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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Gregori, Stefani Rosario | |
| dc.date.accessioned | 2023-12-21T18:45:58Z | - |
| dc.date.available | 2023-12-21T18:45:58Z | - |
| dc.date.issued | 2022-08-01 | |
| dc.identifier.citation | GREGORI, Stefani Rosario. Morfología, remodelación tisular y angiogénesis en placentas de yeguas mestizas. 2022. 141 f. Tese (Doutorado em) - Universidade Federal Rural do Rio de Janeiro, 2022. | por |
| dc.identifier.uri | https://rima.ufrrj.br/jspui/handle/20.500.14407/9851 | - |
| dc.description.abstract | La placenta forma la interfase entre el feto y la madre, siendo un factor determinante y una fuente de moléculas de señalización para mantener un ambiente propicio y lograr una preñez exitosa. Estas funciones son posibles gracias a la formación de una extensa red vascular desde el endometrio hacia la placenta, denominado angiogénesis. La placenta equina se clasifica histológicamente como epiteliocorial microcotiledonaria difusa y adecidua. El objetivo de este estudio fue describir la morfología placentaria, desarrollo tisular y expresión de factores angiogénicos en yeguas. Para ello se utilizaron 15 yeguas mestizas sanas de la región central Argentina y se obtuvieron los úteros gestantes. Los tercios de preñez se determinaron como primer tercio (0 al 120 día de gestación), segundo tercio (120 a los 240 días) y tercer tercio (240 días al parto). Las muestras de interfase materno fetal y copas endometriales fueron destinadas al análisis estructural y ultraestructural, estudio inmunohistoquímico de los principales factores angiogénicos y hormona gonadotrofina coriónica equina, evaluación de la remodelación celular placentaria y estudio histomorfométrico de los vasos sanguíneos. En la gestación temprana el epitelio luminal del endometrio se encontró formado por células cúbicas con formación de pliegues endometriales poco profundos y glándulas en la superficie apical del endometrio materno. A medida que avanza la gestación, se van formando surcos endometriales más profundos que se corresponden físicamente con las proyecciones coriónicas desarrolladas del lado fetal. A partir del día 60 continúa el proceso de plegamiento en vellosidades secundarias y terciarias hasta la formación de microcotiledones organizados (unidad primaria de intercambio hemotrófico) desde el día 100 hasta el día 240 de gestación. A partir del segundo tercio de preñez la capa de células coriónicas de las vellosidades se halló más delgada, permitiendo el reconocimiento de abundantes capilares inmersos en el escaso tejido conectivo que los sostiene, inmediatamente debajo de los epitelios coriónico y endometrial, confirmado por MOAR y por TEM. Los resultados de apoptosis celular junto con una importante actividad mitótica durante el periodo temprano de la preñez, evidencian una activa remodelación tisular, proceso indispensable en la gestación equina, ya que antes de la implantación y previo a la formación de los microcotiledones la nutrición del embrión es histotrófica. La presencia en este órgano de los factores angiogénicos como VEGF, Ang-2 y sus receptores Flk-1 y Tie-2 indican que actuarían complementariamente en el desarrollo vascular, ejercerían su acción en sinergismo y serian una parte esencial de las vías de señalización celular paracrina y autocrina sobre las células endoteliales de los capilares, favoreciendo su crecimiento y estrecha ubicación hacia la superficie epitelial, disminuyendo la distancia interhemal. El estudio histomorfométrico nos permitió identificar que el aumento del área y perímetro vascular de la placenta sumado a la ausencia de inmunomarcación del sistema VEGF/Ang y sus receptores en los endotelios al final de la gestación evidencia que no hay nueva formación de vasos durante este periodo y sumado a un mantenimiento de la inmunomarcación moderada de los factores angiogénicos en las glándulas endometriales, afirma el protagonismo de las mismas en asumir el dominio en la conducción del desarrollo y crecimiento capilar tanto fetal como materno, que se daría en las etapas finales de la gestación. Se determinó que existe muerte por apoptosis en las células trofoblásticas especializadas de las copas endometriales durante todo su desarrollo y cabe resaltar que es el primer estudio en describir y profundizar la angiogénesis en placentas equinas. | por |
| dc.description.sponsorship | CONICET | por |
| dc.format | application/pdf | * |
| dc.language | por | por |
| dc.publisher | Universidade Federal Rural do Rio de Janeiro | por |
