados por acúmulo de oligossacarídeos marcado especialmente pelas lectinas S-WGA, WGA e Con-A. Ultraestruturalmente, a tumefação/vacuolização citoplasmática correspondeu à intensa distensão de lisossomos, formação de corpos residuais densos ou granulares, fragmentos de membranas e corpos mielinoides. O estudo demonstrou a suscetibilidade de Cervus unicolor à swainsonina contida na S. carpinifolia. Possivelmente, a intoxicação nos animais deste estudo ocorreu pela restrição alimentar sofrida pelos animais mais jovens, decorrente da hierarquia entre machos no grupo. Pôde-se determinar ainda a marcada similaridade do quadro clínico e patológico entre os cervos descritos nesse trabalho e outros herbívoros domésticos.por
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico - CNPqpor
dc.formatapplication/pdf*
dc.languageporpor
dc.publisherUniversidade Federal Rural do Rio de Janeiropor
dc.rightsAcesso Abertopor
dc.subjectglycoproteinseng
dc.subjectlysosomal storage diseaseeng
dc.subjectneuropathologyeng
dc.subjectpoisoning plantseng
dc.subjectSida carpinifoliaeng
dc.subjectswainsonineeng
dc.subjectCervus unicolorpor
dc.subjectdoença do armazenamento lisossomalpor
dc.subjectglicoproteínaspor
dc.subjectneuropatologiapor
dc.subjectplantas tóxicaspor
dc.subjectSida carpinifoliapor
dc.subjectswainsoninapor
dc.titleDoença do armazenamento lisossomal causada pela ingestão espontânea de Sida carpinifolia em cervos Sambar (Cervus unicolor) cativos no Rio de Janeiro.por
dc.title.alternativeLysosomal storage disease caused by spontaneous ingestion of Sida carpinifolia in captive-Sambar deer (Cervus unicolor) in Rio de Janeiro State, Brazil.eng
dc.typeTesepor
dc.description.abstractOtherCases of diseases induced by toxic plants in domestic herbivores are well reported throughout the world and have been studied also in Brazil. However, not much is known about the epidemiological and pathological aspectos of these conditions in free-living wildlife or bred in captivity. The risk for developing the toxicoses in captivity has been increasing, since natural habitats are destroyed by human action, and more centers of wildlife conservation and zoological comes are created. This study describes the epidemiological, biological and clinicopathological, lectin-histochemical and ultrastructural aspects of an outbreak of lysosomal storage disease of oligosaccharides induced by ingestion of Sida carpinifolia in young Sambar deer (Cervus unicolor) in the Rio-Zoo Foundation in the State of Rio de Janeiro, Brazil. Nine deer showed neurological signs characterized by motor and proprioceptive deficits. Then neurological signs were mainly depression, incoordination, dysmetria, ataxia, broad-based members, muscle tremors, loss of tongue tone, frequent falls and death. Grossly hematomas were observed secondary to trauma caused by dominant males of the flock, and whitish striations, especially in the renal cortex. Histologic changes included marked swelling/cytoplasmic vacuolization especially in neurons, progressing to neuronal lysis and axonal spheroids, in exocrine pancreas, thyroid follicular cells and renal tubular epithelial cells. In the lectin-histochemical examination the vacuoles were formed by the accumulation of oligosaccharides specially marked by the lectins WGA, WGA and Con-A. Ultrastructurally, the swelling/vacuolation corresponded to intense cytoplasmic distention of lysosomes, formation of residual bodies or dense granular fragments of membranes and mielinoides bodies. The study has shown the susceptibility of Cervus unicolor to swainsonine by ingestion of S. carpinifolia. Possibly poisoning the animals in this study was conducted by food restriction by the hierarchy among males in the group. It might also determine the marked similarity between clinical and pathological aspects in Sambar deer with the one presented by other herbivores.eng
dc.contributor.advisor1Peixoto, Paulo Fernando de Vargas
dc.contributor.advisor1ID270.761.210-34por
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/3002512195318611por
dc.contributor.advisor-co1França , Ticiana do Nascimento
dc.contributor.referee1Tokarnia, Carlos Hubinger
dc.contributor.referee2Dobereiner, Juger
dc.contributor.referee3Carvalho, Eulógio Carlos Queiróz
dc.contributor.referee4Varaschin, Mary Susan
dc.creator.ID043.110.324-04por
dc.creator.Latteshttp://lattes.cnpq.br/0047274636775859por
dc.publisher.countryBrasilpor
dc.publisher.departmentInstituto de Veterináriapor
dc.publisher.initialsUFRRJpor
dc.publisher.programPrograma de Pós-Graduação em Ciências Veterináriaspor
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