| dc.rights | Acesso Aberto | por |
| dc.subject | placenta | por |
| dc.subject | angiogênese | por |
| dc.subject | produção equina | por |
| dc.title | Morfología, remodelación tisular y angiogénesis en placentas de yeguas mestizas | por |
| dc.type | Tese | por |
| dc.description.abstractOther | The placenta forms the interface between the embryo/fetus and the mother, being a determining factor and a source of signaling molecules to maintain a favorable environment and achieve a successful pregnancy. These functions are possible through the formation of an extensive vascular network from endometrium to placenta, term angiogenesis. The equine placenta is classified histologically as diffuse and adeciduate microcotyledonary epitheliochorial. The aim of this study was to describe the placental morphology, tissue development and expression of angiogenic factors in mares. 15 healthy crossbreed mares from the central Argentina region were used and the pregnant uterus were obtained. Pregnancy thirds were determined as first third (0 to 120 days of gestation), second third (120 to 240 days) and third third (240 days to delivery). The samples from the maternal-fetal interface and endometrial cups were used for structural and ultrastructural analysis, immunohistochemical study of the main angiogenic factors and equine chorionic gonadotrophin hormone (eCG), evaluation of placental cell remodeling, and histomorphometric study of blood vessels. In early gestation, the luminal epithelium of the endometrium was found to be formed by cuboidal cells with the formation of shallow endometrial folds and glands on the apical surface of the maternal endometrium. As the pregnacy progresses, deeper endometrial sulci form that physically correspond to the developed chorionic projections on the fetal side. From day 60, the folding process in secondary and tertiary villi continues until the formation of organized microcotyledons (primary unit of hemotrophic exchange) from day 100 to day 240 of gestation. From the second third of pregnancy, the chorionic cell layer of the villi was found to be thinner, allowing the recognition of abundant capillaries immersed in the scarce connective tissue that supports them, immediately below the chorionic and endometrial epithelia, confirmed by MOAR and by TEM. The results of cell apoptosis together with an important mitotic activity during the early period of pregnancy, show an active tissue remodeling, an essential process in equine gestation, since before implantation and prior to the formation of microcotyledons, the nutrition of the embryo it is histotrophic. The presence in this organ of angiogenic factors such as VEGF, Ang-2 and their Flk-1 and Tie-2 receptors indicate that they would act complementary in vascular development, would exert their action in synergy and they would be an essential part of the paracrine and autocrine cell signaling pathways on the endothelial cells of the capillaries, favoring their growth and close location towards the epithelial surface, reducing the interhemal distance. The histomorphometric study allowed us to identify that the increase in the vascular area and perimeter of the placenta, added to the absence of immunostaining of the VEGF/Ang system and its receptors in the endothelium at the end of gestation, shows that there is no new formation of vessels during this period and added to a maintenance of the moderate immunostaining of the angiogenic factors in the endometrial glands, affirms the protagonism of the same in assuming dominance in the conduction of both fetal and maternal capillary development and growth, which would occur in the final stages of gestation. It was determined that there is death by apoptosis in the specialized trophoblastic cells of the endometrial cups throughout their development and it should be noted that this is the first study to describe and deepen angiogenesis in equine placentas. | eng |
| dc.contributor.advisor1 | Romanini, María Cristina | |
| dc.contributor.advisor1ID | DNI 13.727. | por |
| dc.contributor.advisor-co1 | Rodríguez, Nancy | |
| dc.contributor.advisor-co2 | Almeida, Fernando Queroiz de | |
| dc.contributor.advisor-co2ID | 579.744.627-87 | por |
| dc.creator.ID | DNI 33.814..834 | por |
| dc.publisher.country | Brasil | por |
| dc.publisher.department | Pró-Reitoria de Pesquisa e Pós-Graduação | por |
| dc.publisher.initials | UFRRJ | por |
| dc.publisher.program | Programa de Pós-Graduação em Ciência, Tecnologia e Inovação em Agropecuária | por |
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